PMID: 35117215

Association between BRAF mutant classification and the efficacy of pemetrexed-based chemotherapy in Chinese advanced non-small cell lung cancer patients: a multicenter retrospective study.

Translational cancer research
Lei, Lei L, Wang, Wen-Xian WX, Zhu, You-Cai YC, Pu, Xing-Xiang XX, Fang, Yong Y, Wang, Hong H, Zhuang, Wu W, Zhang, Yin-Bin YB, Wang, Li-Ping LP, Xu, Chun-Wei CW, Fang, Mei-Yu MY
2020-10

32 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-140494148-G-A BRAF c.1100C>T p.P367L Missense 8/18 -
7-140453129-AGA-TGTGTT BRAF c.1804_1806delinsAACACA p.S602delinsNT MultiAAMissense 15/18 -
7-140494131-T-A BRAF c.1117A>T p.T373S Missense 8/18 -
7-140494154-G-T BRAF c.1094C>A p.S365* Nonsense 8/18 -
7-140494154-G-C BRAF c.1094C>G p.S365* Nonsense 8/18 -
7-140494118-A-T BRAF c.1130T>A p.V377D Missense 8/18 -
7-140454023-C-T BRAF c.1705G>A p.A569T Missense 14/18 -
7-140477838-TAGG-T BRAF c.1468_1470delCCT p.P490del InFrameDeletion 12/18 -
7-140481411-C-A BRAF c.1397G>T p.G466V Missense 11/18 -
7-140453193-T-C BRAF c.1742A>G p.N581S Missense 15/18 -
7-140453152-A-G BRAF c.1783T>C p.F595L Missense 15/18 -
7-140453150-A-T BRAF c.1785T>A p.F595L Missense 15/18 -
7-140453150-A-C BRAF c.1785T>G p.F595L Missense 15/18 -
7-140481417-C-A BRAF c.1391G>T p.G464V Missense 11/18 -
7-140453154-T-G BRAF c.1781A>C p.D594A Missense 15/18 -
7-140453145-A-T BRAF c.1790T>A p.L597Q Missense 15/18 -
7-140481411-C-G BRAF c.1397G>C p.G466A Missense 11/18 -
7-140481402-C-T BRAF c.1406G>A p.G469E Missense 11/18 -
7-140453148-C-T BRAF c.1787G>A p.G596D Missense 15/18 -
7-140477854-A-C BRAF c.1454T>G p.L485W Missense 12/18 -
7-140453179-C-T BRAF c.1756G>A p.E586K Missense 15/18 -
7-140481408-G-A BRAF c.1400C>T p.S467L Missense 11/18 -
7-140434564-C-T BRAF c.2134G>A p.A712T Missense 18/18 -
7-140481433-C-G BRAF c.1375G>C p.V459L Missense 11/18 -
7-140481433-C-A BRAF c.1375G>T p.V459L Missense 11/18 -
7-140624440-C-T BRAF c.64G>A p.D22N Missense 1/18 -
7-140453138-T-C BRAF c.1797A>G p.T599= Synonymous 15/18 -
7-140453138-T-A BRAF c.1797A>T p.T599= Synonymous 15/18 -
7-140453138-T-G BRAF c.1797A>C p.T599= Synonymous 15/18 -
7-140501213-C-G BRAF c.859G>C p.D287H Missense 6/18 -
7-140481397-C-T BRAF c.1411G>A p.V471I Missense 11/18 -
7-140481457-C-G BRAF c.1351G>C p.E451Q Missense 11/18 -