PMID: 34630336

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers in endocrinology
Hescheler, Daniel A DA, Riemann, Burkhard B, Hartmann, Milan J M MJM, Michel, Maximilian M, Faust, Michael M, Bruns, Christiane J CJ, Alakus, Hakan H, Chiapponi, Costanza C
2021

3380 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
4-55973931-A-T KDR c.1385T>A p.L462* Nonsense 10/30 -
17-37881132-G-A ERBB2 c.2461G>A p.D821N Missense 20/27 -
X-47426120-T-A ARAF c.640T>A p.S214T Missense 7/16 -
15-67482818-G-T SMAD3 c.1222G>T p.D408Y Missense 9/9 -
18-45395617-G-A SMAD2 c.517C>T p.P173S Missense 4/11 -
11-534222-G-C HRAS c.101C>G p.P34R Missense 2/6 -
17-29576094-A-G NF1 c.4067A>G p.E1356G Missense 30/58 -
22-29121246-G-T CHEK2 c.429C>A p.H143Q Missense 3/15 -
17-47696597-C-G SPOP c.351G>C p.M117I Missense 4/10 -
11-32414222-C-G WT1 c.1329G>C p.R448S Missense 8/10 -
11-108216586-G-C ATM c.8535G>C p.W2845C Missense 58/63 -
2-212248348-C-G ERBB4 c.3919G>C p.V1307L Missense 28/28 -
13-32914955-CT-AG BRCA2 c.6463_6464delCTinsAG p.L2155S Missense 11/27 -
4-55136855-AC-TG PDGFRA c.1177_1178delACinsTG p.T393C Missense 8/23 -
9-135772864-T-A TSC1 c.2759A>T p.D920V Missense 21/23 -
9-133748289-T-C ABL1 c.950T>C p.F317S Missense 6/11 -
18-45374913-CCT-ATG SMAD2 c.928_930delAGGinsCAT p.R310H Missense 8/11 -
4-55141029-TG-GC PDGFRA c.1675_1676delTGinsGC p.W559A Missense 12/23 -
9-135772865-C-A TSC1 c.2758G>T p.D920Y Missense 21/23 -
3-49412904-TC-GT RHOA c.118_119delGAinsAC p.E40T Missense 2/5 -
3-49412904-TC-CA RHOA c.118_119delGAinsTG p.E40W Missense 2/5 -
3-49412912-TGT-ATA RHOA c.109_111delACAinsTAT p.T37Y Missense 2/5 -
3-49412904-TC-AG RHOA c.118_119delGAinsCT p.E40L Missense 2/5 -
15-67473647-CG-GC SMAD3 c.727_728delCGinsGC p.R243A Missense 6/9 -
15-67482820-C-G SMAD3 c.1224C>G p.D408E Missense 9/9 -
1-17354253-ACG-TCA SDHB c.529_531delCGTinsTGA p.R177* Nonsense 5/8 -
15-67473692-G-A SMAD3 c.772G>A p.D258N Missense 6/9 -
15-67473636-A-C SMAD3 c.716A>C p.E239A Missense 6/9 -
15-67457264-CGG-TGT SMAD3 c.238_240delCGGinsTGT p.R80C Missense 2/9 -
18-45371753-G-T SMAD2 c.1238C>A p.T413N Missense 10/11 -
15-67477199-C-T SMAD3 c.1006C>T p.P336S Missense 7/9 -
3-47125466-T-C SETD2 c.5804A>G p.E1935G Missense 12/21 -
18-48604700-G-A SMAD4 c.1522G>A p.G508S Missense 12/12 -
18-48591969-AG-GC SMAD4 c.1132_1133delAGinsGC p.R378A Missense 9/12 -
18-48591894-TA-CT SMAD4 c.1057_1058delTAinsCT p.Y353L Missense 9/12 -
15-67473596-TA-GC SMAD3 c.676_677delTAinsGC p.Y226A Missense 6/9 -
18-48604697-AA-GC SMAD4 c.1519_1520delAAinsGC p.K507A Missense 12/12 -
15-67473779-CG-GC SMAD3 c.859_860delCGinsGC p.R287A Missense 6/9 -
18-48573543-T-G SMAD4 c.127T>G p.L43V Missense 2/12 -
15-67477085-TA-GC SMAD3 c.892_893delTAinsGC p.Y298A Missense 7/9 -
18-48593531-AA-GC SMAD4 c.1282_1283delAAinsGC p.K428A Missense 10/12 -
18-48604721-AG-GC SMAD4 c.1543_1544delAGinsGC p.R515A Missense 12/12 -
18-48604772-GC-CA SMAD4 c.1594_1595delGCinsCA p.A532H Missense 12/12 -
15-67473750-T-A SMAD3 c.830T>A p.V277D Missense 6/9 -
15-67479811-GC-AA SMAD3 c.1118_1119delGCinsAA p.R373Q Missense 8/9 -
9-135804155-AGA-TTG TSC1 c.103_105delTCTinsCAA p.S35Q Missense 3/23 -
17-47679320-T-A SPOP c.887A>T p.N296I Missense 9/10 -
17-7576869-TC-AG TP53 c.976_977delGAinsCT p.E326L Missense 9/11 -
17-7577107-ACA-TTG TP53 c.829_831delTGTinsCAA p.C277Q Missense 8/11 -
19-1206946-T-C STK11 c.34T>C p.F12L Missense 1/10 -
19-1206948-C-A STK11 c.36C>A p.F12L Missense 1/10 -
19-1206948-C-G STK11 c.36C>G p.F12L Missense 1/10 -
17-70120190-AA-GC SOX9 c.1192_1193delAAinsGC p.K398A Missense 3/3 -
17-40481655-A-C STAT3 c.1150T>G p.F384V Missense 13/24 -
4-106190881-AA-GC TET2 c.4159_4160delAAinsGC p.N1387A Missense 9/11 -
9-135797211-C-A TSC1 c.658G>T p.V220F Missense 7/23 -
3-10188307-T-G VHL c.450T>G p.N150K Missense 2/3 -
3-10188307-T-A VHL c.450T>A p.N150K Missense 2/3 -
11-102098217-G-C YAP1 c.1181G>C p.R394P Missense 8/9 -
11-102098216-CGA-TGG YAP1 c.1180_1182delCGAinsTGG p.R394W Missense 8/9 -
19-13050428-A-G CALR c.380A>G p.E127G Missense 3/9 -
2-29446376-T-C ALK c.3191A>G p.Q1064R Missense 20/29 -
8-141557681-TG-GC AGO2 c.1633_1634delCAinsGC p.Q545A Missense 13/19 -
8-141551357-CG-GC AGO2 c.1939_1940delCGinsGC p.R647A Missense 15/19 -
19-40741907-GTG-CAT AKT2 c.1063_1065delCACinsATG p.H355M Missense 11/14 -
8-141557567-CT-GC AGO2 c.1747_1748delAGinsGC p.R583A Missense 13/19 -
8-141542551-CG-GC AGO2 c.2434_2435delCGinsGC p.R812A Missense 18/19 -
7-140481376-C-A BRAF c.1432G>T p.G478C Missense 11/18 -
17-41197765-CT-GC BRCA1 c.5521_5522delAGinsGC p.S1841A Missense 23/23 -
17-41209078-CTG-ACA BRCA1 c.5266_5268delCAGinsTGT p.Q1756C Missense 19/23 -
9-5123014-GA-AG JAK2 c.3070_3071delGAinsAG p.E1024R Missense 23/25 -
22-29095873-C-T CHEK2 c.961G>A p.E321K Missense 9/15 -
9-22008885-G-T CDKN2B c.68C>A p.A23E Missense 1/2 -
9-22008835-G-T CDKN2B c.118C>A p.P40T Missense 1/2 -
16-89874750-CA-GC FANCA c.547_548delTGinsGC p.W183A Missense 6/43 -
7-92300798-C-T CDK6 c.589G>A p.A197T Missense 5/8 -
6-41903688-AT-GC CCND3 c.868_869delATinsGC p.I290A Missense 5/5 -
14-95557641-CC-TT DICER1 c.5425_5426delGGinsAA p.G1809K Missense 25/27 -
7-55233009-G-C EGFR c.1759G>C p.D587H Missense 15/28 -
1-201983143-G-C ELF3 c.992G>C p.R331P Missense 8/9 -
19-45856345-G-C ERCC2 c.1827C>G p.D609E Missense 19/23 -
19-45856345-G-T ERCC2 c.1827C>A p.D609E Missense 19/23 -
6-152265548-C-T ESR1 c.1001C>T p.T334I Missense 4/8 -
5-176522552-T-G FGFR4 c.1649T>G p.V550G Missense 13/18 -
13-28589776-C-G FLT3 c.2604G>C p.K868N Missense 21/24 -
13-28589776-C-A FLT3 c.2604G>T p.K868N Missense 21/24 -
5-176522552-T-C FGFR4 c.1649T>C p.V550A Missense 13/18 -
13-28610137-GGA-CTC FLT3 c.1351_1353delTCCinsGAG p.S451E Missense 11/24 -
12-57861837-CG-GC GLI1 c.1138_1139delCGinsGC p.R380A Missense 10/12 -
X-48649736-G-A GATA1 c.220G>A p.V74I Missense 2/6 -
1-65312375-T-G JAK1 c.1944A>C p.K648N Missense 14/25 -
1-65312375-T-A JAK1 c.1944A>T p.K648N Missense 14/25 -
4-55561788-G-A KIT c.178G>A p.D60N Missense 2/21 -
5-149495435-TC-CA PDGFRB c.3211_3212delGAinsTG p.E1071W Missense 23/23 -
15-66729123-AT-CC MAP2K1 c.331_332delATinsCC p.I111P Missense 3/11 -
15-66729124-TC-GG MAP2K1 c.332_333delTCinsGG p.I111R Missense 3/11 -
15-66729123-AT-GC MAP2K1 c.331_332delATinsGC p.I111A Missense 3/11 -
1-156849873-T-C NTRK1 c.2129T>C p.V710A Missense 16/17 -
1-120465035-GA-TT NOTCH2 c.5036_5037delTCinsAA p.L1679Q Missense 28/34 -
9-139390906-G-C NOTCH1 c.7285C>G p.L2429V Missense 34/34 -
9-139399416-A-T NOTCH1 c.4727T>A p.V1576E Missense 26/34 -
2-178098974-C-G NFE2L2 c.71G>C p.W24S Missense 2/5 -
9-139399296-A-G NOTCH1 c.4847T>C p.I1616T Missense 26/34 -
18-48513379-C-T ELAC1 c.1016C>T p.A339V Missense 4/4 -
9-139390918-C-T NOTCH1 c.7273G>A p.A2425T Missense 34/34 -
17-29562967-T-G NF1 c.3902T>G p.L1301R Missense 29/58 -
9-87570399-G-C NTRK2 c.2139G>C p.M713I Missense 17/19 -
9-87570399-G-A NTRK2 c.2139G>A p.M713I Missense 17/19 -
9-87570399-G-T NTRK2 c.2139G>T p.M713I Missense 17/19 -
9-87635148-C-T NTRK2 c.2200C>T p.R734C Missense 18/19 -
20-40790143-G-A PTPRT c.2531C>T p.T844M Missense 17/31 -
17-58677917-C-A PPM1D c.142C>A p.P48T Missense 1/6 -
6-37138906-T-G PIM1 c.246T>G p.N82K Missense 4/6 -
6-37138906-T-A PIM1 c.246T>A p.N82K Missense 4/6 -
19-52716323-CC-GG PPP2R1A c.767_768delCCinsGG p.S256W Missense 6/15 -
17-58677918-C-G PPM1D c.143C>G p.P48R Missense 1/6 -
7-6042176-A-C PMS2 c.445T>G p.Y149D Missense 5/15 -
20-40735442-T-A PTPRT c.3374A>T p.N1125I Missense 24/31 -
3-134911651-G-A EPHB1 c.2116G>A p.D706N Missense 11/16 -
7-55214345-C-A EGFR c.424+3164C>A p.C157* UnclassifiedSNV 4/28 -
10-8100556-CGG-C GATA3 c.530_531delGG p.R177Pfs*126 Frameshift 3/6 -
22-29091787-G-T CHEK2 c.1170C>A p.Y390* Nonsense 11/15 -
22-29090097-G-T CHEK2 c.1384C>A p.L462I Missense 13/15 -
9-8733807-TGAG-T PTPRD c.34_36delCTC p.L12del InFrameDeletion 12/46 -
16-67663378-G-T CTCF c.1779G>T p.K593N Missense 10/12 -
13-32893261-GC-AA BRCA2 c.115_116delGCinsAA p.A39N Missense 3/27 -
13-32893261-GCT-AAG BRCA2 c.115_117delGCTinsAAG p.A39K Missense 3/27 -
13-32893261-GC-CT BRCA2 c.115_116delGCinsCT p.A39L Missense 3/27 -
13-32893261-GCT-ATG BRCA2 c.115_117delGCTinsATG p.A39M Missense 3/27 -
9-97934429-C-T FANCC c.346G>A p.G116S Missense 5/15 -
5-149513553-G-C PDGFRB c.650C>G p.S217C Missense 5/23 -
18-756790-G-A YES1 c.38C>T p.A13V Missense 2/12 -
3-3216952-T-A CRBN c.69A>T p.A23= Synonymous 2/11 -
3-3216952-T-C CRBN c.69A>G p.A23= Synonymous 2/11 -
5-149513554-A-C PDGFRB c.649T>G p.S217A Missense 5/23 -
5-149513552-AGA-CTC PDGFRB c.649_651delTCTinsGAG p.S217E Missense 5/23 -
5-149513554-A-T PDGFRB c.649T>A p.S217T Missense 5/23 -
3-3216952-T-G CRBN c.69A>C p.A23= Synonymous 2/11 -
19-33793247-GC-AG CEBPA c.73_74delGCinsCT p.A25L Missense 1/1 -
19-33793247-G-C CEBPA c.74C>G p.A25G Missense 1/1 -
19-33793247-GC-AT CEBPA c.73_74delGCinsAT p.A25M Missense 1/1 -
19-33793247-GC-TT CEBPA c.73_74delGCinsAA p.A25K Missense 1/1 -
19-33793246-CGC-GTT CEBPA c.73_75delGCGinsAAC p.A25N Missense 1/1 -
19-33793248-C-G CEBPA c.73G>C p.A25P Missense 1/1 -
19-33793247-GC-CT CEBPA c.73_74delGCinsAG p.A25R Missense 1/1 -
9-22008887-CGC-GAT CDKN2B c.64_66delGCGinsATC p.A22I Missense 1/2 -
19-10982458-C-A CARM1 c.80C>A p.A27D Missense 1/16 -
9-22008888-GC-TT CDKN2B c.64_65delGCinsAA p.A22K Missense 1/2 -
9-22008888-GC-AG CDKN2B c.64_65delGCinsCT p.A22L Missense 1/2 -
12-12870825-GC-TA CDKN1B c.52_53delGCinsTA p.A18Y Missense 1/3 -
9-22008888-GC-AT CDKN2B c.64_65delGCinsAT p.A22M Missense 1/2 -
9-22008887-CGC-GTT CDKN2B c.64_66delGCGinsAAC p.A22N Missense 1/2 -
19-33793246-CGC-GAT CEBPA c.73_75delGCGinsATC p.A25I Missense 1/1 -
9-22008888-GC-TG CDKN2B c.64_65delGCinsCA p.A22Q Missense 1/2 -
3-178916848-AG-CC PIK3CA c.235_236delAGinsCC p.R79P Missense 2/21 -
17-37880250-A-G ERBB2 c.2294A>G p.K765R Missense 19/27 -
9-80430654-CA-GT GNAQ c.353_354delTGinsAC p.V118D Missense 3/7 -
6-114267215-C-T HDAC2 c.939G>A p.W313* Nonsense 9/14 -
6-114267216-C-T HDAC2 c.938G>A p.W313* Nonsense 9/14 -
9-133755478-CG-TA ABL1 c.1447_1448delCGinsTA p.R483* Nonsense 9/11 -
17-64299043-C-G PRKCA c.74C>G p.A25G Missense 1/17 -
9-27158071-GCT-TAA TEK c.295_297delGCTinsTAA p.A99* Nonsense 2/23 -
19-17955153-GC-AT JAK3 c.73_74delGCinsAT p.A25I Missense 2/24 -
7-116340308-C-A MET c.1170C>A p.Y390* Nonsense 2/21 -
7-116340308-C-G MET c.1170C>G p.Y390* Nonsense 2/21 -
18-756790-GC-AG YES1 c.37_38delGCinsCT p.A13L Missense 2/12 -
17-42165906-GT-TA HDAC5 c.1447_1448delACinsTA p.T483* Nonsense 12/27 -
9-27197537-GTC-TAA TEK c.1849_1851delGTCinsTAA p.V617* Nonsense 12/23 -
7-116422114-A-T MET c.3595A>T p.K1199* Nonsense 18/21 -
1-160717992-GCC-CAA SLAMF7 c.64_66delGCCinsCAA p.A22Q Missense 2/7 -
1-32745727-GG-TA LCK c.1243_1244delGGinsTA p.G415* Nonsense 12/13 -
2-29455179-C-A ALK c.2623G>T p.G875* Nonsense 15/29 -
7-19015497-C-T HDAC9 c.3091C>T p.Q1031* Nonsense 24/25 -
9-133759454-A-T ABL1 c.1777A>T p.K593* Nonsense 11/11 -
8-56879300-GCT-TAA LYN c.817_819delGCTinsTAA p.A273* Nonsense 9/13 -
4-15780101-GC-AA CD38 c.64_65delGCinsAA p.A22N Missense 1/8 -
4-1795698-GCC-AAG FGFR3 c.37_39delGCCinsAAG p.A13K Missense 2/18 -
4-55961014-C-A KDR c.2926G>T p.G976* Nonsense 21/30 -
2-29456456-CC-TA ALK c.2461_2462delGGinsTA p.G821* Nonsense 14/29 -
18-747992-G-T YES1 c.398C>A p.S133* Nonsense 4/12 -
18-747992-G-C YES1 c.398C>G p.S133* Nonsense 4/12 -
2-242793411-GTC-TTA PDCD1 c.664_666delGACinsTAA p.D222* Nonsense 5/5 -
17-42157804-GGG-TTA HDAC5 c.2788_2790delCCCinsTAA p.P930* Nonsense 22/27 -
3-178927480-GCT-TAA PIK3CA c.1243_1245delGCTinsTAA p.A415* Nonsense 7/21 -
18-756791-C-A YES1 c.37G>T p.A13S Missense 2/12 -
1-9780947-A-T PIK3CD c.1669A>T p.K557* Nonsense 13/24 -
13-32893426-CCT-TAA BRCA2 c.280_282delCCTinsTAA p.P94* Nonsense 3/27 -
15-51520042-C-A CYP19A1 c.385G>T p.E129* Nonsense 4/10 -
17-42170156-AG-TT HDAC5 c.659_660delCTinsAA p.S220* Nonsense 7/27 -
4-55968645-AG-TA KDR c.2017_2018delCTinsTA p.L673* Nonsense 14/30 -
2-209116227-C-A IDH1 c.49G>T p.E17* Nonsense 3/10 -
17-64683360-CC-TA PRKCA c.661_662delCCinsTA p.P221* Nonsense 6/17 -
2-212812253-GT-TA ERBB4 c.322_323delACinsTA p.T108* Nonsense 3/28 -
4-15780101-GC-AT CD38 c.64_65delGCinsAT p.A22I Missense 1/8 -
5-180048156-GC-TA FLT4 c.2116_2117delGCinsTA p.A706* Nonsense 14/30 -
18-756789-GGC-CAT YES1 c.37_39delGCCinsATG p.A13M Missense 2/12 -
9-27197486-GT-TA TEK c.1798_1799delGTinsTA p.V600* Nonsense 12/23 -
17-42169606-GGG-TTA HDAC5 c.964_966delCCCinsTAA p.P322* Nonsense 9/27 -
17-41228525-ATT-TTA BRCA1 c.4462_4464delAATinsTAA p.N1488* Nonsense 13/23 -
17-42170694-T-A HDAC5 c.514A>T p.K172* Nonsense 5/27 -
4-55987291-G-C KDR c.134C>G p.A45G Missense 2/30 -
17-64728866-CCT-TAA PRKCA c.979_981delCCTinsTAA p.P327* Nonsense 9/17 -
14-20813135-G-T PARP2 c.91G>T p.E31* Nonsense 2/16 -
5-180043385-GTC-TTA FLT4 c.3199_3201delGACinsTAA p.D1067* Nonsense 23/30 -
14-20824536-T-A PARP2 c.1172T>A p.L391* Nonsense 12/16 -
5-180040030-C-A FLT4 c.3412G>T p.E1138* Nonsense 25/30 -
X-70327614-GG-TA IL2RG c.1081_1082delCCinsTA p.P361* Nonsense 8/8 -
1-9782651-GG-TA PIK3CD c.2413_2414delGGinsTA p.G805* Nonsense 19/24 -
1-65309858-AAC-TTA JAK1 c.2290_2292delGTTinsTAA p.V764* Nonsense 17/25 -
15-88670417-GTG-TTA NTRK3 c.1267_1269delCACinsTAA p.H423* Nonsense 12/20 -
7-116435805-GG-TA MET c.3895_3896delGGinsTA p.G1299* Nonsense 20/21 -
1-11188999-GGT-TTA MTOR c.5722_5724delACCinsTAA p.T1908* Nonsense 41/58 -
4-55946325-AT-TA KDR c.3853_3854delATinsTA p.M1285* Nonsense 30/30 -
9-133730241-C-T ABL1 c.307C>T p.Q103* Nonsense 3/11 -
9-27180363-G-T TEK c.1027G>T p.E343* Nonsense 7/23 -
17-42164813-GGG-TTA HDAC5 c.1849_1851delCCCinsTAA p.P617* Nonsense 13/27 -
6-170858183-AGC-CTT PSMB1 c.130_132delGCTinsAAG p.A44K Missense 2/6 -
2-212530113-ACT-TCA ERBB4 c.1804_1806delAGTinsTGA p.S602* Nonsense 15/28 -
18-756791-C-G YES1 c.37G>C p.A13P Missense 2/12 -
4-15780101-G-C CD38 c.64G>C p.A22P Missense 1/8 -
9-27192585-CCT-TAA TEK c.1588_1590delCCTinsTAA p.P530* Nonsense 11/23 -
17-64299042-GC-AA PRKCA c.73_74delGCinsAA p.A25K Missense 1/17 -
14-75421892-CGC-ATA PGF c.52_54delGCGinsTAT p.A18Y Missense 1/7 -
15-88679189-GT-TA NTRK3 c.847_848delACinsTA p.T283* Nonsense 9/20 -
10-43606825-T-A RET c.1434T>A p.C478* Nonsense 7/20 -
2-204735329-GCT-ATG CTLA4 c.130_132delGCTinsATG p.A44M Missense 2/4 -
5-149502640-G-T PDGFRB c.2148C>A p.Y716* Nonsense 15/23 -
5-149502640-G-C PDGFRB c.2148C>G p.Y716* Nonsense 15/23 -
1-11190762-C-A MTOR c.5437G>T p.E1813* Nonsense 39/58 -
15-88690613-GAG-TTA NTRK3 c.415_417delCTCinsTAA p.L139* Nonsense 6/20 -
1-160717992-GC-CT SLAMF7 c.64_65delGCinsCT p.A22L Missense 2/7 -
1-156845907-A-T NTRK1 c.1537A>T p.K513* Nonsense 13/17 -
3-51979112-GAT-TAA PARP3 c.754_756delGATinsTAA p.D245* Nonsense 6/11 -
4-55987291-GC-AA KDR c.133_134delGCinsTT p.A45F Missense 2/30 -
1-16464792-GTC-TTA EPHA2 c.955_957delGACinsTAA p.D319* Nonsense 4/17 -
1-165370534-AT-TA RXRG c.1357_1358delATinsTA p.M453* Nonsense 10/10 -
17-42168821-G-A HDAC5 c.1204C>T p.Q402* Nonsense 11/27 -
9-27173234-AC-TA TEK c.775_776delACinsTA p.T259* Nonsense 6/23 -
18-756789-GGC-TTA YES1 c.37_39delGCCinsTAA p.A13* Nonsense 2/12 -
3-178919266-ATT-TAA PIK3CA c.751_753delATTinsTAA p.I251* Nonsense 4/21 -
17-41244489-GG-TA BRCA1 c.3058_3059delCCinsTA p.P1020* Nonsense 10/23 -
18-756791-C-T YES1 c.37G>A p.A13T Missense 2/12 -
4-15780101-GCC-AAG CD38 c.64_66delGCCinsAAG p.A22K Missense 1/8 -
4-15780101-GCC-ATG CD38 c.64_66delGCCinsATG p.A22M Missense 1/8 -
1-32739979-ATC-TAA LCK c.49_51delATCinsTAA p.I17* Nonsense 2/13 -
3-178947853-ATT-TAA PIK3CA c.2728_2730delATTinsTAA p.I910* Nonsense 19/21 -
8-56866441-A-T LYN c.688A>T p.K230* Nonsense 8/13 -
7-73927166-GC-AT GTF2IRD1 c.130_131delGCinsAT p.A44M Missense 3/27 -
7-23509612-C-A IGF2BP3 c.118G>T p.A40S Missense 1/15 -
7-140477845-GT-TA BRAF c.1462_1463delACinsTA p.T488* Nonsense 12/18 -
13-32913674-GAC-TAA BRCA2 c.5182_5184delGACinsTAA p.D1728* Nonsense 11/27 -
9-27228220-C-T TEK c.3217C>T p.Q1073* Nonsense 22/23 -
18-746004-A-T YES1 c.518T>A p.L173* Nonsense 5/12 -
13-32953493-CAC-TAA BRCA2 c.8794_8796delCACinsTAA p.H2932* Nonsense 22/27 -
6-152265442-A-T ESR1 c.895A>T p.K299* Nonsense 4/8 -
5-149514547-C-A PDGFRB c.397G>T p.E133* Nonsense 4/23 -
9-27168564-GT-TA TEK c.436_437delGTinsTA p.V146* Nonsense 3/23 -
17-37884205-GAC-TAA ERBB2 c.3676_3678delGACinsTAA p.D1226* Nonsense 27/27 -
15-88679155-ATT-TTA NTRK3 c.880_882delAATinsTAA p.N294* Nonsense 9/20 -
17-64299042-GC-AG PRKCA c.73_74delGCinsAG p.A25R Missense 1/17 -
16-3828107-A-C CREBBP c.2018T>G p.L673* Nonsense 10/31 -
1-51436077-G-A CDKN2C c.37G>A p.A13T Missense 1/2 -
10-129690933-GC-CG CLRN3 c.115_116delGCinsCG p.A39R Missense 1/3 -
10-129690933-GC-AG CLRN3 c.115_116delGCinsCT p.A39L Missense 1/3 -
10-129690933-GC-TT CLRN3 c.115_116delGCinsAA p.A39N Missense 1/3 -
2-43819494-GC-TT THADA c.37_38delGCinsAA p.A13K Missense 2/38 -
16-56782196-G-T NUP93 c.37G>T p.A13S Missense 2/22 -
X-39937109-GC-TT BCOR c.73_74delGCinsAA p.A25K Missense 2/15 -
12-46123849-GC-CT ARID2 c.115_116delGCinsCT p.A39L Missense 2/21 -
1-179198451-C-A ABL2 c.82G>T p.A28S Missense 1/12 -
X-39937109-G-C BCOR c.74C>G p.A25G Missense 2/15 -
X-39937109-GC-CT BCOR c.73_74delGCinsAG p.A25R Missense 2/15 -
1-179198451-C-T ABL2 c.82G>A p.A28T Missense 1/12 -
X-76972672-T-G ATRX c.69A>C p.A23= Synonymous 2/35 -
X-76972672-T-C ATRX c.69A>G p.A23= Synonymous 2/35 -
X-76972672-T-A ATRX c.69A>T p.A23= Synonymous 2/35 -
1-51436078-C-T CDKN2C c.38C>T p.A13V Missense 1/2 -
1-36941207-GGC-CTT CSF3R c.130_132delGCCinsAAG p.A44K Missense 4/17 -
1-51436077-G-C CDKN2C c.37G>C p.A13P Missense 1/2 -
1-51436077-GCT-TAA CDKN2C c.37_39delGCTinsTAA p.A13* Nonsense 1/2 -
20-57466896-G-C GNAS c.115G>C p.A39P Missense 1/13 -
6-26056574-G-A H1-2 c.83C>T p.A28V Missense 1/1 -
13-73355933-GC-CA DIS3 c.37_38delGCinsTG p.A13W Missense 1/21 -
6-152332843-G-A ESR1 c.1149G>A p.W383* Nonsense 5/8 -
16-10274195-GC-CT GRIN2A c.73_74delGCinsAG p.A25R Missense 2/13 -
3-134670840-G-A EPHB1 c.751G>A p.G251R Missense 3/16 -
3-134670840-G-C EPHB1 c.751G>C p.G251R Missense 3/16 -
1-201980418-G-A ELF3 c.154G>A p.E52K Missense 2/9 -
20-57466896-GC-AT GNAS c.115_116delGCinsAT p.A39I Missense 1/13 -
2-25523050-TG-GT DNMT3A c.134_135delCAinsAC p.A45D Missense 3/23 -
16-10274204-GC-TT GRIN2A c.64_65delGCinsAA p.A22K Missense 2/13 -
17-38573077-T-C TOP2A c.92A>G p.E31G Missense 2/35 -
20-36031692-G-T SRC c.1521G>T p.E507D Missense 14/14 -
13-48878112-GC-AA RB1 c.64_65delGCinsAA p.A22K Missense 1/27 -
20-40743879-G-T PTPRT c.3059C>A p.P1020H Missense 22/31 -
20-40739081-C-A PTPRT c.3146G>T p.S1049I Missense 23/31 -
19-44057574-G-A XRCC1 c.580C>T p.R194W Missense 6/17 -
9-5457381-GG-AC CD274 c.355_356delGGinsAC p.G119T Missense 3/7 -
13-49037877-G-T RB1 c.2117G>T p.C706F Missense 21/27 -
7-55242478-G-C EGFR c.2248G>C p.A750P Missense 19/28 -
17-7578236-A-C TP53 c.613T>G p.Y205D Missense 6/11 -
11-108199929-T-G ATM c.7271T>G p.V2424G Missense 49/63 -
7-55242470-T-C EGFR c.2240T>C p.L747S Missense 19/28 -
16-69745145-G-A NQO1 c.559C>T p.P187S Missense 6/6 -
2-204732714-A-G CTLA4 c.49A>G p.T17A Missense 1/4 -
7-55223621-G-A EGFR c.988G>A p.E330K Missense 8/28 -
5-112116592-C-T APC c.637C>T p.R213* Nonsense 6/16 -
12-112926270-C-T PTPN11 c.1403C>T p.T468M Missense 12/16 -
7-55221822-C-A EGFR c.866C>A p.A289D Missense 7/28 -
7-55233043-G-T EGFR c.1793G>T p.G598V Missense 15/28 -
7-55211080-G-A EGFR c.323G>A p.R108K Missense 3/28 -
7-55221743-A-C EGFR c.787A>C p.T263P Missense 7/28 -
7-55223604-G-T EGFR c.971G>T p.R324L Missense 8/28 -
4-110908980-TT-AG EGF c.2572_2573delTTinsAG p.L858R Missense 17/24 -
17-41219646-T-C BRCA1 c.5053A>G p.T1685A Missense 16/23 -
17-41209088-C-G BRCA1 c.5258G>C p.R1753T Missense 19/23 -
17-41203088-A-T BRCA1 c.5324T>A p.M1775K Missense 20/23 -
17-41215898-G-C BRCA1 c.5145C>G p.S1715R Missense 17/23 -
17-41215898-G-T BRCA1 c.5145C>A p.S1715R Missense 17/23 -
17-41215900-T-G BRCA1 c.5143A>C p.S1715R Missense 17/23 -
17-41199698-A-C BRCA1 c.5429T>G p.V1810G Missense 22/23 -
17-41197778-A-C BRCA1 c.5509T>G p.W1837G Missense 23/23 -
17-41215957-C-G BRCA1 c.5086G>C p.V1696L Missense 17/23 -
17-41215957-C-A BRCA1 c.5086G>T p.V1696L Missense 17/23 -
17-41215900-T-A BRCA1 c.5143A>T p.S1715C Missense 17/23 -
17-41215378-G-A BRCA1 c.5165C>T p.S1722F Missense 18/23 -
17-41219627-G-A BRCA1 c.5072C>T p.T1691I Missense 16/23 -
17-41209145-A-G BRCA1 c.5201T>C p.F1734S Missense 19/23 -
17-41209139-A-C BRCA1 c.5207T>G p.V1736G Missense 19/23 -
17-41219625-C-A BRCA1 c.5074G>T p.D1692Y Missense 16/23 -
17-41209094-C-G BRCA1 c.5252G>C p.R1751P Missense 19/23 -
17-41201205-A-G BRCA1 c.5339T>C p.L1780P Missense 21/23 -
17-41219645-G-A BRCA1 c.5054C>T p.T1685I Missense 16/23 -
10-89692886-T-A PTEN c.370T>A p.C124S Missense 5/9 -
7-55259485-C-T EGFR c.2543C>T p.P848L Missense 21/28 -
10-89692902-G-A PTEN c.386G>A p.G129E Missense 5/9 -
10-89692887-G-C PTEN c.371G>C p.C124S Missense 5/9 -
7-140501302-T-C BRAF c.770A>G p.Q257R Missense 6/18 -
15-66729181-A-G MAP2K1 c.389A>G p.Y130C Missense 3/11 -
15-66727483-G-A MAP2K1 c.199G>A p.D67N Missense 2/11 -
7-140481417-C-T BRAF c.1391G>A p.G464E Missense 11/18 -
10-123279674-G-C FGFR2 c.758C>G p.P253R Missense 7/18 -
10-123279677-G-C FGFR2 c.755C>G p.S252W Missense 7/18 -
10-43609949-G-A RET c.1901G>A p.C634Y Missense 11/20 -
7-140481403-C-T BRAF c.1405G>A p.G469R Missense 11/18 -
4-55595519-C-T KIT c.2009C>T p.T670I Missense 14/21 -
7-55242511-G-T EGFR c.2281G>T p.D761Y Missense 19/28 -
7-140481403-C-G BRAF c.1405G>C p.G469R Missense 11/18 -
9-21971138-C-T CDKN2A c.220G>A p.D74N Missense 2/3 -
7-140481402-C-A BRAF c.1406G>T p.G469V Missense 11/18 -
17-7578269-G-A TP53 c.580C>T p.L194F Missense 6/11 -
13-28592644-C-T FLT3 c.2501G>A p.R834Q Missense 20/24 -
2-47703520-G-C MSH2 c.2020G>C p.G674R Missense 13/16 -
17-7578502-A-G TP53 c.428T>C p.V143A Missense 5/11 -
12-112888202-C-T PTPN11 c.218C>T p.T73I Missense 3/16 -
16-89833576-G-C FANCA c.2574C>G p.S858R Missense 27/43 -
16-89833576-G-T FANCA c.2574C>A p.S858R Missense 27/43 -
16-89833578-T-G FANCA c.2572A>C p.S858R Missense 27/43 -
11-108175462-G-A ATM c.5557G>A p.D1853N Missense 37/63 -
22-30032816-T-C NF2 c.191T>C p.L64P Missense 2/16 -
17-7578205-C-A TP53 c.644G>T p.S215I Missense 6/11 -
17-7578463-C-T TP53 c.467G>A p.R156H Missense 5/11 -
1-43815008-TG-AA MPL c.1543_1544delTGinsAA p.W515K Missense 10/12 -
5-112175240-G-C APC c.3949G>C p.E1317Q Missense 16/16 -
4-55593603-T-A KIT c.1669T>A p.W557R Missense 11/21 -
4-55593603-T-C KIT c.1669T>C p.W557R Missense 11/21 -
7-140453136-A-C BRAF c.1799T>G p.V600G Missense 15/18 -
17-41209134-C-T BRCA1 c.5212G>A p.G1738R Missense 19/23 -
17-41209134-C-G BRCA1 c.5212G>C p.G1738R Missense 19/23 -
17-41197778-A-T BRCA1 c.5509T>A p.W1837R Missense 23/23 -
17-41197778-A-G BRCA1 c.5509T>C p.W1837R Missense 23/23 -
17-41215920-G-A BRCA1 c.5123C>T p.A1708V Missense 17/23 -
17-41215920-G-T BRCA1 c.5123C>A p.A1708E Missense 17/23 -
17-41215947-C-T BRCA1 c.5096G>A p.R1699Q Missense 17/23 -
3-37045935-C-T MLH1 c.350C>T p.T117M Missense 4/19 -
3-37058999-C-T MLH1 c.793C>T p.R265C Missense 10/19 -
17-41203130-A-G BRCA1 c.5282T>C p.F1761S Missense 20/23 -
17-7578463-C-G TP53 c.467G>C p.R156P Missense 5/11 -
17-7578271-T-G TP53 c.578A>C p.H193P Missense 6/11 -
10-89711899-C-T PTEN c.517C>T p.R173C Missense 6/9 -
17-7577098-T-G TP53 c.840A>C p.R280S Missense 8/11 -
19-10602581-C-A KEAP1 c.997G>T p.G333C Missense 3/6 -
19-10602290-C-A KEAP1 c.1288G>T p.G430C Missense 3/6 -
17-7578550-G-A TP53 c.380C>T p.S127F Missense 5/11 -
17-7578415-A-T TP53 c.515T>A p.V172D Missense 5/11 -
17-7577098-T-A TP53 c.840A>T p.R280S Missense 8/11 -
17-7577084-T-A TP53 c.854A>T p.E285V Missense 8/11 -
17-7578443-A-G TP53 c.487T>C p.Y163H Missense 5/11 -
17-7577105-G-A TP53 c.833C>T p.P278L Missense 8/11 -
19-45860626-G-C ERCC2 c.1381C>G p.L461V Missense 15/23 -
17-7577550-C-G TP53 c.731G>C p.G244A Missense 7/11 -
17-7577511-A-G TP53 c.770T>C p.L257P Missense 7/11 -
17-7577509-C-T TP53 c.772G>A p.E258K Missense 7/11 -
17-7578536-T-G TP53 c.394A>C p.K132Q Missense 5/11 -
17-7577577-T-C TP53 c.704A>G p.N235S Missense 7/11 -
17-7578235-T-A TP53 c.614A>T p.Y205F Missense 6/11 -
9-133738364-A-T ABL1 c.764A>T p.E255V Missense 4/11 -
9-133738349-G-A ABL1 c.749G>A p.G250E Missense 4/11 -
17-7577556-C-A TP53 c.725G>T p.C242F Missense 7/11 -
11-69466018-A-G CCND1 c.856A>G p.T286A Missense 5/5 -
17-59878709-C-G BRIP1 c.1045G>C p.A349P Missense 8/20 -
17-59937223-G-C BRIP1 c.139C>G p.P47A Missense 3/20 -
17-59937207-T-C BRIP1 c.155A>G p.K52R Missense 3/20 -
17-7578526-C-A TP53 c.404G>T p.C135F Missense 5/11 -
17-7577526-A-G TP53 c.755T>C p.L252P Missense 7/11 -
4-55599320-GA-TT KIT c.2446_2447delGAinsTT p.D816F Missense 17/21 -
1-43814979-G-A MPL c.1514G>A p.S505N Missense 10/12 -
17-7578527-A-G TP53 c.403T>C p.C135R Missense 5/11 -
17-7578464-G-A TP53 c.466C>T p.R156C Missense 5/11 -
17-7578478-G-C TP53 c.452C>G p.P151R Missense 5/11 -
17-7578467-T-C TP53 c.463A>G p.T155A Missense 5/11 -
13-32937506-G-C BRCA2 c.8167G>C p.D2723H Missense 18/27 -
3-41266112-T-G CTNNB1 c.109T>G p.S37A Missense 3/15 -
17-7578461-C-G TP53 c.469G>C p.V157L Missense 5/11 -
17-7578374-C-T TP53 c.556G>A p.D186N Missense 5/11 -
17-37881440-C-T ERBB2 c.2632C>T p.H878Y Missense 21/27 -
3-10191513-T-C VHL c.506T>C p.L169P Missense 3/3 -
17-7578490-A-C TP53 c.440T>G p.V147G Missense 5/11 -
17-7577566-T-C TP53 c.715A>G p.N239D Missense 7/11 -
17-7578281-G-A TP53 c.568C>T p.P190S Missense 6/11 -
17-7577088-T-G TP53 c.850A>C p.T284P Missense 8/11 -
17-37879601-TT-AG ERBB2 c.1976_1977delTTinsAG p.V659E Missense 17/27 -
3-37090053-C-T MLH1 c.1942C>T p.P648S Missense 17/19 -
7-55241708-G-A EGFR c.2156G>A p.G719D Missense 18/28 -
10-89692901-G-A PTEN c.385G>A p.G129R Missense 5/9 -
10-89692901-G-C PTEN c.385G>C p.G129R Missense 5/9 -
3-10183863-G-A VHL c.332G>A p.S111N Missense 1/3 -
7-152346007-C-T XRCC2 c.563G>A p.R188H Missense 3/3 -
12-25398218-G-A KRAS c.101C>T p.P34L Missense 2/5 -
12-25362838-T-A KRAS c.458A>T p.D153V Missense 5/5 -
12-112915523-A-G PTPN11 c.922A>G p.N308D Missense 8/16 -
12-25398255-G-C KRAS c.64C>G p.Q22E Missense 2/5 -
12-25380285-G-A KRAS c.173C>T p.T58I Missense 3/5 -
11-534286-C-A HRAS c.37G>T p.G13C Missense 2/6 -
7-140477813-T-C BRAF c.1495A>G p.K499E Missense 12/18 -
11-534289-C-T HRAS c.34G>A p.G12S Missense 2/6 -
12-25398254-T-C KRAS c.65A>G p.Q22R Missense 2/5 -
12-25398279-C-T KRAS c.40G>A p.V14I Missense 2/5 -
12-25398218-G-C KRAS c.101C>G p.P34R Missense 2/5 -
12-25380280-C-G KRAS c.178G>C p.G60R Missense 3/5 -
3-10183772-C-T VHL c.241C>T p.P81S Missense 1/3 -
7-55241678-A-G EGFR c.2126A>G p.E709G Missense 18/28 -
17-41258495-A-C BRCA1 c.190T>G p.C64G Missense 4/23 -
7-55242469-TT-CC EGFR c.2239_2240delTTinsCC p.L747P Missense 19/28 -
7-55259482-C-T EGFR c.2540C>T p.T847I Missense 21/28 -
7-55259530-G-A EGFR c.2588G>A p.G863D Missense 21/28 -
7-55259469-G-A EGFR c.2527G>A p.V843I Missense 21/28 -
10-43614996-G-C RET c.2410G>C p.V804L Missense 14/20 -
7-55259512-G-A EGFR c.2570G>A p.G857E Missense 21/28 -
10-43614996-G-T RET c.2410G>T p.V804L Missense 14/20 -
10-43609936-T-C RET c.1888T>C p.C630R Missense 11/20 -
17-59924572-G-A BRIP1 c.517C>T p.R173C Missense 6/20 -
10-43609948-T-C RET c.1900T>C p.C634R Missense 11/20 -
10-43615568-GC-TT RET c.2647_2648delGCinsTT p.A883F Missense 15/20 -
10-43614996-G-A RET c.2410G>A p.V804M Missense 14/20 -
3-41266133-C-G CTNNB1 c.130C>G p.P44A Missense 3/15 -
3-41266137-C-A CTNNB1 c.134C>A p.S45Y Missense 3/15 -
4-55144547-C-T PDGFRA c.2021C>T p.T674I Missense 15/23 -
4-55141036-T-A PDGFRA c.1682T>A p.V561D Missense 12/23 -
16-2120572-G-A TSC2 c.1832G>A p.R611Q Missense 17/42 -
17-7577099-C-G TP53 c.839G>C p.R280T Missense 8/11 -
22-30038263-G-A NF2 c.436G>A p.V146I Missense 4/16 -
17-7577566-T-A TP53 c.715A>T p.N239Y Missense 7/11 -
9-135801023-T-C TSC1 c.314A>G p.H105R Missense 5/23 -
9-135797253-G-C TSC1 c.616C>G p.H206D Missense 7/23 -
9-135797222-AA-GC TSC1 c.646_647delTTinsGC p.F216A Missense 7/23 -
9-135796816-A-C TSC1 c.671T>G p.M224R Missense 8/23 -
9-135802595-T-C TSC1 c.203A>G p.H68R Missense 4/23 -
9-135798770-A-C TSC1 c.473T>G p.F158C Missense 6/23 -
17-7577557-A-T TP53 c.724T>A p.C242S Missense 7/11 -
17-7577556-C-G TP53 c.725G>C p.C242S Missense 7/11 -
17-7578517-G-A TP53 c.413C>T p.A138V Missense 5/11 -
17-37880989-T-C ERBB2 c.2318T>C p.V773A Missense 20/27 -
17-7577529-A-C TP53 c.752T>G p.I251S Missense 7/11 -
17-7577560-A-C TP53 c.721T>G p.S241A Missense 7/11 -
17-7579350-A-C TP53 c.337T>G p.F113V Missense 4/11 -
17-7577506-C-A TP53 c.775G>T p.D259Y Missense 7/11 -
17-7577535-C-A TP53 c.746G>T p.R249M Missense 7/11 -
17-7579358-C-G TP53 c.329G>C p.R110P Missense 4/11 -
17-41197774-A-T BRCA1 c.5513T>A p.V1838E Missense 23/23 -
1-65312418-G-T JAK1 c.1901C>A p.A634D Missense 14/25 -
1-65310517-C-T JAK1 c.2171G>A p.R724H Missense 16/25 -
1-65306942-G-A JAK1 c.2635C>T p.R879C Missense 19/25 -
4-1807889-A-G FGFR3 c.1948A>G p.K650E Missense 14/18 -
9-133738358-A-T ABL1 c.758A>T p.Y253F Missense 4/11 -
9-133738363-G-A ABL1 c.763G>A p.E255K Missense 4/11 -
10-43609950-C-G RET c.1902C>G p.C634W Missense 11/20 -
9-21974681-A-C CDKN2A c.146T>G p.I49S Missense 1/3 -
9-21971099-G-A CDKN2A c.259C>T p.R87W Missense 2/3 -
9-21971057-C-A CDKN2A c.301G>T p.G101W Missense 2/3 -
9-21971138-C-A CDKN2A c.220G>T p.D74Y Missense 2/3 -
9-21971146-T-C CDKN2A c.212A>G p.N71S Missense 2/3 -
9-21974756-C-G CDKN2A c.71G>C p.R24P Missense 1/3 -
9-21971159-C-G CDKN2A c.199G>C p.G67R Missense 2/3 -
9-21971179-GC-CT CDKN2A c.178_179delGCinsAG p.A60R Missense 2/3 -
9-21971188-G-A CDKN2A c.170C>T p.A57V Missense 2/3 -
9-21971024-G-C CDKN2A c.334C>G p.R112G Missense 2/3 -
9-21971062-C-G CDKN2A c.296G>C p.R99P Missense 2/3 -
9-21971018-G-A CDKN2A c.340C>T p.P114S Missense 2/3 -
9-21971191-C-A CDKN2A c.167G>T p.S56I Missense 2/3 -
9-21970981-A-T CDKN2A c.377T>A p.V126D Missense 2/3 -
9-21971108-C-T CDKN2A c.250G>A p.D84N Missense 2/3 -
9-21971199-C-T CDKN2A c.159G>A p.M53I Missense 2/3 -
17-7577090-C-G TP53 c.848G>C p.R283P Missense 8/11 -
3-178916946-G-C PIK3CA c.333G>C p.K111N Missense 2/21 -
3-178916946-G-T PIK3CA c.333G>T p.K111N Missense 2/21 -
3-41266101-C-G CTNNB1 c.98C>G p.S33C Missense 3/15 -
3-41266100-T-G CTNNB1 c.97T>G p.S33A Missense 3/15 -
3-41266113-C-T CTNNB1 c.110C>T p.S37F Missense 3/15 -
22-29121326-T-C CHEK2 c.349A>G p.R117G Missense 3/15 -
12-112926248-G-A PTPN11 c.1381G>A p.A461T Missense 12/16 -
10-89717697-T-C PTEN c.722T>C p.F241S Missense 7/9 -
10-89720825-G-A PTEN c.976G>A p.D326N Missense 8/9 -
10-89717730-A-G PTEN c.755A>G p.D252G Missense 7/9 -
3-41266136-T-G CTNNB1 c.133T>G p.S45A Missense 3/15 -
3-41266110-A-C CTNNB1 c.107A>C p.H36P Missense 3/15 -
3-41266113-C-G CTNNB1 c.110C>G p.S37C Missense 3/15 -
3-41266107-T-G CTNNB1 c.104T>G p.I35S Missense 3/15 -
7-55241678-A-T EGFR c.2126A>T p.E709V Missense 18/28 -
3-12645699-G-A RAF1 c.770C>T p.S257L Missense 7/17 -
12-112926872-C-T PTPN11 c.1492C>T p.R498W Missense 13/16 -
12-112926908-C-G PTPN11 c.1528C>G p.Q510E Missense 13/16 -
4-55593613-T-G KIT c.1679T>G p.V560G Missense 11/21 -
4-55592202-A-T KIT c.1526A>T p.K509I Missense 9/21 -
17-41203088-A-C BRCA1 c.5324T>G p.M1775R Missense 20/23 -
17-41201181-C-T BRCA1 c.5363G>A p.G1788D Missense 21/23 -
13-32953937-G-A BRCA2 c.9004G>A p.E3002K Missense 23/27 -
13-32954180-C-T BRCA2 c.9154C>T p.R3052W Missense 24/27 -
4-55972974-T-A KDR c.1416A>T p.Q472H Missense 11/30 -
4-55972974-T-G KDR c.1416A>C p.Q472H Missense 11/30 -
4-55972946-A-G KDR c.1444T>C p.C482R Missense 11/30 -
7-55259545-A-G EGFR c.2603A>G p.E868G Missense 21/28 -
7-55249007-G-A EGFR c.2305G>A p.V769M Missense 20/28 -
7-55249029-G-A EGFR c.2327G>A p.R776H Missense 20/28 -
4-1806153-C-A FGFR3 c.1172C>A p.A391E Missense 9/18 -
4-1806089-G-T FGFR3 c.1108G>T p.G370C Missense 9/18 -
9-80409488-T-A GNAQ c.626A>T p.Q209L Missense 5/7 -
17-41222967-G-A BRCA1 c.4964C>T p.S1655F Missense 15/23 -
17-41215948-G-A BRCA1 c.5095C>T p.R1699W Missense 17/23 -
8-128750680-A-G MYC c.217A>G p.T73A Missense 2/3 -
12-25398262-C-G KRAS c.57G>C p.L19F Missense 2/5 -
3-10183725-C-G VHL c.194C>G p.S65W Missense 1/3 -
3-10183764-A-G VHL c.233A>G p.N78S Missense 1/3 -
3-10191507-G-A VHL c.500G>A p.R167Q Missense 3/3 -
3-10191506-C-T VHL c.499C>T p.R167W Missense 3/3 -
3-10191488-C-T VHL c.481C>T p.R161* Nonsense 3/3 -
10-89692794-A-G PTEN c.278A>G p.H93R Missense 5/9 -
13-32944557-C-T BRCA2 c.8350C>T p.R2784W Missense 19/27 -
10-89692790-G-C PTEN c.274G>C p.D92H Missense 5/9 -
7-55240690-C-G EGFR c.1934C>G p.S645C Missense 17/28 -
4-55599332-G-T KIT c.2458G>T p.D820Y Missense 17/21 -
4-55594258-T-C KIT c.1961T>C p.V654A Missense 13/21 -
16-2126143-G-A TSC2 c.2714G>A p.R905Q Missense 24/42 -
12-25398262-C-A KRAS c.57G>T p.L19F Missense 2/5 -
3-10183823-T-C VHL c.292T>C p.Y98H Missense 1/3 -
3-10191492-G-T VHL c.485G>T p.C162F Missense 3/3 -
3-178936083-A-T PIK3CA c.1625A>T p.E542V Missense 10/21 -
17-7578427-T-C TP53 c.503A>G p.H168R Missense 5/11 -
10-89653814-C-T PTEN c.112C>T p.P38S Missense 2/9 -
3-41266097-G-C CTNNB1 c.94G>C p.D32H Missense 3/15 -
13-32936812-T-C BRCA2 c.7958T>C p.L2653P Missense 17/27 -
14-35873756-C-A NFKBIA c.95G>T p.S32I Missense 1/6 -
3-12645693-G-A RAF1 c.776C>T p.S259F Missense 7/17 -
3-41266072-T-G CTNNB1 c.69T>G p.S23R Missense 3/15 -
3-41266072-T-A CTNNB1 c.69T>A p.S23R Missense 3/15 -
3-41266070-A-C CTNNB1 c.67A>C p.S23R Missense 3/15 -
3-41266101-C-T CTNNB1 c.98C>T p.S33F Missense 3/15 -
3-41266125-C-T CTNNB1 c.122C>T p.T41I Missense 3/15 -
7-116423414-A-G MET c.3689A>G p.Y1230C Missense 19/21 -
7-116423413-T-C MET c.3688T>C p.Y1230H Missense 19/21 -
13-49027133-C-T RB1 c.1700C>T p.S567L Missense 18/27 -
3-12645687-G-A RAF1 c.782C>T p.P261L Missense 7/17 -
13-32945129-C-T BRCA2 c.8524C>T p.R2842C Missense 20/27 -
13-32936830-G-C BRCA2 c.7976G>C p.R2659T Missense 17/27 -
13-32937507-A-G BRCA2 c.8168A>G p.D2723G Missense 18/27 -
13-32936733-A-T BRCA2 c.7879A>T p.I2627F Missense 17/27 -
13-32937327-A-T BRCA2 c.7988A>T p.E2663V Missense 18/27 -
13-32936794-T-C BRCA2 c.7940T>C p.L2647P Missense 17/27 -
13-32936830-G-A BRCA2 c.7976G>A p.R2659K Missense 17/27 -
17-7577120-C-G TP53 c.818G>C p.R273P Missense 8/11 -
3-41266101-C-A CTNNB1 c.98C>A p.S33Y Missense 3/15 -
3-41266113-C-A CTNNB1 c.110C>A p.S37Y Missense 3/15 -
13-32968854-C-G BRCA2 c.9285C>G p.D3095E Missense 25/27 -
13-32968854-C-A BRCA2 c.9285C>A p.D3095E Missense 25/27 -
13-32937582-G-A BRCA2 c.8243G>A p.G2748D Missense 18/27 -
13-32937507-A-C BRCA2 c.8168A>C p.D2723A Missense 18/27 -
17-7579313-G-A TP53 c.374C>T p.T125M Missense 4/11 -
2-29436860-A-C ALK c.3733T>G p.F1245V Missense 24/29 -
7-55259439-T-G EGFR c.2497T>G p.L833V Missense 21/28 -
2-29436859-A-C ALK c.3734T>G p.F1245C Missense 24/29 -
2-29436893-C-T ALK c.3700G>A p.A1234T Missense 24/29 -
2-29446296-C-T ALK c.3271G>A p.D1091N Missense 20/29 -
9-5089726-C-A JAK2 c.2624C>A p.T875N Missense 20/25 -
4-55593610-T-G KIT c.1676T>G p.V559G Missense 11/21 -
9-5070026-AA-CT JAK2 c.1615_1616delAAinsCT p.K539L Missense 12/25 -
9-5078360-A-G JAK2 c.2047A>G p.R683G Missense 16/25 -
4-55599320-G-T KIT c.2446G>T p.D816Y Missense 17/21 -
4-55593609-G-A KIT c.1675G>A p.V559I Missense 11/21 -
4-55593408-T-G KIT c.1565T>G p.F522C Missense 10/21 -
17-7578534-C-G TP53 c.396G>C p.K132N Missense 5/11 -
17-7578534-C-A TP53 c.396G>T p.K132N Missense 5/11 -
17-7577069-C-T TP53 c.869G>A p.R290H Missense 8/11 -
3-37038192-G-A MLH1 c.199G>A p.G67R Missense 2/19 -
13-32921033-G-A BRCA2 c.7007G>A p.R2336H Missense 13/27 -
17-41276043-C-T BRCA1 c.71G>A p.C24Y Missense 2/23 -
12-25398282-C-T KRAS c.37G>A p.G13S Missense 2/5 -
22-29091207-G-A CHEK2 c.1283C>T p.S428F Missense 12/15 -
11-69466021-C-T CCND1 c.859C>T p.P287S Missense 5/5 -
11-69466021-C-G CCND1 c.859C>G p.P287A Missense 5/5 -
9-21974759-C-T CDKN2A c.68G>A p.G23D Missense 1/3 -
3-10183771-T-G VHL c.240T>G p.S80R Missense 1/3 -
3-10183771-T-A VHL c.240T>A p.S80R Missense 1/3 -
3-10183769-A-C VHL c.238A>C p.S80R Missense 1/3 -
17-7579328-TT-GC TP53 c.358_359delAAinsGC p.K120A Missense 4/11 -
13-28608341-T-C FLT3 c.1715A>G p.Y572C Missense 14/24 -
15-66774176-TC-GA MAP2K1 c.652_653delTCinsGA p.S218D Missense 6/11 -
4-1807371-C-A FGFR3 c.1620C>A p.N540K Missense 12/18 -
4-1806099-A-G FGFR3 c.1118A>G p.Y373C Missense 9/18 -
4-1807890-A-T FGFR3 c.1949A>T p.K650M Missense 14/18 -
7-55260483-G-A EGFR c.2650G>A p.E884K Missense 22/28 -
10-43617419-C-T RET c.2756C>T p.A919V Missense 16/20 -
10-43617424-G-A RET c.2761G>A p.E921K Missense 16/20 -
17-7577093-C-T TP53 c.845G>A p.R282Q Missense 8/11 -
7-140481411-C-A BRAF c.1397G>T p.G466V Missense 11/18 -
19-1221319-C-T STK11 c.842C>T p.P281L Missense 6/10 -
19-1223123-T-C STK11 c.1060T>C p.F354L Missense 8/10 -
19-1223125-C-A STK11 c.1062C>A p.F354L Missense 8/10 -
19-1223125-C-G STK11 c.1062C>G p.F354L Missense 8/10 -
7-140453139-G-A BRAF c.1796C>T p.T599I Missense 15/18 -
19-1220487-G-T STK11 c.580G>T p.D194Y Missense 4/10 -
7-140453193-T-C BRAF c.1742A>G p.N581S Missense 15/18 -
1-65312347-C-A JAK1 c.1972G>T p.V658F Missense 14/25 -
10-123298174-C-T FGFR2 c.680G>A p.G227E Missense 6/18 -
2-158622516-C-T ACVR1 c.983G>A p.G328E Missense 8/11 -
4-55593584-A-C KIT c.1650A>C p.K550N Missense 11/21 -
4-55593584-A-T KIT c.1650A>T p.K550N Missense 11/21 -
4-55594221-A-G KIT c.1924A>G p.K642E Missense 13/21 -
5-67591085-G-T PIK3R1 c.1678G>T p.D560Y Missense 13/16 -
5-67591099-C-G PIK3R1 c.1692C>G p.N564K Missense 13/16 -
5-67591099-C-A PIK3R1 c.1692C>A p.N564K Missense 13/16 -
7-55259455-T-C EGFR c.2513T>C p.L838P Missense 21/28 -
7-55242487-C-T EGFR c.2257C>T p.P753S Missense 19/28 -
1-115258730-C-T NRAS c.52G>A p.A18T Missense 2/7 -
7-55241678-A-C EGFR c.2126A>C p.E709A Missense 18/28 -
12-25398284-CC-AA KRAS c.34_35delGGinsTT p.G12F Missense 2/5 -
12-112888165-G-T PTPN11 c.181G>T p.D61Y Missense 3/16 -
17-37881001-T-C ERBB2 c.2330T>C p.V777A Missense 20/27 -
3-10191605-C-T VHL c.598C>T p.R200W Missense 3/3 -
11-534288-C-T HRAS c.35G>A p.G12D Missense 2/6 -
11-533875-G-T HRAS c.181C>A p.Q61K Missense 3/6 -
11-533874-T-A HRAS c.182A>T p.Q61L Missense 3/6 -
9-21974721-C-G CDKN2A c.106G>C p.A36P Missense 1/3 -
12-58145431-G-A CDK4 c.70C>T p.R24C Missense 2/8 -
12-25398281-C-A KRAS c.38G>T p.G13V Missense 2/5 -
17-7578427-T-G TP53 c.503A>C p.H168P Missense 5/11 -
17-7577536-T-C TP53 c.745A>G p.R249G Missense 7/11 -
21-36259324-A-G RUNX1 c.167T>C p.L56S Missense 4/9 -
12-112888198-G-A PTPN11 c.214G>A p.A72T Missense 3/16 -
12-112888211-A-C PTPN11 c.227A>C p.E76A Missense 3/16 -
17-7579548-G-A TP53 c.139C>T p.P47S Missense 4/11 -
2-158617589-C-T ACVR1 c.1067G>A p.G356D Missense 9/11 -
17-7577102-C-T TP53 c.836G>A p.G279E Missense 8/11 -
17-7579325-G-A TP53 c.362C>T p.S121F Missense 4/11 -
17-7577107-A-C TP53 c.831T>G p.C277W Missense 8/11 -
17-7578472-G-A TP53 c.458C>T p.P153L Missense 5/11 -
17-59793412-G-A BRIP1 c.2392C>T p.R798* Nonsense 17/20 -
17-7577518-T-A TP53 c.763A>T p.I255F Missense 7/11 -
3-10191569-C-G VHL c.562C>G p.L188V Missense 3/3 -
3-10183865-T-C VHL c.334T>C p.Y112H Missense 1/3 -
17-7578460-A-T TP53 c.470T>A p.V157D Missense 5/11 -
17-7577142-C-T TP53 c.796G>A p.G266R Missense 8/11 -
17-7577557-A-G TP53 c.724T>C p.C242R Missense 7/11 -
17-7577559-G-T TP53 c.722C>A p.S241Y Missense 7/11 -
4-55599320-G-C KIT c.2446G>C p.D816H Missense 17/21 -
17-41276061-A-G BRCA1 c.53T>C p.M18T Missense 2/23 -
12-25398280-GC-CT KRAS c.38_39delinsAG p.G13E Missense 2/5 -
16-2122935-T-A TSC2 c.2306T>A p.V769E Missense 21/42 -
16-2121512-C-A TSC2 c.1841C>A p.A614D Missense 18/42 -
17-7578211-C-A TP53 c.638G>T p.R213L Missense 6/11 -
3-10183739-G-A VHL c.208G>A p.E70K Missense 1/3 -
16-2120571-C-T TSC2 c.1831C>T p.R611W Missense 17/42 -
16-2121925-G-A TSC2 c.2087G>A p.C696Y Missense 19/42 -
16-2121515-T-C TSC2 c.1844T>C p.F615S Missense 18/42 -
3-178917478-G-A PIK3CA c.353G>A p.G118D Missense 3/21 -
7-140453145-A-C BRAF c.1790T>G p.L597R Missense 15/18 -
3-10188219-A-G VHL c.362A>G p.D121G Missense 2/3 -
3-138665163-G-C FOXL2 c.402C>G p.C134W Missense 1/1 -
10-43609096-T-C RET c.1852T>C p.C618R Missense 10/20 -
10-43609102-T-C RET c.1858T>C p.C620R Missense 10/20 -
10-89685307-T-C PTEN c.202T>C p.Y68H Missense 3/9 -
10-89685290-A-G PTEN c.185A>G p.K62R Missense 3/9 -
10-89685299-A-G PTEN c.194A>G p.Y65C Missense 3/9 -
10-89692889-A-G PTEN c.373A>G p.K125E Missense 5/9 -
13-49030485-G-C RB1 c.1960G>C p.V654L Missense 19/27 -
10-89692904-C-G PTEN c.388C>G p.R130G Missense 5/9 -
10-123247516-T-C FGFR2 c.1975A>G p.K659E Missense 14/18 -
7-140477861-T-C BRAF c.1447A>G p.K483E Missense 12/18 -
7-140453987-T-C BRAF c.1741A>G p.N581D Missense 14/18 -
7-140453152-A-G BRAF c.1783T>C p.F595L Missense 15/18 -
7-140453150-A-T BRAF c.1785T>A p.F595L Missense 15/18 -
7-140453150-A-C BRAF c.1785T>G p.F595L Missense 15/18 -
7-140453149-C-G BRAF c.1786G>C p.G596R Missense 15/18 -
7-140453146-G-C BRAF c.1789C>G p.L597V Missense 15/18 -
7-140453154-T-A BRAF c.1781A>T p.D594V Missense 15/18 -
2-29445450-C-G ALK c.3383G>C p.G1128A Missense 21/29 -
2-29436860-A-G ALK c.3733T>C p.F1245L Missense 24/29 -
2-29436858-G-T ALK c.3735C>A p.F1245L Missense 24/29 -
2-29436858-G-C ALK c.3735C>G p.F1245L Missense 24/29 -
2-29432739-A-G ALK c.3749T>C p.I1250T Missense 25/29 -
2-29443642-C-G ALK c.3575G>C p.R1192P Missense 23/29 -
2-29445228-A-C ALK c.3497T>G p.M1166R Missense 22/29 -
2-29446382-T-A ALK c.3185A>T p.K1062M Missense 20/29 -
2-29443697-A-C ALK c.3520T>G p.F1174V Missense 23/29 -
2-29443697-A-T ALK c.3520T>A p.F1174I Missense 23/29 -
1-115256538-G-A NRAS c.173C>T p.T58I Missense 3/7 -
14-81609760-T-C TSHR c.1358T>C p.M453T Missense 10/10 -
14-81610289-G-T TSHR c.1887G>T p.L629F Missense 10/10 -
14-81610289-G-C TSHR c.1887G>C p.L629F Missense 10/10 -
4-1807891-G-C FGFR3 c.1950G>C p.K650N Missense 14/18 -
4-1807891-G-T FGFR3 c.1950G>T p.K650N Missense 14/18 -
4-1807890-A-C FGFR3 c.1949A>C p.K650T Missense 14/18 -
11-534288-C-G HRAS c.35G>C p.G12A Missense 2/6 -
4-1807889-A-C FGFR3 c.1948A>C p.K650Q Missense 14/18 -
4-1807890-A-G FGFR3 c.1949A>G p.K650R Missense 14/18 -
9-139399132-C-T NOTCH1 c.5011G>A p.V1671I Missense 26/34 -
10-89717730-A-T PTEN c.755A>T p.D252V Missense 7/9 -
9-80409488-T-G GNAQ c.626A>C p.Q209P Missense 5/7 -
19-1221995-C-T STK11 c.910C>T p.R304W Missense 7/10 -
19-1220629-C-T STK11 c.647C>T p.S216F Missense 5/10 -
11-119148921-TG-GC CBL c.1141_1142delTGinsGC p.C381A Missense 8/16 -
3-37038192-G-T MLH1 c.199G>T p.G67W Missense 2/19 -
10-123279599-C-A FGFR2 c.833G>T p.C278F Missense 7/18 -
7-55242482-C-T EGFR c.2252C>T p.T751I Missense 19/28 -
7-55259535-G-A EGFR c.2593G>A p.E865K Missense 21/28 -
7-55259434-G-A EGFR c.2492G>A p.R831H Missense 21/28 -
13-28592640-A-C FLT3 c.2505T>G p.D835E Missense 20/24 -
13-28592640-A-T FLT3 c.2505T>A p.D835E Missense 20/24 -
4-55599322-C-G KIT c.2448C>G p.D816E Missense 17/21 -
17-7573996-A-G TP53 c.1031T>C p.L344P Missense 10/11 -
3-10191570-T-A VHL c.563T>A p.L188Q Missense 3/3 -
3-10191480-T-C VHL c.473T>C p.L158P Missense 3/3 -
3-10183823-T-A VHL c.292T>A p.Y98N Missense 1/3 -
17-7578393-A-C TP53 c.537T>G p.H179Q Missense 5/11 -
17-7577124-C-G TP53 c.814G>C p.V272L Missense 8/11 -
17-7577124-C-A TP53 c.814G>T p.V272L Missense 8/11 -
7-55249088-G-A EGFR c.2386G>A p.G796S Missense 20/28 -
4-55599322-C-A KIT c.2448C>A p.D816E Missense 17/21 -
13-28592641-T-A FLT3 c.2504A>T p.D835V Missense 20/24 -
7-116423408-A-T MET c.3683A>T p.D1228V Missense 19/21 -
7-116423407-G-A MET c.3682G>A p.D1228N Missense 19/21 -
7-116423474-T-C MET c.3749T>C p.M1250T Missense 19/21 -
20-57484420-C-A GNAS c.601C>A p.R201S Missense 8/13 -
17-7578272-G-T TP53 c.577C>A p.H193N Missense 6/11 -
17-7578416-C-A TP53 c.514G>T p.V172F Missense 5/11 -
17-7578393-A-T TP53 c.537T>A p.H179Q Missense 5/11 -
17-7577543-C-G TP53 c.738G>C p.M246I Missense 7/11 -
17-7577543-C-T TP53 c.738G>A p.M246I Missense 7/11 -
17-7577543-C-A TP53 c.738G>T p.M246I Missense 7/11 -
17-7577123-A-G TP53 c.815T>C p.V272A Missense 8/11 -
17-7578274-T-C TP53 c.575A>G p.Q192R Missense 6/11 -
17-7577545-T-C TP53 c.736A>G p.M246V Missense 7/11 -
17-7577091-G-A TP53 c.847C>T p.R283C Missense 8/11 -
17-7577114-C-G TP53 c.824G>C p.C275S Missense 8/11 -
17-7577112-C-T TP53 c.826G>A p.A276T Missense 8/11 -
17-7577118-C-A TP53 c.820G>T p.V274F Missense 8/11 -
1-115258745-C-A NRAS c.37G>T p.G13C Missense 2/7 -
17-41209130-T-C BRCA1 c.5216A>G p.D1739G Missense 19/23 -
11-108183151-G-T ATM c.5932G>T p.E1978* Nonsense 40/63 -
3-178936093-G-C PIK3CA c.1635G>C p.E545D Missense 10/21 -
12-25398281-C-G KRAS c.38G>C p.G13A Missense 2/5 -
19-40741870-G-A AKT2 c.1102C>T p.R368C Missense 11/14 -
10-89624296-G-T PTEN c.70G>T p.D24Y Missense 1/9 -
17-7578401-G-A TP53 c.529C>T p.P177S Missense 5/11 -
4-55964372-T-A KDR c.2441A>T p.D814V Missense 17/30 -
4-55593610-T-A KIT c.1676T>A p.V559D Missense 11/21 -
17-7578518-C-G TP53 c.412G>C p.A138P Missense 5/11 -
7-6045627-C-T PMS2 c.59G>A p.R20Q Missense 2/15 -
17-7578528-A-T TP53 c.402T>A p.F134L Missense 5/11 -
17-7578454-G-A TP53 c.476C>T p.A159V Missense 5/11 -
3-10188202-C-A VHL c.345C>A p.H115Q Missense 2/3 -
3-10188202-C-G VHL c.345C>G p.H115Q Missense 2/3 -
17-7578388-C-T TP53 c.542G>A p.R181H Missense 5/11 -
16-68856041-G-A CDH1 c.1849G>A p.A617T Missense 12/16 -
16-68856093-C-T CDH1 c.1901C>T p.A634V Missense 12/16 -
13-41240280-T-C FOXO1 c.70A>G p.T24A Missense 1/3 -
9-5073773-T-C JAK2 c.1852T>C p.C618R Missense 14/25 -
10-123258036-T-G FGFR2 c.1645A>C p.N549H Missense 12/18 -
17-41197728-G-T BRCA1 c.5559C>A p.Y1853* Nonsense 23/23 -
17-41197728-G-C BRCA1 c.5559C>G p.Y1853* Nonsense 23/23 -
17-41209100-G-C BRCA1 c.5246C>G p.P1749R Missense 19/23 -
11-119169221-G-A CBL c.2405G>A p.W802* Nonsense 15/16 -
17-7577106-G-C TP53 c.832C>G p.P278A Missense 8/11 -
17-7577139-G-A TP53 c.799C>T p.R267W Missense 8/11 -
10-123310821-G-A FGFR2 c.607C>T p.R203C Missense 5/18 -
11-119148919-T-C CBL c.1139T>C p.L380P Missense 8/16 -
11-119148972-C-T CBL c.1192C>T p.H398Y Missense 8/16 -
11-119148930-T-C CBL c.1150T>C p.C384R Missense 8/16 -
11-119148951-G-A CBL c.1171G>A p.V391I Missense 8/16 -
11-119144732-C-G CBL c.745C>G p.Q249E Missense 4/16 -
11-119169222-G-A CBL c.2406G>A p.W802* Nonsense 15/16 -
11-119149251-G-A CBL c.1259G>A p.R420Q Missense 9/16 -
17-7577547-C-A TP53 c.734G>T p.G245V Missense 7/11 -
17-7577539-G-C TP53 c.742C>G p.R248G Missense 7/11 -
17-7578443-A-C TP53 c.487T>G p.Y163D Missense 5/11 -
17-7578191-A-G TP53 c.658T>C p.Y220H Missense 6/11 -
17-7579368-A-C TP53 c.319T>G p.Y107D Missense 4/11 -
17-7577511-A-T TP53 c.770T>A p.L257Q Missense 7/11 -
17-7578204-A-C TP53 c.645T>G p.S215R Missense 6/11 -
17-7578204-A-T TP53 c.645T>A p.S215R Missense 6/11 -
17-7578196-A-C TP53 c.653T>G p.V218G Missense 6/11 -
17-7578478-G-T TP53 c.452C>A p.P151H Missense 5/11 -
17-7578265-A-T TP53 c.584T>A p.I195N Missense 6/11 -
17-7577100-T-C TP53 c.838A>G p.R280G Missense 8/11 -
17-7578397-T-G TP53 c.533A>C p.H178P Missense 5/11 -
17-7578206-T-G TP53 c.643A>C p.S215R Missense 6/11 -
17-7577096-T-C TP53 c.842A>G p.D281G Missense 8/11 -
9-135800987-A-G TSC1 c.350T>C p.L117P Missense 5/23 -
4-55593610-T-C KIT c.1676T>C p.V559A Missense 11/21 -
4-55593613-T-A KIT c.1679T>A p.V560D Missense 11/21 -
3-10183787-C-T VHL c.256C>T p.P86S Missense 1/3 -
3-10183871-G-C VHL c.340G>C p.G114R Missense 1/3 -
3-10188309-T-G VHL c.452T>G p.I151S Missense 2/3 -
3-10191558-T-C VHL c.551T>C p.L184P Missense 3/3 -
3-10191479-C-G VHL c.472C>G p.L158V Missense 3/3 -
3-10183725-C-T VHL c.194C>T p.S65L Missense 1/3 -
3-10183800-A-T VHL c.269A>T p.N90I Missense 1/3 -
3-10183754-ATCT-A VHL c.227_229delTCT p.F76del InFrameDeletion 1/3 -
9-5070025-C-G JAK2 c.1614C>G p.H538Q Missense 12/25 -
1-115256529-T-G NRAS c.182A>C p.Q61P Missense 3/7 -
9-5070025-C-A JAK2 c.1614C>A p.H538Q Missense 12/25 -
7-116423428-T-G MET c.3703T>G p.Y1235D Missense 19/21 -
3-178938860-A-C PIK3CA c.2102A>C p.H701P Missense 14/21 -
7-140481418-C-T BRAF c.1390G>A p.G464R Missense 11/18 -
7-140481418-C-G BRAF c.1390G>C p.G464R Missense 11/18 -
17-7577106-G-A TP53 c.832C>T p.P278S Missense 8/11 -
2-209113296-C-T IDH1 c.211G>A p.V71I Missense 4/10 -
3-178952072-A-G PIK3CA c.3127A>G p.M1043V Missense 21/21 -
7-140453132-T-G BRAF c.1803A>C p.K601N Missense 15/18 -
7-140453132-T-A BRAF c.1803A>T p.K601N Missense 15/18 -
3-178947827-G-T PIK3CA c.2702G>T p.C901F Missense 19/21 -
9-133750356-A-G ABL1 c.1187A>G p.H396R Missense 7/11 -
12-25380277-G-C KRAS c.181C>G p.Q61E Missense 3/5 -
9-133748414-T-G ABL1 c.1075T>G p.F359V Missense 6/11 -
7-116411990-C-T MET c.2975C>T p.T992I Missense 14/21 -
7-140481411-C-T BRAF c.1397G>A p.G466E Missense 11/18 -
7-140481412-C-T BRAF c.1396G>A p.G466R Missense 11/18 -
7-140481412-C-G BRAF c.1396G>C p.G466R Missense 11/18 -
9-133738356-G-T ABL1 c.756G>T p.Q252H Missense 4/11 -
9-133738356-G-C ABL1 c.756G>C p.Q252H Missense 4/11 -
1-115258744-C-A NRAS c.38G>T p.G13V Missense 2/7 -
1-115258745-C-T NRAS c.37G>A p.G13S Missense 2/7 -
7-140481405-A-C BRAF c.1403T>G p.F468C Missense 11/18 -
9-133748403-A-G ABL1 c.1064A>G p.E355G Missense 6/11 -
9-133748290-C-A ABL1 c.951C>A p.F317L Missense 6/11 -
9-133748290-C-G ABL1 c.951C>G p.F317L Missense 6/11 -
9-133748270-T-C ABL1 c.931T>C p.F311L Missense 6/11 -
9-133748272-C-A ABL1 c.933C>A p.F311L Missense 6/11 -
9-133748272-C-G ABL1 c.933C>G p.F311L Missense 6/11 -
9-133747520-A-G ABL1 c.827A>G p.D276G Missense 5/11 -
3-178936074-C-G PIK3CA c.1616C>G p.P539R Missense 10/21 -
9-133738357-T-C ABL1 c.757T>C p.Y253H Missense 4/11 -
5-1279426-G-A TERT c.2110C>T p.P704S Missense 5/16 -
7-140481417-C-A BRAF c.1391G>T p.G464V Missense 11/18 -
3-178952074-G-C PIK3CA c.3129G>C p.M1043I Missense 21/21 -
3-178916726-G-A PIK3CA c.113G>A p.R38H Missense 2/21 -
7-140453145-AG-GA BRAF c.1789_1790delCTinsTC p.L597S Missense 15/18 -
3-10188320-G-A VHL c.463G>A p.V155M Missense 2/3 -
3-10183785-T-C VHL c.254T>C p.L85P Missense 1/3 -
3-10183797-T-A VHL c.266T>A p.L89H Missense 1/3 -
3-10188210-T-C VHL c.353T>C p.L118P Missense 2/3 -
3-10183797-T-C VHL c.266T>C p.L89P Missense 1/3 -
9-133748288-T-C ABL1 c.949T>C p.F317L Missense 6/11 -
9-133748391-T-C ABL1 c.1052T>C p.M351T Missense 6/11 -
7-6414401-G-T RAC1 c.35G>T p.G12V Missense 1/6 -
1-65312382-G-A JAK1 c.1937C>T p.S646F Missense 14/25 -
19-17945969-C-T JAK3 c.1970G>A p.R657Q Missense 15/24 -
15-66774188-TC-GA MAP2K1 c.664_665delTCinsGA p.S222D Missense 6/11 -
7-116417463-C-T MET c.3280C>T p.H1094Y Missense 16/21 -
7-116422102-C-G MET c.3583C>G p.L1195V Missense 18/21 -
19-1207145-AG-TC STK11 c.233_234delAGinsTC p.K78I Missense 1/10 -
17-41215947-C-A BRCA1 c.5096G>T p.R1699L Missense 17/23 -
17-41209139-A-G BRCA1 c.5207T>C p.V1736A Missense 19/23 -
17-41203115-A-C BRCA1 c.5297T>G p.I1766S Missense 20/23 -
17-41197760-C-G BRCA1 c.5527G>C p.A1843P Missense 23/23 -
17-41197790-C-T BRCA1 c.5497G>A p.V1833M Missense 23/23 -
17-41203121-A-G BRCA1 c.5291T>C p.L1764P Missense 20/23 -
17-41197765-C-T BRCA1 c.5522G>A p.S1841N Missense 23/23 -
17-41201181-C-A BRCA1 c.5363G>T p.G1788V Missense 21/23 -
17-41197729-T-C BRCA1 c.5558A>G p.Y1853C Missense 23/23 -
17-41215899-C-T BRCA1 c.5144G>A p.S1715N Missense 17/23 -
15-90631837-C-A IDH2 c.516G>T p.R172S Missense 4/11 -
17-7577117-A-C TP53 c.821T>G p.V274G Missense 8/11 -
3-10183776-G-C VHL c.245G>C p.R82P Missense 1/3 -
12-25398282-C-G KRAS c.37G>C p.G13R Missense 2/5 -
17-7577105-G-C TP53 c.833C>G p.P278R Missense 8/11 -
6-26056142-T-C H1-2 c.515A>G p.K172R Missense 1/1 -
15-90631839-T-A IDH2 c.514A>T p.R172W Missense 4/11 -
15-90631935-G-A IDH2 c.418C>T p.R140W Missense 4/11 -
15-90631838-C-A IDH2 c.515G>T p.R172M Missense 4/11 -
4-55593613-TT-AG KIT c.1679_1680delTTinsAG p.V560E Missense 11/21 -
17-7577108-C-A TP53 c.830G>T p.C277F Missense 8/11 -
7-140477859-TT-CA BRAF c.1448_1449delAAinsTG p.K483M Missense 12/18 -
7-140453154-T-G BRAF c.1781A>C p.D594A Missense 15/18 -
11-534286-C-G HRAS c.37G>C p.G13R Missense 2/6 -
10-43613908-A-T RET c.2372A>T p.Y791F Missense 13/20 -
7-55242455-T-C EGFR c.2225T>C p.V742A Missense 19/28 -
15-90631839-T-C IDH2 c.514A>G p.R172G Missense 4/11 -
3-178952142-C-T PIK3CA c.3197C>T p.A1066V Missense 21/21 -
15-66727574-A-T MAP2K1 c.290A>T p.K97M Missense 2/11 -
4-55599341-T-G KIT c.2467T>G p.Y823D Missense 17/21 -
10-89711900-G-A PTEN c.518G>A p.R173H Missense 6/9 -
7-140453145-A-T BRAF c.1790T>A p.L597Q Missense 15/18 -
4-55593603-T-G KIT c.1669T>G p.W557G Missense 11/21 -
4-55593608-GGTT-G KIT c.1679_1681delTTG p.V560del InFrameDeletion 11/21 -
7-140481411-C-G BRAF c.1397G>C p.G466A Missense 11/18 -
10-123274774-A-G FGFR2 c.1144T>C p.C382R Missense 9/18 -
10-43613840-G-C RET c.2304G>C p.E768D Missense 13/20 -
10-43613840-G-T RET c.2304G>T p.E768D Missense 13/20 -
9-5073752-T-G JAK2 c.1831T>G p.L611V Missense 14/25 -
7-55241726-C-T EGFR c.2174C>T p.T725M Missense 18/28 -
17-7578272-G-C TP53 c.577C>G p.H193D Missense 6/11 -
10-43615142-C-G RET c.2556C>G p.I852M Missense 14/20 -
3-10183765-T-G VHL c.234T>G p.N78K Missense 1/3 -
10-89725045-T-A PTEN c.1028T>A p.V343E Missense 9/9 -
10-89725056-T-C PTEN c.1039T>C p.F347L Missense 9/9 -
7-55259514-C-A EGFR c.2572C>A p.L858M Missense 21/28 -
17-41219641-A-T BRCA1 c.5058T>A p.H1686Q Missense 16/23 -
17-41219641-A-C BRCA1 c.5058T>G p.H1686Q Missense 16/23 -
2-25463541-G-C DNMT3A c.2141C>G p.S714C Missense 18/23 -
3-49412973-C-A RHOA c.50G>T p.G17V Missense 2/5 -
2-25457242-C-G DNMT3A c.2645G>C p.R882P Missense 23/23 -
19-17945918-A-G JAK3 c.2021T>C p.V674A Missense 15/24 -
12-121431414-G-T HNF1A c.618G>T p.W206C Missense 3/10 -
12-121431414-G-C HNF1A c.618G>C p.W206C Missense 3/10 -
12-121431413-G-T HNF1A c.617G>T p.W206L Missense 3/10 -
17-7577538-C-G TP53 c.743G>C p.R248P Missense 7/11 -
7-140453137-C-T BRAF c.1798G>A p.V600M Missense 15/18 -
4-55140746-T-A PDGFRA c.1607T>A p.V536E Missense 11/23 -
4-55152092-G-T PDGFRA c.2524G>T p.D842Y Missense 18/23 -
10-89720822-C-T PTEN c.973C>T p.L325F Missense 8/9 -
10-89692883-C-T PTEN c.367C>T p.H123Y Missense 5/9 -
10-89692923-G-A PTEN c.407G>A p.C136Y Missense 5/9 -
10-89692922-T-C PTEN c.406T>C p.C136R Missense 5/9 -
7-55259502-A-G EGFR c.2560A>G p.T854A Missense 21/28 -
10-123256219-C-A FGFR2 c.1690G>T p.V564F Missense 13/18 -
10-89720714-A-G PTEN c.865A>G p.K289E Missense 8/9 -
3-52442077-CA-GC BAP1 c.271_272delTGinsGC p.C91A Missense 5/17 -
10-89692791-A-C PTEN c.275A>C p.D92A Missense 5/9 -
11-533873-C-A HRAS c.183G>T p.Q61H Missense 3/6 -
11-533873-C-G HRAS c.183G>C p.Q61H Missense 3/6 -
11-534289-C-A HRAS c.34G>T p.G12C Missense 2/6 -
11-534289-C-G HRAS c.34G>C p.G12R Missense 2/6 -
11-533553-T-C HRAS c.350A>G p.K117R Missense 4/6 -
4-55593431-G-A KIT c.1588G>A p.V530I Missense 10/21 -
4-55593464-A-C KIT c.1621A>C p.M541L Missense 10/21 -
4-55593464-A-T KIT c.1621A>T p.M541L Missense 10/21 -
7-128850341-G-T SMO c.1604G>T p.W535L Missense 9/12 -
12-25398266-G-T KRAS c.53C>A p.A18D Missense 2/5 -
10-89692800-C-T PTEN c.284C>T p.P95L Missense 5/9 -
10-89692908-C-T PTEN c.392C>T p.T131I Missense 5/9 -
10-89692980-A-G PTEN c.464A>G p.Y155C Missense 5/9 -
10-89720852-C-T PTEN c.1003C>T p.R335* Nonsense 8/9 -
10-89717625-T-A PTEN c.650T>A p.V217D Missense 7/9 -
15-88476265-C-T NTRK3 c.1867G>A p.G623R Missense 16/20 -
15-88476265-C-G NTRK3 c.1867G>C p.G623R Missense 16/20 -
13-28602342-T-C FLT3 c.2026A>G p.N676D Missense 16/24 -
17-7577130-A-G TP53 c.808T>C p.F270L Missense 8/11 -
17-7577128-A-T TP53 c.810T>A p.F270L Missense 8/11 -
17-7577128-A-C TP53 c.810T>G p.F270L Missense 8/11 -
3-41266097-G-A CTNNB1 c.94G>A p.D32N Missense 3/15 -
17-7578469-C-A TP53 c.461G>T p.G154V Missense 5/11 -
17-7578427-T-A TP53 c.503A>T p.H168L Missense 5/11 -
17-7578476-G-T TP53 c.454C>A p.P152T Missense 5/11 -
17-7577129-A-G TP53 c.809T>C p.F270S Missense 8/11 -
17-7577118-C-G TP53 c.820G>C p.V274L Missense 8/11 -
17-7574026-C-A TP53 c.1001G>T p.G334V Missense 10/11 -
10-89653782-A-C PTEN c.80A>C p.Y27S Missense 2/9 -
10-89692818-T-C PTEN c.302T>C p.I101T Missense 5/9 -
1-156846342-G-A NTRK1 c.1783G>A p.G595R Missense 14/17 -
1-156846342-G-C NTRK1 c.1783G>C p.G595R Missense 14/17 -
11-534285-C-T HRAS c.38G>A p.G13D Missense 2/6 -
17-7577114-C-A TP53 c.824G>T p.C275F Missense 8/11 -
17-7579328-T-A TP53 c.359A>T p.K120M Missense 4/11 -
17-7578280-G-A TP53 c.569C>T p.P190L Missense 6/11 -
17-7578268-A-G TP53 c.581T>C p.L194P Missense 6/11 -
17-7578217-G-A TP53 c.632C>T p.T211I Missense 6/11 -
10-123247514-C-A FGFR2 c.1977G>T p.K659N Missense 14/18 -
10-123247514-C-G FGFR2 c.1977G>C p.K659N Missense 14/18 -
10-123247569-T-C FGFR2 c.1922A>G p.K641R Missense 14/18 -
10-123247549-C-T FGFR2 c.1942G>A p.A648T Missense 14/18 -
10-123256058-C-G FGFR2 c.1851G>C p.L617F Missense 13/18 -
10-123256060-A-T FGFR2 c.1849T>A p.L617M Missense 13/18 -
10-123256215-T-C FGFR2 c.1694A>G p.E565G Missense 13/18 -
10-123256219-C-T FGFR2 c.1690G>A p.V564I Missense 13/18 -
10-123258034-A-C FGFR2 c.1647T>G p.N549K Missense 12/18 -
10-123258034-A-T FGFR2 c.1647T>A p.N549K Missense 12/18 -
10-123258035-T-C FGFR2 c.1646A>G p.N549S Missense 12/18 -
10-123258035-T-G FGFR2 c.1646A>C p.N549T Missense 12/18 -
10-123246893-T-C FGFR2 c.2032A>G p.R678G Missense 15/18 -
10-123258042-T-C FGFR2 c.1639A>G p.I547V Missense 12/18 -
10-123258070-C-A FGFR2 c.1611G>T p.M537I Missense 12/18 -
10-123258070-C-G FGFR2 c.1611G>C p.M537I Missense 12/18 -
10-123258070-C-T FGFR2 c.1611G>A p.M537I Missense 12/18 -
10-123258076-C-A FGFR2 c.1605G>T p.M535I Missense 12/18 -
10-123258076-C-G FGFR2 c.1605G>C p.M535I Missense 12/18 -
10-123258076-C-T FGFR2 c.1605G>A p.M535I Missense 12/18 -
10-123258105-T-C FGFR2 c.1576A>G p.K526E Missense 12/18 -
10-123276896-T-G FGFR2 c.1021A>C p.T341P Missense 8/18 -
10-123274746-A-C FGFR2 c.1172T>G p.M391R Missense 9/18 -
10-123274794-T-C FGFR2 c.1124A>G p.Y375C Missense 9/18 -
10-123279564-A-G FGFR2 c.868T>C p.W290R Missense 7/18 -
4-1806092-A-T FGFR3 c.1111A>T p.S371C Missense 9/18 -
4-1806126-G-A FGFR3 c.1145G>A p.G382D Missense 9/18 -
4-1806104-G-T FGFR3 c.1123G>T p.G375C Missense 9/18 -
8-38274849-G-T FGFR1 c.1638C>A p.N546K Missense 12/18 -
10-123244913-C-T FGFR2 c.2191G>A p.E731K Missense 16/18 -
7-116339642-G-T MET c.504G>T p.E168D Missense 2/21 -
4-1807335-G-A FGFR3 c.1584G>A p.M528I Missense 12/18 -
4-1807335-G-T FGFR3 c.1584G>T p.M528I Missense 12/18 -
4-1807363-A-G FGFR3 c.1612A>G p.I538V Missense 12/18 -
4-1807370-A-G FGFR3 c.1619A>G p.N540S Missense 12/18 -
4-1807494-G-A FGFR3 c.1663G>A p.V555M Missense 13/18 -
4-1808029-C-G FGFR3 c.2005C>G p.R669G Missense 15/18 -
4-1808331-G-T FGFR3 c.2089G>T p.G697C Missense 16/18 -
13-28592620-T-C FLT3 c.2525A>G p.Y842C Missense 20/24 -
22-30035155-A-G NF2 c.317A>G p.E106G Missense 3/16 -
10-89653827-T-G PTEN c.125T>G p.L42R Missense 2/9 -
10-89624255-G-A PTEN c.29G>A p.S10N Missense 1/9 -
10-89624285-G-A PTEN c.59G>A p.G20E Missense 1/9 -
13-28602340-G-C FLT3 c.2028C>G p.N676K Missense 16/24 -
13-28602340-G-T FLT3 c.2028C>A p.N676K Missense 16/24 -
22-30077457-T-C NF2 c.1604T>C p.L535P Missense 15/16 -
22-30077466-A-C NF2 c.1613A>C p.Q538P Missense 15/16 -
9-133747588-G-C ABL1 c.895G>C p.V299L Missense 5/11 -
9-133747588-G-T ABL1 c.895G>T p.V299L Missense 5/11 -
13-28592642-C-G FLT3 c.2503G>C p.D835H Missense 20/24 -
9-139397768-A-G NOTCH1 c.5033T>C p.L1678P Missense 27/34 -
10-89711875-G-A PTEN c.493G>A p.G165R Missense 6/9 -
17-41267779-T-G BRCA1 c.98A>C p.E33A Missense 3/23 -
10-89711875-G-C PTEN c.493G>C p.G165R Missense 6/9 -
17-41199693-G-C BRCA1 c.5434C>G p.P1812A Missense 22/23 -
7-55249028-C-T EGFR c.2326C>T p.R776C Missense 20/28 -
17-7577517-A-G TP53 c.764T>C p.I255T Missense 7/11 -
17-7578550-G-T TP53 c.380C>A p.S127Y Missense 5/11 -
18-48591919-G-A SMAD4 c.1082G>A p.R361H Missense 9/12 -
3-178952077-T-G PIK3CA c.3132T>G p.N1044K Missense 21/21 -
3-178952077-T-A PIK3CA c.3132T>A p.N1044K Missense 21/21 -
17-7578226-T-A TP53 c.623A>T p.D208V Missense 6/11 -
17-7578404-A-T TP53 c.526T>A p.C176S Missense 5/11 -
17-7578403-C-G TP53 c.527G>C p.C176S Missense 5/11 -
7-128846398-C-T SMO c.1234C>T p.L412F Missense 6/12 -
9-110249348-T-G KLF4 c.1225A>C p.K409Q Missense 4/5 -
21-44514777-T-G U2AF1 c.470A>C p.Q157P Missense 6/8 -
7-55259464-G-A EGFR c.2522G>A p.R841K Missense 21/28 -
3-178928067-C-A PIK3CA c.1345C>A p.P449T Missense 8/21 -
15-66727451-A-C MAP2K1 c.167A>C p.Q56P Missense 2/11 -
15-66729153-T-A MAP2K1 c.361T>A p.C121S Missense 3/11 -
15-66729154-G-C MAP2K1 c.362G>C p.C121S Missense 3/11 -
4-55593659-ACTT-A KIT c.1727_1729delTTC p.L576del InFrameDeletion 11/21 -
4-55599333-A-C KIT c.2459A>C p.D820A Missense 17/21 -
17-7578412-A-G TP53 c.518T>C p.V173A Missense 5/11 -
17-7577548-C-G TP53 c.733G>C p.G245R Missense 7/11 -
10-89624271-A-C PTEN c.45A>C p.R15S Missense 1/9 -
10-89624271-A-T PTEN c.45A>T p.R15S Missense 1/9 -
17-7577574-T-C TP53 c.707A>G p.Y236C Missense 7/11 -
19-11144114-G-A SMARCA4 c.3695G>A p.G1232D Missense 26/35 -
1-115258748-C-G NRAS c.34G>C p.G12R Missense 2/7 -
7-140453136-A-G BRAF c.1799T>C p.V600A Missense 15/18 -
21-44514777-T-C U2AF1 c.470A>G p.Q157R Missense 6/8 -
21-44524456-G-T U2AF1 c.101C>A p.S34Y Missense 2/8 -
1-162748390-T-G DDR2 c.2304T>G p.S768R Missense 17/18 -
17-7577547-C-G TP53 c.734G>C p.G245A Missense 7/11 -
5-176522416-C-G FGFR4 c.1605C>G p.N535K Missense 12/18 -
5-176522416-C-A FGFR4 c.1605C>A p.N535K Missense 12/18 -
5-176522551-G-C FGFR4 c.1648G>C p.V550L Missense 13/18 -
5-176522551-G-T FGFR4 c.1648G>T p.V550L Missense 13/18 -
5-176522552-T-A FGFR4 c.1649T>A p.V550E Missense 13/18 -
17-7577121-G-T TP53 c.817C>A p.R273S Missense 8/11 -
17-7578268-A-C TP53 c.581T>G p.L194R Missense 6/11 -
12-25378562-C-G KRAS c.436G>C p.A146P Missense 4/5 -
17-7577550-C-A TP53 c.731G>T p.G244V Missense 7/11 -
17-7577535-C-T TP53 c.746G>A p.R249K Missense 7/11 -
17-7579329-T-C TP53 c.358A>G p.K120E Missense 4/11 -
17-7578236-A-G TP53 c.613T>C p.Y205H Missense 6/11 -
17-7578503-C-T TP53 c.427G>A p.V143M Missense 5/11 -
17-7577536-T-A TP53 c.745A>T p.R249W Missense 7/11 -
17-7579358-C-A TP53 c.329G>T p.R110L Missense 4/11 -
17-7578538-T-A TP53 c.392A>T p.N131I Missense 5/11 -
17-7578535-T-G TP53 c.395A>C p.K132T Missense 5/11 -
17-7578535-T-C TP53 c.395A>G p.K132R Missense 5/11 -
17-7578398-G-C TP53 c.532C>G p.H178D Missense 5/11 -
17-7578442-T-G TP53 c.488A>C p.Y163S Missense 5/11 -
17-7578266-T-A TP53 c.583A>T p.I195F Missense 6/11 -
17-7577580-T-G TP53 c.701A>C p.Y234S Missense 7/11 -
17-7577565-T-C TP53 c.716A>G p.N239S Missense 7/11 -
17-7577138-C-T TP53 c.800G>A p.R267Q Missense 8/11 -
17-7578407-G-C TP53 c.523C>G p.R175G Missense 5/11 -
17-7577581-A-G TP53 c.700T>C p.Y234H Missense 7/11 -
17-7577115-A-G TP53 c.823T>C p.C275R Missense 8/11 -
17-7577108-C-T TP53 c.830G>A p.C277Y Missense 8/11 -
17-7577094-G-C TP53 c.844C>G p.R282G Missense 8/11 -
10-89692793-C-T PTEN c.277C>T p.H93Y Missense 5/9 -
16-23635348-A-C PALB2 c.2816T>G p.L939W Missense 8/13 -
9-21974679-G-A CDKN2A c.148C>T p.Q50* Nonsense 1/3 -
7-55259538-G-A EGFR c.2596G>A p.E866K Missense 21/28 -
4-55593615-G-A KIT c.1681G>A p.E561K Missense 11/21 -
3-178916936-G-A PIK3CA c.323G>A p.R108H Missense 2/21 -
3-178916941-G-A PIK3CA c.328G>A p.E110K Missense 2/21 -
18-48604665-G-A SMAD4 c.1487G>A p.R496H Missense 12/12 -
18-48604668-G-A SMAD4 c.1490G>A p.R497H Missense 12/12 -
17-37880257-C-G ERBB2 c.2301C>G p.I767M Missense 19/27 -
17-37880261-G-T ERBB2 c.2305G>T p.D769Y Missense 19/27 -
17-7577568-C-G TP53 c.713G>C p.C238S Missense 7/11 -
17-41209133-C-T BRCA1 c.5213G>A p.G1738E Missense 19/23 -
17-41215954-A-G BRCA1 c.5089T>C p.C1697R Missense 17/23 -
17-37879658-G-A ERBB2 c.2033G>A p.R678Q Missense 17/27 -
5-149497359-G-A PDGFRB c.2959C>T p.R987W Missense 22/23 -
5-149503863-A-G PDGFRB c.1973T>C p.L658P Missense 14/23 -
7-55249023-T-C EGFR c.2321T>C p.V774A Missense 20/28 -
12-112888211-A-T PTPN11 c.227A>T p.E76V Missense 3/16 -
12-112910835-A-G PTPN11 c.844A>G p.I282V Missense 7/16 -
12-112891083-G-C PTPN11 c.417G>C p.E139D Missense 4/16 -
17-7577551-C-T TP53 c.730G>A p.G244S Missense 7/11 -
17-7578272-G-A TP53 c.577C>T p.H193Y Missense 6/11 -
17-7578271-T-A TP53 c.578A>T p.H193L Missense 6/11 -
17-7577556-C-T TP53 c.725G>A p.C242Y Missense 7/11 -
17-7577153-C-A TP53 c.785G>T p.G262V Missense 8/11 -
17-7577121-G-C TP53 c.817C>G p.R273G Missense 8/11 -
17-7577551-C-A TP53 c.730G>T p.G244C Missense 7/11 -
3-178952100-C-A PIK3CA c.3155C>A p.T1052K Missense 21/21 -
17-7579349-A-C TP53 c.338T>G p.F113C Missense 4/11 -
17-7578496-A-G TP53 c.434T>C p.L145P Missense 5/11 -
17-7577560-A-T TP53 c.721T>A p.S241T Missense 7/11 -
18-48591918-C-T SMAD4 c.1081C>T p.R361C Missense 9/12 -
7-116339642-G-C MET c.504G>C p.E168D Missense 2/21 -
17-7577535-C-G TP53 c.746G>C p.R249T Missense 7/11 -
17-7578245-G-T TP53 c.604C>A p.R202S Missense 6/11 -
17-7578388-C-A TP53 c.542G>T p.R181L Missense 5/11 -
10-123279564-A-T FGFR2 c.868T>A p.W290R Missense 7/18 -
20-57484596-A-T GNAS c.680A>T p.Q227L Missense 9/13 -
19-4117617-C-T MAP2K2 c.103G>A p.V35M Missense 2/11 -
15-66727463-T-A MAP2K1 c.179T>A p.V60E Missense 2/11 -
19-4117550-A-C MAP2K2 c.170T>G p.F57C Missense 2/11 -
15-66729163-C-T MAP2K1 c.371C>T p.P124L Missense 3/11 -
15-66729175-G-T MAP2K1 c.383G>T p.G128V Missense 3/11 -
7-6426892-C-T RAC1 c.85C>T p.P29S Missense 2/6 -
15-66729162-C-T MAP2K1 c.370C>T p.P124S Missense 3/11 -
15-66727453-A-G MAP2K1 c.169A>G p.K57E Missense 2/11 -
19-4110584-A-T MAP2K2 c.373T>A p.C125S Missense 3/11 -
19-4110583-C-G MAP2K2 c.374G>C p.C125S Missense 3/11 -
15-66774131-G-A MAP2K1 c.607G>A p.E203K Missense 6/11 -
19-4110581-T-C MAP2K2 c.376A>G p.N126D Missense 3/11 -
19-4117584-G-A MAP2K2 c.136C>T p.L46F Missense 2/11 -
17-7578542-G-A TP53 c.388C>T p.L130F Missense 5/11 -
17-7578371-C-T TP53 c.559G>A p.G187S Missense 5/11 -
17-7577575-A-G TP53 c.706T>C p.Y236H Missense 7/11 -
2-198267361-T-C SF3B1 c.1996A>G p.K666E Missense 14/25 -
12-133253151-G-A POLE c.890C>T p.S297F Missense 9/49 -
1-9787030-G-A PIK3CD c.3061G>A p.E1021K Missense 24/24 -
3-41266100-T-C CTNNB1 c.97T>C p.S33P Missense 3/15 -
17-7578394-T-A TP53 c.536A>T p.H179L Missense 5/11 -
17-7578388-C-G TP53 c.542G>C p.R181P Missense 5/11 -
17-7577141-C-A TP53 c.797G>T p.G266V Missense 8/11 -
4-55599333-A-G KIT c.2459A>G p.D820G Missense 17/21 -
12-112888172-A-G PTPN11 c.188A>G p.Y63C Missense 3/16 -
12-56490980-A-G ERBB3 c.2426A>G p.Q809R Missense 20/28 -
12-56491645-G-T ERBB3 c.2537G>T p.S846I Missense 21/28 -
3-178938863-TG-AT PIK3CA c.2105_2106delTGinsAT p.L702H Missense 14/21 -
17-7578457-C-G TP53 c.473G>C p.R158P Missense 5/11 -
17-7578443-A-T TP53 c.487T>A p.Y163N Missense 5/11 -
17-7578529-A-C TP53 c.401T>G p.F134C Missense 5/11 -
7-140453193-T-A BRAF c.1742A>T p.N581I Missense 15/18 -
3-41266098-A-G CTNNB1 c.95A>G p.D32G Missense 3/15 -
7-55259524-T-G EGFR c.2582T>G p.L861R Missense 21/28 -
16-68846047-A-G CDH1 c.1018A>G p.T340A Missense 8/16 -
10-43613906-G-C RET c.2370G>C p.L790F Missense 13/20 -
10-43615592-T-G RET c.2671T>G p.S891A Missense 15/20 -
10-43613906-G-T RET c.2370G>T p.L790F Missense 13/20 -
7-55249055-A-G EGFR c.2353A>G p.T785A Missense 20/28 -
2-178098953-C-G NFE2L2 c.92G>C p.G31A Missense 2/5 -
17-7578253-C-A TP53 c.596G>T p.G199V Missense 6/11 -
1-9780851-G-A PIK3CD c.1573G>A p.E525K Missense 13/24 -
3-178936091-G-C PIK3CA c.1633G>C p.E545Q Missense 10/21 -
12-25378559-T-C KRAS c.439A>G p.K147E Missense 4/5 -
2-29443600-G-T ALK c.3617C>A p.S1206Y Missense 23/29 -
3-10188218-G-T VHL c.361G>T p.D121Y Missense 2/3 -
17-7577093-C-G TP53 c.845G>C p.R282P Missense 8/11 -
17-7578532-A-T TP53 c.398T>A p.M133K Missense 5/11 -
19-11132513-C-T SMARCA4 c.2729C>T p.T910M Missense 19/35 -
12-25378646-A-T KRAS c.352T>A p.C118S Missense 4/5 -
12-25378645-C-G KRAS c.353G>C p.C118S Missense 4/5 -
17-7577129-A-C TP53 c.809T>G p.F270C Missense 8/11 -
17-41215905-A-G BRCA1 c.5138T>C p.V1713A Missense 17/23 -
1-162748390-T-A DDR2 c.2304T>A p.S768R Missense 17/18 -
1-162748388-A-C DDR2 c.2302A>C p.S768R Missense 17/18 -
7-148506443-C-T EZH2 c.2069G>A p.R690H Missense 18/20 -
6-152419922-T-A ESR1 c.1609T>A p.Y537N Missense 8/8 -
10-89692892-G-A PTEN c.376G>A p.A126T Missense 5/9 -
17-29541542-A-G NF1 c.1466A>G p.Y489C Missense 13/58 -
2-29445270-A-C ALK c.3455T>G p.L1152R Missense 22/29 -
4-55144148-C-G PDGFRA c.1977C>G p.N659K Missense 14/23 -
4-55144148-C-A PDGFRA c.1977C>A p.N659K Missense 14/23 -
15-90631837-C-G IDH2 c.516G>C p.R172S Missense 4/11 -
4-106196819-G-C TET2 c.5152G>C p.V1718L Missense 11/11 -
4-106196819-G-T TET2 c.5152G>T p.V1718L Missense 11/11 -
12-133250289-C-G POLE c.1231G>C p.V411L Missense 13/49 -
12-133250289-C-A POLE c.1231G>T p.V411L Missense 13/49 -
12-133249847-G-A POLE c.1376C>T p.S459F Missense 14/49 -
12-112888199-C-T PTPN11 c.215C>T p.A72V Missense 3/16 -
17-7578541-A-C TP53 c.389T>G p.L130R Missense 5/11 -
3-49412966-TG-GT RHOA c.56_57delCAinsAC p.T19N Missense 2/5 -
7-116412024-C-A MET c.3009C>A p.Y1003* Nonsense 14/21 -
7-116412024-C-G MET c.3009C>G p.Y1003* Nonsense 14/21 -
7-55228009-C-G EGFR c.1476C>G p.S492R Missense 12/28 -
2-198267484-G-A SF3B1 c.1873C>T p.R625C Missense 14/25 -
7-55228009-C-A EGFR c.1476C>A p.S492R Missense 12/28 -
7-55228007-A-C EGFR c.1474A>C p.S492R Missense 12/28 -
7-55227926-G-A EGFR c.1393G>A p.G465R Missense 12/28 -
17-7577097-C-T TP53 c.841G>A p.D281N Missense 8/11 -
7-55227924-C-T EGFR c.1391C>T p.S464L Missense 12/28 -
12-12037475-G-A ETV6 c.1106G>A p.R369Q Missense 6/8 -
7-55242511-G-A EGFR c.2281G>A p.D761N Missense 19/28 -
10-89692850-C-G PTEN c.334C>G p.L112V Missense 5/9 -
19-17943438-A-T JAK3 c.2570T>A p.L857Q Missense 19/24 -
19-17949108-C-T JAK3 c.1533G>A p.M511I Missense 11/24 -
19-17949108-C-A JAK3 c.1533G>T p.M511I Missense 11/24 -
12-56481922-G-A ERBB3 c.850G>A p.G284R Missense 7/28 -
4-55589770-TACG-T KIT c.1255_1257delGAC p.D419del InFrameDeletion 8/21 -
12-56481922-G-C ERBB3 c.850G>C p.G284R Missense 7/28 -
17-7578554-A-T TP53 c.376T>A p.Y126N Missense 5/11 -
17-7577586-A-T TP53 c.695T>A p.I232N Missense 7/11 -
17-7577575-A-C TP53 c.706T>G p.Y236D Missense 7/11 -
17-7577507-T-G TP53 c.774A>C p.E258D Missense 7/11 -
19-17948006-G-A JAK3 c.1718C>T p.A573V Missense 13/24 -
17-40359729-T-G STAT5B c.1924A>C p.N642H Missense 16/19 -
19-17949108-C-G JAK3 c.1533G>C p.M511I Missense 11/24 -
2-209113140-C-G IDH1 c.367G>C p.G123R Missense 4/10 -
17-47696467-C-T SPOP c.356G>A p.S119N Missense 5/10 -
1-11184573-G-A MTOR c.6644C>T p.S2215F Missense 47/58 -
17-7577544-A-T TP53 c.737T>A p.M246K Missense 7/11 -
1-156849107-G-T NTRK1 c.1999G>T p.G667C Missense 15/17 -
17-7578406-C-G TP53 c.524G>C p.R175P Missense 5/11 -
17-7578389-G-A TP53 c.541C>T p.R181C Missense 5/11 -
17-7578392-C-T TP53 c.538G>A p.E180K Missense 5/11 -
17-7578407-G-A TP53 c.523C>T p.R175C Missense 5/11 -
2-209113140-C-T IDH1 c.367G>A p.G123R Missense 4/10 -
5-67589138-G-A PIK3R1 c.1126G>A p.G376R Missense 10/16 -
10-89685274-TT-CA PTEN c.169_170delTTinsCA p.L57Q Missense 3/9 -
6-152419923-A-G ESR1 c.1610A>G p.Y537C Missense 8/8 -
5-67591097-A-G PIK3R1 c.1690A>G p.N564D Missense 13/16 -
7-55227884-C-T EGFR c.1351C>T p.R451C Missense 12/28 -
3-178921549-T-G PIK3CA c.1031T>G p.V344G Missense 5/21 -
2-46607402-C-G EPAS1 c.1591C>G p.P531A Missense 12/16 -
9-80409487-T-G GNAQ c.627A>C p.Q209H Missense 5/7 -
3-41266103-G-A CTNNB1 c.100G>A p.G34R Missense 3/15 -
12-25380267-TA-GC KRAS c.190_191delTAinsGC p.Y64A Missense 3/5 -
12-25380282-G-C KRAS c.176C>G p.A59G Missense 3/5 -
3-41266104-G-A CTNNB1 c.101G>A p.G34E Missense 3/15 -
3-41266098-A-T CTNNB1 c.95A>T p.D32V Missense 3/15 -
9-133748288-T-A ABL1 c.949T>A p.F317I Missense 6/11 -
3-41266112-T-C CTNNB1 c.109T>C p.S37P Missense 3/15 -
9-133750356-A-C ABL1 c.1187A>C p.H396P Missense 7/11 -
2-29443679-C-G ALK c.3538G>C p.V1180L Missense 23/29 -
15-66729177-T-C MAP2K1 c.385T>C p.F129L Missense 3/11 -
X-100613633-T-C BTK c.946A>G p.T316A Missense 11/19 -
16-81962183-A-T PLCG2 c.2535A>T p.L845F Missense 24/33 -
16-81962183-A-C PLCG2 c.2535A>C p.L845F Missense 24/33 -
16-81946260-C-T PLCG2 c.1993C>T p.R665W Missense 19/33 -
13-28592623-T-A FLT3 c.2522A>T p.N841I Missense 20/24 -
4-55602664-G-C KIT c.2485G>C p.A829P Missense 18/21 -
2-29445213-A-G ALK c.3512T>C p.I1171T Missense 22/29 -
13-28592642-C-T FLT3 c.2503G>A p.D835N Missense 20/24 -
17-7578455-C-G TP53 c.475G>C p.A159P Missense 5/11 -
17-47696688-T-C SPOP c.260A>G p.Y87C Missense 4/10 -
17-47696432-A-C SPOP c.391T>G p.W131G Missense 5/10 -
16-2130366-C-T TSC2 c.3598C>T p.R1200W Missense 30/42 -
3-178921552-A-T PIK3CA c.1034A>T p.N345I Missense 5/21 -
15-88472468-C-G NTRK3 c.2087G>C p.G696A Missense 17/20 -
2-29443625-G-A ALK c.3592C>T p.L1198F Missense 23/29 -
9-133748282-A-G ABL1 c.943A>G p.T315A Missense 6/11 -
17-41219625-C-G BRCA1 c.5074G>C p.D1692H Missense 16/23 -
1-11190804-C-T MTOR c.5395G>A p.E1799K Missense 39/58 -
11-119148948-G-T CBL c.1168G>T p.D390Y Missense 8/16 -
11-119148880-A-C CBL c.1100A>C p.Q367P Missense 8/16 -
11-119148891-T-C CBL c.1111T>C p.Y371H Missense 8/16 -
11-119148924-A-G CBL c.1144A>G p.K382E Missense 8/16 -
19-18278061-A-G PIK3R2 c.1681A>G p.N561D Missense 13/16 -
11-119148966-T-C CBL c.1186T>C p.C396R Missense 8/16 -
3-10191578-C-G VHL c.571C>G p.H191D Missense 3/3 -
19-18273784-G-A PIK3R2 c.1117G>A p.G373R Missense 10/16 -
19-18278049-G-C PIK3R2 c.1669G>C p.D557H Missense 13/16 -
6-152332832-G-C ESR1 c.1138G>C p.E380Q Missense 5/8 -
1-9777666-C-A PIK3CD c.1002C>A p.N334K Missense 8/24 -
3-178947187-C-T PIK3CA c.2623C>T p.H875Y Missense 18/21 -
7-6045549-C-A PMS2 c.137G>T p.S46I Missense 2/15 -
2-47705451-G-A MSH2 c.2251G>A p.G751R Missense 14/16 -
2-198267483-C-T SF3B1 c.1874G>A p.R625H Missense 14/25 -
2-209113111-AC-TT IDH1 c.395_396delGTinsAA p.R132Q Missense 4/10 -
3-178952007-A-G PIK3CA c.3062A>G p.Y1021C Missense 21/21 -
2-29432655-T-G ALK c.3833A>C p.Y1278S Missense 25/29 -
19-52715971-C-T PPP2R1A c.536C>T p.P179L Missense 5/15 -
18-48591825-G-A SMAD4 c.988G>A p.E330K Missense 9/12 -
17-7577079-C-T TP53 c.859G>A p.E287K Missense 8/11 -
17-7578454-G-T TP53 c.476C>A p.A159D Missense 5/11 -
17-7577123-A-C TP53 c.815T>G p.V272G Missense 8/11 -
17-7578259-A-C TP53 c.590T>G p.V197G Missense 6/11 -
17-7578525-G-C TP53 c.405C>G p.C135W Missense 5/11 -
4-55592103-G-T KIT c.1427G>T p.S476I Missense 9/21 -
12-25380264-C-T KRAS c.194G>A p.S65N Missense 3/5 -
3-128200730-A-C GATA2 c.1075T>G p.L359V Missense 5/6 -
17-7577544-A-C TP53 c.737T>G p.M246R Missense 7/11 -
18-48575159-C-T SMAD4 c.353C>T p.A118V Missense 3/12 -
3-178947865-G-C PIK3CA c.2740G>C p.G914R Missense 19/21 -
17-7578206-T-C TP53 c.643A>G p.S215G Missense 6/11 -
7-140481397-C-A BRAF c.1411G>T p.V471F Missense 11/18 -
7-140481402-C-T BRAF c.1406G>A p.G469E Missense 11/18 -
17-7578191-A-T TP53 c.658T>A p.Y220N Missense 6/11 -
19-10602335-G-C KEAP1 c.1243C>G p.R415G Missense 3/6 -
19-10600447-G-A KEAP1 c.1408C>T p.R470C Missense 4/6 -
17-7579882-C-G TP53 c.31G>C p.E11Q Missense 2/11 -
17-37881414-T-G ERBB2 c.2606T>G p.L869R Missense 21/27 -
19-17948009-G-A JAK3 c.1715C>T p.A572V Missense 13/24 -
17-40474482-T-A STAT3 c.1919A>T p.Y640F Missense 21/24 -
17-40474420-C-A STAT3 c.1981G>T p.D661Y Missense 21/24 -
17-7579359-G-A TP53 c.328C>T p.R110C Missense 4/11 -
11-108138063-A-G ATM c.2632A>G p.T878A Missense 17/63 -
2-178098953-C-A NFE2L2 c.92G>T p.G31V Missense 2/5 -
2-178098954-C-T NFE2L2 c.91G>A p.G31R Missense 2/5 -
2-178098954-C-G NFE2L2 c.91G>C p.G31R Missense 2/5 -
22-22127164-C-T MAPK1 c.964G>A p.E322K Missense 7/9 -
17-7578190-T-G TP53 c.659A>C p.Y220S Missense 6/11 -
16-23649395-A-G PALB2 c.104T>C p.L35P Missense 2/13 -
17-7578542-G-C TP53 c.388C>G p.L130V Missense 5/11 -
13-32900636-G-T BRCA2 c.517G>T p.G173C Missense 7/27 -
3-178936095-A-C PIK3CA c.1637A>C p.Q546P Missense 10/21 -
2-29445213-A-T ALK c.3512T>A p.I1171N Missense 22/29 -
17-29562747-G-C NF1 c.3827G>C p.R1276P Missense 28/58 -
17-7574002-C-G TP53 c.1025G>C p.R342P Missense 10/11 -
7-2979495-A-G CARD11 c.752T>C p.L251P Missense 6/25 -
12-25398255-G-T KRAS c.64C>A p.Q22K Missense 2/5 -
2-158622516-C-A ACVR1 c.983G>T p.G328V Missense 8/11 -
16-56868680-G-T NUP93 c.1772G>T p.G591V Missense 16/22 -
11-534285-C-A HRAS c.38G>T p.G13V Missense 2/6 -
11-533875-G-C HRAS c.181C>G p.Q61E Missense 3/6 -
11-533874-T-G HRAS c.182A>C p.Q61P Missense 3/6 -
11-534286-C-T HRAS c.37G>A p.G13S Missense 2/6 -
17-37868205-G-C ERBB2 c.926G>C p.G309A Missense 8/27 -
6-152419920-T-G ESR1 c.1607T>G p.L536R Missense 8/8 -
6-152419920-TC-AA ESR1 c.1607_1608delTCinsAA p.L536Q Missense 8/8 -
17-37880261-G-C ERBB2 c.2305G>C p.D769H Missense 19/27 -
7-151882672-C-A KMT2C c.5053G>T p.A1685S Missense 34/59 -
17-37881404-C-A ERBB2 c.2596C>A p.L866M Missense 21/27 -
17-47696426-A-C SPOP c.397T>G p.F133V Missense 5/10 -
19-10602619-C-T KEAP1 c.959G>A p.R320Q Missense 3/6 -
18-48604787-G-T SMAD4 c.1609G>T p.D537Y Missense 12/12 -
18-48575105-G-C SMAD4 c.299G>C p.R100T Missense 3/12 -
2-178098959-T-C NFE2L2 c.86A>G p.D29G Missense 2/5 -
17-7578449-C-T TP53 c.481G>A p.A161T Missense 5/11 -
18-48591888-G-C SMAD4 c.1051G>C p.D351H Missense 9/12 -
11-108236086-C-T ATM c.9022C>T p.R3008C Missense 63/63 -
17-7577533-G-A TP53 c.748C>T p.P250S Missense 7/11 -
17-7578395-G-C TP53 c.535C>G p.H179D Missense 5/11 -
3-41268766-A-T CTNNB1 c.1004A>T p.K335I Missense 7/15 -
3-178936095-A-T PIK3CA c.1637A>T p.Q546L Missense 10/21 -
3-178916929-G-C PIK3CA c.316G>C p.G106R Missense 2/21 -
3-178916890-C-T PIK3CA c.277C>T p.R93W Missense 2/21 -
10-89692905-G-C PTEN c.389G>C p.R130P Missense 5/9 -
5-176517769-G-C FGFR4 c.379G>C p.D127H Missense 4/18 -
16-89815152-G-A FANCA c.3263C>T p.S1088F Missense 33/43 -
17-7577563-T-C TP53 c.718A>G p.S240G Missense 7/11 -
17-7577508-T-G TP53 c.773A>C p.E258A Missense 7/11 -
17-7578205-C-T TP53 c.644G>A p.S215N Missense 6/11 -
2-29443589-C-T ALK c.3628G>A p.E1210K Missense 23/29 -
2-61719472-C-T XPO1 c.1711G>A p.E571K Missense 15/25 -
13-32907465-C-A BRCA2 c.1850C>A p.S617* Nonsense 10/27 -
17-7577568-C-A TP53 c.713G>T p.C238F Missense 7/11 -
17-7577517-A-T TP53 c.764T>A p.I255N Missense 7/11 -
16-68845646-G-A CDH1 c.892G>A p.A298T Missense 7/16 -
17-7577142-C-G TP53 c.796G>C p.G266R Missense 8/11 -
17-7578551-A-T TP53 c.379T>A p.S127T Missense 5/11 -
17-7578505-G-A TP53 c.425C>T p.P142L Missense 5/11 -
17-7577508-T-A TP53 c.773A>T p.E258V Missense 7/11 -
17-7578496-A-C TP53 c.434T>G p.L145R Missense 5/11 -
17-7578479-G-T TP53 c.451C>A p.P151T Missense 5/11 -
17-7578507-G-C TP53 c.423C>G p.C141W Missense 5/11 -
17-7578404-A-G TP53 c.526T>C p.C176R Missense 5/11 -
17-7577532-G-A TP53 c.749C>T p.P250L Missense 7/11 -
12-112888210-G-C PTPN11 c.226G>C p.E76Q Missense 3/16 -
12-112926888-G-C PTPN11 c.1508G>C p.G503A Missense 13/16 -
2-198267360-T-G SF3B1 c.1997A>C p.K666T Missense 14/25 -
17-37868208-C-A ERBB2 c.929C>A p.S310Y Missense 8/27 -
1-11169361-C-G MTOR c.7514G>C p.R2505P Missense 56/58 -
3-178916944-A-G PIK3CA c.331A>G p.K111E Missense 2/21 -
3-178927974-G-A PIK3CA c.1252G>A p.E418K Missense 8/21 -
3-178921549-T-C PIK3CA c.1031T>C p.V344A Missense 5/21 -
17-7577097-C-A TP53 c.841G>T p.D281Y Missense 8/11 -
3-178928079-G-C PIK3CA c.1357G>C p.E453Q Missense 8/21 -
17-7578406-C-A TP53 c.524G>T p.R175L Missense 5/11 -
4-55161380-G-A PDGFRA c.3211G>A p.D1071N Missense 23/23 -
17-40481654-A-T STAT3 c.1151T>A p.F384Y Missense 13/24 -
16-68862107-G-A CDH1 c.2195G>A p.R732Q Missense 14/16 -
17-37881312-A-T ERBB2 c.2504A>T p.Y835F Missense 21/27 -
1-11227530-A-G MTOR c.4298T>C p.L1433S Missense 29/58 -
3-178952078-G-A PIK3CA c.3133G>A p.D1045N Missense 21/21 -
10-89692896-G-A PTEN c.380G>A p.G127E Missense 5/9 -
10-89692792-C-G PTEN c.276C>G p.D92E Missense 5/9 -
10-89692792-C-A PTEN c.276C>A p.D92E Missense 5/9 -
4-55961059-G-A KDR c.2881C>T p.R961W Missense 21/30 -
10-89685287-A-G PTEN c.182A>G p.H61R Missense 3/9 -
10-89692913-G-A PTEN c.397G>A p.V133I Missense 5/9 -
17-7578455-C-T TP53 c.475G>A p.A159T Missense 5/11 -
12-56478854-G-C ERBB3 c.310G>C p.V104L Missense 3/28 -
17-7577508-T-C TP53 c.773A>G p.E258G Missense 7/11 -
3-178952019-C-G PIK3CA c.3074C>G p.T1025S Missense 21/21 -
3-178916891-G-A PIK3CA c.278G>A p.R93Q Missense 2/21 -
14-38061231-A-T FOXA1 c.758T>A p.M253K Missense 2/2 -
17-7578478-G-A TP53 c.452C>T p.P151L Missense 5/11 -
17-7578400-G-C TP53 c.530C>G p.P177R Missense 5/11 -
17-7578536-T-C TP53 c.394A>G p.K132E Missense 5/11 -
X-70339254-G-A MED12 c.131G>A p.G44D Missense 2/45 -
2-198267360-T-C SF3B1 c.1997A>G p.K666R Missense 14/25 -
2-48028049-G-A MSH6 c.2927G>A p.R976H Missense 4/10 -
21-36231791-T-C RUNX1 c.593A>G p.D198G Missense 6/9 -
X-70349258-C-T MED12 c.3670C>T p.L1224F Missense 26/45 -
2-29432664-C-A ALK c.3824G>T p.R1275L Missense 25/29 -
X-47426120-T-G ARAF c.640T>G p.S214A Missense 7/16 -
2-29443696-A-C ALK c.3521T>G p.F1174C Missense 23/29 -
X-47426121-C-G ARAF c.641C>G p.S214C Missense 7/16 -
X-47426121-C-T ARAF c.641C>T p.S214F Missense 7/16 -
10-89692779-A-G PTEN c.263A>G p.Y88C Missense 5/9 -
11-108216545-C-T ATM c.8494C>T p.R2832C Missense 58/63 -
11-108218046-T-G ATM c.8625T>G p.N2875K Missense 59/63 -
11-108218046-T-A ATM c.8625T>A p.N2875K Missense 59/63 -
7-140453148-C-T BRAF c.1787G>A p.G596D Missense 15/18 -
11-69456211-T-G CCND1 c.130T>G p.Y44D Missense 1/5 -
7-140453148-C-A BRAF c.1787G>T p.G596V Missense 15/18 -
7-140453155-C-G BRAF c.1780G>C p.D594H Missense 15/18 -
7-140453133-T-G BRAF c.1802A>C p.K601T Missense 15/18 -
17-41209130-T-A BRCA1 c.5216A>T p.D1739V Missense 19/23 -
11-69466019-C-T CCND1 c.857C>T p.T286I Missense 5/5 -
11-69466021-C-A CCND1 c.859C>A p.P287T Missense 5/5 -
17-7577544-A-G TP53 c.737T>C p.M246T Missense 7/11 -
17-7577529-A-T TP53 c.752T>A p.I251N Missense 7/11 -
9-21971096-C-T CDKN2A c.262G>A p.E88K Missense 2/3 -
16-3788618-G-A CREBBP c.4336C>T p.R1446C Missense 26/31 -
9-21971111-G-A CDKN2A c.247C>T p.H83Y Missense 2/3 -
16-67645922-C-T CTCF c.850C>T p.H284Y Missense 4/12 -
16-3788617-C-T CREBBP c.4337G>A p.R1446H Missense 26/31 -
9-21971036-C-T CDKN2A c.322G>A p.D108N Missense 2/3 -
9-21971036-C-A CDKN2A c.322G>T p.D108Y Missense 2/3 -
16-3788618-G-C CREBBP c.4336C>G p.R1446G Missense 26/31 -
12-58145430-C-A CDK4 c.71G>T p.R24L Missense 2/8 -
9-21971017-G-A CDKN2A c.341C>T p.P114L Missense 2/3 -
3-41266137-C-G CTNNB1 c.134C>G p.S45C Missense 3/15 -
3-41266104-G-T CTNNB1 c.101G>T p.G34V Missense 3/15 -
3-41266103-G-C CTNNB1 c.100G>C p.G34R Missense 3/15 -
14-95557629-T-C DICER1 c.5438A>G p.E1813G Missense 25/27 -
3-41266109-C-T CTNNB1 c.106C>T p.H36Y Missense 3/15 -
14-95557629-T-G DICER1 c.5438A>C p.E1813A Missense 25/27 -
3-41266097-G-T CTNNB1 c.94G>T p.D32Y Missense 3/15 -
3-41274911-T-G CTNNB1 c.1161T>G p.N387K Missense 8/15 -
3-41274911-T-A CTNNB1 c.1161T>A p.N387K Missense 8/15 -
3-41266098-A-C CTNNB1 c.95A>C p.D32A Missense 3/15 -
3-41266104-G-C CTNNB1 c.101G>C p.G34A Missense 3/15 -
16-67654646-C-T CTCF c.1133C>T p.P378L Missense 6/12 -
3-41266125-C-A CTNNB1 c.122C>A p.T41N Missense 3/15 -
16-67654643-G-A CTCF c.1130G>A p.R377H Missense 6/12 -
1-11169377-T-A MTOR c.7498A>T p.I2500F Missense 56/58 -
7-148508727-T-A EZH2 c.1937A>T p.Y646F Missense 16/20 -
7-148508728-A-G EZH2 c.1936T>C p.Y646H Missense 16/20 -
17-37880219-TT-CC ERBB2 c.2263_2264delTTinsCC p.L755P Missense 19/27 -
7-148508728-A-T EZH2 c.1936T>A p.Y646N Missense 16/20 -
7-148508727-T-G EZH2 c.1937A>C p.Y646S Missense 16/20 -
22-41565529-G-T EP300 c.4195G>T p.D1399Y Missense 26/31 -
22-41565529-G-A EP300 c.4195G>A p.D1399N Missense 26/31 -
17-37881000-G-A ERBB2 c.2329G>A p.V777M Missense 20/27 -
17-37880220-T-G ERBB2 c.2264T>G p.L755W Missense 19/27 -
12-56478854-G-A ERBB3 c.310G>A p.V104M Missense 3/28 -
19-45867687-T-C ERCC2 c.713A>G p.N238S Missense 8/23 -
19-10610247-C-A KEAP1 c.463G>T p.V155F Missense 2/6 -
19-10600417-C-A KEAP1 c.1438G>T p.G480W Missense 4/6 -
15-90631934-C-A IDH2 c.419G>T p.R140L Missense 4/11 -
19-10602310-C-A KEAP1 c.1268G>T p.G423V Missense 3/6 -
19-10602314-C-T KEAP1 c.1264G>A p.D422N Missense 3/6 -
13-73649905-G-A KLF5 c.1255G>A p.E419K Missense 4/4 -
19-4117551-A-C MAP2K2 c.169T>G p.F57V Missense 2/11 -
12-25380276-T-G KRAS c.182A>C p.Q61P Missense 3/5 -
19-4117551-A-G MAP2K2 c.169T>C p.F57L Missense 2/11 -
19-4117549-A-T MAP2K2 c.171T>A p.F57L Missense 2/11 -
19-4117549-A-C MAP2K2 c.171T>G p.F57L Missense 2/11 -
13-73649905-G-C KLF5 c.1255G>C p.E419Q Missense 4/4 -
15-66727441-T-C MAP2K1 c.157T>C p.F53L Missense 2/11 -
15-66727443-T-A MAP2K1 c.159T>A p.F53L Missense 2/11 -
15-66727443-T-G MAP2K1 c.159T>G p.F53L Missense 2/11 -
15-66727454-A-C MAP2K1 c.170A>C p.K57T Missense 2/11 -
15-66729163-C-A MAP2K1 c.371C>A p.P124Q Missense 3/11 -
15-40675107-C-T KNSTRN c.71C>T p.S24F Missense 1/9 -
17-7578265-A-C TP53 c.584T>G p.I195S Missense 6/11 -
17-7578466-G-T TP53 c.464C>A p.T155N Missense 5/11 -
16-67645923-A-C CTCF c.851A>C p.H284P Missense 4/12 -
16-67645922-C-A CTCF c.850C>A p.H284N Missense 4/12 -
1-11217299-A-G MTOR c.4379T>C p.L1460P Missense 30/58 -
1-11217231-A-G MTOR c.4447T>C p.C1483R Missense 30/58 -
8-128750681-C-T MYC c.218C>T p.T73I Missense 2/3 -
1-11217230-C-T MTOR c.4448G>A p.C1483Y Missense 30/58 -
1-11184573-G-T MTOR c.6644C>A p.S2215Y Missense 47/58 -
2-16082317-C-T MYCN c.131C>T p.P44L Missense 2/3 -
1-11217230-C-A MTOR c.4448G>T p.C1483F Missense 30/58 -
1-11189847-A-G MTOR c.5662T>C p.F1888L Missense 40/58 -
1-11189845-G-T MTOR c.5664C>A p.F1888L Missense 40/58 -
1-11189845-G-C MTOR c.5664C>G p.F1888L Missense 40/58 -
3-138374245-C-A PIK3CB c.3199G>T p.D1067Y Missense 24/24 -
3-138374244-T-G PIK3CB c.3200A>C p.D1067A Missense 24/24 -
3-138374244-T-A PIK3CB c.3200A>T p.D1067V Missense 24/24 -
12-133253185-G-A POLE c.856C>T p.P286S Missense 9/49 -
5-67588951-C-T PIK3R1 c.1042C>T p.R348* Nonsense 9/16 -
12-133253184-G-T POLE c.857C>A p.P286H Missense 9/49 -
3-178916854-G-A PIK3CA c.241G>A p.E81K Missense 2/21 -
3-12645699-G-C RAF1 c.770C>G p.S257W Missense 7/17 -
7-6426893-C-T RAC1 c.86C>T p.P29L Missense 2/6 -
10-89711891-G-A PTEN c.509G>A p.S170N Missense 6/9 -
13-49033955-A-T RB1 c.2092A>T p.R698W Missense 20/27 -
10-89692905-G-T PTEN c.389G>T p.R130L Missense 5/9 -
12-112888211-A-G PTPN11 c.227A>G p.E76G Missense 3/16 -
12-112926888-G-T PTPN11 c.1508G>T p.G503V Missense 13/16 -
10-89692883-C-G PTEN c.367C>G p.H123D Missense 5/9 -
10-89692898-A-C PTEN c.382A>C p.K128Q Missense 5/9 -
10-89692923-G-T PTEN c.407G>T p.C136F Missense 5/9 -
10-89690805-G-A PTEN c.212G>A p.C71Y Missense 4/9 -
3-49412905-C-G RHOA c.118G>C p.E40Q Missense 2/5 -
3-49412898-T-C RHOA c.125A>G p.Y42C Missense 2/5 -
11-14316390-T-A RRAS2 c.215A>T p.Q72L Missense 3/6 -
7-151188049-T-C RHEB c.104A>G p.Y35C Missense 2/8 -
7-151188050-A-T RHEB c.103T>A p.Y35N Missense 2/8 -
2-198267483-C-A SF3B1 c.1874G>T p.R625L Missense 14/25 -
18-45374881-C-T SMAD2 c.962G>A p.R321Q Missense 8/11 -
3-49412973-C-T RHOA c.50G>A p.G17E Missense 2/5 -
18-48604789-C-G SMAD4 c.1611C>G p.D537E Missense 12/12 -
18-48604789-C-A SMAD4 c.1611C>A p.D537E Missense 12/12 -
2-39281778-T-A SOS1 c.697A>T p.N233Y Missense 5/23 -
17-47699360-C-T SPOP c.148G>A p.E50K Missense 3/10 -
17-47696461-C-T SPOP c.362G>A p.R121Q Missense 5/10 -
17-47696599-T-C SPOP c.349A>G p.M117V Missense 4/10 -
17-47696643-A-C SPOP c.305T>G p.F102C Missense 4/10 -
17-47696426-A-G SPOP c.397T>C p.F133L Missense 5/10 -
17-47696424-G-T SPOP c.399C>A p.F133L Missense 5/10 -
17-47696424-G-C SPOP c.399C>G p.F133L Missense 5/10 -
17-47696689-A-T SPOP c.259T>A p.Y87N Missense 4/10 -
17-40481576-T-C STAT3 c.1229A>G p.H410R Missense 13/24 -
17-7573996-A-C TP53 c.1031T>G p.L344R Missense 10/11 -
17-7578380-C-G TP53 c.550G>C p.D184H Missense 5/11 -
17-7579374-C-A TP53 c.313G>T p.G105C Missense 4/11 -
17-7577505-T-A TP53 c.776A>T p.D259V Missense 7/11 -
17-7578458-G-A TP53 c.472C>T p.R158C Missense 5/11 -
17-7578532-A-C TP53 c.398T>G p.M133R Missense 5/11 -
17-7576853-C-A TP53 c.993G>T p.Q331H Missense 9/11 -
17-7576853-C-G TP53 c.993G>C p.Q331H Missense 9/11 -
17-7577138-C-G TP53 c.800G>C p.R267P Missense 8/11 -
17-7574017-C-A TP53 c.1010G>T p.R337L Missense 10/11 -
17-7578440-T-C TP53 c.490A>G p.K164E Missense 5/11 -
17-7578177-C-A TP53 c.672G>T p.E224D Missense 6/11 -
17-7578479-G-C TP53 c.451C>G p.P151A Missense 5/11 -
17-7578211-C-G TP53 c.638G>C p.R213P Missense 6/11 -
17-7578412-A-C TP53 c.518T>G p.V173G Missense 5/11 -
17-7578499-T-G TP53 c.431A>C p.Q144P Missense 5/11 -
17-7578499-T-A TP53 c.431A>T p.Q144L Missense 5/11 -
17-7578527-A-C TP53 c.403T>G p.C135G Missense 5/11 -
17-7578395-G-T TP53 c.535C>A p.H179N Missense 5/11 -
17-7577575-A-T TP53 c.706T>A p.Y236N Missense 7/11 -
17-7578203-C-G TP53 c.646G>C p.V216L Missense 6/11 -
17-7578203-C-A TP53 c.646G>T p.V216L Missense 6/11 -
17-7577117-A-G TP53 c.821T>C p.V274A Missense 8/11 -
17-7577123-A-T TP53 c.815T>A p.V272E Missense 8/11 -
17-7578535-T-A TP53 c.395A>T p.K132M Missense 5/11 -
17-7578268-A-T TP53 c.581T>A p.L194H Missense 6/11 -
17-7577127-C-T TP53 c.811G>A p.E271K Missense 8/11 -
17-7578202-A-T TP53 c.647T>A p.V216E Missense 6/11 -
17-7578412-A-T TP53 c.518T>A p.V173E Missense 5/11 -
17-7577095-G-C TP53 c.843C>G p.D281E Missense 8/11 -
17-7577555-G-C TP53 c.726C>G p.C242W Missense 7/11 -
17-7578402-G-C TP53 c.528C>G p.C176W Missense 5/11 -
17-7577130-A-C TP53 c.808T>G p.F270V Missense 8/11 -
17-7577572-T-C TP53 c.709A>G p.M237V Missense 7/11 -
17-7578527-A-T TP53 c.403T>A p.C135S Missense 5/11 -
17-7578526-C-G TP53 c.404G>C p.C135S Missense 5/11 -
17-7577097-C-G TP53 c.841G>C p.D281H Missense 8/11 -
17-7579355-A-C TP53 c.332T>G p.L111R Missense 4/11 -
17-7577081-T-A TP53 c.857A>T p.E286V Missense 8/11 -
17-7578235-T-G TP53 c.614A>C p.Y205S Missense 6/11 -
17-7577551-C-G TP53 c.730G>C p.G244R Missense 7/11 -
1-11217229-G-C MTOR c.4449C>G p.C1483W Missense 30/58 -
1-11169375-A-C MTOR c.7500T>G p.I2500M Missense 56/58 -
17-7578467-T-G TP53 c.463A>C p.T155P Missense 5/11 -
17-7579355-A-G TP53 c.332T>C p.L111P Missense 4/11 -
17-7577517-A-C TP53 c.764T>G p.I255S Missense 7/11 -
17-7578509-A-G TP53 c.421T>C p.C141R Missense 5/11 -
17-7577106-G-T TP53 c.832C>A p.P278T Missense 8/11 -
17-7577144-A-G TP53 c.794T>C p.L265P Missense 8/11 -
17-7577112-C-G TP53 c.826G>C p.A276P Missense 8/11 -
17-7577559-G-C TP53 c.722C>G p.S241C Missense 7/11 -
17-7578458-G-C TP53 c.472C>G p.R158G Missense 5/11 -
17-7577509-C-G TP53 c.772G>C p.E258Q Missense 7/11 -
2-178098800-T-C NFE2L2 c.245A>G p.E82G Missense 2/5 -
2-178098806-G-T NFE2L2 c.239C>A p.T80K Missense 2/5 -
2-178098799-T-G NFE2L2 c.246A>C p.E82D Missense 2/5 -
2-178098960-C-G NFE2L2 c.85G>C p.D29H Missense 2/5 -
2-178098804-C-T NFE2L2 c.241G>A p.G81S Missense 2/5 -
2-178098957-G-A NFE2L2 c.88C>T p.L30F Missense 2/5 -
2-178098810-C-T NFE2L2 c.235G>A p.E79K Missense 2/5 -
2-178098807-T-C NFE2L2 c.238A>G p.T80A Missense 2/5 -
2-178098806-G-C NFE2L2 c.239C>G p.T80R Missense 2/5 -
2-178098803-C-T NFE2L2 c.242G>A p.G81D Missense 2/5 -
2-178098960-C-T NFE2L2 c.85G>A p.D29N Missense 2/5 -
17-29677227-C-T NF1 c.7348C>T p.R2450* Nonsense 50/58 -
2-178098801-C-G NFE2L2 c.244G>C p.E82Q Missense 2/5 -
2-178098807-T-G NFE2L2 c.238A>C p.T80P Missense 2/5 -
2-178098960-C-A NFE2L2 c.85G>T p.D29Y Missense 2/5 -
2-178098944-C-T NFE2L2 c.101G>A p.R34Q Missense 2/5 -
17-29562747-G-A NF1 c.3827G>A p.R1276Q Missense 28/58 -
2-178098810-C-G NFE2L2 c.235G>C p.E79Q Missense 2/5 -
17-7577082-C-G TP53 c.856G>C p.E286Q Missense 8/11 -
17-7578460-A-C TP53 c.470T>G p.V157G Missense 5/11 -
3-178922363-T-C PIK3CA c.1132T>C p.C378R Missense 6/21 -
3-178936082-G-C PIK3CA c.1624G>C p.E542Q Missense 10/21 -
3-178922324-G-A PIK3CA c.1093G>A p.E365K Missense 6/21 -
3-178928226-C-T PIK3CA c.1412C>T p.P471L Missense 9/21 -
16-56782199-G-A NUP93 c.40G>A p.E14K Missense 2/22 -
3-178921567-A-G PIK3CA c.1049A>G p.D350G Missense 5/21 -
3-178952018-A-G PIK3CA c.3073A>G p.T1025A Missense 21/21 -
3-178936094-C-G PIK3CA c.1636C>G p.Q546E Missense 10/21 -
3-178951964-G-C PIK3CA c.3019G>C p.G1007R Missense 21/21 -
17-7578449-C-A TP53 c.481G>T p.A161S Missense 5/11 -
3-178916930-G-T PIK3CA c.317G>T p.G106V Missense 2/21 -
19-52715971-C-G PPP2R1A c.536C>G p.P179R Missense 5/15 -
19-52715983-G-A PPP2R1A c.548G>A p.R183Q Missense 5/15 -
19-52715982-C-T PPP2R1A c.547C>T p.R183W Missense 5/15 -
19-52715982-C-G PPP2R1A c.547C>G p.R183G Missense 5/15 -
17-7577117-A-T TP53 c.821T>A p.V274D Missense 8/11 -
17-7577105-G-T TP53 c.833C>A p.P278H Missense 8/11 -
17-7577099-C-A TP53 c.839G>T p.R280I Missense 8/11 -
17-7578262-C-G TP53 c.587G>C p.R196P Missense 6/11 -
17-7577571-A-T TP53 c.710T>A p.M237K Missense 7/11 -
17-7577081-T-C TP53 c.857A>G p.E286G Missense 8/11 -
3-10183752-T-A VHL c.221T>A p.V74D Missense 1/3 -
3-10188240-T-A VHL c.383T>A p.L128H Missense 2/3 -
3-10188315-T-C VHL c.458T>C p.L153P Missense 2/3 -
3-10188309-T-C VHL c.452T>C p.I151T Missense 2/3 -
17-7577581-A-T TP53 c.700T>A p.Y234N Missense 7/11 -
17-7579355-A-T TP53 c.332T>A p.L111Q Missense 4/11 -
17-7577569-A-G TP53 c.712T>C p.C238R Missense 7/11 -
3-10188200-C-A VHL c.343C>A p.H115N Missense 2/3 -
3-10183864-C-G VHL c.333C>G p.S111R Missense 1/3 -
3-10183864-C-A VHL c.333C>A p.S111R Missense 1/3 -
3-10183862-A-C VHL c.331A>C p.S111R Missense 1/3 -
7-140439727-C-T BRAF c.2012G>A p.R671Q Missense 17/18 -
3-138426040-C-G PIK3CB c.1491G>C p.E497D Missense 11/24 -
1-156843599-G-A NTRK1 c.1025G>A p.R342Q Missense 8/17 -
3-138426040-C-A PIK3CB c.1491G>T p.E497D Missense 11/24 -
12-133250250-G-C POLE c.1270C>G p.L424V Missense 13/49 -
3-138374293-C-T PIK3CB c.3151G>A p.E1051K Missense 24/24 -
13-32899321-G-T BRCA2 c.425G>T p.S142I Missense 4/27 -
9-21971156-C-T CDKN2A c.202G>A p.A68T Missense 2/3 -
2-29443615-C-T ALK c.3602G>A p.G1201E Missense 23/29 -
10-89692900-G-C PTEN c.384G>C p.K128N Missense 5/9 -
10-89692900-G-T PTEN c.384G>T p.K128N Missense 5/9 -
19-40742257-G-C AKT2 c.867C>G p.I289M Missense 10/14 -
17-7578197-C-T TP53 c.652G>A p.V218M Missense 6/11 -
2-29443600-G-C ALK c.3617C>G p.S1206C Missense 23/29 -
2-29443610-C-T ALK c.3607G>A p.D1203N Missense 23/29 -
2-29445270-A-G ALK c.3455T>C p.L1152P Missense 22/29 -
2-29445213-A-C ALK c.3512T>G p.I1171S Missense 22/29 -
2-29443624-A-G ALK c.3593T>C p.L1198P Missense 23/29 -
2-29432681-TCC-GCT ALK c.3805_3807delGGAinsAGC p.G1269S Missense 25/29 -
2-29443696-A-G ALK c.3521T>C p.F1174S Missense 23/29 -
17-58740529-C-A PPM1D c.1434C>A p.C478* Nonsense 6/6 -
3-10183724-T-G VHL c.193T>G p.S65A Missense 1/3 -
4-106157703-T-G TET2 c.2604T>G p.F868L Missense 3/11 -
2-29519781-A-G ALK c.1790T>C p.V597A Missense 9/29 -
2-29419650-C-T ALK c.4150G>A p.E1384K Missense 28/29 -
2-29445216-A-C ALK c.3509T>G p.I1170S Missense 22/29 -
2-29474094-T-C ALK c.2081A>G p.H694R Missense 12/29 -
2-29451923-C-T ALK c.2642G>A p.G881D Missense 16/29 -
2-29420497-C-G ALK c.3984G>C p.M1328I Missense 27/29 -
2-29420497-C-T ALK c.3984G>A p.M1328I Missense 27/29 -
2-29420497-C-A ALK c.3984G>T p.M1328I Missense 27/29 -
2-29445273-G-C ALK c.3452C>G p.T1151R Missense 22/29 -
2-29445465-C-T ALK c.3368G>A p.G1123D Missense 21/29 -
2-29445466-C-T ALK c.3367G>A p.G1123S Missense 21/29 -
10-123279605-A-C FGFR2 c.827T>G p.F276C Missense 7/18 -
2-29436875-A-C ALK c.3718T>G p.L1240V Missense 24/29 -
4-55955969-C-T KDR c.3193G>A p.A1065T Missense 24/30 -
9-21974684-G-A CDKN2A c.143C>T p.P48L Missense 1/3 -
17-7577520-A-G TP53 c.761T>C p.I254T Missense 7/11 -
11-119148991-G-A CBL c.1211G>A p.C404Y Missense 8/16 -
12-112926890-A-G PTPN11 c.1510A>G p.M504V Missense 13/16 -
12-112926884-T-A PTPN11 c.1504T>A p.S502T Missense 13/16 -
9-21971108-C-G CDKN2A c.250G>C p.D84H Missense 2/3 -
17-7577115-A-C TP53 c.823T>G p.C275G Missense 8/11 -
6-37138950-G-A PIM1 c.290G>A p.S97N Missense 4/6 -
17-7578445-A-T TP53 c.485T>A p.I162N Missense 5/11 -
17-7578448-G-T TP53 c.482C>A p.A161D Missense 5/11 -
17-7578179-C-T TP53 c.670G>A p.E224K Missense 6/11 -
17-7577506-C-T TP53 c.775G>A p.D259N Missense 7/11 -
17-7576854-T-C TP53 c.992A>G p.Q331R Missense 9/11 -
17-7578490-A-T TP53 c.440T>A p.V147D Missense 5/11 -
17-7578554-A-C TP53 c.376T>G p.Y126D Missense 5/11 -
7-55242433-G-A EGFR c.2203G>A p.G735S Missense 19/28 -
4-55152112-C-A PDGFRA c.2544C>A p.N848K Missense 18/23 -
17-37881378-A-G ERBB2 c.2570A>G p.N857S Missense 21/27 -
11-533881-C-T HRAS c.175G>A p.A59T Missense 3/6 -
9-80412493-C-T GNAQ c.548G>A p.R183Q Missense 4/7 -
19-3115012-C-T GNA11 c.547C>T p.R183C Missense 4/7 -
9-27157925-G-A TEK c.149G>A p.R50H Missense 2/23 -
17-29560133-C-G NF1 c.3610C>G p.R1204G Missense 27/58 -
17-29560133-C-T NF1 c.3610C>T p.R1204W Missense 27/58 -
7-55259446-A-T EGFR c.2504A>T p.H835L Missense 21/28 -
6-37138901-C-T PIM1 c.241C>T p.P81S Missense 4/6 -
17-7578194-GCAC-G TP53 c.652_654delGTG p.V218del InFrameDeletion 6/11 -
6-37138769-C-T PIM1 c.202C>T p.H68Y Missense 3/6 -
17-41201179-C-T BRCA1 c.5365G>A p.A1789T Missense 21/23 -
19-52716323-C-T PPP2R1A c.767C>T p.S256F Missense 6/15 -
4-1962801-G-A NSD2 c.3295G>A p.E1099K Missense 18/22 -
17-7578196-A-T TP53 c.653T>A p.V218E Missense 6/11 -
17-41199719-C-G BRCA1 c.5408G>C p.G1803A Missense 22/23 -
17-41199707-A-C BRCA1 c.5420T>G p.I1807S Missense 22/23 -
17-41197789-A-T BRCA1 c.5498T>A p.V1833E Missense 23/23 -
17-41199695-T-C BRCA1 c.5432A>G p.Q1811R Missense 22/23 -
22-29091840-T-C CHEK2 c.1117A>G p.K373E Missense 11/15 -
1-11182179-G-T MTOR c.6667C>A p.Q2223K Missense 48/58 -
17-41197783-C-G BRCA1 c.5504G>C p.R1835P Missense 23/23 -
17-41197781-C-T BRCA1 c.5506G>A p.E1836K Missense 23/23 -
17-41197776-C-G BRCA1 c.5511G>C p.W1837C Missense 23/23 -
17-41197776-C-A BRCA1 c.5511G>T p.W1837C Missense 23/23 -
17-41197766-T-G BRCA1 c.5521A>C p.S1841R Missense 23/23 -
17-41197764-A-T BRCA1 c.5523T>A p.S1841R Missense 23/23 -
17-41197764-A-C BRCA1 c.5523T>G p.S1841R Missense 23/23 -
17-41197760-C-T BRCA1 c.5527G>A p.A1843T Missense 23/23 -
17-41197726-A-G BRCA1 c.5561T>C p.L1854P Missense 23/23 -
17-41276044-A-G BRCA1 c.70T>C p.C24R Missense 2/23 -
17-41267767-G-C BRCA1 c.110C>G p.T37R Missense 3/23 -
17-41267761-C-T BRCA1 c.116G>A p.C39Y Missense 3/23 -
17-41267746-C-A BRCA1 c.131G>T p.C44F Missense 3/23 -
17-41219642-T-C BRCA1 c.5057A>G p.H1686R Missense 16/23 -
17-41219633-A-C BRCA1 c.5066T>G p.M1689R Missense 16/23 -
17-41219627-G-T BRCA1 c.5072C>A p.T1691K Missense 16/23 -
17-41215389-C-A BRCA1 c.5154G>T p.W1718C Missense 18/23 -
17-41215389-C-G BRCA1 c.5154G>C p.W1718C Missense 18/23 -
17-41209092-C-G BRCA1 c.5254G>C p.A1752P Missense 19/23 -
17-41203124-C-A BRCA1 c.5288G>T p.G1763V Missense 20/23 -
13-28592629-T-C FLT3 c.2516A>G p.D839G Missense 20/24 -
5-67569817-G-T PIK3R1 c.478G>T p.E160* Nonsense 4/16 -
4-55599339-A-T KIT c.2465A>T p.N822I Missense 17/21 -
7-140624424-G-T BRAF c.80C>A p.A27D Missense 1/18 -
17-41215902-A-C BRCA1 c.5141T>G p.V1714G Missense 17/23 -
17-41215390-C-G BRCA1 c.5153G>C p.W1718S Missense 18/23 -
10-89692899-A-C PTEN c.383A>C p.K128T Missense 5/9 -
1-11217303-C-G MTOR c.4375G>C p.A1459P Missense 30/58 -
17-41245898-A-C BRCA1 c.1650T>G p.N550K Missense 10/23 -
17-41245898-A-T BRCA1 c.1650T>A p.N550K Missense 10/23 -
5-67569823-C-T PIK3R1 c.484C>T p.R162* Nonsense 4/16 -
10-89720870-T-G PTEN c.1021T>G p.F341V Missense 8/9 -
11-534269-CGC-ATA HRAS c.52_54delGCGinsTAT p.A18Y Missense 2/6 -
19-11134266-C-T SMARCA4 c.2932C>T p.R978* Nonsense 20/35 -
7-116417457-G-A MET c.3274G>A p.V1092I Missense 16/21 -
17-7576857-A-G TP53 c.989T>C p.L330P Missense 9/11 -
12-25380274-C-T KRAS c.184G>A p.E62K Missense 3/5 -
5-149503838-G-T PDGFRB c.1998C>A p.N666K Missense 14/23 -
5-149503838-G-C PDGFRB c.1998C>G p.N666K Missense 14/23 -
7-140624388-GC-AT BRAF c.115_116delGCinsAT p.A39M Missense 1/18 -
7-140624389-C-G BRAF c.115G>C p.A39P Missense 1/18 -
7-140624389-C-T BRAF c.115G>A p.A39T Missense 1/18 -
9-139390942-G-C NOTCH1 c.7249C>G p.P2417A Missense 34/34 -
7-140624388-GC-TT BRAF c.115_116delGCinsAA p.A39K Missense 1/18 -
13-28608281-A-C FLT3 c.1775T>G p.V592G Missense 14/24 -
13-28610138-G-A FLT3 c.1352C>T p.S451F Missense 11/24 -
22-41565575-A-G EP300 c.4241A>G p.Y1414C Missense 26/31 -
4-55593613-T-C KIT c.1679T>C p.V560A Missense 11/21 -
3-138417865-C-T PIK3CB c.1654G>A p.E552K Missense 13/24 -
2-212537981-C-T ERBB4 c.1624G>A p.E542K Missense 14/28 -
5-67589147-A-G PIK3R1 c.1135A>G p.K379E Missense 10/16 -
17-7572986-G-A TP53 c.1123C>T p.Q375* Nonsense 11/11 -
17-37880997-G-A ERBB2 c.2326G>A p.G776S Missense 20/27 -
7-140453179-C-T BRAF c.1756G>A p.E586K Missense 15/18 -
1-115256530-G-C NRAS c.181C>G p.Q61E Missense 3/7 -
1-115258744-C-G NRAS c.38G>C p.G13A Missense 2/7 -
3-178952090-G-A PIK3CA c.3145G>A p.G1049S Missense 21/21 -
7-140453153-A-T BRAF c.1782T>A p.D594E Missense 15/18 -
4-55561764-G-A KIT c.154G>A p.D52N Missense 2/21 -
7-140481408-G-A BRAF c.1400C>T p.S467L Missense 11/18 -
2-212295699-C-T ERBB4 c.2614G>A p.E872K Missense 21/28 -
4-55599348-T-C KIT c.2474T>C p.V825A Missense 17/21 -
20-36031762-C-T SRC c.1591C>T p.Q531* Nonsense 14/14 -
3-41266124-A-C CTNNB1 c.121A>C p.T41P Missense 3/15 -
3-41266125-C-G CTNNB1 c.122C>G p.T41S Missense 3/15 -
3-41266124-A-T CTNNB1 c.121A>T p.T41S Missense 3/15 -
4-55593666-TATG-T KIT c.1735_1737delGAT p.D579del InFrameDeletion 11/21 -
7-151859891-G-A KMT2C c.10771C>T p.Q3591* Nonsense 43/59 -
4-55152104-G-T PDGFRA c.2536G>T p.D846Y Missense 18/23 -
4-55152092-GA-AT PDGFRA c.2524_2525delGAinsAT p.D842I Missense 18/23 -
22-24176339-G-A SMARCB1 c.1130G>A p.R377H Missense 9/9 -
17-7578452-T-C TP53 c.478A>G p.M160V Missense 5/11 -
10-123279680-C-T FGFR2 c.752G>A p.R251Q Missense 7/18 -
6-152129084-GCC-ATG ESR1 c.37_39delGCCinsATG p.A13M Missense 1/8 -
9-133738330-A-G ABL1 c.730A>G p.M244V Missense 4/11 -
9-133738342-C-G ABL1 c.742C>G p.L248V Missense 4/11 -
12-112888189-G-A PTPN11 c.205G>A p.E69K Missense 3/16 -
12-112926884-T-C PTPN11 c.1504T>C p.S502P Missense 13/16 -
12-112888166-A-T PTPN11 c.182A>T p.D61V Missense 3/16 -
12-112888163-G-T PTPN11 c.179G>T p.G60V Missense 3/16 -
7-55249130-G-A EGFR c.2428G>A p.G810S Missense 20/28 -
7-55249020-A-G EGFR c.2318A>G p.H773R Missense 20/28 -
18-48591826-A-C SMAD4 c.989A>C p.E330A Missense 9/12 -
13-28608281-A-G FLT3 c.1775T>C p.V592A Missense 14/24 -
18-48593405-G-C SMAD4 c.1156G>C p.G386R Missense 10/12 -
3-10191480-T-A VHL c.473T>A p.L158Q Missense 3/3 -
3-178916731-GCT-AAG PIK3CA c.118_120delGCTinsAAG p.A40K Missense 2/21 -
13-28592637-G-C FLT3 c.2508C>G p.I836M Missense 20/24 -
11-108236087-G-A ATM c.9023G>A p.R3008H Missense 63/63 -
13-32937362-A-G BRCA2 c.8023A>G p.I2675V Missense 18/27 -
17-7578410-T-A TP53 c.520A>T p.R174W Missense 5/11 -
17-7578455-C-A TP53 c.475G>T p.A159S Missense 5/11 -
2-212288942-T-A ERBB4 c.2804A>T p.K935I Missense 23/28 -
2-212288955-C-A ERBB4 c.2791G>T p.D931Y Missense 23/28 -
2-212530135-T-A ERBB4 c.1784A>T p.D595V Missense 15/28 -
2-212578341-G-T ERBB4 c.916C>A p.R306S Missense 8/28 -
2-212587147-T-C ERBB4 c.854A>G p.Y285C Missense 7/28 -
7-116412023-A-G MET c.3008A>G p.Y1003C Missense 14/21 -
17-74732959-G-A SRSF2 c.284C>T p.P95L Missense 1/3 -
17-74732959-G-C SRSF2 c.284C>G p.P95R Missense 1/3 -
5-176520181-A-G FGFR4 c.1100A>G p.Y367C Missense 9/18 -
3-10188245-G-C VHL c.388G>C p.V130L Missense 2/3 -
13-28608260-T-A FLT3 c.1796A>T p.Y599F Missense 14/24 -
4-1807862-G-A FGFR3 c.1921G>A p.D641N Missense 14/18 -
7-140453137-C-A BRAF c.1798G>T p.V600L Missense 15/18 -
17-7578253-C-T TP53 c.596G>A p.G199E Missense 6/11 -
1-11174420-C-T MTOR c.7255G>A p.E2419K Missense 53/58 -
17-7579542-C-G TP53 c.145G>C p.D49H Missense 4/11 -
10-89653833-G-A PTEN c.131G>A p.G44D Missense 2/9 -
19-45860619-G-A ERCC2 c.1388C>T p.P463L Missense 15/23 -
10-89692835-G-T PTEN c.319G>T p.D107Y Missense 5/9 -
17-41203094-G-A BRCA1 c.5318C>T p.T1773I Missense 20/23 -
17-7577126-T-A TP53 c.812A>T p.E271V Missense 8/11 -
17-37868210-T-C ERBB2 c.931T>C p.C311R Missense 8/27 -
2-198267371-G-C SF3B1 c.1986C>G p.H662Q Missense 14/25 -
13-32900639-C-T BRCA2 c.520C>T p.R174C Missense 7/27 -
17-7577552-C-T TP53 c.729G>A p.M243I Missense 7/11 -
17-7578400-G-A TP53 c.530C>T p.P177L Missense 5/11 -
17-7578446-T-C TP53 c.484A>G p.I162V Missense 5/11 -
17-7578470-C-T TP53 c.460G>A p.G154S Missense 5/11 -
21-36231782-C-T RUNX1 c.602G>A p.R201Q Missense 6/9 -
21-36231792-C-T RUNX1 c.592G>A p.D198N Missense 6/9 -
21-36252865-C-T RUNX1 c.497G>A p.R166Q Missense 5/9 -
21-36259172-G-A RUNX1 c.319C>T p.R107C Missense 4/9 -
7-140453987-T-A BRAF c.1741A>T p.N581Y Missense 14/18 -
7-140481393-T-C BRAF c.1415A>G p.Y472C Missense 11/18 -
1-162745497-A-T DDR2 c.1912A>T p.I638F Missense 15/18 -
17-41215926-C-T BRCA1 c.5117G>A p.G1706E Missense 17/23 -
1-162729671-G-T DDR2 c.757G>T p.G253C Missense 8/18 -
7-55227933-A-C EGFR c.1400A>C p.K467T Missense 12/28 -
7-55227926-G-C EGFR c.1393G>C p.G465R Missense 12/28 -
1-162748407-G-T DDR2 c.2321G>T p.G774V Missense 17/18 -
1-162729630-T-G DDR2 c.716T>G p.L239R Missense 8/18 -
1-162724415-C-G DDR2 c.187C>G p.L63V Missense 5/18 -
1-162741822-G-A DDR2 c.1513G>A p.G505S Missense 13/18 -
17-41215390-C-A BRCA1 c.5153G>T p.W1718L Missense 18/23 -
17-41219633-A-G BRCA1 c.5066T>C p.M1689T Missense 16/23 -
22-29121000-T-C CHEK2 c.557A>G p.N186S Missense 4/15 -
2-25467449-C-A DNMT3A c.1627G>T p.G543C Missense 14/23 -
2-25469564-G-A DNMT3A c.1204C>T p.Q402* Nonsense 10/23 -
2-25470536-C-T DNMT3A c.938G>A p.W313* Nonsense 8/23 -
22-29091846-G-A CHEK2 c.1111C>T p.H371Y Missense 11/15 -
19-1220428-A-G STK11 c.521A>G p.H174R Missense 4/10 -
2-39278343-A-C SOS1 c.806T>G p.M269R Missense 6/23 -
3-178916731-G-T PIK3CA c.118G>T p.A40S Missense 2/21 -
17-37868241-A-G ERBB2 c.962A>G p.E321G Missense 8/27 -
12-56478851-C-G ERBB3 c.307C>G p.R103G Missense 3/28 -
17-37868279-T-A ERBB2 c.1000T>A p.C334S Missense 8/27 -
17-37868280-G-C ERBB2 c.1001G>C p.C334S Missense 8/27 -
12-56481857-C-A ERBB3 c.785C>A p.P262H Missense 7/28 -
2-212537975-G-A ERBB4 c.1630C>T p.R544W Missense 14/28 -
2-212566827-C-T ERBB4 c.1354G>A p.E452K Missense 12/28 -
2-212578308-C-T ERBB4 c.949G>A p.E317K Missense 8/28 -
17-37881616-C-T ERBB2 c.2686C>T p.R896C Missense 22/27 -
17-37868205-G-A ERBB2 c.926G>A p.G309E Missense 8/27 -
17-37880997-GG-CT ERBB2 c.2326_2327delGGinsCT p.G776L Missense 20/27 -
4-55594262-T-G KIT c.1965T>G p.N655K Missense 13/21 -
4-55594262-T-A KIT c.1965T>A p.N655K Missense 13/21 -
4-55599334-T-G KIT c.2460T>G p.D820E Missense 17/21 -
4-55599334-T-A KIT c.2460T>A p.D820E Missense 17/21 -
4-55595599-C-T KIT c.2089C>T p.H697Y Missense 14/21 -
4-55593591-T-A KIT c.1657T>A p.Y553N Missense 11/21 -
2-25466800-G-A DNMT3A c.1903C>T p.R635W Missense 16/23 -
1-11187096-A-G MTOR c.6322T>C p.F2108L Missense 45/58 -
1-11187094-G-T MTOR c.6324C>A p.F2108L Missense 45/58 -
1-11187094-G-C MTOR c.6324C>G p.F2108L Missense 45/58 -
15-66729179-C-A MAP2K1 c.387C>A p.F129L Missense 3/11 -
15-66729179-C-G MAP2K1 c.387C>G p.F129L Missense 3/11 -
1-11187857-C-T MTOR c.6040G>A p.E2014K Missense 44/58 -
15-66729175-G-A MAP2K1 c.383G>A p.G128D Missense 3/11 -
15-66729100-T-A MAP2K1 c.308T>A p.I103N Missense 3/11 -
7-116417464-A-G MET c.3281A>G p.H1094R Missense 16/21 -
3-128202759-G-A GATA2 c.961C>T p.L321F Missense 4/6 -
3-128202761-C-T GATA2 c.959G>A p.G320D Missense 4/6 -
7-128846031-G-A SMO c.961G>A p.V321M Missense 5/12 -
4-55144144-T-C PDGFRA c.1973T>C p.V658A Missense 14/23 -
4-55152090-G-A PDGFRA c.2522G>A p.R841K Missense 18/23 -
7-128849189-G-C SMO c.1417G>C p.D473H Missense 8/12 -
4-55152101-C-T PDGFRA c.2533C>T p.H845Y Missense 18/23 -
4-55152126-G-A PDGFRA c.2558G>A p.G853D Missense 18/23 -
4-55141083-C-T PDGFRA c.1729C>T p.P577S Missense 12/23 -
17-7578496-A-T TP53 c.434T>A p.L145Q Missense 5/11 -
19-1220489-C-G STK11 c.582C>G p.D194E Missense 4/10 -
19-1220489-C-A STK11 c.582C>A p.D194E Missense 4/10 -
17-41267746-C-T BRCA1 c.131G>A p.C44Y Missense 3/23 -
19-18271909-C-T PIK3R2 c.512C>T p.A171V Missense 5/16 -
7-128849148-C-T SMO c.1376C>T p.A459V Missense 8/12 -
5-131976454-C-T RAD50 c.3709C>T p.L1237F Missense 24/25 -
2-209108317-C-T IDH1 c.532G>A p.V178I Missense 6/10 -
1-11217290-T-G MTOR c.4388A>C p.Y1463S Missense 30/58 -
3-178936097-G-A PIK3CA c.1639G>A p.E547K Missense 10/21 -
17-41199702-C-A BRCA1 c.5425G>T p.V1809F Missense 22/23 -
17-41223049-T-C BRCA1 c.4882A>G p.M1628V Missense 15/23 -
12-25398220-A-C KRAS c.99T>G p.D33E Missense 2/5 -
12-25398220-A-T KRAS c.99T>A p.D33E Missense 2/5 -
11-533552-C-G HRAS c.351G>C p.K117N Missense 4/6 -
7-6426860-G-A RAC1 c.53G>A p.C18Y Missense 2/6 -
7-55233109-G-A EGFR c.1859G>A p.C620Y Missense 15/28 -
9-139399408-GCAC-G NOTCH1 c.4732_4734delGTG p.V1578del InFrameDeletion 26/34 -
7-55249028-C-G EGFR c.2326C>G p.R776G Missense 20/28 -
17-41267755-T-C BRCA1 c.122A>G p.H41R Missense 3/23 -
13-32900750-G-A BRCA2 c.631G>A p.V211I Missense 7/27 -
3-37042482-A-G MLH1 c.244A>G p.T82A Missense 3/19 -
13-32921033-G-C BRCA2 c.7007G>C p.R2336P Missense 13/27 -
3-37035151-A-G MLH1 c.113A>G p.N38S Missense 1/19 -
3-37058999-C-A MLH1 c.793C>A p.R265S Missense 10/19 -
3-37083767-T-G MLH1 c.1676T>G p.L559R Missense 15/19 -
3-37090087-G-C MLH1 c.1976G>C p.R659P Missense 17/19 -
17-41258546-A-C BRCA1 c.139T>G p.C47G Missense 4/23 -
13-28592641-T-G FLT3 c.2504A>C p.D835A Missense 20/24 -
3-37092119-T-C MLH1 c.2246T>C p.L749P Missense 19/19 -
2-47702310-G-C MSH2 c.1906G>C p.A636P Missense 12/16 -
10-89624296-G-A PTEN c.70G>A p.D24N Missense 1/9 -
10-89653808-G-C PTEN c.106G>C p.G36R Missense 2/9 -
10-89653846-C-G PTEN c.144C>G p.N48K Missense 2/9 -
10-89692793-C-G PTEN c.277C>G p.H93D Missense 5/9 -
10-89692851-T-C PTEN c.335T>C p.L112P Missense 5/9 -
10-89692991-A-G PTEN c.475A>G p.R159G Missense 5/9 -
10-89711876-G-T PTEN c.494G>T p.G165V Missense 6/9 -
10-89711900-G-C PTEN c.518G>C p.R173P Missense 6/9 -
10-89711902-T-A PTEN c.520T>A p.Y174N Missense 6/9 -
10-89717712-C-T PTEN c.737C>T p.P246L Missense 7/9 -
17-7577090-C-T TP53 c.848G>A p.R283H Missense 8/11 -
17-7577093-C-A TP53 c.845G>T p.R282L Missense 8/11 -
17-7577111-G-T TP53 c.827C>A p.A276D Missense 8/11 -
17-7577586-A-G TP53 c.695T>C p.I232T Missense 7/11 -
17-7578207-A-C TP53 c.642T>G p.H214Q Missense 6/11 -
17-7578539-T-A TP53 c.391A>T p.N131Y Missense 5/11 -
13-28608320-A-G FLT3 c.1736T>C p.V579A Missense 14/24 -
9-5078362-A-C JAK2 c.2049A>C p.R683S Missense 16/25 -
16-56782202-C-T NUP93 c.43C>T p.Q15* Nonsense 2/22 -
17-7577530-T-A TP53 c.751A>T p.I251F Missense 7/11 -
19-11138521-C-T SMARCA4 c.3277C>T p.R1093* Nonsense 24/35 -
17-41222976-A-T BRCA1 c.4955T>A p.M1652K Missense 15/23 -
17-41222961-A-G BRCA1 c.4970T>C p.L1657P Missense 15/23 -
17-41222964-C-T BRCA1 c.4967G>A p.G1656D Missense 15/23 -
17-41222952-T-C BRCA1 c.4979A>G p.E1660G Missense 15/23 -
17-41215945-T-C BRCA1 c.5098A>G p.T1700A Missense 17/23 -
17-41215939-T-C BRCA1 c.5104A>G p.K1702E Missense 17/23 -
17-41215936-A-G BRCA1 c.5107T>C p.Y1703H Missense 17/23 -
17-41215935-T-G BRCA1 c.5108A>C p.Y1703S Missense 17/23 -
17-41215932-A-G BRCA1 c.5111T>C p.F1704S Missense 17/23 -
17-41215929-A-G BRCA1 c.5114T>C p.L1705P Missense 17/23 -
17-41209131-C-A BRCA1 c.5215G>T p.D1739Y Missense 19/23 -
17-41209146-A-G BRCA1 c.5200T>C p.F1734L Missense 19/23 -
17-41209144-A-T BRCA1 c.5202T>A p.F1734L Missense 19/23 -
17-41209144-A-C BRCA1 c.5202T>G p.F1734L Missense 19/23 -
17-41209129-A-T BRCA1 c.5217T>A p.D1739E Missense 19/23 -
17-41209129-A-C BRCA1 c.5217T>G p.D1739E Missense 19/23 -
17-41209119-C-T BRCA1 c.5227G>A p.G1743R Missense 19/23 -
17-41209119-C-G BRCA1 c.5227G>C p.G1743R Missense 19/23 -
17-7578260-C-A TP53 c.589G>T p.V197L Missense 6/11 -
17-41209110-G-T BRCA1 c.5236C>A p.H1746N Missense 19/23 -
17-41209091-G-A BRCA1 c.5255C>T p.A1752V Missense 19/23 -
17-41203131-A-T BRCA1 c.5281T>A p.F1761I Missense 20/23 -
17-41203103-C-A BRCA1 c.5309G>T p.G1770V Missense 20/23 -
17-7578448-G-A TP53 c.482C>T p.A161V Missense 5/11 -
10-89720808-T-C PTEN c.959T>C p.L320S Missense 8/9 -
7-55259454-C-G EGFR c.2512C>G p.L838V Missense 21/28 -
9-21971107-T-C CDKN2A c.251A>G p.D84G Missense 2/3 -
17-7577521-T-A TP53 c.760A>T p.I254F Missense 7/11 -
9-93607773-G-A SYK c.475G>A p.A159T Missense 3/14 -
19-10602764-G-A KEAP1 c.814C>T p.R272C Missense 3/6 -
17-7576857-A-C TP53 c.989T>G p.L330R Missense 9/11 -
16-2126142-C-G TSC2 c.2713C>G p.R905G Missense 24/42 -
6-152415537-T-C ESR1 c.1387T>C p.S463P Missense 7/8 -
17-7577564-G-C TP53 c.717C>G p.N239K Missense 7/11 -
7-2979559-C-T CARD11 c.688G>A p.D230N Missense 6/25 -
7-2963931-C-T CARD11 c.1876G>A p.E626K Missense 15/25 -
17-7577563-T-G TP53 c.718A>C p.S240R Missense 7/11 -
18-48604656-A-C SMAD4 c.1478A>C p.D493A Missense 12/12 -
1-155874287-A-G RIT1 c.244T>C p.F82L Missense 5/6 -
1-155874285-A-T RIT1 c.246T>A p.F82L Missense 5/6 -
1-155874285-A-C RIT1 c.246T>G p.F82L Missense 5/6 -
4-106197378-A-G TET2 c.5711A>G p.H1904R Missense 11/11 -
17-7579328-T-C TP53 c.359A>G p.K120R Missense 4/11 -
13-28608087-C-T FLT3 c.1879G>A p.A627T Missense 15/24 -
7-140481402-CC-AG BRAF c.1405_1406delGGinsCT p.G469L Missense 11/18 -
3-49412973-C-G RHOA c.50G>C p.G17A Missense 2/5 -
17-7573983-C-A TP53 c.1044G>T p.L348F Missense 10/11 -
17-7578530-A-C TP53 c.400T>G p.F134V Missense 5/11 -
17-37676233-A-T CDK12 c.2988A>T p.L996F Missense 11/14 -
10-89624270-G-A PTEN c.44G>A p.R15K Missense 1/9 -
19-52716327-G-T PPP2R1A c.771G>T p.W257C Missense 6/15 -
17-37665993-G-T CDK12 c.2645G>T p.R882L Missense 7/14 -
17-37649051-G-A CDK12 c.2156G>A p.W719* Nonsense 4/14 -
17-37667817-A-G CDK12 c.2702A>G p.Y901C Missense 8/14 -
9-37015165-G-C PAX5 c.239C>G p.P80R Missense 3/10 -
19-45855507-G-C ERCC2 c.2150C>G p.A717G Missense 22/23 -
19-45856370-C-T ERCC2 c.1802G>A p.R601Q Missense 19/23 -
16-14042077-A-G ERCC4 c.2624A>G p.E875G Missense 11/11 -
5-112170822-C-G APC c.1918C>G p.R640G Missense 15/16 -
2-198267491-C-G SF3B1 c.1866G>C p.E622D Missense 14/25 -
2-198267491-C-A SF3B1 c.1866G>T p.E622D Missense 14/25 -
2-198267371-G-T SF3B1 c.1986C>A p.H662Q Missense 14/25 -
17-7578484-G-A TP53 c.446C>T p.S149F Missense 5/11 -
17-41234558-A-G BRCA1 c.4220T>C p.L1407P Missense 12/23 -
3-178952018-A-T PIK3CA c.3073A>T p.T1025S Missense 21/21 -
9-8518054-C-T PTPRD c.1337G>A p.G446E Missense 21/46 -
9-8341947-C-T PTPRD c.4693G>A p.V1565I Missense 40/46 -
7-140453135-CA-AT BRAF c.1799_1800delinsAT p.V600D Missense 15/18 -
10-43615003-A-G RET c.2417A>G p.Y806C Missense 14/20 -
17-7579382-G-A TP53 c.305C>T p.T102I Missense 4/11 -
9-21974723-C-G CDKN2A c.104G>C p.G35A Missense 1/3 -
7-55249053-C-T EGFR c.2351C>T p.S784F Missense 20/28 -
7-55241677-GAA-CAT EGFR c.2125_2127delGAAinsCAT p.E709H Missense 18/28 -
4-55141018-A-G PDGFRA c.1664A>G p.Y555C Missense 12/23 -
3-12645694-A-C RAF1 c.775T>G p.S259A Missense 7/17 -
17-7578466-G-A TP53 c.464C>T p.T155I Missense 5/11 -
3-10183788-C-A VHL c.257C>A p.P86H Missense 1/3 -
9-21974732-A-G CDKN2A c.95T>C p.L32P Missense 1/3 -
9-21971179-G-A CDKN2A c.179C>T p.A60V Missense 2/3 -
12-25362830-A-G KRAS c.466T>C p.F156L Missense 5/5 -
12-25362828-G-C KRAS c.468C>G p.F156L Missense 5/5 -
1-115256532-C-T NRAS c.179G>A p.G60E Missense 3/7 -
12-25380238-T-G KRAS c.220A>C p.T74P Missense 3/5 -
11-533466-G-A HRAS c.437C>T p.A146V Missense 4/6 -
2-39234309-C-T SOS1 c.2536G>A p.E846K Missense 16/23 -
2-39250247-C-T SOS1 c.1322G>A p.C441Y Missense 10/23 -
12-112888301-A-C PTPN11 c.317A>C p.D106A Missense 3/16 -
12-112888165-G-A PTPN11 c.181G>A p.D61N Missense 3/16 -
12-112888220-A-G PTPN11 c.236A>G p.Q79R Missense 3/16 -
12-112926851-C-T PTPN11 c.1471C>T p.P491S Missense 13/16 -
3-10191492-G-A VHL c.485G>A p.C162Y Missense 3/3 -
3-30732963-G-C TGFBR2 c.1576G>C p.E526Q Missense 7/7 -
3-30732997-G-C TGFBR2 c.1610G>C p.R537P Missense 7/7 -
7-55249020-A-T EGFR c.2318A>T p.H773L Missense 20/28 -
7-140501336-C-G BRAF c.736G>C p.A246P Missense 6/18 -
7-140501351-T-G BRAF c.721A>C p.T241P Missense 6/18 -
3-41266149-A-G CTNNB1 c.146A>G p.K49R Missense 3/15 -
9-133748415-T-G ABL1 c.1076T>G p.F359C Missense 6/11 -
2-158630624-G-C ACVR1 c.619C>G p.Q207E Missense 6/11 -
10-89720853-G-T PTEN c.1004G>T p.R335L Missense 8/9 -
17-7578529-A-T TP53 c.401T>A p.F134Y Missense 5/11 -
19-52716323-C-A PPP2R1A c.767C>A p.S256Y Missense 6/15 -
19-52715979-C-T PPP2R1A c.544C>T p.R182W Missense 5/15 -
15-67479811-G-A SMAD3 c.1118G>A p.R373H Missense 8/9 -
7-6045564-T-G PMS2 c.122A>C p.E41A Missense 2/15 -
17-7577103-C-T TP53 c.835G>A p.G279R Missense 8/11 -
4-55594197-C-T KIT c.1900C>T p.R634W Missense 13/21 -
9-133748403-A-C ABL1 c.1064A>C p.E355A Missense 6/11 -
19-52716325-T-G PPP2R1A c.769T>G p.W257G Missense 6/15 -
17-7578398-G-A TP53 c.532C>T p.H178Y Missense 5/11 -
1-65303679-T-C JAK1 c.3076A>G p.K1026E Missense 22/25 -
1-65303651-T-C JAK1 c.3104A>G p.Y1035C Missense 22/25 -
1-65305399-A-G JAK1 c.2729T>C p.L910P Missense 20/25 -
1-65304242-A-G JAK1 c.2873T>C p.F958S Missense 21/25 -
17-7578380-C-T TP53 c.550G>A p.D184N Missense 5/11 -
17-7578177-C-G TP53 c.672G>C p.E224D Missense 6/11 -
17-7577542-T-C TP53 c.739A>G p.N247D Missense 7/11 -
17-7577112-C-A TP53 c.826G>T p.A276S Missense 8/11 -
17-7578254-C-T TP53 c.595G>A p.G199R Missense 6/11 -
17-7577578-T-C TP53 c.703A>G p.N235D Missense 7/11 -
17-7578209-G-A TP53 c.640C>T p.H214Y Missense 6/11 -
17-7578548-G-A TP53 c.382C>T p.P128S Missense 5/11 -
14-81610105-T-C TSHR c.1703T>C p.I568T Missense 10/10 -
17-41209124-A-C BRCA1 c.5222T>G p.V1741G Missense 19/23 -
17-41228529-T-C BRCA1 c.4460A>G p.K1487R Missense 13/23 -
1-115256562-G-A NRAS c.149C>T p.T50I Missense 3/7 -
5-67589138-G-C PIK3R1 c.1126G>C p.G376R Missense 10/16 -
14-81609858-A-T TSHR c.1456A>T p.I486F Missense 10/10 -
7-140481409-A-C BRAF c.1399T>G p.S467A Missense 11/18 -
1-43804317-C-T MPL c.317C>T p.P106L Missense 3/12 -
20-31023821-G-T ASXL1 c.3306G>T p.E1102D Missense 13/13 -
10-43609070-G-A RET c.1826G>A p.C609Y Missense 10/20 -
10-89692978-C-G PTEN c.462C>G p.F154L Missense 5/9 -
7-140481433-C-G BRAF c.1375G>C p.V459L Missense 11/18 -
7-140481433-C-A BRAF c.1375G>T p.V459L Missense 11/18 -
9-101908796-C-A TGFBR1 c.1160C>A p.S387Y Missense 7/9 -
10-89711924-T-C PTEN c.542T>C p.L181P Missense 6/9 -
10-89653808-G-A PTEN c.106G>A p.G36R Missense 2/9 -
4-106164913-C-T TET2 c.3781C>T p.R1261C Missense 6/11 -
11-119148892-A-C CBL c.1112A>C p.Y371S Missense 8/16 -
10-89692993-G-T PTEN c.477G>T p.R159S Missense 5/9 -
10-89692886-T-C PTEN c.370T>C p.C124R Missense 5/9 -
3-52442078-A-T BAP1 c.271T>A p.C91S Missense 5/17 -
3-52442077-C-G BAP1 c.272G>C p.C91S Missense 5/17 -
13-49030386-C-T RB1 c.1861C>T p.R621C Missense 19/27 -
13-49030344-C-A RB1 c.1819C>A p.L607I Missense 19/27 -
10-89692799-C-T PTEN c.283C>T p.P95S Missense 5/9 -
10-89692976-T-C PTEN c.460T>C p.F154L Missense 5/9 -
10-89692978-C-A PTEN c.462C>A p.F154L Missense 5/9 -
3-52441237-C-A BAP1 c.533G>T p.G178V Missense 7/17 -
3-52442065-G-T BAP1 c.284C>A p.A95D Missense 5/17 -
16-23649416-T-C PALB2 c.83A>G p.Y28C Missense 2/13 -
9-139399344-A-G NOTCH1 c.4799T>C p.L1600P Missense 26/34 -
7-55249092-G-A EGFR c.2390G>A p.C797Y Missense 20/28 -
10-123298199-C-T FGFR2 c.655G>A p.E219K Missense 6/18 -
10-123279620-C-T FGFR2 c.812G>A p.G271E Missense 7/18 -
10-123247567-T-C FGFR2 c.1924A>G p.I642V Missense 14/18 -
10-123258093-C-T FGFR2 c.1588G>A p.D530N Missense 12/18 -
10-123260351-T-C FGFR2 c.1550A>G p.K517R Missense 11/18 -
2-212537918-C-T ERBB4 c.1687G>A p.E563K Missense 14/28 -
2-212295807-C-T ERBB4 c.2506G>A p.E836K Missense 21/28 -
9-21974723-C-A CDKN2A c.104G>T p.G35V Missense 1/3 -
9-133738343-T-G ABL1 c.743T>G p.L248R Missense 4/11 -
17-7573988-C-T TP53 c.1039G>A p.A347T Missense 10/11 -
3-41266136-T-A CTNNB1 c.133T>A p.S45T Missense 3/15 -
3-178952081-G-A PIK3CA c.3136G>A p.A1046T Missense 21/21 -
5-1293767-G-A TERT c.1234C>T p.H412Y Missense 2/16 -
4-55599338-A-C KIT c.2464A>C p.N822H Missense 17/21 -
3-178928080-A-C PIK3CA c.1358A>C p.E453A Missense 8/21 -
4-55968180-T-A KDR c.2150A>T p.D717V Missense 15/30 -
3-41266122-C-T CTNNB1 c.119C>T p.T40I Missense 3/15 -
9-5078362-A-T JAK2 c.2049A>T p.R683S Missense 16/25 -
19-1220433-G-A STK11 c.526G>A p.D176N Missense 4/10 -
19-1222987-G-T STK11 c.924G>T p.W308C Missense 8/10 -
7-128849190-A-G SMO c.1418A>G p.D473G Missense 8/12 -
17-7576857-A-T TP53 c.989T>A p.L330H Missense 9/11 -
7-55242422-G-T EGFR c.2192G>T p.W731L Missense 19/28 -
7-55242430-G-C EGFR c.2200G>C p.E734Q Missense 19/28 -
7-55249103-T-C EGFR c.2401T>C p.Y801H Missense 20/28 -
7-55241615-T-C EGFR c.2063T>C p.L688P Missense 18/28 -
16-2126142-C-T TSC2 c.2713C>T p.R905W Missense 24/42 -
19-10610642-C-T KEAP1 c.68G>A p.C23Y Missense 2/6 -
12-112926900-C-A PTPN11 c.1520C>A p.T507K Missense 13/16 -
10-89711881-A-G PTEN c.499A>G p.T167A Missense 6/9 -
17-7579442-G-A TP53 c.245C>T p.P82L Missense 4/11 -
9-21971145-G-C CDKN2A c.213C>G p.N71K Missense 2/3 -
9-21971145-G-T CDKN2A c.213C>A p.N71K Missense 2/3 -
16-2134716-G-A TSC2 c.4493G>A p.S1498N Missense 34/42 -
7-116412023-A-T MET c.3008A>T p.Y1003F Missense 14/21 -
12-25398237-A-G KRAS c.82T>C p.F28L Missense 2/5 -
12-25398235-A-T KRAS c.84T>A p.F28L Missense 2/5 -
12-25398235-A-C KRAS c.84T>G p.F28L Missense 2/5 -
16-89871768-A-C FANCA c.629T>G p.L210R Missense 7/43 -
16-89816213-C-A FANCA c.3164G>T p.R1055L Missense 32/43 -
16-89866018-A-G FANCA c.821T>C p.L274P Missense 9/43 -
16-89849452-T-C FANCA c.1529A>G p.Y510C Missense 16/43 -
16-89849506-T-C FANCA c.1475A>G p.H492R Missense 16/43 -
2-39249915-T-C SOS1 c.1654A>G p.R552G Missense 10/23 -
17-7577584-G-T TP53 c.697C>A p.H233N Missense 7/11 -
17-7578428-G-T TP53 c.502C>A p.H168N Missense 5/11 -
17-7578209-G-T TP53 c.640C>A p.H214N Missense 6/11 -
10-89725051-T-A PTEN c.1034T>A p.L345Q Missense 9/9 -
17-7577119-ACG-CTT TP53 c.817_819delCGTinsAAG p.R273K Missense 8/11 -
10-89711876-G-A PTEN c.494G>A p.G165E Missense 6/9 -
3-41266112-T-A CTNNB1 c.109T>A p.S37T Missense 3/15 -
7-116417499-C-G MET c.3316C>G p.H1106D Missense 16/21 -
10-43614997-T-G RET c.2411T>G p.V804G Missense 14/20 -
7-55249113-A-G EGFR c.2411A>G p.E804G Missense 20/28 -
7-55259493-G-A EGFR c.2551G>A p.V851I Missense 21/28 -
X-100608956-T-A BTK c.1652A>T p.Y551F Missense 17/19 -
9-133750304-G-A ABL1 c.1135G>A p.V379I Missense 7/11 -
9-133755488-T-C ABL1 c.1457T>C p.F486S Missense 9/11 -
9-133748414-T-A ABL1 c.1075T>A p.F359I Missense 6/11 -
14-81610301-C-G TSHR c.1899C>G p.D633E Missense 10/10 -
14-81610301-C-A TSHR c.1899C>A p.D633E Missense 10/10 -
9-133750328-T-A ABL1 c.1159T>A p.L387M Missense 7/11 -
14-81610299-G-T TSHR c.1897G>T p.D633Y Missense 10/10 -
14-81610299-G-C TSHR c.1897G>C p.D633H Missense 10/10 -
9-21974780-A-G CDKN2A c.47T>C p.L16P Missense 1/3 -
3-178952030-G-T PIK3CA c.3085G>T p.D1029Y Missense 21/21 -
17-7578260-C-T TP53 c.589G>A p.V197M Missense 6/11 -
5-112174368-A-G APC c.3077A>G p.N1026S Missense 16/16 -
17-7574005-A-C TP53 c.1022T>G p.F341C Missense 10/11 -
17-7573984-A-G TP53 c.1043T>C p.L348S Missense 10/11 -
17-7574015-A-T TP53 c.1012T>A p.F338I Missense 10/11 -
17-7574017-C-G TP53 c.1010G>C p.R337P Missense 10/11 -
3-178937054-G-A PIK3CA c.1735G>A p.E579K Missense 11/21 -
14-81610270-C-T TSHR c.1868C>T p.A623V Missense 10/10 -
17-41203088-AT-TC BRCA1 c.5323_5324delATinsGA p.M1775E Missense 20/23 -
9-135797330-A-G TSC1 c.539T>C p.L180P Missense 7/23 -
9-135797297-A-T TSC1 c.572T>A p.L191H Missense 7/23 -
5-1268680-T-C TERT c.2537A>G p.Y846C Missense 9/16 -
5-1266605-G-T TERT c.2628C>A p.H876Q Missense 10/16 -
5-1266605-G-C TERT c.2628C>G p.H876Q Missense 10/16 -
10-43609939-G-T RET c.1891G>T p.D631Y Missense 11/20 -
10-43609076-G-A RET c.1832G>A p.C611Y Missense 10/20 -
10-43609948-T-A RET c.1900T>A p.C634S Missense 11/20 -
10-43609949-G-C RET c.1901G>C p.C634S Missense 11/20 -
10-43609051-A-C RET c.1807A>C p.K603Q Missense 10/20 -
7-140501249-C-T BRAF c.823G>A p.E275K Missense 6/18 -
7-140477853-C-G BRAF c.1455G>C p.L485F Missense 12/18 -
7-140453139-G-C BRAF c.1796C>G p.T599R Missense 15/18 -
7-140453134-T-G BRAF c.1801A>C p.K601Q Missense 15/18 -
17-37879903-C-T ERBB2 c.2198C>T p.T733I Missense 18/27 -
17-37881392-A-G ERBB2 c.2584A>G p.T862A Missense 21/27 -
12-12871170-C-A CDKN1B c.397C>A p.P133T Missense 1/3 -
7-116422081-G-C MET c.3562G>C p.V1188L Missense 18/21 -
7-116422081-G-T MET c.3562G>T p.V1188L Missense 18/21 -
11-534259-G-T HRAS c.64C>A p.Q22K Missense 2/6 -
9-133753906-G-A ABL1 c.1375G>A p.E459K Missense 8/11 -
10-89624273-A-G PTEN c.47A>G p.Y16C Missense 1/9 -
10-89624295-A-T PTEN c.69A>T p.L23F Missense 1/9 -
10-89624295-A-C PTEN c.69A>C p.L23F Missense 1/9 -
10-89624287-TT-GC PTEN c.61_62delTTinsGC p.F21A Missense 1/9 -
4-55593640-T-G KIT c.1706T>G p.V569G Missense 11/21 -
3-10183722-G-C VHL c.191G>C p.R64P Missense 1/3 -
2-39249913-C-A SOS1 c.1656G>T p.R552S Missense 10/23 -
2-39249913-C-G SOS1 c.1656G>C p.R552S Missense 10/23 -
9-21971068-A-C CDKN2A c.290T>G p.L97R Missense 2/3 -
9-21971152-T-C CDKN2A c.206A>G p.E69G Missense 2/3 -
9-21971098-C-G CDKN2A c.260G>C p.R87P Missense 2/3 -
9-21971159-C-T CDKN2A c.199G>A p.G67S Missense 2/3 -
12-112888198-G-T PTPN11 c.214G>T p.A72S Missense 3/16 -
1-17355219-G-A SDHB c.299C>T p.S100F Missense 4/8 -
11-533883-G-A HRAS c.173C>T p.T58I Missense 3/6 -
18-48591826-A-G SMAD4 c.989A>G p.E330G Missense 9/12 -
11-108218030-A-C ATM c.8609A>C p.D2870A Missense 59/63 -
17-7577561-A-C TP53 c.720T>G p.S240R Missense 7/11 -
17-7577561-A-T TP53 c.720T>A p.S240R Missense 7/11 -
17-7577099-CT-GC TP53 c.838_839delAGinsGC p.R280A Missense 8/11 -
17-7578532-A-G TP53 c.398T>C p.M133T Missense 5/11 -
17-47696434-T-G SPOP c.389A>C p.D130A Missense 5/10 -
17-41276034-CA-GC BRCA1 c.79_80delTGinsGC p.C27A Missense 2/23 -
10-123325027-C-A FGFR2 c.301G>T p.D101Y Missense 3/18 -
4-55599321-A-C KIT c.2447A>C p.D816A Missense 17/21 -
3-41274897-T-A CTNNB1 c.1147T>A p.W383R Missense 8/15 -
3-41274897-T-C CTNNB1 c.1147T>C p.W383R Missense 8/15 -
10-89711892-T-G PTEN c.510T>G p.S170R Missense 6/9 -
10-89711892-T-A PTEN c.510T>A p.S170R Missense 6/9 -
9-21971108-C-A CDKN2A c.250G>T p.D84Y Missense 2/3 -
7-55242500-A-G EGFR c.2270A>G p.K757R Missense 19/28 -
11-119148963-C-G CBL c.1183C>G p.P395A Missense 8/16 -
10-89653803-C-A PTEN c.101C>A p.A34D Missense 2/9 -
17-7577129-A-T TP53 c.809T>A p.F270Y Missense 8/11 -
10-89720678-A-G PTEN c.829A>G p.T277A Missense 8/9 -
12-25398284-CC-AG KRAS c.34_35delGGinsCT p.G12L Missense 2/5 -
17-7577113-A-C TP53 c.825T>G p.C275W Missense 8/11 -
4-55599327-A-G KIT c.2453A>G p.K818R Missense 17/21 -
2-209113362-G-A IDH1 c.145C>T p.R49C Missense 4/10 -
19-11143984-C-T SMARCA4 c.3565C>T p.R1189* Nonsense 26/35 -
17-37880213-AA-GC ERBB2 c.2257_2258delAAinsGC p.K753A Missense 19/27 -
17-47696431-CA-GC SPOP c.391_392delTGinsGC p.W131A Missense 5/10 -
9-21971111-G-T CDKN2A c.247C>A p.H83N Missense 2/3 -
13-49030485-G-T RB1 c.1960G>T p.V654L Missense 19/27 -
10-89720875-G-C PTEN c.1026G>C p.K342N Missense 8/9 -
10-89720875-G-T PTEN c.1026G>T p.K342N Missense 8/9 -
X-53241007-C-A KDM5C c.1204G>T p.D402Y Missense 9/26 -
4-55599299-T-G KIT c.2425T>G p.C809G Missense 17/21 -
7-55242464-A-T EGFR c.2234A>T p.K745M Missense 19/28 -
10-89692839-T-C PTEN c.323T>C p.L108P Missense 5/9 -
7-55259532-G-A EGFR c.2590G>A p.A864T Missense 21/28 -
10-89653846-C-A PTEN c.144C>A p.N48K Missense 2/9 -
2-48033352-C-T MSH6 c.3656C>T p.T1219I Missense 8/10 -
19-1220595-G-A STK11 c.613G>A p.A205T Missense 5/10 -
3-10188208-G-C VHL c.351G>C p.W117C Missense 2/3 -
19-1220437-T-A STK11 c.530T>A p.I177N Missense 4/10 -
19-1220395-G-A STK11 c.488G>A p.G163D Missense 4/10 -
4-55152112-C-G PDGFRA c.2544C>G p.N848K Missense 18/23 -
2-39250269-C-G SOS1 c.1300G>C p.G434R Missense 10/23 -
3-10188213-T-C VHL c.356T>C p.F119S Missense 2/3 -
2-39250269-C-T SOS1 c.1300G>A p.G434R Missense 10/23 -
10-43615568-G-A RET c.2647G>A p.A883T Missense 15/20 -
10-43615577-C-T RET c.2656C>T p.R886W Missense 15/20 -
4-55599321-A-G KIT c.2447A>G p.D816G Missense 17/21 -
7-6045549-C-T PMS2 c.137G>A p.S46N Missense 2/15 -
9-133748288-T-G ABL1 c.949T>G p.F317V Missense 6/11 -
9-133748289-T-G ABL1 c.950T>G p.F317C Missense 6/11 -
9-133750319-C-A ABL1 c.1150C>A p.L384M Missense 7/11 -
9-133747528-G-A ABL1 c.835G>A p.E279K Missense 5/11 -
22-30032762-T-G NF2 c.137T>G p.L46R Missense 2/16 -
22-30054210-C-A NF2 c.632C>A p.A211D Missense 7/16 -
17-40481655-A-G STAT3 c.1150T>C p.F384L Missense 13/24 -
4-55593608-G-C KIT c.1674G>C p.K558N Missense 11/21 -
4-55593608-G-T KIT c.1674G>T p.K558N Missense 11/21 -
4-55599338-A-T KIT c.2464A>T p.N822Y Missense 17/21 -
17-37880214-AA-TG ERBB2 c.2258_2259delAAinsTG p.K753M Missense 19/27 -
16-3786706-CA-GC CREBBP c.4504_4505delTGinsGC p.W1502A Missense 27/31 -
16-3786752-G-A CREBBP c.4459C>T p.H1487Y Missense 27/31 -
16-3788649-A-C CREBBP c.4305T>G p.D1435E Missense 26/31 -
16-3788649-A-T CREBBP c.4305T>A p.D1435E Missense 26/31 -
16-3788605-T-C CREBBP c.4349A>G p.Y1450C Missense 26/31 -
4-55599260-A-G KIT c.2386A>G p.R796G Missense 17/21 -
17-12032541-C-T MAP2K4 c.977C>T p.P326L Missense 9/11 -
17-12028632-G-A MAP2K4 c.835G>A p.A279T Missense 8/11 -
17-11998899-G-A MAP2K4 c.401G>A p.R134Q Missense 4/11 -
17-12032525-G-A MAP2K4 c.961G>A p.V321M Missense 9/11 -
17-11998958-C-T MAP2K4 c.460C>T p.R154W Missense 4/11 -
17-12016565-A-T MAP2K4 c.701A>T p.N234I Missense 7/11 -
17-12032474-C-T MAP2K4 c.910C>T p.R304* Nonsense 9/11 -
17-12016616-G-A MAP2K4 c.752G>A p.S251N Missense 7/11 -
17-41222974-C-T BRCA1 c.4957G>A p.V1653M Missense 15/23 -
4-1807791-A-G FGFR3 c.1850A>G p.D617G Missense 14/18 -
1-65304242-A-C JAK1 c.2873T>G p.F958C Missense 21/25 -
1-65304243-A-C JAK1 c.2872T>G p.F958V Missense 21/25 -
1-65312365-A-G JAK1 c.1954T>C p.Y652H Missense 14/25 -
7-140476879-TC-AT BRAF c.1526_1527delGAinsAT p.R509H Missense 13/18 -
17-7577063-T-C TP53 c.875A>G p.K292R Missense 8/11 -
7-116423383-G-A MET c.3658G>A p.V1220I Missense 19/21 -
22-30032860-A-G NF2 c.235A>G p.K79E Missense 2/16 -
14-81610320-A-G TSHR c.1918A>G p.I640V Missense 10/10 -
20-57484596-A-G GNAS c.680A>G p.Q227R Missense 9/13 -
15-66729136-T-C MAP2K1 c.344T>C p.L115P Missense 3/11 -
16-2114343-G-A TSC2 c.1514G>A p.R505Q Missense 15/42 -
4-55593609-GT-TG KIT c.1675_1676delGTinsTG p.V559C Missense 11/21 -
14-81610297-C-T TSHR c.1895C>T p.T632I Missense 10/10 -
7-140453143-C-T BRAF c.1792G>A p.A598T Missense 15/18 -
17-7578476-G-A TP53 c.454C>T p.P152S Missense 5/11 -
17-7577554-T-G TP53 c.727A>C p.M243L Missense 7/11 -
17-7577554-T-A TP53 c.727A>T p.M243L Missense 7/11 -
7-55259502-A-T EGFR c.2560A>T p.T854S Missense 21/28 -
12-133252327-A-G POLE c.1100T>C p.F367S Missense 11/49 -
9-127912061-G-A PPP6C c.809C>T p.S270L Missense 7/7 -
9-127912080-G-A PPP6C c.790C>T p.R264C Missense 7/7 -
17-37676233-A-C CDK12 c.2988A>C p.L996F Missense 11/14 -
17-40474419-T-A STAT3 c.1982A>T p.D661V Missense 21/24 -
1-115256528-T-C NRAS c.183A>G p.Q61= Synonymous 3/7 -
3-10183865-T-G VHL c.334T>G p.Y112D Missense 1/3 -
9-8521481-C-T PTPRD c.757G>A p.V253I Missense 20/46 -
11-533467-C-T HRAS c.436G>A p.A146T Missense 4/6 -
3-128200720-C-T GATA2 c.1085G>A p.R362Q Missense 5/6 -
7-2976852-T-A CARD11 c.1160A>T p.D387V Missense 9/25 -
7-2984163-C-T CARD11 c.367G>A p.G123S Missense 5/25 -
17-7578446-T-A TP53 c.484A>T p.I162F Missense 5/11 -
2-25457243-G-T DNMT3A c.2644C>A p.R882S Missense 23/23 -
4-106157701-T-C TET2 c.2602T>C p.F868L Missense 3/11 -
4-106157703-T-A TET2 c.2604T>A p.F868L Missense 3/11 -
17-37881064-CA-TG ERBB2 c.2393_2394delCAinsTG p.T798M Missense 20/27 -
3-38182259-T-C MYD88 c.695T>C p.M219T Missense 4/5 -
7-140453137-C-G BRAF c.1798G>C p.V600L Missense 15/18 -
1-161326622-C-T SDHC c.397C>T p.R133* Nonsense 5/6 -
17-7578407-G-T TP53 c.523C>A p.R175S Missense 5/11 -
3-10188200-C-T VHL c.343C>T p.H115Y Missense 2/3 -
2-178098973-C-G NFE2L2 c.72G>C p.W24C Missense 2/5 -
17-7578206-T-A TP53 c.643A>T p.S215C Missense 6/11 -
4-55592064-A-G KIT c.1388A>G p.N463S Missense 9/21 -
3-10191498-A-G VHL c.491A>G p.Q164R Missense 3/3 -
9-21971116-G-A CDKN2A c.242C>T p.P81L Missense 2/3 -
10-89692932-T-A PTEN c.416T>A p.L139* Nonsense 5/9 -
10-89692932-T-G PTEN c.416T>G p.L139* Nonsense 5/9 -
4-106190860-C-T TET2 c.4138C>T p.H1380Y Missense 9/11 -
20-40739108-C-A PTPRT c.3119G>T p.R1040L Missense 23/31 -
17-37868282-A-T ERBB2 c.1003A>T p.S335C Missense 8/27 -
20-40743873-G-T PTPRT c.3065C>A p.A1022E Missense 22/31 -
1-201983085-G-C ELF3 c.934G>C p.A312P Missense 8/9 -
1-201982986-AT-CC ELF3 c.835_836delATinsCC p.I279P Missense 8/9 -
17-56774124-G-A RAD51C c.475G>A p.D159N Missense 3/9 -
13-73636638-C-T KLF5 c.901C>T p.P301S Missense 2/4 -
17-56774063-G-C RAD51C c.414G>C p.L138F Missense 3/9 -
17-7578428-G-A TP53 c.502C>T p.H168Y Missense 5/11 -
17-56787287-G-A RAD51C c.773G>A p.R258H Missense 5/9 -
9-80409487-T-A GNAQ c.627A>T p.Q209H Missense 5/7 -
17-7576886-C-G TP53 c.960G>C p.K320N Missense 9/11 -
20-57484597-G-T GNAS c.681G>T p.Q227H Missense 9/13 -
X-70339253-G-A MED12 c.130G>A p.G44S Missense 2/45 -
X-70339230-T-G MED12 c.107T>G p.L36R Missense 2/45 -
X-70339253-G-C MED12 c.130G>C p.G44R Missense 2/45 -
X-70339253-G-T MED12 c.130G>T p.G44C Missense 2/45 -
X-70339254-G-C MED12 c.131G>C p.G44A Missense 2/45 -
X-70339251-A-C MED12 c.128A>C p.Q43P Missense 2/45 -
17-7578207-A-T TP53 c.642T>A p.H214Q Missense 6/11 -
7-6038824-C-T PMS2 c.620G>A p.G207E Missense 6/15 -
14-81610258-A-G TSHR c.1856A>G p.D619G Missense 10/10 -
10-89693000-G-C PTEN c.484G>C p.D162H Missense 5/9 -
17-7577587-T-A TP53 c.694A>T p.I232F Missense 7/11 -
17-7577039-G-A TP53 c.899C>T p.P300L Missense 8/11 -
17-7577604-C-T TP53 c.677G>A p.G226D Missense 7/11 -
17-7577574-T-G TP53 c.707A>C p.Y236S Missense 7/11 -
9-139399362-C-T NOTCH1 c.4781G>A p.R1594Q Missense 26/34 -
2-209113106-G-T IDH1 c.401C>A p.A134D Missense 4/10 -
14-95560476-C-T DICER1 c.5113G>A p.E1705K Missense 24/27 -
14-95560464-C-T DICER1 c.5125G>A p.D1709N Missense 24/27 -
14-95560462-A-T DICER1 c.5127T>A p.D1709E Missense 24/27 -
12-56492633-A-G ERBB3 c.2783A>G p.E928G Missense 23/28 -
2-198267360-T-A SF3B1 c.1997A>T p.K666M Missense 14/25 -
13-28589780-A-C FLT3 c.2600T>G p.I867S Missense 21/24 -
17-7578481-G-A TP53 c.449C>T p.T150I Missense 5/11 -
5-67590445-C-T PIK3R1 c.1507C>T p.R503W Missense 12/16 -
X-70339254-G-T MED12 c.131G>T p.G44V Missense 2/45 -
2-209113298-C-T IDH1 c.209G>A p.G70D Missense 4/10 -
15-90630431-C-T IDH2 c.880G>A p.V294M Missense 7/11 -
17-37649052-G-A CDK12 c.2157G>A p.W719* Nonsense 4/14 -
15-66727442-T-C MAP2K1 c.158T>C p.F53S Missense 2/11 -
2-209110148-A-C IDH1 c.415T>G p.Y139D Missense 5/10 -
17-7578419-C-T TP53 c.511G>A p.E171K Missense 5/11 -
1-11174383-A-G MTOR c.7292T>C p.L2431P Missense 53/58 -
17-7578373-T-G TP53 c.557A>C p.D186A Missense 5/11 -
2-29443600-GA-CG ALK c.3616_3617delTCinsCG p.S1206R Missense 23/29 -
17-7576864-A-C TP53 c.982T>G p.F328V Missense 9/11 -
6-41903706-G-A CCND3 c.851C>T p.P284L Missense 5/5 -
6-41903731-G-A CCND3 c.826C>T p.Q276* Nonsense 5/5 -
6-41903688-A-C CCND3 c.869T>G p.I290R Missense 5/5 -
6-41903710-T-C CCND3 c.847A>G p.T283A Missense 5/5 -
19-4101103-C-T MAP2K2 c.619G>A p.E207K Missense 6/11 -
9-139399365-A-G NOTCH1 c.4778T>C p.L1593P Missense 26/34 -
7-148508727-T-C EZH2 c.1937A>G p.Y646C Missense 16/20 -
1-11188164-G-C MTOR c.5930C>G p.T1977R Missense 43/58 -
9-139399356-A-T NOTCH1 c.4787T>A p.L1596H Missense 26/34 -
9-139399350-C-G NOTCH1 c.4793G>C p.R1598P Missense 26/34 -
9-139399368-A-G NOTCH1 c.4775T>C p.F1592S Missense 26/34 -
1-155874523-T-A RIT1 c.236A>T p.Q79L Missense 4/6 -
7-55266530-TC-GG EGFR c.2822_2823delTCinsGG p.I941R Missense 23/28 -
7-55241662-TTG-AAC EGFR c.2110_2112delTTGinsAAC p.L704N Missense 18/28 -
1-65311203-C-A JAK1 c.2108G>T p.S703I Missense 15/25 -
19-17945970-G-A JAK3 c.1969C>T p.R657W Missense 15/24 -
1-11168338-C-G MTOR c.7534G>C p.D2512H Missense 57/58 -
1-11188164-G-T MTOR c.5930C>A p.T1977K Missense 43/58 -
19-17948010-C-T JAK3 c.1714G>A p.A572T Missense 13/24 -
11-17741694-T-G MYOD1 c.365T>G p.L122R Missense 1/3 -
10-89692893-C-T PTEN c.377C>T p.A126V Missense 5/9 -
10-89717726-G-T PTEN c.751G>T p.G251C Missense 7/9 -
17-37881342-A-C ERBB2 c.2534A>C p.D845A Missense 21/27 -
2-46607400-C-T EPAS1 c.1589C>T p.A530V Missense 12/16 -
4-55152114-A-G PDGFRA c.2546A>G p.Y849C Missense 18/23 -
4-55602733-G-A KIT c.2554G>A p.V852I Missense 18/21 -
1-155874530-C-A RIT1 c.229G>T p.A77S Missense 4/6 -
1-155874530-C-G RIT1 c.229G>C p.A77P Missense 4/6 -
1-11189847-A-T MTOR c.5662T>A p.F1888I Missense 40/58 -
1-11188078-C-G MTOR c.6016G>C p.V2006L Missense 43/58 -
1-11188078-C-T MTOR c.6016G>A p.V2006I Missense 43/58 -
1-243800963-C-T AKT3 c.511G>A p.G171R Missense 6/14 -
1-243800963-C-G AKT3 c.511G>C p.G171R Missense 6/14 -
17-7578438-C-G TP53 c.492G>C p.K164N Missense 5/11 -
17-7578438-C-A TP53 c.492G>T p.K164N Missense 5/11 -
17-47696708-G-C SPOP c.240C>G p.S80R Missense 4/10 -
17-47696668-G-C SPOP c.280C>G p.P94A Missense 4/10 -
17-47696597-C-T SPOP c.351G>A p.M117I Missense 4/10 -
17-47699369-C-T SPOP c.139G>A p.E47K Missense 3/10 -
X-47426806-T-C ARAF c.1051T>C p.F351L Missense 10/16 -
X-47426808-C-A ARAF c.1053C>A p.F351L Missense 10/16 -
X-47426808-C-G ARAF c.1053C>G p.F351L Missense 10/16 -
1-155874261-C-T RIT1 c.270G>A p.M90I Missense 5/6 -
1-155874261-C-A RIT1 c.270G>T p.M90I Missense 5/6 -
1-155874166-C-A RIT1 c.365G>T p.R122L Missense 5/6 -
2-47705451-G-C MSH2 c.2251G>C p.G751R Missense 14/16 -
16-2137898-C-T TSC2 c.5024C>T p.P1675L Missense 39/42 -
2-46607399-G-A EPAS1 c.1588G>A p.A530T Missense 12/16 -
2-46607406-A-G EPAS1 c.1595A>G p.Y532C Missense 12/16 -
3-10183734-C-G VHL c.203C>G p.S68W Missense 1/3 -
12-25380247-A-G KRAS c.211T>C p.Y71H Missense 3/5 -
7-140477794-A-T BRAF c.1514T>A p.L505H Missense 12/18 -
17-7578461-C-T TP53 c.469G>A p.V157I Missense 5/11 -
17-40475070-T-G STAT3 c.1840A>C p.S614R Missense 20/24 -
17-74732923-G-T SRSF2 c.320C>A p.P107H Missense 1/3 -
14-95557642-C-T DICER1 c.5425G>A p.G1809R Missense 25/27 -
14-95557639-C-G DICER1 c.5428G>C p.D1810H Missense 25/27 -
12-112888169-A-G PTPN11 c.185A>G p.Y62C Missense 3/16 -
3-12645694-A-G RAF1 c.775T>C p.S259P Missense 7/17 -
3-178937019-A-G PIK3CA c.1700A>G p.K567R Missense 11/21 -
1-243809253-T-A AKT3 c.371A>T p.Q124L Missense 5/14 -
7-55249019-C-T EGFR c.2317C>T p.H773Y Missense 20/28 -
17-58740503-G-A PPM1D c.1408G>A p.D470N Missense 6/6 -
3-10188292-G-T VHL c.435G>T p.Q145H Missense 2/3 -
3-10188292-G-C VHL c.435G>C p.Q145H Missense 2/3 -
4-55151636-T-C PDGFRA c.2422T>C p.F808L Missense 17/23 -
4-55151638-T-A PDGFRA c.2424T>A p.F808L Missense 17/23 -
17-7577564-G-T TP53 c.717C>A p.N239K Missense 7/11 -
4-55151638-T-G PDGFRA c.2424T>G p.F808L Missense 17/23 -
17-7578194-G-A TP53 c.655C>T p.P219S Missense 6/11 -
19-52716327-G-C PPP2R1A c.771G>C p.W257C Missense 6/15 -
19-52716329-G-A PPP2R1A c.773G>A p.R258H Missense 6/15 -
4-55592190-A-T KIT c.1514A>T p.N505I Missense 9/21 -
19-18273784-G-C PIK3R2 c.1117G>C p.G373R Missense 10/16 -
14-95560475-T-G DICER1 c.5114A>C p.E1705A Missense 24/27 -
2-46607403-C-T EPAS1 c.1592C>T p.P531L Missense 12/16 -
16-3786703-T-G CREBBP c.4508A>C p.Y1503S Missense 27/31 -
3-41266160-G-A CTNNB1 c.157G>A p.E53K Missense 3/15 -
5-149505134-G-A PDGFRB c.1681C>T p.R561C Missense 12/23 -
19-10600426-C-T KEAP1 c.1429G>A p.G477S Missense 4/6 -
2-46607402-C-T EPAS1 c.1591C>T p.P531S Missense 12/16 -
2-47702211-G-A MSH2 c.1807G>A p.D603N Missense 12/16 -
20-40743955-C-T PTPRT c.2983G>A p.V995M Missense 22/31 -
17-37879604-G-A ERBB2 c.1979G>A p.G660D Missense 17/27 -
2-212248444-G-A ERBB4 c.3823C>T p.R1275W Missense 28/28 -
7-140453142-G-A BRAF c.1793C>T p.A598V Missense 15/18 -
17-47696450-A-C SPOP c.373T>G p.F125V Missense 5/10 -
16-68844181-G-A CDH1 c.769G>A p.D257N Missense 6/16 -
1-43815008-T-C MPL c.1543T>C p.W515R Missense 10/12 -
7-55225431-G-A EGFR c.1283G>A p.G428D Missense 11/28 -
2-29443630-A-T ALK c.3587T>A p.L1196Q Missense 23/29 -
19-10602850-G-C KEAP1 c.728C>G p.S243C Missense 3/6 -
19-10610154-C-G KEAP1 c.556G>C p.G186R Missense 2/6 -
9-133753888-G-A ABL1 c.1357G>A p.E453K Missense 8/11 -
9-133747558-G-T ABL1 c.865G>T p.V289F Missense 5/11 -
9-101891173-A-G TGFBR1 c.134A>G p.N45S Missense 2/9 -
9-101891193-G-A TGFBR1 c.154G>A p.G52R Missense 2/9 -
9-101891193-G-C TGFBR1 c.154G>C p.G52R Missense 2/9 -
7-55259515-T-A EGFR c.2573T>A p.L858Q Missense 21/28 -
17-7578423-C-T TP53 c.507G>A p.M169I Missense 5/11 -
9-127920559-G-A PPP6C c.340C>T p.H114Y Missense 4/7 -
2-47703668-C-T MSH2 c.2168C>T p.S723F Missense 13/16 -
14-95560463-T-G DICER1 c.5126A>C p.D1709A Missense 24/27 -
3-38182032-C-G MYD88 c.656C>G p.S206C Missense 3/5 -
4-55593649-A-C KIT c.1715A>C p.D572A Missense 11/21 -
4-55589846-G-A KIT c.1328G>A p.C443Y Missense 8/21 -
10-43613829-T-C RET c.2293T>C p.S765P Missense 13/20 -
10-43615611-G-A RET c.2690G>A p.R897Q Missense 15/20 -
16-23632707-G-A PALB2 c.3089C>T p.T1030I Missense 10/13 -
16-23614913-A-G PALB2 c.3428T>A p.L1143H Missense 13/13 -
3-38182292-G-A MYD88 c.728G>A p.S230N Missense 4/5 -
7-6441968-G-A RAC1 c.470G>A p.C157Y Missense 6/6 -
4-55133834-G-T PDGFRA c.1047G>T p.W349C Missense 7/23 -
4-55133834-G-C PDGFRA c.1047G>C p.W349C Missense 7/23 -
7-116412022-T-A MET c.3007T>A p.Y1003N Missense 14/21 -
9-21971117-G-T CDKN2A c.241C>A p.P81T Missense 2/3 -
15-99500332-G-C IGF1R c.3765G>C p.M1255I Missense 21/21 -
15-99500332-G-A IGF1R c.3765G>A p.M1255I Missense 21/21 -
15-99500332-G-T IGF1R c.3765G>T p.M1255I Missense 21/21 -
4-55593605-G-C KIT c.1671G>C p.W557C Missense 11/21 -
4-55593667-A-G KIT c.1733A>G p.Y578C Missense 11/21 -
4-55593605-G-T KIT c.1671G>T p.W557C Missense 11/21 -
10-89720841-A-G PTEN c.992A>G p.D331G Missense 8/9 -
10-89692791-A-G PTEN c.275A>G p.D92G Missense 5/9 -
10-89692878-C-A PTEN c.362C>A p.A121E Missense 5/9 -
10-89717655-C-T PTEN c.680C>T p.S227F Missense 7/9 -
1-8073509-C-A ERRFI1 c.1150G>T p.E384* Nonsense 4/4 -
17-37667840-G-A CDK12 c.2725G>A p.G909R Missense 8/14 -
17-7578421-G-A TP53 c.509C>T p.T170M Missense 5/11 -
17-37667840-G-C CDK12 c.2725G>C p.G909R Missense 8/14 -
10-112724635-G-A SHOC2 c.519G>A p.M173I Missense 2/9 -
9-5078361-G-A JAK2 c.2048G>A p.R683K Missense 16/25 -
18-45368254-C-G SMAD2 c.1348G>C p.D450H Missense 11/11 -
1-43815008-TG-GC MPL c.1543_1544delTGinsGC p.W515A Missense 10/12 -
18-45374945-C-G SMAD2 c.898G>C p.D300H Missense 8/11 -
17-7577067-T-C TP53 c.871A>G p.K291E Missense 8/11 -
6-26056352-G-A H1-2 c.305C>T p.S102F Missense 1/1 -
17-47696438-T-C SPOP c.385A>G p.K129E Missense 5/10 -
4-55144121-C-A PDGFRA c.1950C>A p.H650Q Missense 14/23 -
4-55144121-C-G PDGFRA c.1950C>G p.H650Q Missense 14/23 -
4-55144147-A-G PDGFRA c.1976A>G p.N659S Missense 14/23 -
5-67576506-G-C PIK3R1 c.785G>C p.R262T Missense 6/16 -
5-67569292-G-A PIK3R1 c.409G>A p.E137K Missense 3/16 -
19-19260064-C-T MEF2B c.229G>A p.E77K Missense 3/9 -
19-19260045-T-A MEF2B c.248A>T p.D83V Missense 3/9 -
19-19260088-A-G MEF2B c.205T>C p.Y69H Missense 3/9 -
4-55599320-G-A KIT c.2446G>A p.D816N Missense 17/21 -
7-148511174-G-C EZH2 c.1728C>G p.C576W Missense 15/20 -
12-112884198-G-C PTPN11 c.133G>C p.V45L Missense 2/16 -
10-89692889-AA-CT PTEN c.373_374delAAinsCT p.K125L Missense 5/9 -
4-55146568-A-G PDGFRA c.2242A>G p.R748G Missense 16/23 -
4-55152114-A-C PDGFRA c.2546A>C p.Y849S Missense 18/23 -
5-67576373-G-T PIK3R1 c.652G>T p.E218* Nonsense 6/16 -
5-67576780-A-C PIK3R1 c.862A>C p.K288Q Missense 7/16 -
19-19260052-T-A MEF2B c.241A>T p.N81Y Missense 3/9 -
17-37866662-G-C ERBB2 c.829G>C p.D277H Missense 7/27 -
17-37879583-C-G ERBB2 c.1958C>G p.S653C Missense 17/27 -
18-48591808-G-A SMAD4 c.971G>A p.C324Y Missense 9/12 -
17-7577520-A-C TP53 c.761T>G p.I254S Missense 7/11 -
2-29445216-A-T ALK c.3509T>A p.I1170N Missense 22/29 -
5-176522551-G-A FGFR4 c.1648G>A p.V550M Missense 13/18 -
1-11217312-A-T MTOR c.4366T>A p.W1456R Missense 30/58 -
1-11217312-A-G MTOR c.4366T>C p.W1456R Missense 30/58 -
17-7578475-G-C TP53 c.455C>G p.P152R Missense 5/11 -
10-89692869-A-C PTEN c.353A>C p.H118P Missense 5/9 -
10-89692885-C-A PTEN c.369C>A p.H123Q Missense 5/9 -
10-89692885-C-G PTEN c.369C>G p.H123Q Missense 5/9 -
10-89720676-A-G PTEN c.827A>G p.N276S Missense 8/9 -
10-89692986-A-G PTEN c.470A>G p.E157G Missense 5/9 -
10-89685307-T-G PTEN c.202T>G p.Y68D Missense 3/9 -
9-8449782-G-T PTPRD c.3931C>A p.P1311T Missense 34/46 -
17-7577541-T-C TP53 c.740A>G p.N247S Missense 7/11 -
10-89653817-G-C PTEN c.115G>C p.A39P Missense 2/9 -
12-12022535-C-T ETV6 c.641C>T p.P214L Missense 5/8 -
12-12038959-A-G ETV6 c.1252A>G p.R418G Missense 7/8 -
1-9777666-C-G PIK3CD c.1002C>G p.N334K Missense 8/24 -
3-41266107-T-C CTNNB1 c.104T>C p.I35T Missense 3/15 -
17-41244057-C-A BRCA1 c.3491G>T p.S1164I Missense 10/23 -
3-49412982-C-A RHOA c.41G>T p.G14V Missense 2/5 -
13-32900736-C-G BRCA2 c.617C>G p.S206C Missense 7/27 -
16-14021989-T-C ERCC4 c.689T>C p.L230P Missense 4/11 -
16-14041518-C-A ERCC4 c.2065C>A p.R689S Missense 11/11 -
15-66729222-G-A MAP2K1 c.430G>A p.E144K Missense 3/11 -
15-66727462-G-A MAP2K1 c.178G>A p.V60M Missense 2/11 -
15-66727367-C-T MAP2K1 c.83C>T p.T28I Missense 2/11 -
15-66727394-T-C MAP2K1 c.110T>C p.L37P Missense 2/11 -
15-66729159-T-A MAP2K1 c.367T>A p.S123T Missense 3/11 -
6-152419920-T-C ESR1 c.1607T>C p.L536P Missense 8/8 -
1-11187796-G-A MTOR c.6101C>T p.A2034V Missense 44/58 -
1-11174395-A-C MTOR c.7280T>G p.L2427R Missense 53/58 -
1-11182158-A-C MTOR c.6688T>G p.L2230V Missense 48/58 -
1-11177096-C-T MTOR c.6981G>A p.M2327I Missense 50/58 -
1-155874530-C-T RIT1 c.229G>A p.A77T Missense 4/6 -
17-7578289-C-T TP53 c.560G>A p.G187D Missense 6/11 -
17-7578511-G-A TP53 c.419C>T p.T140I Missense 5/11 -
17-7578444-G-C TP53 c.486C>G p.I162M Missense 5/11 -
17-7577552-C-G TP53 c.729G>C p.M243I Missense 7/11 -
17-7577552-C-A TP53 c.729G>T p.M243I Missense 7/11 -
4-55593630-A-G KIT c.1696A>G p.N566D Missense 11/21 -
19-40747910-G-A AKT2 c.508C>T p.R170W Missense 6/14 -
17-37879881-C-T ERBB2 c.2176C>T p.L726F Missense 18/27 -
7-140454006-G-T BRAF c.1722C>A p.H574Q Missense 14/18 -
7-140454006-G-C BRAF c.1722C>G p.H574Q Missense 14/18 -
7-140494148-G-C BRAF c.1100C>G p.P367R Missense 8/18 -
3-49405969-A-C RHOA c.169T>G p.L57V Missense 3/5 -
7-6043355-G-A PMS2 c.319C>T p.R107W Missense 4/15 -
13-32932066-G-C BRCA2 c.7805G>C p.R2602T Missense 16/27 -
17-7578445-A-C TP53 c.485T>G p.I162S Missense 5/11 -
7-6426908-C-G RAC1 c.101C>G p.P34R Missense 2/6 -
7-6431629-A-G RAC1 c.182A>G p.Q61R Missense 3/6 -
13-73336064-C-T DIS3 c.2339G>A p.R780K Missense 17/21 -
3-138409981-C-T PIK3CB c.1897G>A