PMID: 26084293

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma.

Oncotarget
Hutchinson, Katherine E KE, Johnson, Douglas B DB, Johnson, Adam S AS, Sanchez, Violeta V, Kuba, Maria M, Lu, Pengcheng P, Chen, Xi X, Kelley, Mark C MC, Wang, Qingguo Q, Zhao, Zhongming Z, Kris, Mark M, Berger, Michael F MF, Sosman, Jeffrey A JA, Pao, William W
2015-09-08

66 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
2-212587251-C-T ERBB4 c.750G>A p.M250I Missense 7/28 -
9-135781200-G-A TSC1 c.1765C>T p.P589S Missense 15/23 -
4-55594215-G-A KIT c.1918G>A p.E640K Missense 13/21 -
7-140549968-T-G BRAF c.183A>C p.I61= Synonymous 2/18 -
17-29654691-C-T NF1 c.5443C>T p.Q1815* Nonsense 38/58 -
2-212426786-G-A ERBB4 c.2329C>T p.H777Y Missense 20/28 -
2-212652800-T-C ERBB4 c.506A>G p.N169S Missense 4/28 -
7-140624394-G-A BRAF c.110C>T p.S37L Missense 1/18 -
4-55143609-G-A PDGFRA c.1841G>A p.G614E Missense 13/23 -
5-149501466-G-A PDGFRB c.2321C>T p.P774L Missense 16/23 -
2-212288912-C-A ERBB4 c.2834G>T p.C945F Missense 23/28 -
10-89711913-T-A PTEN c.531T>A p.Y177* Nonsense 6/9 -
16-2110741-A-C TSC2 c.1046A>C p.Y349S Missense 11/42 -
2-212248740-T-G ERBB4 c.3527A>C p.K1176T Missense 28/28 -
1-11187710-G-A MTOR c.6187C>T p.Q2063* Nonsense 44/58 -
4-55161359-G-A PDGFRA c.3190G>A p.D1064N Missense 23/23 -
5-149505118-C-T PDGFRB c.1697G>A p.W566* Nonsense 12/23 -
5-149505117-C-T PDGFRB c.1698G>A p.W566* Nonsense 12/23 -
7-92355008-C-T CDK6 c.469G>A p.G157R Missense 4/8 -
7-92355008-C-G CDK6 c.469G>C p.G157R Missense 4/8 -
12-56495786-C-T ERBB3 c.3976C>T p.P1326S Missense 28/28 -
17-37884011-G-A ERBB2 c.3482G>A p.R1161Q Missense 27/27 -
X-47426634-C-G ARAF c.879C>G p.N293K Missense 10/16 -
X-47426634-C-A ARAF c.879C>A p.N293K Missense 10/16 -
2-212576779-G-T ERBB4 c.1120C>A p.H374N Missense 9/28 -
3-12633234-G-A RAF1 c.1166C>T p.A389V Missense 11/17 -
2-212615376-G-A ERBB4 c.610C>T p.H204Y Missense 5/28 -
2-212288973-G-A ERBB4 c.2773C>T p.P925S Missense 23/28 -
17-29546100-G-T NF1 c.1605G>T p.Q535H Missense 14/58 -
17-29546100-G-C NF1 c.1605G>C p.Q535H Missense 14/58 -
12-58143283-G-A CDK4 c.637C>T p.L213F Missense 6/8 -
7-140624467-C-A BRAF c.37G>T p.E13* Nonsense 1/18 -
7-140624394-G-T BRAF c.110C>A p.S37* Nonsense 1/18 -
9-80409488-T-C GNAQ c.626A>G p.Q209R Missense 5/7 -
10-89711875-G-A PTEN c.493G>A p.G165R Missense 6/9 -
10-89711875-G-C PTEN c.493G>C p.G165R Missense 6/9 -
2-212488718-G-A ERBB4 c.2131C>T p.R711C Missense 18/28 -
3-12633229-T-A RAF1 c.1171A>T p.R391W Missense 11/17 -
4-55161380-G-A PDGFRA c.3211G>A p.D1071N Missense 23/23 -
7-140624470-C-G BRAF c.34G>C p.A12P Missense 1/18 -
17-29496957-T-A NF1 c.528T>A p.D176E Missense 5/58 -
16-2112989-G-A TSC2 c.1378G>A p.A460T Missense 14/42 -
7-140624470-C-T BRAF c.34G>A p.A12T Missense 1/18 -
17-29546050-C-T NF1 c.1555C>T p.Q519* Nonsense 14/58 -
7-140453987-T-A BRAF c.1741A>T p.N581Y Missense 14/18 -
7-55268965-G-A EGFR c.3031G>A p.V1011M Missense 25/28 -
2-212566827-C-T ERBB4 c.1354G>A p.E452K Missense 12/28 -
3-12645688-G-A RAF1 c.781C>T p.P261S Missense 7/17 -
17-29576033-C-T NF1 c.4006C>T p.Q1336* Nonsense 30/58 -
7-140624393-CG-AA BRAF c.110_111delCGinsTT p.S37F Missense 1/18 -
1-115258681-G-A NRAS c.101C>T p.P34L Missense 2/7 -
7-140453185-G-A BRAF c.1750C>T p.L584F Missense 15/18 -
7-140624470-C-A BRAF c.34G>T p.A12S Missense 1/18 -
7-140549968-T-A BRAF c.183A>T p.I61= Synonymous 2/18 -
9-135786451-G-T TSC1 c.1079C>A p.T360N Missense 11/23 -
16-2134508-G-T TSC2 c.4285G>T p.A1429S Missense 34/42 -
7-140624393-CG-AT BRAF c.110_111delCGinsAT p.S37Y Missense 1/18 -
7-55241647-C-T EGFR c.2095C>T p.P699S Missense 18/28 -
4-55131118-C-T PDGFRA c.661C>T p.L221F Missense 5/23 -
10-89711913-T-G PTEN c.531T>G p.Y177* Nonsense 6/9 -
4-55130065-C-G PDGFRA c.599C>G p.T200S Missense 4/23 -
4-55130064-A-T PDGFRA c.598A>T p.T200S Missense 4/23 -
4-110902129-C-T EGF c.2369C>T p.A790V Missense 15/24 -
2-212251811-G-A ERBB4 c.3248C>T p.A1083V Missense 27/28 -
17-29496957-T-G NF1 c.528T>G p.D176E Missense 5/58 -
5-149501578-C-T PDGFRB c.2209G>A p.D737N Missense 16/23 -