PMID: 18287029

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

Proceedings of the National Academy of Sciences of the United States of America
Tsai, James J, Lee, John T JT, Wang, Weiru W, Zhang, Jiazhong J, Cho, Hanna H, Mamo, Shumeye S, Bremer, Ryan R, Gillette, Sam S, Kong, Jun J, Haass, Nikolas K NK, Sproesser, Katrin K, Li, Ling L, Smalley, Keiran S M KS, Fong, Daniel D, Zhu, Yong-Liang YL, Marimuthu, Adhirai A, Nguyen, Hoa H, Lam, Billy B, Liu, Jennifer J, Cheung, Ivana I, Rice, Julie J, Suzuki, Yoshihisa Y, Luu, Catherine C, Settachatgul, Calvin C, Shellooe, Rafe R, Cantwell, John J, Kim, Sung-Hou SH, Schlessinger, Joseph J, Zhang, Kam Y J KY, West, Brian L BL, Powell, Ben B, Habets, Gaston G, Zhang, Chao C, Ibrahim, Prabha N PN, Hirth, Peter P, Artis, Dean R DR, Herlyn, Meenhard M, Bollag, Gideon G
2008-02-26

16 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-140439613-T-C BRAF c.2126A>G p.Q709R Missense 17/18 -
7-140439676-GC-CG BRAF c.2062_2063delGCinsCG p.A688R Missense 17/18 -
7-140476753-GA-CT BRAF c.1652_1653delTCinsAG p.I551K Missense 13/18 -
7-140439721-T-G BRAF c.2018A>C p.Y673S Missense 17/18 -
7-140476721-T-C BRAF c.1685A>G p.Q562R Missense 13/18 -
7-140434530-TT-CC BRAF c.2167_2168delAAinsGG p.K723G Missense 18/18 -
7-140434534-G-A BRAF c.2164C>T p.P722S Missense 18/18 -
7-140453172-AG-TT BRAF c.1762_1763delCTinsAA p.L588N Missense 15/18 -
7-140449189-TT-GC BRAF c.1889_1890delAAinsGC p.K630S Missense 16/18 -
7-140434559-AGA-CTC BRAF c.2137_2139delTCTinsGAG p.S713E Missense 18/18 -
7-140476778-AT-GC BRAF c.1627_1628delATinsGC p.I543A Missense 13/18 -
7-140434539-GA-TC BRAF c.2158_2159delTCinsGA p.S720E Missense 18/18 -
7-140439738-AAA-CTC BRAF c.1999_2001delTTTinsGAG p.F667E Missense 17/18 -
7-140439622-AG-CT BRAF c.2116_2117delCTinsAG p.L706S Missense 17/18 -
7-140476775-A-C BRAF c.1631T>G p.I544S Missense 13/18 -
7-140434551-AG-TC BRAF c.2146_2147delCTinsGA p.L716E Missense 18/18 -