PMID: 34347347

MET D1228N and D1246N are the Same Resistance Mutation in MET Exon 14 Skipping.

The oncologist
Tsai, Jonathan M JM, Hata, Aaron N AN, Lennerz, Jochen K JK
2021-12

23 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
9-133738306-G-A ABL1 c.706G>A p.E236K Missense 4/11 -
9-133760115-T-G ABL1 c.2438T>G p.L813R Missense 11/11 -
7-140434459-C-A BRAF c.2239G>T p.A747S Missense 18/18 -
7-55248986-G-T EGFR c.2284G>T p.E762* Nonsense 20/28 -
7-140476758-T-G BRAF c.1648A>C p.M550L Missense 13/18 -
9-133753840-A-C ABL1 c.1309A>C p.M437L Missense 8/11 -
7-116422057-G-A MET c.3538G>A p.D1180N Missense 18/21 -
17-37856548-A-T ERBB2 c.57A>T p.G19= Synonymous 1/27 -
17-37856548-A-G ERBB2 c.57A>G p.G19= Synonymous 1/27 -
17-37856548-A-C ERBB2 c.57A>C p.G19= Synonymous 1/27 -
9-133759449-T-G ABL1 c.1772T>G p.L591R Missense 11/11 -
7-116423407-G-A MET c.3682G>A p.D1228N Missense 19/21 -
7-55221821-G-A EGFR c.865G>A p.A289T Missense 7/28 -
7-55233046-TC-AG EGFR c.1796_1797delTCinsAG p.V599E Missense 15/28 -
7-116411990-C-T MET c.2975C>T p.T992I Missense 14/21 -
10-123258036-T-G FGFR2 c.1645A>C p.N549H Missense 12/18 -
9-133748391-T-C ABL1 c.1052T>C p.M351T Missense 6/11 -
1-226252152-G-C H3-3A c.100G>C p.G34R Missense 2/4 -
1-226252135-A-T H3-3A c.83A>T p.K28M Missense 2/4 -
7-140494247-G-A BRAF c.1001C>T p.P334L Missense 8/18 -
1-226252155-G-A H3-3A c.103G>A p.G35R Missense 2/4 -
1-226252155-G-C H3-3A c.103G>C p.G35R Missense 2/4 -
9-133750278-T-C ABL1 c.1109T>C p.L370P Missense 7/11 -