NRAS NRAS proto-oncogene, GTPase

Canonical transcript: NM_002524

243 unique variant annotations were identified in 883 publications
Gene-Specific Resource Links:
OMIM
Entrez
Ensembl
HGNC
COSMIC
ClinGen
PubMed
GeneReviews
ClinVar
gnomAD v3
gnomAD v2.1
Variant ID cDot pDot Consequence Exon Intron Reference Count
1-115251162-C-A c.564G>T p.Val188Val Synonymous 5/7 - 1
1-115251162-C-G c.564G>C p.Val188Val Synonymous 5/7 - 1
1-115251162-C-T c.564G>A p.Val188Val Synonymous 5/7 - 1
1-115251162-TC-T c.564del p.Met189Cysfs*19 Frameshift 5/7 - 1
1-115251169-C-A c.557G>T p.Cys186Phe Missense 5/7 - 2
1-115251169-C-G c.557G>C p.Cys186Ser Missense 5/7 - 3
1-115251170-A-T c.556T>A p.Cys186Ser Missense 5/7 - 3
1-115251172-GG-AA c.553_554delinsTT p.Pro185Leu Missense 5/7 - 1
1-115251178-CC-AC c.548delinsT p.Gly183Val Missense 5/7 - 1
1-115251179-C-T c.547G>A p.Gly183Arg Missense 5/7 - 1
1-115251183-A-G c.543T>C p.Cys181Cys Synonymous 5/7 - 1
1-115251184-CA-GC c.541_542delinsGC p.Cys181Ala Missense 5/7 - 7
1-115251184-C-G c.542G>C p.Cys181Ser Missense 5/7 - 6
1-115251185-A-T c.541T>A p.Cys181Ser Missense 5/7 - 6
1-115251190-T-C c.536A>G p.Gln179Arg Missense 5/7 - 1
1-115251217-TT-GC c.508_509delinsGC p.Lys170Ala Missense 5/7 - 1
1-115251225-TC-AT c.500_501delinsAT p.Arg167His Missense 5/7 - 1
1-115251234-GC-AA c.491_492delinsTT p.Arg164Leu Missense 5/7 - 2
1-115251236-G-A c.490C>T p.Arg164Cys Missense 5/7 - 1
1-115251244-CT-GC c.481_482delinsGC p.Arg161Ala Missense 5/7 - 2
1-115251249-C-A c.477G>T p.Leu159Leu Synonymous 5/7 - 1
1-115251259-A-G c.467T>C p.Phe156Ser Missense 5/7 - 1
1-115251258-A-C c.468T>G p.Phe156Leu Missense 5/7 - 1
1-115251258-A-T c.468T>A p.Phe156Leu Missense 5/7 - 1
1-115251260-A-G c.466T>C p.Phe156Leu Missense 5/7 - 1
1-115251260-A-T c.466T>A p.Phe156Ile Missense 5/7 - 1
1-115251263-C-T c.463G>A p.Ala155Thr Missense 5/7 - 1
1-115251268-T-A c.458A>T p.Glu153Val Missense 5/7 - 1
1-115251268-T-G c.458A>C p.Glu153Ala Missense 5/7 - 1
1-115251271-A-C c.455T>G p.Val152Gly Missense 5/7 - 1
1-115252202-G-A c.438C>T p.Ala146Ala Synonymous 4/7 - 2
1-115252202-G-C c.438C>G p.Ala146Ala Synonymous 4/7 - 2
1-115252202-G-T c.438C>A p.Ala146Ala Synonymous 4/7 - 2
1-115252203-G-A c.437C>T p.Ala146Val Missense 4/7 - 15
1-115252204-C-A c.436G>T p.Ala146Ser Missense 4/7 - 1
1-115252204-C-G c.436G>C p.Ala146Pro Missense 4/7 - 7
1-115252204-C-T c.436G>A p.Ala146Thr Missense 4/7 - 34
1-115252209-G-A c.431C>T p.Thr144Ile Missense 4/7 - 1
1-115252213-C-T c.427G>A p.Glu143Lys Missense 4/7 - 1
1-115252222-G-A c.418C>T p.Pro140Ser Missense 4/7 - 1
1-115252228-C-G c.412G>C p.Gly138Arg Missense 4/7 - 3
1-115252228-C-T c.412G>A p.Gly138Arg Missense 4/7 - 3
1-115252231-A-T c.409T>A p.Tyr137Asn Missense 4/7 - 1
1-115252236-T-C c.404A>G p.Lys135Arg Missense 4/7 - 1
1-115252239-G-A c.401C>T p.Ala134Val Missense 4/7 - 1
1-115252245-T-C c.395A>G p.Glu132Gly Missense 4/7 - 1
1-115252245-TC-AC c.395delinsT p.Glu132Val Missense 4/7 - 1
1-115252246-C-T c.394G>A p.Glu132Lys Missense 4/7 - 1
1-115252247-G-A c.393C>T p.His131His Synonymous 4/7 - 1
1-115252248-T-C c.392A>G p.His131Arg Missense 4/7 - 10
1-115252255-G-A c.385C>T p.Gln129* Nonsense 4/7 - 1
1-115252255-G-C c.385C>G p.Gln129Glu Missense 4/7 - 1
1-115252260-G-A c.380C>T p.Thr127Ile Missense 4/7 - 1
1-115252272-CT-GC c.367_368delinsGC p.Arg123Ala Missense 4/7 - 1
1-115252280-C-T c.360G>A p.Leu120Leu Synonymous 4/7 - 2
1-115252281-A-C c.359T>G p.Leu120Trp Missense 4/7 - 1
1-115252287-C-T c.353G>A p.Cys118Tyr Missense 4/7 - 2
1-115252287-C-G c.353G>C p.Cys118Ser Missense 4/7 - 2
1-115252288-A-T c.352T>A p.Cys118Ser Missense 4/7 - 2
1-115252289-C-A c.351G>T p.Lys117Asn Missense 4/7 - 18
1-115252289-C-G c.351G>C p.Lys117Asn Missense 4/7 - 19
1-115252290-T-C c.350A>G p.Lys117Arg Missense 4/7 - 2
1-115252294-T-G c.346A>C p.Asn116His Missense 4/7 - 1
1-115252298-CC-C c.344del p.Gly115Glufs*46 Frameshift 4/7 - 1
1-115252310-AGG-TAA c.328_330delinsTTA p.Pro110Leu Nonsense 4/7 - 1
1-115252311-G-A c.329C>T p.Pro110Leu Missense 4/7 - 1
1-115252311-GG-TA c.328_329delinsTA p.Pro110Tyr Missense 4/7 - 1
1-115252312-G-A c.328C>T p.Pro110Ser Missense 4/7 - 1
1-115252312-G-C c.328C>G p.Pro110Ala Missense 4/7 - 5
1-115252317-TC-TG c.322delinsC p.Asp108His Missense 4/7 - 1
1-115252317-T-G c.323A>C p.Asp108Ala Missense 4/7 - 1
1-115256421-C-G c.290G>C p.Arg97Thr Missense 3/7 - 1
1-115256427-A-G c.284T>C p.Leu95Pro Missense 3/7 - 1
1-115256436-T-G c.275A>C p.Asp92Ala Missense 3/7 - 1
1-115256437-C-T c.274G>A p.Asp92Asn Missense 3/7 - 1
1-115256443-AA-A c.270del p.Phe90Leufs*14 Frameshift 3/7 - 2
1-115256463-G-A c.248C>T p.Ala83Val Missense 3/7 - 1
1-115256466-A-G c.245T>C p.Phe82Ser Missense 3/7 - 1
1-115256471-A-G c.240T>C p.Cys80Cys Synonymous 3/7 - 1
1-115256473-A-G c.238T>C p.Cys80Arg Missense 3/7 - 1
1-115256484-T-C c.227A>G p.Glu76Gly Missense 3/7 - 1
1-115256485-C-T c.226G>A p.Glu76Lys Missense 3/7 - 2
1-115256486-CGCCTGTCCTCA-C c.215_225del p.Met72Argfs*11 Frameshift 3/7 - 1
1-115256491-T-C c.220A>G p.Thr74Ala Missense 3/7 - 1
1-115256495-CAT-TGT c.215_216delinsCA p.Met72Thr Missense 3/7 - 1
1-115256497-T-A c.214A>T p.Met72Leu Missense 3/7 - 1
1-115256497-T-G c.214A>C p.Met72Leu Missense 3/7 - 1
1-115256500-A-C c.211T>G p.Tyr71Asp Missense 3/7 - 1
1-115256501-T-A c.210A>T p.Gln70His Missense 3/7 - 1
1-115256504-G-A c.207C>T p.Asp69Asp Synonymous 3/7 - 1
1-115256504-G-C c.207C>G p.Asp69Glu Missense 3/7 - 1
1-115256504-G-T c.207C>A p.Asp69Glu Missense 3/7 - 1
1-115256506-C-A c.205G>T p.Asp69Tyr Missense 3/7 - 1
1-115256506-C-T c.205G>A p.Asp69Asn Missense 3/7 - 2
1-115256508-C-A c.203G>T p.Arg68Ile Missense 3/7 - 1
1-115256508-C-G c.203G>C p.Arg68Thr Missense 3/7 - 2
1-115256508-C-T c.203G>A p.Arg68Lys Missense 3/7 - 2
1-115256513-G-A c.198C>T p.Ala66Ala Synonymous 3/7 - 1
1-115256513-G-C c.198C>G p.Ala66Ala Synonymous 3/7 - 1
1-115256513-GG-AG c.198delinsT p.Ala66Ala Missense 3/7 - 1
1-115256513-G-T c.198C>A p.Ala66Ala Synonymous 3/7 - 1
1-115256514-G-A c.197C>T p.Ala66Val Missense 3/7 - 1
1-115256514-GC-TT c.196_197delinsAA p.Ala66Asn Missense 3/7 - 1
1-115256515-C-G c.196G>C p.Ala66Pro Missense 3/7 - 1
1-115256518-T-A c.193A>T p.Ser65Cys Missense 3/7 - 1
1-115256520-T-C c.191A>G p.Tyr64Cys Missense 3/7 - 1
1-115256521-A-C c.190T>G p.Tyr64Asp Missense 3/7 - 3
1-115256521-A-T c.190T>A p.Tyr64Asn Missense 3/7 - 2
1-115256524-C-T c.187G>A p.Glu63Lys Missense 3/7 - 14
1-115256525-T-C c.186A>G p.Glu62Glu Synonymous 3/7 - 1
1-115256525-TTC-CTTATG c.184_186delinsCATAAG p.Glu62delinsHisLys MultiAAMissense 3/7 - 1
1-115256527-C-A c.184G>T p.Glu62* Nonsense 3/7 - 1
1-115256527-C-G c.184G>C p.Glu62Gln Missense 3/7 - 1
1-115256527-C-T c.184G>A p.Glu62Lys Missense 3/7 - 3
1-115256527-TC-T c.184del p.Glu62Lysfs*6 Frameshift 3/7 - 1
1-115256528-T-A c.183A>T p.Gln61His Missense 3/7 - 163
1-115256528-T-C c.183A>G p.Gln61Gln Synonymous 3/7 - 4
1-115256528-T-G c.183A>C p.Gln61His Missense 3/7 - 169
1-115256528-TT-CC c.182_183delinsGG p.Gln61Arg Missense 3/7 - 1
1-115256528-TTG-AAC c.181_183delinsGTT p.Gln61Val Missense 3/7 - 1
1-115256528-TTG-CTT c.181_183delinsAAG p.Gln61Lys Missense 3/7 - 1
1-115256528-TTG-GAC c.181_183delinsGTC p.Gln61Val Missense 3/7 - 1
1-115256529-T-A c.182A>T p.Gln61Leu Missense 3/7 - 313
1-115256529-T-C c.182A>G p.Gln61Arg Missense 3/7 - 674
1-115256529-T-G c.182A>C p.Gln61Pro Missense 3/7 - 20
1-115256529-TG-AT c.181_182delinsAT p.Gln61Ile Missense 3/7 - 1
1-115256529-TG-CT c.181_182delinsAG p.Gln61Arg Missense 3/7 - 1
1-115256529-TG-GC c.181_182delinsGC p.Gln61Ala Missense 3/7 - 2
1-115256529-TG-GT c.181_182delinsAC p.Gln61Thr Missense 3/7 - 1
1-115256530-G-A c.181C>T p.Gln61* Nonsense 3/7 - 5
1-115256530-G-C c.181C>G p.Gln61Glu Missense 3/7 - 18
1-115256530-G-T c.181C>A p.Gln61Lys Missense 3/7 - 730
1-115256530-GT-TA c.180_181delinsTA p.Gln61Lys Missense 3/7 - 1
1-115256531-T-A c.180A>T p.Gly60Gly Synonymous 3/7 - 2
1-115256532-C-A c.179G>T p.Gly60Val Missense 3/7 - 2
1-115256532-C-T c.179G>A p.Gly60Glu Missense 3/7 - 25
1-115256533-C-T c.178G>A p.Gly60Arg Missense 3/7 - 7
1-115256534-AGC-TAA c.175_177delinsTTA p.Ala59Leu Nonsense 3/7 - 2
1-115256535-G-C c.176C>G p.Ala59Gly Missense 3/7 - 3
1-115256535-GC-TG c.175_176delinsCA p.Ala59His Missense 3/7 - 1
1-115256535-G-T c.176C>A p.Ala59Asp Missense 3/7 - 6
1-115256536-C-A c.175G>T p.Ala59Ser Missense 3/7 - 1
1-115256536-C-T c.175G>A p.Ala59Thr Missense 3/7 - 29
1-115256538-G-A c.173C>T p.Thr58Ile Missense 3/7 - 4
1-115256538-G-C c.173C>G p.Thr58Arg Missense 3/7 - 1
1-115256539-T-C c.172A>G p.Thr58Ala Missense 3/7 - 4
1-115256540-A-C c.171T>G p.Asp57Glu Missense 3/7 - 2
1-115256540-A-T c.171T>A p.Asp57Glu Missense 3/7 - 2
1-115256542-C-T c.169G>A p.Asp57Asn Missense 3/7 - 1
1-115256550-T-C c.161A>G p.Asp54Gly Missense 3/7 - 1
1-115256551-C-T c.160G>A p.Asp54Asn Missense 3/7 - 1
1-115256556-A-C c.155T>G p.Leu52Trp Missense 3/7 - 1
1-115256556-A-G c.155T>C p.Leu52Ser Missense 3/7 - 1
1-115256555-C-T c.156G>A p.Leu52Leu Synonymous 3/7 - 1
1-115256557-A-C c.154T>G p.Leu52Val Missense 3/7 - 1
1-115256557-A-G c.154T>C p.Leu52Leu Synonymous 3/7 - 1
1-115256559-C-T c.152G>A p.Cys51Tyr Missense 3/7 - 1
1-115256562-G-A c.149C>T p.Thr50Ile Missense 3/7 - 17
1-115256565-T-G c.146A>C p.Glu49Ala Missense 3/7 - 1
1-115256566-C-T c.145G>A p.Glu49Lys Missense 3/7 - 2
1-115256569-C-G c.142G>C p.Gly48Arg Missense 3/7 - 1
1-115256571-T-G c.140A>C p.Asp47Ala Missense 3/7 - 3
1-115256573-T-C c.138A>G p.Ile46Met Missense 3/7 - 2
1-115256577-A-G c.134T>C p.Val45Ala Missense 3/7 - 1
1-115256592-TA-GC c.118_119delinsGC p.Tyr40Ala Missense 3/7 - 1
1-115256592-T-C c.119A>G p.Tyr40Cys Missense 3/7 - 2
1-115256595-G-A c.116C>T p.Ser39Phe Missense 3/7 - 2
1-115256598-T-G c.113A>C p.Asp38Ala Missense 3/7 - 2
1-115256599-C-T c.112G>A p.Asp38Asn Missense 3/7 - 1
1-115258669-A-G c.111+2T>C - IntronicSNV - 2/6 1
1-115258672-T-C c.110A>G p.Glu37Gly Missense 2/7 - 4
1-115258672-T-G c.110A>C p.Glu37Ala Missense 2/7 - 1
1-115258673-C-T c.109G>A p.Glu37Lys Missense 2/7 - 1
1-115258677-G-A c.105C>T p.Thr35Thr Synonymous 2/7 - 1
1-115258677-G-C c.105C>G p.Thr35Thr Synonymous 2/7 - 1
1-115258677-G-T c.105C>A p.Thr35Thr Synonymous 2/7 - 1
1-115258678-G-C c.104C>G p.Thr35Ser Missense 2/7 - 3
1-115258679-T-A c.103A>T p.Thr35Ser Missense 2/7 - 3
1-115258679-T-C c.103A>G p.Thr35Ala Missense 2/7 - 1
1-115258681-G-A c.101C>T p.Pro34Leu Missense 2/7 - 3
1-115258682-G-T c.100C>A p.Pro34Thr Missense 2/7 - 1
1-115258683-A-C c.99T>G p.Asp33Glu Missense 2/7 - 2
1-115258683-A-G c.99T>C p.Asp33Asp Synonymous 2/7 - 2
1-115258683-A-T c.99T>A p.Asp33Glu Missense 2/7 - 1
1-115258685-C-T c.97G>A p.Asp33Asn Missense 2/7 - 1
1-115258686-A-G c.96T>C p.Tyr32Tyr Synonymous 2/7 - 1
1-115258687-T-C c.95A>G p.Tyr32Cys Missense 2/7 - 1
1-115258688-A-G c.94T>C p.Tyr32His Missense 2/7 - 1
1-115258689-T-C c.93A>G p.Glu31Glu Synonymous 2/7 - 1
1-115258690-T-G c.92A>C p.Glu31Ala Missense 2/7 - 1
1-115258691-C-T c.91G>A p.Glu31Lys Missense 2/7 - 1
1-115258698-AAA-GAG c.82_84delinsCTC p.Phe28Leu Missense 2/7 - 1
1-115258699-A-G c.83T>C p.Phe28Ser Missense 2/7 - 1
1-115258698-A-C c.84T>G p.Phe28Leu Missense 2/7 - 1
1-115258698-A-T c.84T>A p.Phe28Leu Missense 2/7 - 1
1-115258700-A-G c.82T>C p.Phe28Leu Missense 2/7 - 1
1-115258701-G-A c.81C>T p.His27His Synonymous 2/7 - 2
1-115258711-A-T c.71T>A p.Ile24Asn Missense 2/7 - 8
1-115258713-T-C c.69A>G p.Leu23Leu Synonymous 2/7 - 1
1-115258718-G-A c.64C>T p.Gln22* Nonsense 2/7 - 1
1-115258718-G-T c.64C>A p.Gln22Lys Missense 2/7 - 4
1-115258725-C-A c.57G>T p.Leu19Leu Synonymous 2/7 - 1
1-115258725-CAG-TTT c.55_57delinsAAA p.Leu19Lys Missense 2/7 - 1
1-115258725-C-G c.57G>C p.Leu19Leu Synonymous 2/7 - 1
1-115258725-C-T c.57G>A p.Leu19Leu Synonymous 2/7 - 1
1-115258727-G-A c.55C>T p.Leu19Leu Synonymous 2/7 - 1
1-115258729-G-A c.53C>T p.Ala18Val Missense 2/7 - 1
1-115258730-C-G c.52G>C p.Ala18Pro Missense 2/7 - 1
1-115258730-C-T c.52G>A p.Ala18Thr Missense 2/7 - 15
1-115258732-C-A c.50G>T p.Ser17Ile Missense 2/7 - 1
1-115258732-C-T c.50G>A p.Ser17Asn Missense 2/7 - 6
1-115258733-T-C c.49A>G p.Ser17Gly Missense 2/7 - 2
1-115258736-T-C c.46A>G p.Lys16Glu Missense 2/7 - 1
1-115258737-CC-AC c.45delinsT p.Gly15Gly Missense 2/7 - 3
1-115258737-CCC-AGC c.44_45delinsCT p.Gly15Ala Missense 2/7 - 1
1-115258738-C-G c.44G>C p.Gly15Ala Missense 2/7 - 1
1-115258739-C-A c.43G>T p.Gly15Trp Missense 2/7 - 1
1-115258742-C-T c.40G>A p.Val14Ile Missense 2/7 - 1
1-115258743-A-C c.39T>G p.Gly13Gly Synonymous 2/7 - 2
1-115258743-A-G c.39T>C p.Gly13Gly Synonymous 2/7 - 2
1-115258743-A-T c.39T>A p.Gly13Gly Synonymous 2/7 - 2
1-115258744-C-A c.38G>T p.Gly13Val Missense 2/7 - 70
1-115258744-CC-AA c.37_38delinsTT p.Gly13Phe Missense 2/7 - 1
1-115258744-C-G c.38G>C p.Gly13Ala Missense 2/7 - 23
1-115258744-C-T c.38G>A p.Gly13Asp Missense 2/7 - 157
1-115258745-C-A c.37G>T p.Gly13Cys Missense 2/7 - 38
1-115258745-C-G c.37G>C p.Gly13Arg Missense 2/7 - 144
1-115258745-C-T c.37G>A p.Gly13Ser Missense 2/7 - 19
1-115258746-A-C c.36T>G p.Gly12Gly Synonymous 2/7 - 1
1-115258746-A-G c.36T>C p.Gly12Gly Synonymous 2/7 - 1
1-115258746-A-T c.36T>A p.Gly12Gly Synonymous 2/7 - 1
1-115258747-C-A c.35G>T p.Gly12Val Missense 2/7 - 152
1-115258747-CC-AA c.34_35delinsTT p.Gly12Phe Missense 2/7 - 2
1-115258747-CC-AT c.34_35delinsAT p.Gly12Ile Missense 2/7 - 1
1-115258747-C-G c.35G>C p.Gly12Ala Missense 2/7 - 60
1-115258747-C-T c.35G>A p.Gly12Asp Missense 2/7 - 353
1-115258748-C-A c.34G>T p.Gly12Cys Missense 2/7 - 94
1-115258748-C-G c.34G>C p.Gly12Arg Missense 2/7 - 48
1-115258748-C-T c.34G>A p.Gly12Ser Missense 2/7 - 113
1-115258750-G-A c.32C>T p.Ala11Val Missense 2/7 - 1
1-115258751-C-T c.31G>A p.Ala11Thr Missense 2/7 - 2
1-115258752-TC-AC c.30delinsT p.Gly10Gly Missense 2/7 - 2
1-115258753-C-T c.29G>A p.Gly10Glu Missense 2/7 - 2