PMID: 30935124

5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.

Medicina (Kaunas, Lithuania)
Nastasă, Cristina C, Tamaian, Radu R, Oniga, Ovidiu O, Tiperciuc, Brîndușa B
2019-03-31

16 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-140439613-T-C BRAF c.2126A>G p.Q709R Missense 17/18 -
7-140439676-GC-CG BRAF c.2062_2063delGCinsCG p.A688R Missense 17/18 -
7-140476753-GA-CT BRAF c.1652_1653delTCinsAG p.I551K Missense 13/18 -
7-140439721-T-G BRAF c.2018A>C p.Y673S Missense 17/18 -
7-140476721-T-C BRAF c.1685A>G p.Q562R Missense 13/18 -
7-140434530-TT-CC BRAF c.2167_2168delAAinsGG p.K723G Missense 18/18 -
7-140434534-G-A BRAF c.2164C>T p.P722S Missense 18/18 -
7-140453172-AG-TT BRAF c.1762_1763delCTinsAA p.L588N Missense 15/18 -
7-140449189-TT-GC BRAF c.1889_1890delAAinsGC p.K630S Missense 16/18 -
7-140434559-AGA-CTC BRAF c.2137_2139delTCTinsGAG p.S713E Missense 18/18 -
7-140476778-AT-GC BRAF c.1627_1628delATinsGC p.I543A Missense 13/18 -
7-140434539-GA-TC BRAF c.2158_2159delTCinsGA p.S720E Missense 18/18 -
7-140439738-AAA-CTC BRAF c.1999_2001delTTTinsGAG p.F667E Missense 17/18 -
7-140439622-AG-CT BRAF c.2116_2117delCTinsAG p.L706S Missense 17/18 -
7-140476775-A-C BRAF c.1631T>G p.I544S Missense 13/18 -
7-140434551-AG-TC BRAF c.2146_2147delCTinsGA p.L716E Missense 18/18 -