The BVdb contains the following variants within the queried genomic coordinates:
Chr7:140753326-140753346


BRAF B-Raf proto-oncogene, serine/threonine kinase

Canonical transcript: NM_004333.6

179 unique variant annotations were identified

Variant ID cDot pDot Consequence Exon Intron Reference Count
7-140453145-A-C c.1790T>G p.Leu597Arg Missense 15/18 - 187
7-140453136-A-T c.1799T>A p.Val600Glu Missense 15/18 - 15115
7-140453136-AC-TT c.1798_1799delinsAA p.Val600Lys Missense 15/18 - 1394
7-140453136-A-C c.1799T>G p.Val600Gly Missense 15/18 - 161
7-140453134-T-C c.1801A>G p.Lys601Glu Missense 15/18 - 626
7-140453139-G-A c.1796C>T p.Thr599Ile Missense 15/18 - 104
7-140453136-AC-CT c.1798_1799delinsAG p.Val600Arg Missense 15/18 - 476
7-140453135-CA-GT c.1799_1800delinsAC p.Val600Asp Missense 15/18 - 418
7-140453146-G-C c.1789C>G p.Leu597Val Missense 15/18 - 154
7-140453130-G-T c.1805C>A p.Ser602Tyr Missense 15/18 - 8
7-140453132-T-G c.1803A>C p.Lys601Asn Missense 15/18 - 139
7-140453132-T-A c.1803A>T p.Lys601Asn Missense 15/18 - 157
7-140453145-AG-GA c.1789_1790delinsTC p.Leu597Ser Missense 15/18 - 104
7-140453137-C-T c.1798G>A p.Val600Met Missense 15/18 - 249
7-140453145-A-T c.1790T>A p.Leu597Gln Missense 15/18 - 169
7-140453146-G-T c.1789C>A p.Leu597Ile Missense 15/18 - 5
7-140453132-TTTCA-AT c.1799_1803delinsAT p.Val600_Lys601delinsAsp MultiAAMissense 15/18 - 2
7-140453132-ATTT-A c.1801_1803del p.Lys601del InFrameDeletion 15/18 - 36
7-140453136-A-G c.1799T>C p.Val600Ala Missense 15/18 - 102
7-140453135-C-T c.1800G>A p.Val600Val Synonymous 15/18 - 35
7-140453133-T-G c.1802A>C p.Lys601Thr Missense 15/18 - 29
7-140453135-C-G c.1800G>C p.Val600Val Synonymous 15/18 - 27
7-140453135-C-A c.1800G>T p.Val600Val Synonymous 15/18 - 32
7-140453134-TTCA-T c.1799_1801del p.Val600_Lys601delinsGlu MultiAAMissense 15/18 - 42
7-140453137-C-CTGTTGT c.1797_1798insACAACA p.Thr599_Val600insThrThr InFrameInsertion 15/18 - 16
7-140453137-C-A c.1798G>T p.Val600Leu Missense 15/18 - 63
7-140453133-T-C c.1802A>G p.Lys601Arg Missense 15/18 - 21
7-140453135-CA-AT c.1799_1800delinsAT p.Val600Asp Missense 15/18 - 193
7-140453128-G-A c.1807C>T p.Arg603* Nonsense 15/18 - 29
7-140453132-T-C c.1803A>G p.Lys601Lys Synonymous 15/18 - 12
7-140453139-G-C c.1796C>G p.Thr599Arg Missense 15/18 - 47
7-140453134-T-G c.1801A>C p.Lys601Gln Missense 15/18 - 41
7-140453147-A-C c.1788T>G p.Gly596Gly Synonymous 15/18 - 3
7-140453130-G-A c.1805C>T p.Ser602Phe Missense 15/18 - 9
7-140453143-C-T c.1792G>A p.Ala598Thr Missense 15/18 - 14
7-140453147-A-T c.1788T>A p.Gly596Gly Synonymous 15/18 - 3
7-140453147-A-G c.1788T>C p.Gly596Gly Synonymous 15/18 - 6
7-140453127-C-T c.1808G>A p.Arg603Gln Missense 15/18 - 24
7-140453136-AC-TG c.1798_1799delinsCA p.Val600Gln Missense 15/18 - 22
7-140453137-C-G c.1798G>C p.Val600Leu Missense 15/18 - 61
7-140453136-AC-TA c.1798_1799delinsTA p.Val600* Nonsense 15/18 - 25
7-140453133-T-A c.1802A>T p.Lys601Ile Missense 15/18 - 32
7-140453132-TTTCA-GAGAT c.1799_1803delinsATCTC p.Val600_Lys601delinsAspLeu MultiAAMissense 15/18 - 1
7-140453138-TG-AGGGA c.1796_1797delinsTCCCT p.Thr599delinsIlePro MultiAAMissense 15/18 - 2
7-140453135-CAC-AAA c.1798_1800delinsTTT p.Val600Phe Missense 15/18 - 19
7-140453138-CTGT-C c.1795_1797del p.Thr599del InFrameDeletion 15/18 - 11
7-140453140-T-C c.1795A>G p.Thr599Ala Missense 15/18 - 14
7-140453139-GT-TC c.1795_1796delinsGA p.Thr599Glu Missense 15/18 - 8
7-140453133-TT-AG c.1801_1802delinsCT p.Lys601Leu Missense 15/18 - 9
7-140453142-G-A c.1793C>T p.Ala598Val Missense 15/18 - 38
7-140453131-A-C c.1804T>G p.Ser602Ala Missense 15/18 - 3
7-140453140-T-TAAC c.1794_1795insGTT p.Ala598_Thr599insVal InFrameInsertion 15/18 - 13
7-140453138-T-C c.1797A>G p.Thr599Thr Synonymous 15/18 - 12
7-140453138-T-A c.1797A>T p.Thr599Thr Synonymous 15/18 - 9
7-140453138-T-G c.1797A>C p.Thr599Thr Synonymous 15/18 - 13
7-140453136-A-ACTGTACCTGCAAGAAAGT c.1798_1799insACTTTCTTGCAGGTACAG p.Thr599_Val600insAspPheLeuAlaGlyThr InFrameInsertion 15/18 - 1
7-140453129-A-C c.1806T>G p.Ser602Ser Synonymous 15/18 - 2
7-140453129-A-G c.1806T>C p.Ser602Ser Synonymous 15/18 - 2
7-140453129-A-T c.1806T>A p.Ser602Ser Synonymous 15/18 - 2
7-140453139-G-GTTGCAAGACCAAAGTTACCCTTCT c.1795_1796insAGAAGGGTAACTTTGGTCTTGCAA p.Ala598_Thr599insLysLysGlyAsnPheGlyLeuAla InFrameInsertion 15/18 - 1
7-140453144-T-C c.1791A>G p.Leu597Leu Synonymous 15/18 - 12
7-140453132-TTT-GATCTC c.1801_1803delinsGAGATC p.Lys601delinsGluIle MultiAAMissense 15/18 - 1
7-140453145-A-G c.1790T>C p.Leu597Pro Missense 15/18 - 15
7-140453134-TCA-AGG c.1799_1801delinsCCT p.Val600_Lys601delinsAla* MultiAAMissense 15/18 - 1
7-140453140-T-A c.1795A>T p.Thr599Ser Missense 15/18 - 3
7-140453135-CAC-ATG c.1798_1800delinsCAT p.Val600His Missense 15/18 - 2
7-140453136-AC-CA c.1798_1799delinsTG p.Val600Trp Missense 15/18 - 1
7-140453144-TAG-ATA c.1789_1791delinsTAT p.Leu597Tyr Missense 15/18 - 1
7-140453130-GA-TC c.1804_1805inv p.Ser602Asp Missense 15/18 - 2
7-140453136-CA-C c.1799del p.Val600Glyfs*50 Frameshift 15/18 - 2
7-140453142-G-T c.1793C>A p.Ala598Asp Missense 15/18 - 1
7-140453136-A-ACTGTAGTCT c.1798_1799insAGACTACAG p.Thr599_Val600insGluThrThr InFrameInsertion 15/18 - 1
7-140453135-CA-AAGTG c.1799_1800delinsCACTT p.Val600delinsAlaLeu MultiAAMissense 15/18 - 2
7-140453131-ATTTCAC-A c.1798_1803del p.Val600_Lys601del InFrameDeletion 15/18 - 2
7-140453145-AG-TT c.1789_1790delinsAA p.Leu597Lys Missense 15/18 - 3
7-140453127-C-A c.1808G>T p.Arg603Leu Missense 15/18 - 6
7-140453131-A-G c.1804T>C p.Ser602Pro Missense 15/18 - 3
7-140453141-A-T c.1794T>A p.Ala598Ala Synonymous 15/18 - 10
7-140453141-A-G c.1794T>C p.Ala598Ala Synonymous 15/18 - 10
7-140453141-A-C c.1794T>G p.Ala598Ala Synonymous 15/18 - 7
7-140453138-TG-CA c.1796_1797inv p.Thr599Met Missense 15/18 - 1
7-140453136-AC-GT c.1798_1799inv p.Val600Thr Missense 15/18 - 1
7-140453135-CA-TT c.1799_1800delinsAA p.Val600Glu Missense 15/18 - 20
7-140453138-TGT-GTC c.1795_1797delinsGAC p.Thr599Asp Missense 15/18 - 2
7-140453140-T-TTAC c.1794_1795insGTA p.Ala598_Thr599insVal InFrameInsertion 15/18 - 5
7-140453142-G-C c.1793C>G p.Ala598Gly Missense 15/18 - 1
7-140453139-G-T c.1796C>A p.Thr599Lys Missense 15/18 - 6
7-140453136-A-ACTGTTGCAAGACCAAAGT c.1798_1799insACTTTGGTCTTGCAACAG p.Asp594_Thr599dup InFrameInsertion 15/18 - 12
7-140453143-C-CTGT c.1791_1792insACA p.Leu597_Ala598insThr InFrameInsertion 15/18 - 1
7-140453144-T-A c.1791A>T p.Leu597Leu Synonymous 15/18 - 10
7-140453144-T-G c.1791A>C p.Leu597Leu Synonymous 15/18 - 7
7-140453146-G-A c.1789C>T p.Leu597Leu Synonymous 15/18 - 14
7-140453139-G-GTCC c.1795_1796insGGA p.Ala598_Thr599insArg InFrameInsertion 15/18 - 1
7-140453136-A-AAAT c.1798_1799insATT p.Val600delinsAspLeu MultiAAMissense 15/18 - 1
7-140453126-TCG-CAT c.1807_1809delinsATG p.Arg603Met Missense 15/18 - 1
7-140453132-TTT-ACA c.1801_1803delinsTGT p.Lys601Cys Missense 15/18 - 1
7-140453132-TTT-CCA c.1801_1803delinsTGG p.Lys601Trp Missense 15/18 - 1
7-140453126-TCG-ATA c.1807_1809delinsTAT p.Arg603Tyr Missense 15/18 - 1
7-140453138-TGT-ATA c.1795_1797delinsTAT p.Thr599Tyr Missense 15/18 - 1
7-140453144-TAG-GTC c.1789_1791delinsGAC p.Leu597Asp Missense 15/18 - 2
7-140453144-TAG-CCA c.1789_1791delinsTGG p.Leu597Trp Missense 15/18 - 1
7-140453144-TAG-GTT c.1789_1791delinsAAC p.Leu597Asn Missense 15/18 - 1
7-140453126-TCG-GTT c.1807_1809delinsAAC p.Arg603Asn Missense 15/18 - 1
7-140453129-AGA-CAT c.1804_1806delinsATG p.Ser602Met Missense 15/18 - 1
7-140453129-AGA-CTT c.1804_1806delinsAAG p.Ser602Lys Missense 15/18 - 1
7-140453138-TGT-CCA c.1795_1797delinsTGG p.Thr599Trp Missense 15/18 - 2
7-140453132-TTT-AAA c.1801_1803inv p.Lys601Phe Missense 15/18 - 1
7-140453126-TCG-AAA c.1807_1809delinsTTT p.Arg603Phe Missense 15/18 - 1
7-140453129-AGA-TTG c.1804_1806delinsCAA p.Ser602Gln Missense 15/18 - 1
7-140453138-TGT-ACA c.1795_1797inv p.Thr599Cys Missense 15/18 - 1
7-140453138-TGT-AAA c.1795_1797delinsTTT p.Thr599Phe Missense 15/18 - 1
7-140453135-CAC-GTT c.1798_1800delinsAAC p.Val600Asn Missense 15/18 - 2
7-140453141-AGC-CAT c.1792_1794delinsATG p.Ala598Met Missense 15/18 - 1
7-140453141-AGC-CTT c.1792_1794delinsAAG p.Ala598Lys Missense 15/18 - 1
7-140453141-AGC-CCA c.1792_1794delinsTGG p.Ala598Trp Missense 15/18 - 1
7-140453135-CAC-ATA c.1798_1800delinsTAT p.Val600Tyr Missense 15/18 - 1
7-140453138-TG-GT c.1796_1797delinsAC p.Thr599Asn Missense 15/18 - 1
7-140453144-TAG-ACA c.1789_1791delinsTGT p.Leu597Cys Missense 15/18 - 1
7-140453135-CAC-ACA c.1798_1800delinsTGT p.Val600Cys Missense 15/18 - 1
7-140453129-AGA-CTC c.1804_1806delinsGAG p.Ser602Glu Missense 15/18 - 1
7-140453141-AGC-TTG c.1792_1794delinsCAA p.Ala598Gln Missense 15/18 - 1
7-140453138-TGT-ATG c.1795_1797delinsCAT p.Thr599His Missense 15/18 - 1
7-140453137-C-CCCT c.1797_1798insAGG p.Thr599_Val600insArg InFrameInsertion 15/18 - 1
7-140453136-A-ACTGTAATCT c.1798_1799insAGATTACAG p.Thr599_Val600insGluIleThr InFrameInsertion 15/18 - 1
7-140453142-GC-AA c.1792_1793delinsTT p.Ala598Phe Missense 15/18 - 1
7-140453139-G-GTTA c.1795_1796insTAA p.Ala598_Thr599insIle InFrameInsertion 15/18 - 1
7-140453139-G-GTTGCAAGACCAAAGTCACCGATCTTCT c.1795_1796insAGAAGATCGGTGACTTTGGTCTTGCAA p.Ala598_Thr599insLysLysIleGlyAspPheGlyLeuAla InFrameInsertion 15/18 - 1
7-140453136-A-ACTGTTGTCT c.1798_1799insAGACAACAG p.Thr599_Val600insGluThrThr InFrameInsertion 15/18 - 1
7-140453145-AG-TA c.1789_1790delinsTA p.Leu597* Nonsense 15/18 - 4
7-140453134-T-A c.1801A>T p.Lys601* Nonsense 15/18 - 3
7-140453126-TCG-CCA c.1807_1809delinsTGG p.Arg603Trp Missense 15/18 - 1
7-140453144-TA-AT c.1790_1791delinsAT p.Leu597His Missense 15/18 - 1
7-140453139-G-GTAA c.1795_1796insTTA p.Ala598_Thr599insIle InFrameInsertion 15/18 - 1
7-140453131-A-T c.1804T>A p.Ser602Thr Missense 15/18 - 4
7-140453130-G-C c.1805C>G p.Ser602Cys Missense 15/18 - 1
7-140453129-AGA-TGTGTT c.1804_1806delinsAACACA p.Ser602delinsAsnThr MultiAAMissense 15/18 - 2
7-140453135-CACTGT-AGGGAG c.1795_1800delinsCTCCCT p.Thr599_Val600delinsLeuPro MultiAAMissense 15/18 - 2
7-140453138-T-TGTA c.1794_1796dup p.Thr599dup InFrameInsertion 15/18 - 4
7-140453145-AG-GC c.1789_1790delinsGC p.Leu597Ala Missense 15/18 - 2
7-140453139-G-GTGA c.1795_1796insTCA p.Ala598_Thr599insIle InFrameInsertion 15/18 - 1
7-140453126-ATCG-A c.1807_1809del p.Arg603del InFrameDeletion 15/18 - 1
7-140453137-ACTG-A c.1796_1798del p.Thr599_Val600delinsMet MultiAAMissense 15/18 - 1
7-140453139-G-GTTGCAAGGA c.1795_1796insTCCTTGCAA p.Ala598_Thr599insIleLeuAla InFrameInsertion 15/18 - 1
7-140453137-C-CTGTAGCTTT c.1797_1798insAAAGCTACA p.Thr599_Val600insLysAlaThr InFrameInsertion 15/18 - 2
7-140453129-AGA-TGTGTC c.1804_1806delinsGACACA p.Ser602delinsAspThr MultiAAMissense 15/18 - 1
7-140453133-TT-CC c.1801_1802delinsGG p.Lys601Gly Missense 15/18 - 1
7-140453136-A-ACTGTTGCCT c.1798_1799insAGGCAACAG p.Thr599_Val600insGluAlaThr InFrameInsertion 15/18 - 1
7-140453133-T-TTTACTG c.1801_1802insCAGTAA p.Thr599_Val600dup InFrameInsertion 15/18 - 1
7-140453132-T-TTTTACTGTG c.1802_1803insCACAGTAAA p.Val600_Lys601insAsnThrVal InFrameInsertion 15/18 - 1
7-140453135-TCAC-T c.1798_1800del p.Val600del InFrameDeletion 15/18 - 1
7-140453136-A-ACTGTTGCGATCT c.1798_1799insAGATCGCAACAG p.Thr599_Val600insGluIleAlaThr InFrameInsertion 15/18 - 1
7-140453132-TTTCA-GT c.1799_1803delinsAC p.Val600_Lys601delinsAsp MultiAAMissense 15/18 - 1
7-140453138-TGTA-T c.1794_1796del p.Thr599del InFrameDeletion 15/18 - 4
7-140453135-CAC-GAT c.1798_1800delinsATC p.Val600Ile Missense 15/18 - 3
7-140453132-TTT-CTCCTC c.1801_1803delinsGAGGAG p.Lys601delinsGluGlu MultiAAMissense 15/18 - 1
7-140453143-C-A c.1792G>T p.Ala598Ser Missense 15/18 - 1
7-140453136-AC-TCCCT c.1798_1799delinsAGGGA p.Val600delinsArgGlu MultiAAMissense 15/18 - 3
7-140453139-GT-AC c.1795_1796inv p.Thr599Val Missense 15/18 - 1
7-140453134-TCA-T c.1799_1800del p.Val600Glufs*11 Frameshift 15/18 - 3
7-140453137-C-CTTG c.1797_1798insCAA p.Thr599_Val600insGln InFrameInsertion 15/18 - 1
7-140453136-AC-GA c.1798_1799delinsTC p.Val600Ser Missense 15/18 - 2
7-140453130-GA-AT c.1804_1805delinsAT p.Ser602Ile Missense 15/18 - 1
7-140453126-TCG-ACA c.1807_1809delinsTGT p.Arg603Cys Missense 15/18 - 1
7-140453126-T-C c.1809A>G p.Arg603Arg Synonymous 15/18 - 2
7-140453141-A-AAAC c.1793_1794insGTT p.Ala598_Thr599insPhe InFrameInsertion 15/18 - 1
7-140453126-TCGAGATTTCACTG-GA c.1796_1809delinsTC p.Thr599_Arg603delinsIle MultiAAMissense 15/18 - 1
7-140453137-C-TGTA c.1798delinsTACA p.Val600delinsTyrMet MultiAAMissense 15/18 - 1
7-140453135-CA-AAGGT c.1799_1800delinsACCTT p.Val600delinsAspLeu MultiAAMissense 15/18 - 1
7-140453137-C-CAAT c.1797_1798insATT p.Thr599_Val600insIle InFrameInsertion 15/18 - 1
7-140453139-G-GGTA c.1795_1796insTAC p.Thr599delinsIlePro MultiAAMissense 15/18 - 1
7-140453141-TAGC-T c.1792_1794del p.Ala598del InFrameDeletion 15/18 - 1
7-140453136-A-ACTGTAGCTT c.1798_1799insAAGCTACAG p.Thr599_Val600insGluAlaThr InFrameInsertion 15/18 - 1
7-140453139-TG-T c.1796del p.Thr599Lysfs*2 Frameshift 15/18 - 1
7-140453138-T-TATG c.1796_1797insCAT p.Thr599_Val600insIle InFrameInsertion 15/18 - 1
7-140453136-A-ACTGTAGATTTCT c.1798_1799insAGAAATCTACAG p.Thr599_Val600insGluLysSerThr InFrameInsertion 15/18 - 1
7-140453126-TCGAGATTTCAC-GAGAAGAGCCAA c.1798_1809delinsTTGGCTCTTCTC p.Val600_Arg603delinsLeuAlaLeuLeu MultiAAMissense 15/18 - 1
7-140453128-G-T c.1807C>A p.Arg603Arg Synonymous 15/18 - 1
7-140453126-T-G c.1809A>C p.Arg603Arg Synonymous 15/18 - 1
7-140453126-T-A c.1809A>T p.Arg603Arg Synonymous 15/18 - 1