PMID: 34944600

Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia.

Bai, Zhengli Z, Xu, Menglong M, Mei, Ying Y, Hu, Tuo T, Zhang, Panpan P, Chen, Manman M, Lv, Wenxiu W, Lu, Chenchen C, Tan, Shuhua S

6 variants were identified in this publication

Variant ID Gene cDNA Protein Consequence Exon Intron
1-55518353-CT-GG PCSK9 c.688_689delCTinsGG p.L230G Missense 5/12 -
8-133894154-C-G TG c.685C>G p.P229A Missense 6/48 -
1-55518353-CT-GC PCSK9 c.688_689delCTinsGC p.L230A Missense 5/12 -
1-55518353-CT-TC PCSK9 c.688_689delCTinsTC p.L230S Missense 5/12 -
8-133894148-AG-GC TG c.679_680delAGinsGC p.R227A Missense 6/48 -
19-11218139-AA-GG LDLR c.889_890delAAinsGG p.N297G Missense 6/18 -