PMID: 34918496

Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Kim, Soon-Chan SC, Park, Ji Won JW, Seo, Ha-Young HY, Kim, Minjung M, Park, Jae-Hyeon JH, Kim, Ga-Hye GH, Lee, Ja Oh JO, Shin, Young-Kyoung YK, Bae, Jeong Mo JM, Koo, Bon-Kyoung BK, Jeong, Seung-Yong SY, Ku, Ja-Lok JL

2022-02

557 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
17-16068463-C-T	NCOR1	c.448G>A	p.G150R	Missense	5/46	-
13-28626755-C-T	FLT3	c.541G>A	p.A181T	Missense	5/24	-
13-21563311-G-A	LATS2	c.608C>T	p.A203V	Missense	4/8	-
19-13419248-C-T	CACNA1A	c.1763G>A	p.R588H	Missense	13/47	-
X-39923607-G-A	BCOR	c.3484C>T	p.R1162C	Missense	7/15	-
7-151932991-G-A	KMT2C	c.2680C>T	p.R894W	Missense	16/59	-
4-187557893-T-C	FAT1	c.3818A>G	p.H1273R	Missense	5/27	-
7-151935910-C-T	KMT2C	c.2534G>A	p.G845E	Missense	15/59	-
1-11319442-C-T	MTOR	c.25G>A	p.A9T	Missense	2/58	-
17-16068343-G-A	NCOR1	c.568C>T	p.R190*	Nonsense	5/46	-
11-71948536-C-G	INPPL1	c.3248C>G	p.A1083G	Missense	26/28	-
17-7579331-G-C	TP53	c.356C>G	p.A119G	Missense	4/11	-
6-33756532-G-A	LEMD2	c.362C>T	p.A121V	Missense	1/9	-
2-241696840-ATCCTCC-A	KIF1A	c.2748_2753delGGAGGA	p.E916_E917del	InFrameDeletion	27/49	-
7-151932990-C-T	KMT2C	c.2681G>A	p.R894Q	Missense	16/59	-
17-16068340-C-T	NCOR1	c.571G>A	p.E191K	Missense	5/46	-
1-145440273-T-G	TXNIP	c.579T>G	p.D193E	Missense	5/8	-
17-16068396-G-A	NCOR1	c.515C>T	p.S172L	Missense	5/46	-
2-241696840-ATCC-A	KIF1A	c.2751_2753delGGA	p.E917del	InFrameDeletion	27/49	-
19-13318672-CCTGCTG-C	CACNA1A	c.6970_6975delCAGCAG	p.Q2324_Q2325del	InFrameDeletion	47/47	-
18-42532072-A-C	SETBP1	c.2767A>C	p.I923L	Missense	4/6	-
10-112356281-A-C	SMC3	c.2089A>C	p.N697H	Missense	19/29	-
19-15281611-T-G	NOTCH3	c.4762A>C	p.N1588H	Missense	26/33	-
X-53566722-T-G	HUWE1	c.11528A>C	p.E3843A	Missense	75/84	-
2-43451739-CCTG-C	ZFP36L2	c.1201_1203delCAG	p.Q401del	InFrameDeletion	2/2	-
6-29910581-C-A	HLA-A	c.121C>A	p.R41S	Missense	2/8	-
19-13318672-CCTG-C	CACNA1A	c.6973_6975delCAG	p.Q2325del	InFrameDeletion	47/47	-
7-151932985-G-A	KMT2C	c.2686C>T	p.P896S	Missense	16/59	-
1-27023769-C-T	ARID1A	c.875C>T	p.T292I	Missense	1/20	-
22-21347167-C-T	LZTR1	c.1234C>T	p.R412C	Missense	11/21	-
1-120458550-A-C	NOTCH2	c.6795T>G	p.N2265K	Missense	34/34	-
19-36215969-G-A	KMT2B	c.3509G>A	p.R1170H	Missense	10/37	-
X-47040781-AGGG-A	RBM10	c.1418_1420delGGG	p.G473del	InFrameDeletion	13/24	-
4-55161404-G-A	PDGFRA	c.3235G>A	p.D1079N	Missense	23/23	-
3-121200622-G-A	POLQ	c.6008C>T	p.P2003L	Missense	19/30	-
16-3807363-T-TG	CREBBP	c.3623_3623dupC	p.Q1209Tfs*25	Frameshift	19/31	-
3-168833624-AC-A	MECOM	c.2035delG	p.V679Wfs*37	Frameshift	8/17	-
17-7800488-CG-C	CHD3	c.1795delG	p.E599Rfs*11	Frameshift	11/40	-
3-30713133-TA-T	TGFBR2	c.458delA	p.Y153Lfs*10	Frameshift	4/7	-
4-55151624-C-T	PDGFRA	c.2410C>T	p.R804*	Nonsense	17/23	-
6-152201867-C-T	ESR1	c.721C>T	p.R241W	Missense	3/8	-
9-70912543-A-T	CBWD3	c.864A>T	p.E288D	Missense	12/15	-
6-31324488-C-CGGAG	HLA-B	c.319_320insCTCC	p.G107Afs*33	Frameshift	2/8	-
7-117144338-AGA-TGT	CFTR	c.85_87delAGAinsTGT	p.R29C	Missense	2/27	-
X-153595780-G-A	FLNA	c.853C>T	p.R285C	Missense	5/48	-
16-72821593-AGCC-A	ZFHX3	c.10579_10581delGGC	p.G3527del	InFrameDeletion	10/10	-
1-120510817-G-A	NOTCH2	c.1147C>T	p.P383S	Missense	7/34	-
16-72992310-C-T	ZFHX3	c.1735G>A	p.A579T	Missense	2/10	-
9-139390839-A-G	NOTCH1	c.7352T>C	p.L2451P	Missense	34/34	-
13-72256001-G-T	DACH1	c.896C>A	p.T297N	Missense	2/11	-
13-21619978-T-A	LATS2	c.188A>T	p.Q63L	Missense	2/8	-
1-158592945-T-C	SPTA1	c.5948A>G	p.E1983G	Missense	43/52	-
19-1430254-C-G	DAZAP1	c.764C>G	p.A255G	Missense	10/12	-
14-92537396-G-GCTGCTGC	ATXN3	c.873_874insGCAGCAG	p.Q292Afs*28	SpliceAcceptorInsertion	10/11	-
22-36700141-GGAA-G	MYH9	c.2287_2289delTTC	p.F763del	InFrameDeletion	19/41	-
17-29559719-T-C	NF1	c.3316T>C	p.Y1106H	Missense	26/58	-
1-201983060-C-A	ELF3	c.909C>A	p.F303L	Missense	8/9	-
10-43596057-C-T	RET	c.224C>T	p.T75M	Missense	2/20	-
19-630075-C-T	POLRMT	c.287G>A	p.S96N	Missense	3/21	-
4-187524698-C-T	FAT1	c.10982G>A	p.R3661H	Missense	19/27	-
11-118343133-G-A	KMT2A	c.1259G>A	p.R420Q	Missense	3/36	-
21-36164610-T-C	RUNX1	c.1265A>G	p.E422G	Missense	9/9	-
15-90634852-G-A	IDH2	c.140C>T	p.A47V	Missense	2/11	-
8-38285563-ATGC-A	FGFR1	c.495_497delGCA	p.L165_H166delinsF	MultiAAMissense	5/18	-
22-41513333-ACAG-A	EP300	c.239_241delAGC	p.Q80del	InFrameDeletion	2/31	-
11-118374726-C-T	KMT2A	c.8119C>T	p.R2707W	Missense	27/36	-
X-47032531-G-A	RBM10	c.437G>A	p.R146H	Missense	5/24	-
14-92537354-C-CTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	ATXN3	c.915_916insCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA	p.G306Qfs*38	Frameshift	10/11	-
6-31324495-AGGT-A	HLA-B	c.311_313delACC	p.N104_L105delinsM	MultiAAMissense	2/8	-
2-43453439-G-C	ZFP36L2	c.16C>G	p.L6V	Missense	1/2	-
21-33074680-G-A	SCAF4	c.334C>T	p.R112C	Missense	5/20	-
6-31324493-GC-G	HLA-B	c.315delG	p.R106Afs*45	Frameshift	2/8	-
X-53440264-G-A	SMC1A	c.533C>T	p.A178V	Missense	4/25	-
17-80789385-G-A	ZNF750	c.946C>T	p.P316S	Missense	2/3	-
22-41572510-G-A	EP300	c.5039G>A	p.R1680H	Missense	30/31	-
X-96502837-C-T	DIAPH2	c.2843C>T	p.T948I	Missense	23/27	-
2-198274610-G-A	SF3B1	c.788C>T	p.A263V	Missense	7/25	-
16-2135264-G-A	TSC2	c.4603G>A	p.D1535N	Missense	36/42	-
7-151945228-G-A	KMT2C	c.2291C>T	p.S764F	Missense	14/59	-
X-53619395-C-T	HUWE1	c.3935G>A	p.R1312H	Missense	33/84	-
9-131339475-C-T	SPTAN1	c.853C>T	p.R285*	Nonsense	7/57	-
6-33740476-G-A	LEMD2	c.1441C>T	p.R481C	Missense	9/9	-
X-41055978-T-C	USP9X	c.4220T>C	p.L1407P	Missense	28/45	-
17-7793036-G-A	CHD3	c.155G>A	p.R52Q	Missense	2/40	-
1-27057847-TC-T	ARID1A	c.1558delC	p.Q520Sfs*99	Frameshift	3/20	-
5-79968644-G-A	MSH3	c.994G>A	p.A332T	Missense	6/24	-
17-29496992-C-A	NF1	c.563C>A	p.A188E	Missense	5/58	-
19-13395982-CT-C	CACNA1A	c.3591delA	p.E1198Rfs*43	Frameshift	21/47	-
14-21867864-A-C	CHD8	c.4818T>G	p.S1606R	Missense	26/38	-
3-142279185-A-C	ATR	c.1461T>G	p.I487M	Missense	6/47	-
14-21876693-A-C	CHD8	c.2508T>G	p.D836E	Missense	13/38	-
9-139396287-C-T	NOTCH1	c.5551G>A	p.A1851T	Missense	30/34	-
5-56111878-G-C	MAP3K1	c.478G>C	p.A160P	Missense	1/20	-
19-47503784-G-A	ARHGAP35	c.4339G>A	p.A1447T	Missense	7/7	-
2-212989514-G-T	ERBB4	c.197C>A	p.T66N	Missense	2/28	-
3-41267246-G-A	CTNNB1	c.830G>A	p.G277D	Missense	6/15	-
17-70119722-A-C	SOX9	c.724A>C	p.K242Q	Missense	3/3	-
11-108192116-G-A	ATM	c.6541G>A	p.E2181K	Missense	45/63	-
17-70119713-A-C	SOX9	c.715A>C	p.T239P	Missense	3/3	-
17-70119716-A-C	SOX9	c.718A>C	p.T240P	Missense	3/3	-
9-137710547-G-C	COL5A1	c.4276G>C	p.G1426R	Missense	55/66	-
13-20626437-C-T	ZMYM2	c.2479C>T	p.R827*	Nonsense	14/25	-
19-10602698-C-T	KEAP1	c.880G>A	p.D294N	Missense	3/6	-
20-31019177-A-G	ASXL1	c.772A>G	p.I258V	Missense	9/13	-
19-11143974-A-T	SMARCA4	c.3555A>T	p.Q1185H	Missense	26/35	-
19-11097584-T-C	SMARCA4	c.764T>C	p.M255T	Missense	5/35	-
10-89711899-C-A	PTEN	c.517C>A	p.R173S	Missense	6/9	-
4-187628197-G-C	FAT1	c.2785C>G	p.P929A	Missense	2/27	-
5-112155043-T-G	APC	c.1312+2T>G	-	IntronicSNV	-	10/15
9-8500963-C-T	PTPRD	c.1919G>A	p.G640D	Missense	24/46	-
3-52440298-G-T	BAP1	c.754C>A	p.R252S	Missense	9/17	-
1-27100903-TGG-T	ARID1A	c.4187_4188delGG	p.G1396Afs*48	Frameshift	18/20	-
19-33409241-G-A	CEP89	c.1273C>T	p.Q425*	Nonsense	13/19	-
8-69243423-C-T	C8orf34	c.176C>T	p.P59L	Missense	1/14	-
15-51503059-GT-G	CYP19A1	c.1457delA	p.N486Tfs*5	Frameshift	10/10	-
16-3843494-C-T	CREBBP	c.1109G>A	p.R370Q	Missense	4/31	-
2-25966872-T-TG	ASXL2	c.2333dupC	p.V779Sfs*25	Frameshift	13/13	-
14-92547328-G-A	ATXN3	c.853C>T	p.R285*	Nonsense	9/11	-
9-139410148-C-T	NOTCH1	c.1690G>A	p.E564K	Missense	11/34	-
13-48878166-G-C	RB1	c.118G>C	p.E40Q	Missense	1/27	-
13-32937510-G-A	BRCA2	c.8171G>A	p.G2724E	Missense	18/27	-
10-43617395-G-C	RET	c.2732G>C	p.G911A	Missense	16/20	-
16-339531-C-T	AXIN1	c.2371G>A	p.G791R	Missense	10/11	-
X-96185790-G-A	DIAPH2	c.1037G>A	p.R346Q	Missense	10/27	-
9-137323779-C-T	RXRA	c.1072C>T	p.R358W	Missense	8/10	-
6-31324139-A-G	HLA-B	c.424T>C	p.Y142H	Missense	3/8	-
X-76940033-A-G	ATRX	c.715T>C	p.F239L	Missense	9/35	-
6-152129060-C-A	ESR1	c.13C>A	p.L5I	Missense	1/8	-
1-158587844-G-T	SPTA1	c.6533C>A	p.A2178D	Missense	46/52	-
14-95562618-C-T	DICER1	c.4639G>A	p.D1547N	Missense	23/27	-
13-32929193-A-C	BRCA2	c.7203A>C	p.R2401S	Missense	14/27	-
17-16062106-T-G	NCOR1	c.700A>C	p.S234R	Missense	6/46	-
5-56168782-A-G	MAP3K1	c.1636A>G	p.T546A	Missense	9/20	-
4-55138668-A-G	PDGFRA	c.1345A>G	p.I449V	Missense	9/23	-
22-36718479-G-A	MYH9	c.700C>T	p.R234C	Missense	6/41	-
14-92537354-C-CTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	ATXN3	c.915_916insCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA	p.G306Qfs*39	Frameshift	10/11	-
12-56491686-C-T	ERBB3	c.2578C>T	p.P860S	Missense	21/28	-
19-3978160-G-T	EEF2	c.1724C>A	p.P575Q	Missense	12/15	-
9-131344821-A-G	SPTAN1	c.1636A>G	p.T546A	Missense	13/57	-
19-13318672-CCTGCTGCTG-C	CACNA1A	c.6967_6975delCAGCAGCAG	p.Q2323_Q2325del	InFrameDeletion	47/47	-
8-38282110-G-A	FGFR1	c.853C>T	p.P285S	Missense	7/18	-
7-152012326-A-G	KMT2C	c.487T>C	p.W163R	Missense	4/59	-
9-139396362-C-T	NOTCH1	c.5476G>A	p.E1826K	Missense	30/34	-
15-42034890-G-A	MGA	c.4732G>A	p.V1578I	Missense	15/24	-
16-68855966-GC-G	CDH1	c.1779delC	p.I594Yfs*19	Frameshift	12/16	-
7-1276048-G-A	UNCX	c.1031G>A	p.R344H	Missense	3/3	-
9-133730467-C-T	ABL1	c.533C>T	p.T178I	Missense	3/11	-
6-150005540-T-C	LATS1	c.685A>G	p.S229G	Missense	4/8	-
19-3983221-G-A	EEF2	c.287C>T	p.A96V	Missense	3/15	-
15-59323374-T-C	RNF111	c.353T>C	p.L118P	Missense	2/14	-
1-158626362-C-T	SPTA1	c.2890G>A	p.A964T	Missense	20/52	-
X-70470502-G-A	ZMYM3	c.853C>T	p.R285W	Missense	5/25	-
1-6246837-ATTC-A	RPL22	c.279_281delGAA	p.K93del	InFrameDeletion	4/4	-
2-29450487-A-C	ALK	c.2867T>G	p.V956G	Missense	17/29	-
22-50717107-G-A	PLXNB2	c.4565C>T	p.T1522I	Missense	29/37	-
6-152163812-C-T	ESR1	c.533C>T	p.S178F	Missense	2/8	-
18-48573504-G-A	SMAD4	c.88G>A	p.G30R	Missense	2/12	-
14-95592924-G-T	DICER1	c.896C>A	p.S299*	Nonsense	7/27	-
X-53409252-T-C	SMC1A	c.3338A>G	p.Y1113C	Missense	22/25	-
9-8524957-C-T	PTPRD	c.647G>A	p.R216H	Missense	18/46	-
22-36722692-G-A	MYH9	c.533C>T	p.A178V	Missense	5/41	-
15-57489983-CA-C	TCF12	c.546delA	p.V183Sfs*62	Frameshift	8/21	-
11-100998483-G-A	PGR	c.1319C>T	p.T440M	Missense	1/8	-
17-7800487-C-CG	CHD3	c.1795_1795dup	p.E599Gfs*3	Frameshift	11/40	-
19-36214675-A-C	KMT2B	c.3101A>C	p.E1034A	Missense	8/37	-
17-70119704-A-AC	SOX9	c.710_710dupC	p.P238Tfs*14	Frameshift	3/3	-
7-148514363-T-C	EZH2	c.1361A>G	p.D454G	Missense	11/20	-
7-55087060-T-C	EGFR	c.88+2T>C	-	IntronicSNV	-	1/27
X-123224815-G-A	STAG2	c.3578+1G>A	-	IntronicSNV	-	32/34
X-41198337-G-A	DDX3X	c.151+1G>A	-	IntronicSNV	-	3/16
9-80646014-A-G	GNAQ	c.136+2T>C	-	IntronicSNV	-	1/6
12-6702576-GAGATACCTTCAT-G	CHD4	c.2509_2514+6del12	-	SpliceDonorDeletion	16/40	16/39
7-151884446-G-A	KMT2C	c.4909C>T	p.L1637F	Missense	33/59	-
9-131371463-T-G	SPTAN1	c.4658T>G	p.L1553R	Missense	36/57	-
9-137328444-C-T	RXRA	c.1373C>T	p.P458L	Missense	10/10	-
10-89717673-G-C	PTEN	c.698G>C	p.R233P	Missense	7/9	-
12-6701976-C-T	CHD4	c.2660G>A	p.R887Q	Missense	18/40	-
12-49431832-C-T	KMT2D	c.9307G>A	p.A3103T	Missense	35/55	-
12-112893764-C-T	PTPN11	c.653C>T	p.T218M	Missense	6/16	-
17-16089983-A-G	NCOR1	c.127T>C	p.Y43H	Missense	3/46	-
17-80788691-G-A	ZNF750	c.1499C>T	p.A500V	Missense	3/3	-
19-622742-G-A	POLRMT	c.1466C>T	p.A489V	Missense	8/21	-
19-33793313-G-A	CEBPA	c.8C>T	p.S3L	Missense	1/1	-
22-50726388-C-T	PLXNB2	c.1459G>A	p.G487S	Missense	6/37	-
X-31200876-T-A	DMD	c.9953A>T	p.E3318V	Missense	68/79	-
X-70469472-A-T	ZMYM3	c.1309T>A	p.F437I	Missense	7/25	-
X-153588540-T-C	FLNA	c.3623A>G	p.Y1208C	Missense	22/48	-
2-241676493-C-A	KIF1A	c.3994G>T	p.A1332S	Missense	38/49	-
3-47098492-G-A	SETD2	c.6782C>T	p.A2261V	Missense	15/21	-
3-138474797-A-G	PIK3CB	c.196T>C	p.Y66H	Missense	4/24	-
4-55131130-T-C	PDGFRA	c.673T>C	p.Y225H	Missense	5/23	-
15-59323836-AAGG-A	RNF111	c.818_820delGAG	p.G273del	InFrameDeletion	2/14	-
3-138431118-A-G	PIK3CB	c.1331T>C	p.M444T	Missense	10/24	-
8-38271515-T-C	FGFR1	c.2213A>G	p.H738R	Missense	17/18	-
12-46243386-T-C	ARID2	c.1739T>C	p.V580A	Missense	14/21	-
14-21897136-A-G	CHD8	c.1202T>C	p.V401A	Missense	3/38	-
16-2138238-A-G	TSC2	c.5171A>G	p.Q1724R	Missense	41/42	-
16-72821086-C-A	ZFHX3	c.11089G>T	p.G3697*	Nonsense	10/10	-
1-27023137-GGGTGGC-G	ARID1A	c.246_251delTGGCGG	p.G86_G87del	InFrameDeletion	1/20	-
4-106196925-AT-TG	TET2	c.5258_5259delATinsTG	p.N1753M	Missense	11/11	-
X-53430809-T-C	SMC1A	c.2213A>G	p.E738G	Missense	14/25	-
X-32361384-C-G	DMD	c.5606G>C	p.R1869T	Missense	40/79	-
17-29670046-T-C	NF1	c.7082T>C	p.M2361T	Missense	48/58	-
22-36690263-G-A	MYH9	c.3712C>T	p.Q1238*	Nonsense	28/41	-
10-63852189-G-T	ARID5B	c.2967G>T	p.M989I	Missense	10/10	-
10-63829479-G-T	ARID5B	c.1122G>T	p.W374C	Missense	8/10	-
4-106156508-G-A	TET2	c.1409G>A	p.C470Y	Missense	3/11	-
6-161505595-G-A	MAP3K4	c.2318G>A	p.S773N	Missense	7/27	-
9-36966631-T-C	PAX5	c.695A>G	p.Q232R	Missense	6/10	-
5-80024712-T-A	MSH3	c.1496T>A	p.V499E	Missense	10/24	-
5-79950628-T-G	MSH3	c.82T>G	p.F28V	Missense	1/24	-
17-63554450-T-A	AXIN2	c.289A>T	p.T97S	Missense	2/11	-
17-63533657-GA-TT	AXIN2	c.1496_1497delTCinsAA	p.L499Q	Missense	6/11	-
1-27100114-G-A	ARID1A	c.3910G>A	p.A1304T	Missense	16/20	-
1-27057758-C-T	ARID1A	c.1466C>T	p.P489L	Missense	3/20	-
5-112179037-A-AT	APC	c.7746_7747insT	p.K2583*	Nonsense	16/16	-
5-79974774-T-A	MSH3	c.1202T>A	p.V401E	Missense	8/24	-
18-45375011-C-T	SMAD2	c.832G>A	p.A278T	Missense	8/11	-
1-27106282-A-C	ARID1A	c.5893A>C	p.T1965P	Missense	20/20	-
17-63554316-G-T	AXIN2	c.423C>A	p.N141K	Missense	2/11	-
17-56448381-T-C	RNF43	c.266A>G	p.Y89C	Missense	3/10	-
18-42643128-A-C	SETBP1	c.4256A>C	p.K1419T	Missense	6/6	-
X-20173527-T-C	RPS6KA3	c.2212A>G	p.T738A	Missense	22/22	-
X-41206250-G-A	DDX3X	c.1754G>A	p.R585H	Missense	15/17	-
1-201982155-T-G	ELF3	c.679T>G	p.F227V	Missense	6/9	-
3-138409867-C-A	PIK3CB	c.2011G>T	p.G671W	Missense	15/24	-
4-187629955-T-C	FAT1	c.1027A>G	p.T343A	Missense	2/27	-
7-1276195-A-G	UNCX	c.1178A>G	p.Q393R	Missense	3/3	-
17-16021266-T-G	NCOR1	c.1991A>C	p.N664T	Missense	18/46	-
X-32486689-T-G	DMD	c.3088A>C	p.K1030Q	Missense	23/79	-
11-100998496-C-T	PGR	c.1306G>A	p.E436K	Missense	1/8	-
7-152132868-A-T	KMT2C	c.4T>A	p.S2T	Missense	1/59	-
8-117878908-C-T	RAD21	c.61G>A	p.A21T	Missense	2/14	-
19-13318473-G-T	CACNA1A	c.7175C>A	p.A2392E	Missense	47/47	-
19-13409421-G-A	CACNA1A	c.3026C>T	p.A1009V	Missense	19/47	-
18-42531198-G-T	SETBP1	c.1893G>T	p.K631N	Missense	4/6	-
22-36680286-T-C	MYH9	c.5618A>G	p.K1873R	Missense	40/41	-
1-158619653-A-T	SPTA1	c.3562T>A	p.F1188I	Missense	25/52	-
5-112179727-C-A	APC	c.8436C>A	p.N2812K	Missense	16/16	-
19-13616866-GGTC-G	CACNA1A	c.171_173delGAC	p.T58del	InFrameDeletion	1/47	-
1-158624411-GA-AG	SPTA1	c.3025_3026delTCinsCT	p.S1009L	Missense	21/52	-
8-117878965-A-T	RAD21	c.4T>A	p.F2I	Missense	2/14	-
1-16475304-C-T	EPHA2	c.392G>A	p.G131D	Missense	3/17	-
3-168838939-C-T	MECOM	c.1037G>A	p.R346Q	Missense	7/17	-
7-151873937-C-A	KMT2C	c.8601G>T	p.K2867N	Missense	38/59	-
12-6692223-C-A	CHD4	c.4117G>T	p.G1373C	Missense	27/40	-
14-95562408-G-T	DICER1	c.4849C>A	p.L1617I	Missense	23/27	-
15-42019399-A-G	MGA	c.3452A>G	p.E1151G	Missense	10/24	-
16-72831636-A-G	ZFHX3	c.4945T>C	p.S1649P	Missense	9/10	-
18-42532614-G-A	SETBP1	c.3309G>A	p.M1103I	Missense	4/6	-
19-617321-C-T	POLRMT	c.3646G>A	p.A1216T	Missense	21/21	-
19-625176-C-T	POLRMT	c.901G>A	p.A301T	Missense	4/21	-
19-17950372-T-C	JAK3	c.1355A>G	p.E452G	Missense	10/24	-
22-36688121-G-A	MYH9	c.4255C>T	p.Q1419*	Nonsense	31/41	-
17-58740591-T-A	PPM1D	c.1496T>A	p.V499E	Missense	6/6	-
17-29541572-T-A	NF1	c.1496T>A	p.L499Q	Missense	13/58	-
6-161469783-AT-TG	MAP3K4	c.479_480delATinsTG	p.N160M	Missense	3/27	-
17-58733979-G-A	PPM1D	c.1037G>A	p.C346Y	Missense	5/6	-
11-32456702-A-G	WT1	c.190T>C	p.S69P	Missense	1/10	-
19-18272856-C-T	PIK3R2	c.896C>T	p.P299L	Missense	7/16	-
20-39791328-A-G	PLCG1	c.644A>G	p.Q215R	Missense	6/32	-
21-36164863-C-T	RUNX1	c.1012G>A	p.A338T	Missense	9/9	-
2-25497946-C-T	DNMT3A	c.503G>A	p.G168D	Missense	6/23	-
5-56183288-A-G	MAP3K1	c.4198A>G	p.T1400A	Missense	18/20	-
7-6441995-A-C	RAC1	c.497A>C	p.K166T	Missense	6/6	-
9-137534139-G-A	COL5A1	c.106G>A	p.A36T	Missense	1/66	-
3-142281529-A-G	ATR	c.715T>C	p.Y239H	Missense	4/47	-
1-51439718-G-A	CDKN2C	c.283G>A	p.D95N	Missense	2/2	-
1-198697544-A-G	PTPRC	c.1796A>G	p.Y599C	Missense	16/33	-
1-198676010-AT-TG	PTPRC	c.833_834delATinsTG	p.N278M	Missense	9/33	-
1-229588361-G-A	NUP133	c.3010C>T	p.H1004Y	Missense	22/26	-
2-25976508-C-T	ASXL2	c.1037G>A	p.G346D	Missense	11/13	-
5-176637843-T-C	NSD1	c.2443T>C	p.C815R	Missense	5/23	-
7-148481145-A-G	CUL1	c.1274A>G	p.Y425C	Missense	11/22	-
7-151900107-A-G	KMT2C	c.4004T>C	p.V1335A	Missense	26/59	-
8-55371857-T-C	SOX17	c.547T>C	p.F183L	Missense	2/2	-
9-8465545-C-G	PTPRD	c.3635G>C	p.G1212A	Missense	32/46	-
12-14631307-T-C	ATF7IP	c.2998T>C	p.S1000P	Missense	12/15	-
12-49444462-T-C	KMT2D	c.2909A>G	p.E970G	Missense	12/55	-
17-56435524-G-T	RNF43	c.1613C>A	p.P538H	Missense	9/10	-
19-36211426-G-A	KMT2B	c.1177G>A	p.A393T	Missense	3/37	-
19-52709282-T-C	PPP2R1A	c.236T>C	p.L79P	Missense	3/15	-
X-32360342-C-T	DMD	c.5797G>A	p.A1933T	Missense	41/79	-
X-47424224-G-A	ARAF	c.229G>A	p.A77T	Missense	4/16	-
X-53222362-C-A	KDM5C	c.4470G>T	p.E1490D	Missense	26/26	-
X-53423204-C-T	SMC1A	c.2805G>A	p.M935I	Missense	18/25	-
X-53569416-T-C	HUWE1	c.11464A>G	p.T3822A	Missense	74/84	-
X-53442040-T-A	SMC1A	c.188A>T	p.D63V	Missense	2/25	-
16-72821603-G-GCCA	ZFHX3	c.10571_10572insTGG	p.G3527dup	InFrameInsertion	10/10	-
16-72821612-G-GCCA	ZFHX3	c.10562_10563insTGG	p.G3527dup	InFrameInsertion	10/10	-
2-219449358-T-C	CNOT9	c.344T>C	p.I115T	Missense	4/8	-
4-1955099-G-A	NSD2	c.2186G>A	p.R729H	Missense	12/22	-
13-21549287-T-C	LATS2	c.2989A>G	p.M997V	Missense	8/8	-
17-44115990-G-A	KANSL1	c.2455C>T	p.H819Y	Missense	10/15	-
17-58701032-T-C	PPM1D	c.623T>C	p.V208A	Missense	2/6	-
19-36221628-G-A	KMT2B	c.5297G>A	p.S1766N	Missense	26/37	-
22-36698702-T-C	MYH9	c.2411A>G	p.Q804R	Missense	20/41	-
22-50728239-A-G	PLXNB2	c.775T>C	p.Y259H	Missense	3/37	-
1-198717305-A-C	PTPRC	c.2915A>C	p.N972T	Missense	27/33	-
10-63700160-CAGA-C	ARID5B	c.495_497delAGA	p.D166del	InFrameDeletion	3/10	-
4-187628620-A-G	FAT1	c.2362T>C	p.Y788H	Missense	2/27	-
2-212570048-A-G	ERBB4	c.1193T>C	p.I398T	Missense	10/28	-
22-41513266-ATGG-A	EP300	c.176_178delGTG	p.G59del	InFrameDeletion	2/31	-
14-95571495-A-G	DICER1	c.3182T>C	p.L1061P	Missense	20/27	-
15-75702479-G-C	SIN3A	c.1157C>G	p.S386C	Missense	7/21	-
16-3778042-C-T	CREBBP	c.7006G>A	p.A2336T	Missense	31/31	-
19-11144086-A-C	SMARCA4	c.3667A>C	p.N1223H	Missense	26/35	-
22-50716694-G-A	PLXNB2	c.4739C>T	p.A1580V	Missense	31/37	-
X-39933950-T-C	BCOR	c.649A>G	p.M217V	Missense	4/15	-
X-53577999-G-A	HUWE1	c.9248C>T	p.A3083V	Missense	65/84	-
X-70472970-C-T	ZMYM3	c.136G>A	p.A46T	Missense	2/25	-
X-76907820-C-A	ATRX	c.4341G>T	p.E1447D	Missense	15/35	-
X-79698705-A-C	TENT5D	c.667A>C	p.I223L	Missense	3/3	-
13-21565507-T-C	LATS2	c.379A>G	p.R127G	Missense	3/8	-
14-95574352-A-G	DICER1	c.2515T>C	p.S839P	Missense	16/27	-
16-72993149-G-T	ZFHX3	c.896C>A	p.T299N	Missense	2/10	-
16-68857527-T-C	CDH1	c.2162T>C	p.L721P	Missense	13/16	-
X-153595213-C-T	FLNA	c.874G>A	p.E292K	Missense	6/48	-
3-12645769-T-G	RAF1	c.700A>C	p.T234P	Missense	7/17	-
16-68857523-TTTG-T	CDH1	c.2158_2160delTTG	p.L721del	InFrameDeletion	13/16	-
14-92537396-G-GCTGCTGCTGCTGC	ATXN3	c.873_874insGCAGCAGCAGCAG	p.Q292Afs*30	SpliceAcceptorInsertion	10/11	-
16-68857520-GC-CT	CDH1	c.2155_2156delGCinsCT	p.A719L	Missense	13/16	-
1-93300383-ATGC-A	RPL5	c.237_239delTGC	p.Y79_A80delins*	MultiAAMissense	4/8	-
2-29449802-C-T	ALK	c.3053G>A	p.G1018D	Missense	18/29	-
2-70315740-A-T	PCBP1	c.865A>T	p.N289Y	Missense	1/1	-
9-131344833-G-A	SPTAN1	c.1648G>A	p.A550T	Missense	13/57	-
X-41073869-T-G	USP9X	c.5238T>G	p.N1746K	Missense	34/45	-
2-212566772-T-G	ERBB4	c.1409A>C	p.H470P	Missense	12/28	-
2-212566775-T-G	ERBB4	c.1406A>C	p.Y469S	Missense	12/28	-
2-212566778-T-G	ERBB4	c.1403A>C	p.Y468S	Missense	12/28	-
6-74228684-C-T	EEF1A1	c.592G>A	p.G198S	Missense	4/8	-
9-8528774-G-T	PTPRD	c.358C>A	p.Q120K	Missense	15/46	-
11-100998802-C-T	PGR	c.1000G>A	p.G334R	Missense	1/8	-
12-52345618-G-T	ACVR1B	c.91G>T	p.A31S	Missense	1/9	-
22-41513796-A-C	EP300	c.700A>C	p.T234P	Missense	2/31	-
22-50717332-G-A	PLXNB2	c.4498C>T	p.R1500C	Missense	28/37	-
17-70119731-G-C	SOX9	c.733G>C	p.V245L	Missense	3/3	-
22-50725547-TGGC-T	PLXNB2	c.1752_1754delGCC	p.P585del	InFrameDeletion	8/37	-
1-93299207-T-C	RPL5	c.179T>C	p.I60T	Missense	3/8	-
3-142231136-G-C	ATR	c.4818C>G	p.H1606Q	Missense	27/47	-
8-55371977-G-A	SOX17	c.667G>A	p.D223N	Missense	2/2	-
19-13409601-G-A	CACNA1A	c.2846C>T	p.T949M	Missense	19/47	-
4-55131157-A-C	PDGFRA	c.700A>C	p.T234P	Missense	5/23	-
4-55139835-T-A	PDGFRA	c.1496T>A	p.V499E	Missense	10/23	-
7-151948037-T-C	KMT2C	c.1636A>G	p.M546V	Missense	12/59	-
1-158641236-A-T	SPTA1	c.1496T>A	p.L499Q	Missense	12/52	-
1-93299216-A-T	RPL5	c.188A>T	p.Q63L	Missense	3/8	-
X-53432812-T-C	SMC1A	c.1622A>G	p.N541S	Missense	10/25	-
14-21897442-G-T	CHD8	c.896C>A	p.P299H	Missense	3/38	-
17-58701109-A-C	PPM1D	c.700A>C	p.S234R	Missense	2/6	-
7-152027800-T-A	KMT2C	c.275A>T	p.E92V	Missense	3/59	-
8-38287343-T-C	FGFR1	c.215A>G	p.Q72R	Missense	3/18	-
X-70587402-TCACTGA-T	TAF1	c.234_239delCACTGA	p.T59_E60del	InFrameDeletion	2/38	-
2-158617423-C-A	ACVR1	c.1233G>T	p.L411F	Missense	9/11	-
17-16001716-G-C	NCOR1	c.2785C>G	p.Q929E	Missense	21/46	-
18-60985688-G-GGCC	BCL2	c.211_212insGGC	p.S70_P71insR	InFrameInsertion	2/3	-
5-176562379-A-T	NSD1	c.275A>T	p.D92V	Missense	2/23	-
X-32716072-G-A	DMD	c.875C>T	p.P292L	Missense	9/79	-
21-33044181-TTGAAC-T	SCAF4	c.2970_2974delGTTCA	p.N992Rfs*2	Frameshift	20/20	-
19-1430253-G-GGC	DAZAP1	c.763_764insGC	p.A255Gfs*81	Frameshift	10/12	-
3-30713130-AAT-A	TGFBR2	c.459_460delTA	p.Y153*	Frameshift	4/7	-
6-31323337-TG-T	HLA-B	c.651delC	p.I218Sfs*8	Frameshift	4/8	-
16-68857316-AT-A	CDH1	c.1955delT	p.L652*	Frameshift	13/16	-
6-29911270-A-AC	HLA-A	c.569_570insC	p.E190Dfs*31	Frameshift	3/8	-
2-48026678-AG-A	MSH6	c.1559delG	p.G520Vfs*51	Frameshift	4/10	-
8-55372092-G-GC	SOX17	c.788_788dup	p.E264Gfs*101	Frameshift	2/2	-
9-133760086-AG-A	ABL1	c.2409delG	p.E803Dfs*11	Frameshift	11/11	-
5-112136995-CA-C	APC	c.749delA	p.H250Lfs*43	Frameshift	8/16	-
5-56111872-GC-G	MAP3K1	c.477delC	p.A160Pfs*25	Frameshift	1/20	-
6-36651971-C-A	CDKN1A	c.93C>A	p.S31R	Missense	2/3	-
3-52588797-GC-G	PBRM1	c.4230delG	p.P1411Lfs*21	Frameshift	27/30	-
2-43452259-G-GC	ZFP36L2	c.683_683dup	p.A229Rfs*245	Frameshift	2/2	-
17-37884037-C-G	ERBB2	c.3508C>G	p.P1170A	Missense	27/27	-
5-112116592-C-T	APC	c.637C>T	p.R213*	Nonsense	6/16	-
12-25398279-C-T	KRAS	c.40G>A	p.V14I	Missense	2/5	-
5-176637240-G-T	NSD1	c.1840G>T	p.V614L	Missense	5/23	-
3-37053590-G-A	MLH1	c.677G>A	p.R226Q	Missense	8/19	-
5-176637576-T-C	NSD1	c.2176T>C	p.S726P	Missense	5/23	-
5-112151204-C-T	APC	c.847C>T	p.R283*	Nonsense	9/16	-
5-112175216-G-T	APC	c.3925G>T	p.E1309*	Nonsense	16/16	-
3-12645699-G-A	RAF1	c.770C>T	p.S257L	Missense	7/17	-
16-72993831-A-C	ZFHX3	c.214T>G	p.S72A	Missense	2/10	-
16-72991715-A-G	ZFHX3	c.2330T>C	p.V777A	Missense	2/10	-
5-67588148-G-A	PIK3R1	c.978G>A	p.M326I	Missense	8/16	-
16-72992667-C-G	ZFHX3	c.1378G>C	p.E460Q	Missense	2/10	-
19-1223125-C-G	STK11	c.1062C>G	p.F354L	Missense	8/10	-
18-60985773-C-T	BCL2	c.127G>A	p.A43T	Missense	2/3	-
14-38061742-C-T	FOXA1	c.247G>A	p.A83T	Missense	2/2	-
4-187629770-A-C	FAT1	c.1212T>G	p.S404R	Missense	2/27	-
17-29496986-A-T	NF1	c.557A>T	p.D186V	Missense	5/58	-
2-21231524-G-A	APOB	c.8216C>T	p.P2739L	Missense	26/29	-
2-21250914-G-A	APOB	c.1853C>T	p.A618V	Missense	14/29	-
7-6026988-G-A	PMS2	c.1408C>T	p.P470S	Missense	11/15	-
22-36684354-T-C	MYH9	c.4876A>G	p.I1626V	Missense	34/41	-
5-112175423-C-T	APC	c.4132C>T	p.Q1378*	Nonsense	16/16	-
17-7577096-T-C	TP53	c.842A>G	p.D281G	Missense	8/11	-
17-7578541-A-T	TP53	c.389T>A	p.L130H	Missense	5/11	-
7-55227953-A-G	EGFR	c.1420A>G	p.T474A	Missense	12/28	-
2-29416366-G-C	ALK	c.4587C>G	p.D1529E	Missense	29/29	-
17-7579705-C-T	TP53	c.91G>A	p.V31I	Missense	3/11	-
12-49434235-C-T	KMT2D	c.7318G>A	p.V2440I	Missense	32/55	-
12-49434999-A-G	KMT2D	c.6554T>C	p.L2185P	Missense	32/55	-
4-1803246-C-T	FGFR3	c.598C>T	p.R200C	Missense	5/18	-
4-1803601-C-T	FGFR3	c.779C>T	p.P260L	Missense	7/18	-
22-36700168-G-A	MYH9	c.2263C>T	p.R755C	Missense	19/41	-
12-49436060-G-A	KMT2D	c.5921C>T	p.T1974M	Missense	29/55	-
22-36692946-G-A	MYH9	c.3215C>T	p.A1072V	Missense	25/41	-
22-36745241-T-C	MYH9	c.41A>G	p.K14R	Missense	2/41	-
5-56177443-G-A	MAP3K1	c.2416G>A	p.D806N	Missense	14/20	-
6-161519350-CCTG-C	MAP3K4	c.3596_3598delCTG	p.A1199del	InFrameDeletion	17/27	-
3-178952076-A-G	PIK3CA	c.3131A>G	p.N1044S	Missense	21/21	-
X-153596212-G-A	FLNA	c.620C>T	p.P207L	Missense	3/48	-
17-7578524-G-C	TP53	c.406C>G	p.Q136E	Missense	5/11	-
4-106196951-A-G	TET2	c.5284A>G	p.I1762V	Missense	11/11	-
6-37139063-G-A	PIM1	c.403G>A	p.E135K	Missense	4/6	-
2-21260084-G-A	APOB	c.581C>T	p.T194M	Missense	6/29	-
7-151932961-G-A	KMT2C	c.2710C>T	p.R904*	Nonsense	16/59	-
5-35861068-T-C	IL7R	c.197T>C	p.I66T	Missense	2/8	-
7-151882672-C-A	KMT2C	c.5053G>T	p.A1685S	Missense	34/59	-
7-151962265-C-T	KMT2C	c.1042G>A	p.D348N	Missense	8/59	-
7-151970951-C-T	KMT2C	c.851G>A	p.R284Q	Missense	7/59	-
18-45395793-C-T	SMAD2	c.341G>A	p.R114H	Missense	4/11	-
17-7578449-C-T	TP53	c.481G>A	p.A161T	Missense	5/11	-
13-72440658-TGCCGCC-T	DACH1	c.244_249delGGCGGC	-	InFrameDeletion	1/11	-
6-29910801-C-A	HLA-A	c.341C>A	p.A114D	Missense	2/8	-
9-70863777-G-T	CBWD3	c.394G>T	p.D132Y	Missense	4/15	-
4-187630590-G-A	FAT1	c.392C>T	p.A131V	Missense	2/27	-
6-29910716-C-G	HLA-A	c.256C>G	p.Q86E	Missense	2/8	-
6-29910730-T-A	HLA-A	c.270T>A	p.N90K	Missense	2/8	-
X-41205855-C-T	DDX3X	c.1595C>T	p.T532M	Missense	14/17	-
3-178952086-T-A	PIK3CA	c.3141T>A	p.H1047Q	Missense	21/21	-
17-16097870-C-A	NCOR1	c.14G>T	p.G5V	Missense	2/46	-
7-151945225-T-C	KMT2C	c.2294A>G	p.E765G	Missense	14/59	-
14-92537354-C-G	ATXN3	c.916G>C	p.G306R	Missense	10/11	-
17-63533904-G-A	AXIN2	c.1250C>T	p.A417V	Missense	6/11	-
6-29911228-A-C	HLA-A	c.527A>C	p.E176A	Missense	3/8	-
5-56176548-C-T	MAP3K1	c.2098C>T	p.Q700*	Nonsense	12/20	-
1-158619728-A-C	SPTA1	c.3487T>G	p.S1163A	Missense	25/52	-
11-108117799-G-A	ATM	c.1010G>A	p.R337H	Missense	8/63	-
16-68847225-C-T	CDH1	c.1147C>T	p.Q383*	Nonsense	9/16	-
4-187628398-C-G	FAT1	c.2584G>C	p.V862L	Missense	2/27	-
7-151970859-C-T	KMT2C	c.943G>A	p.G315S	Missense	7/59	-
7-151970877-G-A	KMT2C	c.925C>T	p.P309S	Missense	7/59	-
9-137313594-C-T	RXRA	c.853C>T	p.R285W	Missense	6/10	-
5-56177743-G-A	MAP3K1	c.2716G>A	p.V906I	Missense	14/20	-
1-158612236-A-G	SPTA1	c.4702T>C	p.C1568R	Missense	33/52	-
4-55561758-G-A	KIT	c.148G>A	p.V50M	Missense	2/21	-
3-178948044-A-G	PIK3CA	c.2816A>G	p.D939G	Missense	20/21	-
6-29910750-C-T	HLA-A	c.290C>T	p.T97I	Missense	2/8	-
6-29910742-G-C	HLA-A	c.282G>C	p.Q94H	Missense	2/8	-
7-151945334-T-C	KMT2C	c.2185A>G	p.N729D	Missense	14/59	-
6-29911203-A-C	HLA-A	c.502A>C	p.K168Q	Missense	3/8	-
7-151945204-G-A	KMT2C	c.2315C>T	p.S772L	Missense	14/59	-
7-151970859-C-A	KMT2C	c.943G>T	p.G315C	Missense	7/59	-
6-29910557-T-A	HLA-A	c.97T>A	p.F33I	Missense	2/8	-
1-120572547-T-C	NOTCH2	c.137A>G	p.N46S	Missense	2/34	-
7-151945071-G-GT	KMT2C	c.2447_2447dup	p.Y816*	Nonsense	14/59	-
17-56448297-C-T	RNF43	c.350G>A	p.R117H	Missense	3/10	-
6-29910558-T-C	HLA-A	c.98T>C	p.F33S	Missense	2/8	-
4-187542755-T-C	FAT1	c.4985A>G	p.N1662S	Missense	10/27	-
4-187509861-G-C	FAT1	c.13652C>G	p.A4551G	Missense	27/27	-
7-6026775-T-C	PMS2	c.1621A>G	p.K541E	Missense	11/15	-
13-28624294-G-A	FLT3	c.680C>T	p.T227M	Missense	6/24	-
14-92537387-T-G	ATXN3	c.883A>C	p.K295Q	Missense	10/11	-
12-14587301-A-G	ATF7IP	c.1589A>G	p.K530R	Missense	3/15	-
4-187525020-A-C	FAT1	c.10660T>G	p.S3554A	Missense	19/27	-
14-103342049-T-C	TRAF3	c.386T>C	p.M129T	Missense	5/12	-
14-92548785-C-T	ATXN3	c.634G>A	p.V212M	Missense	8/11	-
14-21899631-C-T	CHD8	c.172G>A	p.V58M	Missense	2/38	-
7-151949068-C-G	KMT2C	c.1577G>C	p.R526P	Missense	11/59	-
6-31323337-T-C	HLA-B	c.652A>G	p.I218V	Missense	4/8	-
6-1313952-A-G	FOXQ1	c.1013A>G	p.E338G	Missense	1/1	-
19-622336-T-G	POLRMT	c.1664A>C	p.E555A	Missense	9/21	-
4-187629538-C-T	FAT1	c.1444G>A	p.V482I	Missense	2/27	-
6-26056604-G-A	H1-2	c.53C>T	p.A18V	Missense	1/1	-
4-187538942-T-G	FAT1	c.8798A>C	p.Q2933P	Missense	10/27	-
17-44109474-G-A	KANSL1	c.3029C>T	p.P1010L	Missense	14/15	-
6-31324536-T-G	HLA-B	c.272A>C	p.Y91S	Missense	2/8	-
1-120572572-C-T	NOTCH2	c.112G>A	p.E38K	Missense	2/34	-
4-106155751-G-A	TET2	c.652G>A	p.V218M	Missense	3/11	-
18-42532693-C-A	SETBP1	c.3388C>A	p.P1130T	Missense	4/6	-
7-151932916-C-G	KMT2C	c.2755G>C	p.V919L	Missense	16/59	-
4-187627792-T-C	FAT1	c.3190A>G	p.R1064G	Missense	2/27	-
4-187531022-A-G	FAT1	c.10001T>C	p.V3334A	Missense	15/27	-
2-21266774-GGCAGCGCCA-G	APOB	c.35_43delTGGCGCTGC	p.L12_L14del	InFrameDeletion	1/29	-
4-187629140-G-C	FAT1	c.1842C>G	p.F614L	Missense	2/27	-
5-56177848-TCAA-T	MAP3K1	c.2845_2847delACA	p.T949del	InFrameDeletion	14/20	-
1-120611960-C-T	NOTCH2	c.61G>A	p.A21T	Missense	1/34	-
6-29910725-C-G	HLA-A	c.265C>G	p.R89G	Missense	2/8	-
18-42532606-G-A	SETBP1	c.3301G>A	p.V1101I	Missense	4/6	-
16-72831357-CTTG-C	ZFHX3	c.5221_5223delCAA	p.Q1741del	InFrameDeletion	9/10	-
6-29910340-A-G	HLA-A	c.10A>G	p.M4V	Missense	1/8	-
16-72821618-ACCG-A	ZFHX3	c.10554_10556delCGG	p.G3527del	InFrameDeletion	10/10	-
6-31324506-C-T	HLA-B	c.302G>A	p.S101N	Missense	2/8	-
12-31944778-T-C	H3-5	c.323A>G	p.N108S	Missense	1/1	-
6-31324154-G-A	HLA-B	c.409C>T	p.H137Y	Missense	3/8	-
4-187540635-T-G	FAT1	c.7105A>C	p.T2369P	Missense	10/27	-
4-187540918-G-C	FAT1	c.6822C>G	p.D2274E	Missense	10/27	-
4-187549428-C-T	FAT1	c.4690G>A	p.A1564T	Missense	9/27	-
7-151859683-G-A	KMT2C	c.10979C>T	p.S3660L	Missense	43/59	-
4-55575594-G-A	KIT	c.1120G>A	p.V374I	Missense	7/21	-
14-92537396-G-GCTGCTGCTGC	ATXN3	c.873_874insGCAGCAGCAG	p.Q292Afs*29	SpliceAcceptorInsertion	10/11	-
9-139405111-G-A	NOTCH1	c.2734C>T	p.R912W	Missense	17/34	-
6-161494597-G-A	MAP3K4	c.2050G>A	p.D684N	Missense	5/27	-
3-121229066-T-C	POLQ	c.1636A>G	p.T546A	Missense	11/30	-
18-42643270-G-T	SETBP1	c.4398G>T	p.E1466D	Missense	6/6	-
19-13319691-G-GGGT	CACNA1A	c.6658_6659insACC	p.H2219dup	InFrameInsertion	46/47	-
7-151945256-G-A	KMT2C	c.2263C>T	p.Q755*	Nonsense	14/59	-
13-33344896-AT-TG	PDS5B	c.4169_4170delATinsTG	p.N1390M	Missense	33/35	-
17-58740630-A-T	PPM1D	c.1535A>T	p.N512I	Missense	6/6	-
2-70315174-T-A	PCBP1	c.299T>A	p.L100Q	Missense	1/1	-
5-112164663-T-TA	APC	c.1738_1738dupA	p.E582Gfs*20	SpliceDonorInsertion	14/16	-
12-6700659-G-A	CHD4	c.3313C>T	p.R1105W	Missense	22/40	-
7-151932997-C-T	KMT2C	c.2674G>A	p.G892R	Missense	16/59	-
7-151932945-C-T	KMT2C	c.2726G>A	p.R909K	Missense	16/59	-
5-112175468-CT-C	APC	c.4179delT	p.D1394Ifs*21	Frameshift	16/16	-
21-36164605-A-G	RUNX1	c.1270T>C	p.S424P	Missense	9/9	-
16-3781323-AAGG-A	CREBBP	c.5039_5041delCCT	p.S1680del	InFrameDeletion	30/31	-
17-7579314-T-C	TP53	c.373A>G	p.T125A	Missense	4/11	-
17-16068377-C-G	NCOR1	c.534G>C	p.K178N	Missense	5/46	-
6-152415657-C-T	ESR1	c.1507C>T	p.R503W	Missense	7/8	-
7-151962290-C-G	KMT2C	c.1017G>C	p.K339N	Missense	8/59	-
1-27087443-C-T	ARID1A	c.2017C>T	p.Q673*	Nonsense	5/20	-
16-2138118-G-A	TSC2	c.5138G>A	p.R1713H	Missense	40/42	-
2-46609572-A-C	EPAS1	c.2296A>C	p.T766P	Missense	15/16	-
7-151935853-T-C	KMT2C	c.2591A>G	p.E864G	Missense	15/59	-
7-151927025-A-G	KMT2C	c.2959T>C	p.Y987H	Missense	18/59	-
7-151927021-C-A	KMT2C	c.2963G>T	p.C988F	Missense	18/59	-
7-2968245-C-T	CARD11	c.1741G>A	p.A581T	Missense	13/25	-
18-48593466-C-T	SMAD4	c.1217C>T	p.A406V	Missense	10/12	-
3-178916933-A-G	PIK3CA	c.320A>G	p.N107S	Missense	2/21	-
18-48584527-A-C	SMAD4	c.700A>C	p.S234R	Missense	6/12	-
7-151962126-C-T	KMT2C	c.1181G>A	p.C394Y	Missense	8/59	-
10-89711895-G-T	PTEN	c.513G>T	p.Q171H	Missense	6/9	-
12-133256105-C-T	POLE	c.556G>A	p.A186T	Missense	6/49	-
4-106197365-G-A	TET2	c.5698G>A	p.V1900I	Missense	11/11	-
5-112174026-T-A	APC	c.2735T>A	p.L912*	Nonsense	16/16	-
1-27100914-A-G	ARID1A	c.4196A>G	p.Q1399R	Missense	18/20	-
1-27057936-GC-G	ARID1A	c.1650delC	p.Y551Tfs*68	Frameshift	3/20	-
2-148657040-GA-G	ACVR2A	c.285delA	p.D96Tfs*54	Frameshift	3/11	-
5-112179035-GA-G	APC	c.7749delA	p.A2584Qfs*9	Frameshift	16/16	-
19-1434835-G-C	DAZAP1	c.1148G>C	p.G383A	Missense	12/12	-
17-7216092-G-A	GPS2	c.967C>T	p.R323*	Nonsense	11/11	-
14-92537354-C-CCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	ATXN3	c.915_916insCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG	p.Q296_Q305dup	InFrameInsertion	10/11	-
17-7216143-T-C	GPS2	c.916A>G	p.T306A	Missense	11/11	-
1-158597507-G-C	SPTA1	c.5572C>G	p.L1858V	Missense	40/52	-
4-1980558-G-GC	NSD2	c.4028_4028dup	p.E1344Rfs*91	Frameshift	22/22	-
17-41246418-C-T	BRCA1	c.1130G>A	p.S377N	Missense	10/23	-
17-56435160-A-AC	RNF43	c.1976_1976dupG	p.P660Sfs*87	Frameshift	9/10	-
17-37881117-C-T	ERBB2	c.2446C>T	p.R816C	Missense	20/27	-
12-133257806-G-A	POLE	c.122C>T	p.T41M	Missense	2/49	-
12-25398243-T-A	KRAS	c.76A>T	p.N26Y	Missense	2/5	-
6-26056286-C-G	H1-2	c.371G>C	p.G124A	Missense	1/1	-
X-53407978-A-C	SMC1A	c.3468T>G	p.D1156E	Missense	23/25	-
16-72828867-T-C	ZFHX3	c.7714A>G	p.M2572V	Missense	9/10	-
14-21869061-C-A	CHD8	c.4343G>T	p.R1448L	Missense	22/38	-
1-27056151-C-T	ARID1A	c.1147C>T	p.P383S	Missense	2/20	-