PMID: 35509869

Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma: a randomized, multicenter phase II trial.

Innovation (Cambridge (Mass.))

Lu, Zhihao Z, Zhang, Yanqiao Y, Fan, Qingxia Q, Pan, Yueyin Y, Jiang, Da D, Lu, Ping P, Zhang, Jingdong J, Yuan, Xianglin X, Feng, Jifeng J, Yang, Shujun S, Yue, Wenbin W, Zhao, Lin L, Xu, Yunhua Y, Luo, Jinhua J, Shen, Lin L

2022-05-10

689 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
2-190719754-C-T	PMS1	c.1756C>T	p.R586C	Missense	9/13	-
5-150924780-G-A	FAT2	c.5908C>T	p.Q1970*	Nonsense	10/24	-
7-105187463-C-T	RINT1	c.622C>T	p.H208Y	Missense	5/15	-
13-32915201-G-A	BRCA2	c.6709G>A	p.D2237N	Missense	11/27	-
X-63410775-G-A	AMER1	c.2392C>T	p.Q798*	Nonsense	2/2	-
12-133257804-C-T	POLE	c.124G>A	p.D42N	Missense	2/49	-
19-11105504-G-T	SMARCA4	c.1420G>T	p.E474*	Nonsense	9/35	-
X-76854916-C-T	ATRX	c.5920G>A	p.G1974R	Missense	25/35	-
19-11144050-G-T	SMARCA4	c.3631G>T	p.E1211*	Nonsense	26/35	-
5-176707759-G-A	NSD1	c.5816G>A	p.R1939H	Missense	18/23	-
12-404813-C-T	KDM5A	c.4381G>A	p.E1461K	Missense	26/28	-
12-58144527-C-A	CDK4	c.544G>T	p.A182S	Missense	5/8	-
9-5054660-C-T	JAK2	c.712C>T	p.Q238*	Nonsense	7/25	-
11-119156070-C-T	CBL	c.1735C>T	p.P579S	Missense	11/16	-
17-7579581-G-GC	TP53	c.105dupG	p.P36Afs*7	Frameshift	4/11	-
17-38792336-T-C	SMARCE1	c.388A>G	p.M130V	Missense	7/11	-
12-115118778-G-A	TBX3	c.563C>T	p.P188L	Missense	2/7	-
4-106157123-C-G	TET2	c.2024C>G	p.S675*	Nonsense	3/11	-
13-26959350-G-A	CDK8	c.517G>A	p.D173N	Missense	6/13	-
1-23235546-C-T	EPHB2	c.2384C>T	p.P795L	Missense	13/16	-
4-187539870-C-T	FAT1	c.7870G>A	p.D2624N	Missense	10/27	-
17-29508755-C-G	NF1	c.682C>G	p.P228A	Missense	7/58	-
4-55603372-G-C	KIT	c.2728G>C	p.D910H	Missense	20/21	-
2-47639691-G-A	MSH2	c.784G>A	p.E262K	Missense	4/16	-
10-43612052-C-G	RET	c.2157C>G	p.F719L	Missense	12/20	-
17-7578521-GT-G	TP53	c.408delA	p.Q136Hfs*34	Frameshift	5/11	-
22-29106013-A-C	CHEK2	c.827T>G	p.I276S	Missense	7/15	-
1-27023957-C-T	ARID1A	c.1063C>T	p.Q355*	Nonsense	1/20	-
19-19256623-C-T	MEF2B	c.1090G>A	p.D364N	Missense	9/9	-
7-86416228-G-C	GRM3	c.1120G>C	p.D374H	Missense	3/6	-
13-32906448-G-A	BRCA2	c.833G>A	p.S278N	Missense	10/27	-
2-141274473-C-T	LRP1B	c.8134G>A	p.D2712N	Missense	50/91	-
14-95562404-G-A	DICER1	c.4853C>T	p.S1618L	Missense	23/27	-
16-9923482-C-A	GRIN2A	c.1805G>T	p.G602V	Missense	9/13	-
13-32913395-T-A	BRCA2	c.4903T>A	p.L1635M	Missense	11/27	-
2-225422482-C-T	CUL3	c.158G>A	p.S53N	Missense	2/16	-
3-142275310-C-T	ATR	c.1993G>A	p.E665K	Missense	9/47	-
9-139413912-C-A	NOTCH1	c.848G>T	p.C283F	Missense	5/34	-
7-128850837-C-T	SMO	c.1684C>T	p.R562W	Missense	10/12	-
7-128845587-G-A	SMO	c.884G>A	p.C295Y	Missense	4/12	-
17-41245839-G-C	BRCA1	c.1709C>G	p.P570R	Missense	10/23	-
2-225379401-C-A	CUL3	c.467G>T	p.C156F	Missense	4/16	-
8-118834821-T-A	EXT1	c.1300A>T	p.I434L	Missense	5/11	-
17-41244742-C-A	BRCA1	c.2806G>T	p.D936Y	Missense	10/23	-
3-41267306-C-T	CTNNB1	c.890C>T	p.T297M	Missense	6/15	-
17-41247885-G-C	BRCA1	c.648C>G	p.I216M	Missense	9/23	-
9-139400074-C-T	NOTCH1	c.4274G>A	p.C1425Y	Missense	25/34	-
17-45369824-G-T	ITGB3	c.1580G>T	p.C527F	Missense	10/15	-
5-150946836-G-A	FAT2	c.1657C>T	p.Q553*	Nonsense	2/24	-
2-141093220-C-A	LRP1B	c.12080G>T	p.G4027V	Missense	78/91	-
3-142274812-G-C	ATR	c.2248C>G	p.Q750E	Missense	10/47	-
X-76939304-C-A	ATRX	c.1444G>T	p.E482*	Nonsense	9/35	-
16-23641722-C-T	PALB2	c.1753G>A	p.D585N	Missense	5/13	-
11-108150279-C-T	ATM	c.3346C>T	p.Q1116*	Nonsense	23/63	-
19-50919923-G-T	POLD1	c.3010G>T	p.A1004S	Missense	24/27	-
1-78429845-C-T	FUBP1	c.943G>A	p.D315N	Missense	12/20	-
9-139412645-C-T	NOTCH1	c.1199G>A	p.C400Y	Missense	7/34	-
11-124749208-C-A	ROBO3	c.3656C>A	p.P1219H	Missense	24/28	-
13-110437088-G-C	IRS2	c.1313C>G	p.S438W	Missense	1/2	-
1-43812186-C-T	MPL	c.1051C>T	p.R351C	Missense	7/12	-
18-45422975-C-G	SMAD2	c.153G>C	p.K51N	Missense	2/11	-
8-38271675-G-T	FGFR1	c.2181C>A	p.N727K	Missense	16/18	-
16-23640960-C-A	PALB2	c.2514+1G>T	-	IntronicSNV	-	5/12
14-65544623-GTGCTCACC-G	MAX	c.295_295+7delGGTGAGCA	-	SpliceDonorDeletion	4/5	4/4
9-139393350-C-G	NOTCH1	c.6180+1G>C	-	IntronicSNV	-	33/33
22-41564872-G-A	EP300	c.4172+1G>A	-	IntronicSNV	-	25/30
9-139412203-C-A	NOTCH1	c.1441+1G>T	-	IntronicSNV	-	8/33
1-162743387-G-A	DDR2	c.1856+1G>A	-	IntronicSNV	-	14/17
2-225422374-A-G	CUL3	c.264+2T>C	-	IntronicSNV	-	2/15
16-89816137-C-T	FANCA	c.3239+1G>A	-	IntronicSNV	-	32/42
9-139396452-C-T	NOTCH1	c.5472+1G>A	-	IntronicSNV	-	29/33
7-116413069-T-C	MET	c.3028+1026T>C	-	IntronicSNV	-	14/20
7-116412715-G-A	MET	c.3028+672G>A	-	IntronicSNV	-	14/20
2-47707949-G-A	MSH2	c.2573G>A	p.G858E	Missense	15/16	-
7-151859516-C-G	KMT2C	c.11146G>C	p.E3716Q	Missense	43/59	-
9-101585547-G-T	GALNT12	c.381G>T	p.E127D	Missense	2/10	-
3-134670281-C-G	EPHB1	c.192C>G	p.F64L	Missense	3/16	-
17-59793338-G-T	BRIP1	c.2466C>A	p.Y822*	Nonsense	17/20	-
19-38976585-G-A	RYR1	c.5290G>A	p.G1764R	Missense	34/106	-
16-3779311-G-T	CREBBP	c.5737C>A	p.P1913T	Missense	31/31	-
5-180057673-C-A	FLT4	c.282G>T	p.K94N	Missense	3/30	-
3-142274802-C-T	ATR	c.2258G>A	p.C753Y	Missense	10/47	-
7-128850882-C-T	SMO	c.1729C>T	p.H577Y	Missense	10/12	-
6-138195996-C-T	TNFAIP3	c.310C>T	p.L104F	Missense	3/9	-
19-3121092-C-T	GNA11	c.995C>T	p.T332I	Missense	7/7	-
X-76849283-G-A	ATRX	c.5993C>T	p.A1998V	Missense	26/35	-
2-212295717-T-C	ERBB4	c.2596A>G	p.R866G	Missense	21/28	-
7-124475378-T-A	POT1	c.1460A>T	p.D487V	Missense	15/19	-
3-52620463-T-G	PBRM1	c.3290A>C	p.E1097A	Missense	21/30	-
14-81610060-C-T	TSHR	c.1658C>T	p.A553V	Missense	10/10	-
2-212285243-C-G	ERBB4	c.3058G>C	p.E1020Q	Missense	25/28	-
20-56140727-G-A	PCK1	c.1736G>A	p.S579N	Missense	10/10	-
6-161969962-C-A	PRKN	c.1007G>T	p.G336V	Missense	9/12	-
19-39018359-G-T	RYR1	c.10759G>T	p.D3587Y	Missense	73/106	-
X-76939471-T-C	ATRX	c.1277A>G	p.E426G	Missense	9/35	-
19-39003123-C-T	RYR1	c.9472C>T	p.L3158=	Synonymous	63/106	-
5-56168534-C-G	MAP3K1	c.1490C>G	p.S497C	Missense	8/20	-
5-149497317-G-C	PDGFRB	c.3001C>G	p.P1001A	Missense	22/23	-
19-11138522-G-T	SMARCA4	c.3278G>T	p.R1093L	Missense	24/35	-
19-18273048-C-T	PIK3R2	c.938C>T	p.S313F	Missense	8/16	-
3-10140451-G-C	FANCD2	c.4233G>C	p.E1411D	Missense	43/44	-
17-8110112-C-A	AURKB	c.493G>T	p.E165*	Nonsense	6/9	-
9-8319833-C-T	PTPRD	c.5668G>A	p.E1890K	Missense	45/46	-
17-11998919-G-C	MAP2K4	c.421G>C	p.E141Q	Missense	4/11	-
11-1251811-G-T	MUC5B	c.1451G>T	p.S484I	Missense	12/49	-
19-52723445-G-T	PPP2R1A	c.1306G>T	p.V436L	Missense	11/15	-
4-187540116-T-C	FAT1	c.7624A>G	p.I2542V	Missense	10/27	-
X-76812933-T-C	ATRX	c.6688A>G	p.M2230V	Missense	30/35	-
3-142231159-G-C	ATR	c.4795C>G	p.L1599V	Missense	27/47	-
5-1280423-C-G	TERT	c.1800G>C	p.E600D	Missense	4/16	-
5-1280423-C-A	TERT	c.1800G>T	p.E600D	Missense	4/16	-
9-8339011-C-T	PTPRD	c.5290G>A	p.A1764T	Missense	43/46	-
3-85961615-G-T	CADM2	c.622G>T	p.V208L	Missense	6/10	-
5-150923429-G-A	FAT2	c.7259C>T	p.S2420F	Missense	10/24	-
1-113456527-C-T	SLC16A1	c.1489G>A	p.E497K	Missense	5/5	-
5-56111669-C-T	MAP3K1	c.269C>T	p.S90F	Missense	1/20	-
17-70119833-A-C	SOX9	c.835A>C	p.S279R	Missense	3/3	-
14-81610529-G-C	TSHR	c.2127G>C	p.Q709H	Missense	10/10	-
7-55249087-C-A	EGFR	c.2385C>A	p.F795L	Missense	20/28	-
8-90993664-A-G	NBN	c.259T>C	p.F87L	Missense	3/16	-
2-46603826-G-C	EPAS1	c.1183G>C	p.E395Q	Missense	9/16	-
16-16142076-G-C	ABCC1	c.1296G>C	p.Q432H	Missense	10/31	-
1-19062279-C-T	PAX7	c.1309C>T	p.P437S	Missense	8/9	-
5-149511558-G-T	PDGFRB	c.1227C>A	p.F409L	Missense	8/23	-
5-79965940-C-G	MSH3	c.604C>G	p.Q202E	Missense	4/24	-
13-110434817-C-T	IRS2	c.3584G>A	p.G1195E	Missense	1/2	-
X-1321321-T-A	CRLF2	c.434A>T	p.D145V	Missense	4/8	-
1-182544612-T-C	RNASEL	c.2141A>G	p.K714R	Missense	7/7	-
11-55135882-G-T	OR4A15	c.523G>T	p.A175S	Missense	1/1	-
4-187541873-T-A	FAT1	c.5867A>T	p.D1956V	Missense	10/27	-
2-141200075-C-T	LRP1B	c.10412G>A	p.C3471Y	Missense	66/91	-
19-41743993-G-A	AXL	c.928G>A	p.A310T	Missense	7/20	-
19-41727854-G-T	AXL	c.479G>T	p.C160F	Missense	4/20	-
17-38792297-T-C	SMARCE1	c.427A>G	p.I143V	Missense	7/11	-
19-17945802-G-T	JAK3	c.2058C>A	p.D686E	Missense	16/24	-
10-98156987-C-T	TLL2	c.1340G>A	p.S447N	Missense	11/21	-
4-55948708-G-A	KDR	c.3757C>T	p.P1253S	Missense	28/30	-
5-150924657-T-C	FAT2	c.6031A>G	p.M2011V	Missense	10/24	-
11-118343552-T-C	KMT2A	c.1678T>C	p.S560P	Missense	3/36	-
16-89846329-T-A	FANCA	c.1663A>T	p.I555F	Missense	18/43	-
5-80109463-A-T	MSH3	c.2716A>T	p.I906L	Missense	20/24	-
11-102100519-C-G	YAP1	c.1363C>G	p.L455V	Missense	9/9	-
3-121350742-T-C	HCLS1	c.1412A>G	p.H471R	Missense	14/14	-
4-187524768-T-A	FAT1	c.10912A>T	p.M3638L	Missense	19/27	-
8-119122705-T-A	EXT1	c.581A>T	p.N194I	Missense	1/11	-
9-21971110-GTGC-G	CDKN2A	c.246_248delGCA	p.H83del	InFrameDeletion	2/3	-
2-178098969-TGCCTCCAAAGTA-T	NFE2L2	c.65_76del12	p.I22_Q26delinsK	MultiAAMissense	2/5	-
16-72993566-C-A	ZFHX3	c.479G>T	p.G160V	Missense	2/10	-
9-87563525-A-C	NTRK2	c.1913A>C	p.H638P	Missense	16/19	-
9-139393400-G-T	NOTCH1	c.6131C>A	p.A2044E	Missense	33/34	-
4-84383641-G-A	ABRAXAS1	c.1211C>T	p.S404L	Missense	9/9	-
13-49054172-G-A	RB1	c.2752G>A	p.D918N	Missense	27/27	-
3-142272737-C-T	ATR	c.2462G>A	p.R821K	Missense	11/47	-
2-191859791-G-A	STAT1	c.940C>T	p.Q314*	Nonsense	10/25	-
X-63411576-G-C	AMER1	c.1591C>G	p.R531G	Missense	2/2	-
7-86416139-A-G	GRM3	c.1031A>G	p.N344S	Missense	3/6	-
20-54961571-C-A	AURKA	c.61G>T	p.G21C	Missense	3/9	-
5-138253519-A-C	CTNNA1	c.1478A>C	p.K493T	Missense	11/18	-
7-26224262-T-C	NFE2L3	c.944T>C	p.L315P	Missense	4/4	-
5-150924566-T-A	FAT2	c.6122A>T	p.E2041V	Missense	10/24	-
14-95570111-C-A	DICER1	c.3622G>T	p.E1208*	Nonsense	21/27	-
1-3644331-C-T	TP73	c.982C>T	p.R328C	Missense	8/14	-
19-15291023-C-G	NOTCH3	c.3187G>C	p.D1063H	Missense	20/33	-
2-141660628-A-T	LRP1B	c.3627T>A	p.N1209K	Missense	23/91	-
8-38283744-C-T	FGFR1	c.641G>A	p.S214N	Missense	6/18	-
2-178098948-T-G	NFE2L2	c.97A>C	p.S33R	Missense	2/5	-
9-139412314-T-C	NOTCH1	c.1331A>G	p.Y444C	Missense	8/34	-
10-88635796-C-A	BMPR1A	c.21C>A	p.Y7*	Nonsense	3/13	-
5-180045784-G-A	FLT4	c.2987C>T	p.S996F	Missense	21/30	-
X-63410384-G-A	AMER1	c.2783C>T	p.S928L	Missense	2/2	-
6-108985540-G-T	FOXO3	c.1504G>T	p.A502S	Missense	2/3	-
3-142243002-C-G	ATR	c.3985G>C	p.E1329Q	Missense	22/47	-
6-110778074-G-C	SLC22A16	c.200C>G	p.S67C	Missense	2/8	-
1-158815398-C-T	MNDA	c.592C>T	p.R198W	Missense	5/7	-
1-11316126-C-T	MTOR	c.628G>A	p.V210I	Missense	5/58	-
13-110435892-C-T	IRS2	c.2509G>A	p.E837K	Missense	1/2	-
1-201983085-G-A	ELF3	c.934G>A	p.A312T	Missense	8/9	-
2-29917871-C-A	ALK	c.797G>T	p.C266F	Missense	3/29	-
2-178098923-TGACTGAAGTCAAATACTTCTC-T	NFE2L2	c.101_121del21	p.R34_S40del	InFrameDeletion	2/5	-
X-47032581-CG-TA	RBM10	c.487_488delCGinsTA	p.R163*	Nonsense	5/24	-
3-49941008-A-G	MST1R	c.35T>C	p.L12P	Missense	1/20	-
1-27057934-C-A	ARID1A	c.1642C>A	p.Q548K	Missense	3/20	-
11-118344347-G-C	KMT2A	c.2473G>C	p.E825Q	Missense	3/36	-
1-157559112-C-T	FCRL4	c.189G>A	p.W63*	Nonsense	3/12	-
12-133244193-C-G	POLE	c.2215G>C	p.V739L	Missense	20/49	-
16-3632483-C-T	SLX4	c.5365G>A	p.G1789S	Missense	15/15	-
18-61310656-T-G	SERPINB4	c.156A>C	p.Q52H	Missense	2/8	-
8-48744474-C-T	PRKDC	c.8165G>A	p.R2721R	Missense	61/87	-
19-18274113-C-G	PIK3R2	c.1331C>G	p.A444G	Missense	11/16	-
2-141526854-G-T	LRP1B	c.5686C>A	p.P1896T	Missense	35/91	-
12-56481811-C-T	ERBB3	c.739C>T	p.R247W	Missense	7/28	-
15-75705154-G-T	SIN3A	c.706C>A	p.P236T	Missense	5/21	-
20-56140480-T-G	PCK1	c.1489T>G	p.W497G	Missense	10/10	-
9-139405641-A-T	NOTCH1	c.2550T>A	p.Y850*	Nonsense	16/34	-
2-141027824-C-T	LRP1B	c.13234G>A	p.V4412I	Missense	86/91	-
2-141116504-A-T	LRP1B	c.11143T>A	p.C3715S	Missense	73/91	-
13-110435561-G-A	IRS2	c.2840C>T	p.S947L	Missense	1/2	-
9-5054612-C-G	JAK2	c.664C>G	p.H222D	Missense	7/25	-
17-59761484-C-T	BRIP1	c.2923G>A	p.E975K	Missense	20/20	-
9-5029900-G-A	JAK2	c.344G>A	p.R115K	Missense	4/25	-
5-150943192-G-A	FAT2	c.3268C>T	p.Q1090*	Nonsense	3/24	-
1-162729727-C-G	DDR2	c.813C>G	p.I271M	Missense	8/18	-
19-19627087-G-T	NDUFA13	c.40G>T	p.G14W	Missense	1/5	-
4-106197188-G-C	TET2	c.5521G>C	p.E1841Q	Missense	11/11	-
7-40027547-G-C	CDK13	c.1561G>C	p.E521Q	Missense	2/14	-
6-27100520-G-C	H2BC11	c.10C>G	p.P4A	Missense	1/1	-
16-72827349-G-C	ZFHX3	c.9232C>G	p.Q3078E	Missense	9/10	-
17-29559842-C-G	NF1	c.3439C>G	p.L1147V	Missense	26/58	-
5-150924752-T-A	FAT2	c.5936A>T	p.E1979V	Missense	10/24	-
5-161128751-C-A	GABRA6	c.1334C>A	p.T445K	Missense	9/9	-
10-8100286-CGCCTCT-C	GATA3	c.263_268delCTCTGC	p.P88_L89del	InFrameDeletion	3/6	-
9-101611335-GGA-CGG	GALNT12	c.1707_1709delinsCGG	p.D570G	Missense	10/10	-
9-21971005-GC-TT	CDKN2A	c.352_353delinsTT	p.A118N	Missense	2/3	-
16-14020564-G-A	ERCC4	c.535G>A	p.E179K	Missense	3/11	-
9-101585594-C-A	GALNT12	c.428C>A	p.A143E	Missense	2/10	-
8-145739707-C-G	RECQL4	c.1744G>C	p.E582Q	Missense	11/22	-
6-26032111-C-A	H3C2	c.178G>T	p.E60*	Nonsense	1/1	-
12-133240704-T-C	POLE	c.2592A>G	p.I864M	Missense	23/49	-
19-17952523-T-A	JAK3	c.910A>T	p.K304*	Nonsense	7/24	-
9-8521429-A-G	PTPRD	c.809T>C	p.M270T	Missense	20/46	-
9-8633317-C-G	PTPRD	c.352G>C	p.E118Q	Missense	14/46	-
X-123220578-A-T	STAG2	c.3235A>T	p.T1079S	Missense	30/35	-
X-70341505-A-T	MED12	c.940A>T	p.S314C	Missense	7/45	-
12-130184695-C-A	TMEM132D	c.628G>T	p.A210S	Missense	2/9	-
X-123181224-T-G	STAG2	c.688T>G	p.L230V	Missense	9/35	-
15-99251255-G-A	IGF1R	c.559G>A	p.E187K	Missense	2/21	-
5-176715911-G-T	NSD1	c.6243G>T	p.L2081F	Missense	21/23	-
7-151833978-T-C	KMT2C	c.14675A>G	p.D4892G	Missense	59/59	-
9-139412594-G-T	NOTCH1	c.1250C>A	p.S417*	Nonsense	7/34	-
19-15299065-G-T	NOTCH3	c.1473C>A	p.F491L	Missense	9/33	-
9-139400106-G-C	NOTCH1	c.4242C>G	p.C1414W	Missense	25/34	-
8-139144994-C-T	FAM135B	c.4063G>A	p.E1355K	Missense	20/20	-
X-70345563-G-A	MED12	c.2422G>A	p.G808S	Missense	17/45	-
2-141214057-A-T	LRP1B	c.9930T>A	p.N3310K	Missense	62/91	-
17-37676279-G-A	CDK12	c.3034G>A	p.E1012K	Missense	11/14	-
1-45295387-G-C	PTCH2	c.982C>G	p.L328V	Missense	8/22	-
X-76938202-G-A	ATRX	c.2546C>T	p.S849F	Missense	9/35	-
15-101938686-C-G	PCSK6	c.917G>C	p.G306R	Missense	8/23	-
16-23647615-G-C	PALB2	c.252C>G	p.I84M	Missense	4/13	-
14-75514432-C-G	MLH3	c.1927G>C	p.G643R	Missense	2/13	-
X-1540725-G-C	ASMTL	c.1071C>G	p.N357K	Missense	9/13	-
9-139391615-G-C	NOTCH1	c.6576C>G	p.D2192E	Missense	34/34	-
7-151853332-C-A	KMT2C	c.11770G>T	p.E3924*	Nonsense	45/59	-
12-56495462-GA-AG	ERBB3	c.3652_3653delinsAG	p.E1218R	Missense	28/28	-
19-50905061-CC-AG	POLD1	c.343_344delinsAG	p.P115S	Missense	4/27	-
12-133212514-G-C	POLE	c.5775C>G	p.I1925M	Missense	42/49	-
1-45296645-A-C	PTCH2	c.688T>G	p.S230A	Missense	6/22	-
22-29121040-C-A	CHEK2	c.517G>T	p.E173*	Nonsense	4/15	-
15-99459957-G-T	IGF1R	c.2053G>T	p.E685*	Nonsense	10/21	-
11-32456678-C-T	WT1	c.214G>A	p.D77N	Missense	1/10	-
16-72828093-G-A	ZFHX3	c.8488C>T	p.L2830=	Synonymous	9/10	-
4-187517850-G-A	FAT1	c.12844C>T	p.P4282S	Missense	25/27	-
6-32172148-C-A	NOTCH4	c.2884G>T	p.G962*	Nonsense	19/30	-
16-72832508-G-C	ZFHX3	c.4073C>G	p.S1358*	Nonsense	9/10	-
7-151859747-C-A	KMT2C	c.10915G>T	p.E3639*	Nonsense	43/59	-
9-87482239-C-A	NTRK2	c.1526C>A	p.S509Y	Missense	14/19	-
22-41573738-C-G	EP300	c.6023C>G	p.S2008C	Missense	31/31	-
12-432854-G-A	KDM5A	c.2062C>T	p.L688F	Missense	15/28	-
2-212248519-G-C	ERBB4	c.3748C>G	p.R1250G	Missense	28/28	-
12-48367919-C-G	COL2A1	c.4270G>C	p.E1424Q	Missense	53/54	-
22-41564566-G-C	EP300	c.3988G>C	p.D1330H	Missense	24/31	-
11-69588836-G-A	FGF4	c.400C>T	p.R134W	Missense	2/3	-
3-189612104-C-T	TP63	c.1856C>T	p.T619I	Missense	14/14	-
3-89499354-C-G	EPHA3	c.2524C>G	p.R842G	Missense	15/17	-
X-70352024-G-A	MED12	c.4221G>A	p.M1407I	Missense	30/45	-
1-120510804-C-A	NOTCH2	c.1160G>T	p.G387V	Missense	7/34	-
1-120467977-C-A	NOTCH2	c.4462G>T	p.E1488*	Nonsense	25/34	-
7-81355310-C-G	HGF	c.1064G>C	p.R355P	Missense	9/18	-
19-18277103-A-C	PIK3R2	c.1550A>C	p.E517A	Missense	12/16	-
X-63412484-T-G	AMER1	c.683A>C	p.N228T	Missense	2/2	-
2-141625174-T-A	LRP1B	c.4564A>T	p.S1522C	Missense	27/91	-
19-19257412-G-T	MEF2B	c.721C>A	p.P241T	Missense	7/9	-
3-49924847-T-A	MST1R	c.4096A>T	p.S1366C	Missense	20/20	-
17-12011176-G-T	MAP2K4	c.583G>T	p.V195L	Missense	5/11	-
19-15296472-T-C	NOTCH3	c.1970A>G	p.E657G	Missense	13/33	-
8-128752819-C-G	MYC	c.980C>G	p.P327R	Missense	3/3	-
13-26923284-T-A	CDK8	c.280T>A	p.W94R	Missense	3/13	-
1-179078228-C-G	ABL2	c.2174G>C	p.R725T	Missense	12/12	-
5-150922182-G-A	FAT2	c.8506C>T	p.L2836=	Synonymous	10/24	-
13-28931774-G-C	FLT1	c.2165C>G	p.T722R	Missense	15/30	-
9-98224185-G-C	PTCH1	c.2656C>G	p.L886V	Missense	16/24	-
6-27839793-G-C	H3C11	c.301C>G	p.L101V	Missense	1/1	-
3-178742809-A-G	ZMAT3	c.866T>C	p.V289A	Missense	6/6	-
5-35871166-G-C	IL7R	c.388G>C	p.E130Q	Missense	4/8	-
16-2122854-C-T	TSC2	c.2225C>T	p.S742L	Missense	21/42	-
1-46724383-C-G	RAD54L	c.236C>G	p.S79*	Nonsense	4/18	-
5-150925787-T-C	FAT2	c.4901A>G	p.D1634G	Missense	10/24	-
2-178098864-G-A	NFE2L2	c.181C>T	p.Q61*	Nonsense	2/5	-
5-35871190-GTC-ATG	IL7R	c.412_414delinsATG	p.V138M	Missense	4/8	-
17-37883091-TC-AT	ERBB2	c.2994_2995delinsAT	p.S998_P999delinsRS	MultiAAMissense	25/27	-
19-19257097-A-G	MEF2B	c.866T>C	p.V289A	Missense	8/9	-
12-465622-C-A	KDM5A	c.754G>T	p.A252S	Missense	6/28	-
22-24176347-A-G	SMARCB1	c.1138A>G	p.N380D	Missense	9/9	-
1-235345700-T-C	ARID4B	c.2534A>G	p.K845R	Missense	20/24	-
18-18586364-T-G	ROCK1	c.1833A>C	p.E611D	Missense	16/33	-
16-11349199-G-A	SOCS1	c.137C>T	p.P46L	Missense	2/2	-
9-139412225-A-T	NOTCH1	c.1420T>A	p.F474I	Missense	8/34	-
12-21630903-T-C	RECQL	c.701A>G	p.D234G	Missense	7/15	-
17-15964897-T-C	NCOR1	c.5699A>G	p.Y1900C	Missense	37/46	-
5-176638671-C-T	NSD1	c.3271C>T	p.L1091F	Missense	5/23	-
19-41765781-C-A	AXL	c.2657C>A	p.A886E	Missense	20/20	-
7-105182915-G-C	RINT1	c.334G>C	p.E112Q	Missense	4/15	-
7-135047791-T-A	CNOT4	c.1988A>T	p.Q663L	Missense	12/12	-
11-108218066-C-A	ATM	c.8645C>A	p.S2882*	Nonsense	59/63	-
5-180056990-C-A	FLT4	c.629G>T	p.W210L	Missense	5/30	-
7-55211017-G-T	EGFR	c.260G>T	p.G87V	Missense	3/28	-
7-151841829-G-T	KMT2C	c.14312C>A	p.S4771Y	Missense	55/59	-
19-11491609-C-A	EPOR	c.778G>T	p.V260L	Missense	6/8	-
9-97912289-T-C	FANCC	c.602A>G	p.E201G	Missense	7/15	-
7-138189038-G-C	TRIM24	c.368G>C	p.G123A	Missense	2/19	-
8-30999023-G-A	WRN	c.3045G>A	p.W1015*	Nonsense	25/35	-
17-56435033-C-A	RNF43	c.2104G>T	p.G702*	Nonsense	9/10	-
3-47158236-T-A	SETD2	c.4463A>T	p.N1488I	Missense	4/21	-
4-143130130-G-C	INPP4B	c.886C>G	p.L296V	Missense	13/26	-
5-150906914-G-A	FAT2	c.10189C>T	p.R3397*	Nonsense	17/24	-
3-142211986-C-T	ATR	c.6066G>A	p.M2022I	Missense	35/47	-
19-11488857-C-T	EPOR	c.1330G>A	p.E444K	Missense	8/8	-
19-11488952-G-C	EPOR	c.1235C>G	p.S412W	Missense	8/8	-
14-45645084-G-C	FANCM	c.3127G>C	p.V1043L	Missense	14/23	-
9-98238431-C-T	PTCH1	c.1613G>A	p.G538E	Missense	12/24	-
16-3786769-T-A	CREBBP	c.4442A>T	p.D1481V	Missense	27/31	-
4-55133746-C-G	PDGFRA	c.959C>G	p.T320S	Missense	7/23	-
3-142184025-C-A	ATR	c.6955G>T	p.G2319*	Nonsense	41/47	-
5-150889697-G-A	FAT2	c.11944C>T	p.H3982Y	Missense	22/24	-
3-142178153-T-C	ATR	c.7265A>G	p.K2422R	Missense	43/47	-
16-396631-G-T	AXIN1	c.395C>A	p.S132*	Nonsense	2/11	-
2-173420890-GC-TT	PDK1	c.12_13delinsTT	p.R5W	Missense	1/11	-
9-139412222-G-T	NOTCH1	c.1423C>A	p.Q475K	Missense	8/34	-
11-118361958-G-A	KMT2A	c.4744G>A	p.E1582K	Missense	14/36	-
16-2093624-C-G	NTHL1	c.653G>C	p.G210A	Missense	4/6	-
17-37680952-G-T	CDK12	c.3121G>T	p.E1041*	Nonsense	12/14	-
2-141253247-G-T	LRP1B	c.8921C>A	p.S2974*	Nonsense	56/91	-
4-40245166-C-A	RHOH	c.160C>A	p.L54M	Missense	3/3	-
1-94645323-G-C	ARHGAP29	c.2438C>G	p.S813*	Nonsense	20/23	-
15-40675169-G-A	KNSTRN	c.133G>A	p.G45S	Missense	1/9	-
1-45291951-C-A	PTCH2	c.3085G>T	p.G1029C	Missense	19/22	-
17-15978916-C-G	NCOR1	c.3602G>C	p.R1201T	Missense	27/46	-
4-187517710-C-T	FAT1	c.12984G>A	p.W4328*	Nonsense	25/27	-
14-75514513-C-A	MLH3	c.1846G>T	p.E616*	Nonsense	2/13	-
13-110437578-C-T	IRS2	c.823G>A	p.D275N	Missense	1/2	-
2-84811192-C-A	DNAH6	c.2299C>A	p.P767T	Missense	15/77	-
17-70120487-C-T	SOX9	c.1489C>T	p.H497Y	Missense	3/3	-
1-51436045-C-T	CDKN2C	c.5C>T	p.A2V	Missense	1/2	-
19-33793010-C-T	CEBPA	c.311G>A	p.G104D	Missense	1/1	-
2-178098963-TATCTTGCCTCCA-T	NFE2L2	c.70_81del12	p.W24_D27del	InFrameDeletion	2/5	-
11-22646634-AAGCCAGTGGACT-A	FANCF	c.711_722del12	p.V238_L241del	InFrameDeletion	1/1	-
6-35423662-AG-CA	FANCE	c.387_388delinsCA	p.D130N	Missense	2/10	-
19-2206772-AGA-CAT	DOT1L	c.832_834delAGAinsCAT	p.R278H	Missense	10/28	-
4-187549912-G-C	FAT1	c.4329C>G	p.F1443L	Missense	8/27	-
22-41560089-T-C	EP300	c.3761T>C	p.M1254T	Missense	22/31	-
20-41306747-G-T	PTPRT	c.912C>A	p.Y304*	Nonsense	7/31	-
3-119534187-C-G	NR1I2	c.955C>G	p.L319V	Missense	7/9	-
2-178096513-G-A	NFE2L2	c.818C>T	p.S273L	Missense	5/5	-
7-128470764-G-T	FLNC	c.73G>T	p.E25*	Nonsense	1/48	-
13-103515081-A-G	ERCC5	c.1582A>G	p.T528A	Missense	8/15	-
3-47098316-C-T	SETD2	c.6958G>A	p.V2320I	Missense	15/21	-
3-134960091-A-C	EPHB1	c.2448A>C	p.E816D	Missense	13/16	-
10-88649965-A-G	BMPR1A	c.214A>G	p.I72V	Missense	4/13	-
4-106155661-A-C	TET2	c.562A>C	p.K188Q	Missense	3/11	-
6-106553740-C-A	PRDM1	c.1705C>A	p.Q569K	Missense	5/7	-
7-151848556-GA-G	KMT2C	c.12637delT	p.S4213Lfs*5	Frameshift	50/59	-
2-39213063-T-TA	SOS1	c.3903_3903dupT	p.I1302Yfs*3	Frameshift	23/23	-
5-150948092-CA-C	FAT2	c.401delT	p.V134Gfs*11	Frameshift	2/24	-
20-31022403-TC-T	ASXL1	c.1888delC	p.H630Tfs*73	Frameshift	13/13	-
17-7579472-GGGGGGAGCAGCCTCTGGCA-G	TP53	c.197_215del19	p.M66Tfs*51	Frameshift	4/11	-
14-95582036-TGA-T	DICER1	c.1874_1875delTC	p.V625Dfs*11	Frameshift	11/27	-
17-7578185-GGCTCA-G	TP53	c.660_664delTGAGC	p.E221Afs*2	Frameshift	6/11	-
19-15288708-C-CA	NOTCH3	c.4030dupT	p.C1344Lfs*219	Frameshift	24/33	-
6-26271206-GCT-G	H3C8	c.405_406delAG	p.R135Sfs*8	Frameshift	1/1	-
3-52437685-ACT-A	BAP1	c.1474_1475delAG	p.S492Yfs*6	Frameshift	13/17	-
17-7576903-GA-G	TP53	c.943delT	p.S315Lfs*30	Frameshift	9/11	-
17-37682362-GC-G	CDK12	c.3557delC	p.P1186Qfs*2	Frameshift	13/14	-
17-7578207-TA-T	TP53	c.642delT	p.H214Qfs*33	Frameshift	6/11	-
9-98248077-C-CA	PTCH1	c.473_473dupT	p.M158Ifs*6	Frameshift	3/24	-
3-52441275-C-CA	BAP1	c.494_494dupT	p.M165Ifs*18	Frameshift	7/17	-
22-29121082-TA-T	CHEK2	c.475delT	p.Y159Tfs*2	Frameshift	4/15	-
1-120461957-AGCTGCCACTGCAG-A	NOTCH2	c.5747_5759del13	p.A1916Vfs*10	Frameshift	31/34	-
3-47139451-CCT-C	SETD2	c.5135_5136delAG	p.K1712Rfs*15	Frameshift	9/21	-
16-9857251-A-AG	GRIN2A	c.4149dupC	p.S1384Lfs*15	Frameshift	13/13	-
5-79968651-A-AT	MSH3	c.1002_1002dupT	p.T335Yfs*18	Frameshift	6/24	-
1-120484160-ACTCATTGATG-A	NOTCH2	c.2961_2970delCATCAATGAG	p.I988Afs*45	Frameshift	18/34	-
14-95566256-AGATTACAGTTGCT-A	DICER1	c.4054_4066del13	p.S1352Cfs*23	Frameshift	22/27	-
12-133210842-GT-G	POLE	c.5933delA	p.N1978Tfs*21	Frameshift	43/49	-
12-46233114-A-C	ARID2	c.1333A>C	p.M445L	Missense	11/21	-
1-186122981-A-G	HMCN1	c.15118A>G	p.N5040D	Missense	97/107	-
11-118307253-T-C	KMT2A	c.26T>C	p.F9S	Missense	1/36	-
2-212251627-C-G	ERBB4	c.3432G>C	p.E1144D	Missense	27/28	-
3-134851889-C-T	EPHB1	c.1295C>T	p.A432V	Missense	5/16	-
3-186504346-T-G	EIF4A2	c.683T>G	p.F228C	Missense	7/11	-
5-56155650-C-CG	MAP3K1	c.743_743dupG	p.R249Tfs*52	Frameshift	3/20	-
5-138118990-GA-G	CTNNA1	c.230delA	p.D77Vfs*18	Frameshift	3/18	-
14-35871857-C-CAG	NFKBIA	c.648_649insCT	p.G217Lfs*22	Frameshift	5/6	-
12-459846-TC-T	KDM5A	c.1249delG	p.D417Tfs*8	Frameshift	10/28	-
5-150887137-GTGTCCTTCTGAACAACC-G	FAT2	c.12079_12095del17	p.G4027Lfs*62	Frameshift	23/24	-
9-139403494-TCCACGCAGGTG-T	NOTCH1	c.2988_2998del11	p.T997Rfs*24	Frameshift	19/34	-
9-139410493-CA-C	NOTCH1	c.1609delT	p.C537Afs*94	Frameshift	10/34	-
13-110434673-GTC-G	IRS2	c.3726_3727delGA	p.E1242Dfs*82	Frameshift	1/2	-
5-138269587-CAA-C	CTNNA1	c.2533_2534delAA	p.K845Vfs*32	Frameshift	18/18	-
17-56437530-A-AG	RNF43	c.931dupC	p.L311Pfs*132	Frameshift	8/10	-
17-7579348-GA-G	TP53	c.338delT	p.F113Sfs*10	Frameshift	4/11	-
4-187539676-AAGAAC-A	FAT1	c.8059_8063delGTTCT	p.V2687Cfs*4	Frameshift	10/27	-
X-63412261-A-AT	AMER1	c.905dupA	p.N302Kfs*22	Frameshift	2/2	-
9-139399212-AG-A	NOTCH1	c.4930delC	p.L1644Cfs*5	Frameshift	26/34	-
9-139399456-CCG-C	NOTCH1	c.4685_4686delCG	p.A1562Gfs*47	Frameshift	26/34	-
X-39931781-T-TA	BCOR	c.2817_2817dupT	p.T940Yfs*6	Frameshift	4/15	-
19-15271746-TG-T	NOTCH3	c.6692delC	p.P2231Qfs*15	Frameshift	33/33	-
20-30946604-A-G	ASXL1	c.26A>G	p.K9R	Missense	1/13	-
22-41574264-G-C	EP300	c.6549G>C	p.L2183F	Missense	31/31	-
22-41565527-T-G	EP300	c.4193T>G	p.L1398R	Missense	26/31	-
11-124742785-T-A	ROBO3	c.1336T>A	p.L446M	Missense	9/28	-
2-209116253-C-T	IDH1	c.23G>A	p.G8D	Missense	3/10	-
1-120484157-G-C	NOTCH2	c.2973C>G	p.C991W	Missense	18/34	-
5-150947076-G-T	FAT2	c.1417C>A	p.P473T	Missense	2/24	-
22-41566442-C-G	EP300	c.4319C>G	p.P1440R	Missense	27/31	-
4-187521442-G-A	FAT1	c.11713C>T	p.Q3905*	Nonsense	22/27	-
19-2222502-T-A	DOT1L	c.3334T>A	p.S1112T	Missense	24/28	-
1-120460299-G-A	NOTCH2	c.6016C>T	p.Q2006*	Nonsense	33/34	-
3-49924868-T-C	MST1R	c.4075A>G	p.T1359A	Missense	20/20	-
17-7578370-C-T	TP53	c.559+1G>A	-	IntronicSNV	-	5/10
13-49033844-C-T	RB1	c.1981C>T	p.R661W	Missense	20/27	-
17-7577556-C-A	TP53	c.725G>T	p.C242F	Missense	7/11	-
1-115258745-C-G	NRAS	c.37G>C	p.G13R	Missense	2/7	-
17-7578208-T-C	TP53	c.641A>G	p.H214R	Missense	6/11	-
17-7578526-C-A	TP53	c.404G>T	p.C135F	Missense	5/11	-
17-7574018-G-A	TP53	c.1009C>T	p.R337C	Missense	10/11	-
17-7578203-C-T	TP53	c.646G>A	p.V216M	Missense	6/11	-
17-7577079-C-A	TP53	c.859G>T	p.E287*	Nonsense	8/11	-
5-112128191-C-T	APC	c.694C>T	p.R232*	Nonsense	7/16	-
17-7579528-C-T	TP53	c.159G>A	p.W53*	Nonsense	4/11	-
3-12645699-G-A	RAF1	c.770C>T	p.S257L	Missense	7/17	-
13-32950836-C-T	BRCA2	c.8662C>T	p.R2888C	Missense	21/27	-
9-98232138-G-A	PTCH1	c.1804C>T	p.R602*	Nonsense	13/24	-
17-7578427-T-G	TP53	c.503A>C	p.H168P	Missense	5/11	-
12-25398262-C-G	KRAS	c.57G>C	p.L19F	Missense	2/5	-
13-48941648-C-T	RB1	c.958C>T	p.R320*	Nonsense	10/27	-
9-21971120-G-A	CDKN2A	c.238C>T	p.R80*	Nonsense	2/3	-
9-21974792-G-T	CDKN2A	c.35C>A	p.S12*	Nonsense	1/3	-
17-7577518-T-A	TP53	c.763A>T	p.I255F	Missense	7/11	-
22-29121242-G-A	CHEK2	c.433C>T	p.R145W	Missense	3/15	-
17-7578479-G-A	TP53	c.451C>T	p.P151S	Missense	5/11	-
10-89690842-C-A	PTEN	c.249C>A	p.C83*	Nonsense	4/9	-
19-40741238-C-T	AKT2	c.1195G>A	p.D399N	Missense	12/14	-
17-7578431-G-A	TP53	c.499C>T	p.Q167*	Nonsense	5/11	-
12-48393725-G-A	COL2A1	c.269C>T	p.P90L	Missense	2/54	-
17-7577100-T-C	TP53	c.838A>G	p.R280G	Missense	8/11	-
17-7577105-G-C	TP53	c.833C>G	p.P278R	Missense	8/11	-
17-7578272-G-C	TP53	c.577C>G	p.H193D	Missense	6/11	-
4-55131142-G-A	PDGFRA	c.685G>A	p.E229K	Missense	5/23	-
17-7578493-C-T	TP53	c.437G>A	p.W146*	Nonsense	5/11	-
17-17119708-TG-T	FLCN	c.1285delC	p.H429Tfs*39	Frameshift	11/14	-
7-81334827-C-T	HGF	c.1889G>A	p.R630Q	Missense	17/18	-
17-7578500-G-A	TP53	c.430C>T	p.Q144*	Nonsense	5/11	-
7-81346551-G-A	HGF	c.1402C>T	p.R468C	Missense	11/18	-
7-116339521-A-G	MET	c.383A>G	p.D128G	Missense	2/21	-
17-7578176-C-T	TP53	c.672+1G>A	-	IntronicSNV	-	6/10
10-123279522-C-T	FGFR2	c.910G>A	p.D304N	Missense	7/18	-
22-30057288-C-G	NF2	c.770C>G	p.P257R	Missense	8/16	-
22-38374090-G-A	SOX10	c.481C>T	p.R161C	Missense	3/4	-
17-7578550-G-T	TP53	c.380C>A	p.S127Y	Missense	5/11	-
6-162864433-T-A	PRKN	c.80A>T	p.K27M	Missense	2/12	-
17-7578503-C-T	TP53	c.427G>A	p.V143M	Missense	5/11	-
17-7578268-A-C	TP53	c.581T>G	p.L194R	Missense	6/11	-
17-7579358-C-A	TP53	c.329G>T	p.R110L	Missense	4/11	-
17-7578535-T-C	TP53	c.395A>G	p.K132R	Missense	5/11	-
17-7578442-T-G	TP53	c.488A>C	p.Y163S	Missense	5/11	-
17-7578413-C-A	TP53	c.517G>T	p.V173L	Missense	5/11	-
17-7577581-A-G	TP53	c.700T>C	p.Y234H	Missense	7/11	-
17-7577094-G-C	TP53	c.844C>G	p.R282G	Missense	8/11	-
3-178921548-G-A	PIK3CA	c.1030G>A	p.V344M	Missense	5/21	-
17-7579575-G-A	TP53	c.112C>T	p.Q38*	Nonsense	4/11	-
17-7578554-A-G	TP53	c.376T>C	p.Y126H	Missense	5/11	-
17-7578271-T-A	TP53	c.578A>T	p.H193L	Missense	6/11	-
10-89717708-C-T	PTEN	c.733C>T	p.Q245*	Nonsense	7/9	-
17-7579415-C-T	TP53	c.272G>A	p.W91*	Nonsense	4/11	-
17-7578227-C-A	TP53	c.622G>T	p.D208Y	Missense	6/11	-
X-76937290-G-A	ATRX	c.3458C>T	p.S1153L	Missense	9/35	-
17-7577575-A-G	TP53	c.706T>C	p.Y236H	Missense	7/11	-
17-7577046-C-A	TP53	c.892G>T	p.E298*	Nonsense	8/11	-
9-21971186-G-A	CDKN2A	c.172C>T	p.R58*	Nonsense	2/3	-
2-178098954-C-G	NFE2L2	c.91G>C	p.G31R	Missense	2/5	-
18-48591825-G-A	SMAD4	c.988G>A	p.E330K	Missense	9/12	-
9-139412588-C-T	NOTCH1	c.1255+1G>A	-	IntronicSNV	-	7/33
22-22127164-C-T	MAPK1	c.964G>A	p.E322K	Missense	7/9	-
2-178098959-T-C	NFE2L2	c.86A>G	p.D29G	Missense	2/5	-
5-131931451-TA-T	RAD50	c.2165delA	p.K722Rfs*14	Frameshift	13/25	-
17-41201137-C-T	BRCA1	c.5406+1G>A	-	IntronicSNV	-	21/22
19-10602619-C-T	KEAP1	c.959G>A	p.R320Q	Missense	3/6	-
5-180057744-C-T	FLT4	c.211G>A	p.G71R	Missense	3/30	-
17-7578205-C-T	TP53	c.644G>A	p.S215N	Missense	6/11	-
17-41246531-CT-C	BRCA1	c.1016delA	p.K339Rfs*2	Frameshift	10/23	-
17-7578441-G-C	TP53	c.489C>G	p.Y163*	Nonsense	5/11	-
17-7576852-C-A	TP53	c.993+1G>T	-	IntronicSNV	-	9/10
17-7578224-T-A	TP53	c.625A>T	p.R209*	Nonsense	6/11	-
17-7577082-C-A	TP53	c.856G>T	p.E286*	Nonsense	8/11	-
5-56177644-G-A	MAP3K1	c.2617G>A	p.V873I	Missense	14/20	-
17-11998898-C-T	MAP2K4	c.400C>T	p.R134W	Missense	4/11	-
17-7579529-C-T	TP53	c.158G>A	p.W53*	Nonsense	4/11	-
2-178098810-C-G	NFE2L2	c.235G>C	p.E79Q	Missense	2/5	-
16-3788618-G-A	CREBBP	c.4336C>T	p.R1446C	Missense	26/31	-
22-41565529-G-A	EP300	c.4195G>A	p.D1399N	Missense	26/31	-
2-178098960-C-G	NFE2L2	c.85G>C	p.D29H	Missense	2/5	-
2-178098967-T-A	NFE2L2	c.78A>T	p.Q26H	Missense	2/5	-
2-178098956-A-C	NFE2L2	c.89T>G	p.L30R	Missense	2/5	-
9-139413085-G-A	NOTCH1	c.1057C>T	p.R353C	Missense	6/34	-
1-27106617-C-G	ARID1A	c.6228C>G	p.Y2076*	Nonsense	20/20	-
17-7579406-G-T	TP53	c.281C>A	p.S94*	Nonsense	4/11	-
17-7577127-C-T	TP53	c.811G>A	p.E271K	Missense	8/11	-
17-7578189-A-T	TP53	c.660T>A	p.Y220*	Nonsense	6/11	-
17-7579313-G-T	TP53	c.374C>A	p.T125K	Missense	4/11	-
17-7574017-C-A	TP53	c.1010G>T	p.R337L	Missense	10/11	-
17-7579355-A-C	TP53	c.332T>G	p.L111R	Missense	4/11	-
17-7577579-G-T	TP53	c.702C>A	p.Y234*	Nonsense	7/11	-
17-7577571-A-T	TP53	c.710T>A	p.M237K	Missense	7/11	-
7-55221800-G-A	EGFR	c.844G>A	p.E282K	Missense	7/28	-
12-46230605-G-A	ARID2	c.854G>A	p.R285Q	Missense	8/21	-
19-17949174-C-A	JAK3	c.1467G>T	p.Q489H	Missense	11/24	-
17-7574021-C-A	TP53	c.1006G>T	p.E336*	Nonsense	10/11	-
9-139412664-C-T	NOTCH1	c.1180G>A	p.G394S	Missense	7/34	-
X-63413105-C-T	AMER1	c.62G>A	p.R21H	Missense	2/2	-
22-41568590-G-A	EP300	c.4540G>A	p.E1514K	Missense	28/31	-
12-112926915-G-A	PTPN11	c.1535G>A	p.R512Q	Missense	13/16	-
1-193104712-G-A	CDC73	c.416G>A	p.R139Q	Missense	5/17	-
17-41246446-C-T	BRCA1	c.1102G>A	p.E368K	Missense	10/23	-
17-7578410-T-A	TP53	c.520A>T	p.R174W	Missense	5/11	-
18-48591925-G-T	SMAD4	c.1088G>T	p.C363F	Missense	9/12	-
7-152007126-C-T	KMT2C	c.774G>A	p.W258*	Nonsense	6/59	-
17-41256183-G-T	BRCA1	c.397C>A	p.R133S	Missense	6/23	-
5-150885331-CG-TA	FAT2	c.12844_12845delCGinsTA	p.R4282*	Nonsense	24/24	-
9-80537095-G-T	GNAQ	c.303C>A	p.Y101*	Nonsense	2/7	-
4-187519130-G-A	FAT1	c.12253C>T	p.Q4085*	Nonsense	23/27	-
5-251542-C-T	SDHA	c.1753C>T	p.R585W	Missense	13/15	-
2-178098959-T-G	NFE2L2	c.86A>C	p.D29A	Missense	2/5	-
17-7577095-GTC-G	TP53	c.841_842delGA	p.D281Pfs*24	Frameshift	8/11	-
17-7578397-TG-T	TP53	c.532delC	p.H178Tfs*69	Frameshift	5/11	-
17-7579409-AG-A	TP53	c.277delC	p.L93Cfs*30	Frameshift	4/11	-
17-7577087-G-C	TP53	c.851C>G	p.T284R	Missense	8/11	-
17-7578283-GC-G	TP53	c.565delG	p.A189Pfs*58	Frameshift	6/11	-
17-58740401-A-AT	PPM1D	c.1307_1307dupT	p.P437Tfs*6	Frameshift	6/6	-
4-106197666-G-A	TET2	c.5999G>A	p.R2000K	Missense	11/11	-
8-145740620-G-A	RECQL4	c.1397C>T	p.P466L	Missense	8/22	-
9-98248148-G-A	PTCH1	c.403C>T	p.R135*	Nonsense	3/24	-
16-3788649-A-C	CREBBP	c.4305T>G	p.D1435E	Missense	26/31	-
2-29474092-C-T	ALK	c.2083G>A	p.G695S	Missense	12/29	-
4-187542642-C-A	FAT1	c.5098G>T	p.E1700*	Nonsense	10/27	-
20-31023408-C-T	ASXL1	c.2893C>T	p.R965*	Nonsense	13/13	-
17-33428330-C-T	RAD51D	c.793G>A	p.G265R	Missense	9/10	-
9-139412204-C-T	NOTCH1	c.1441G>A	p.G481S	Missense	8/34	-
9-139412252-C-T	NOTCH1	c.1393G>A	p.A465T	Missense	8/34	-
22-22127163-T-G	MAPK1	c.965A>C	p.E322A	Missense	7/9	-
17-7577520-A-C	TP53	c.761T>G	p.I254S	Missense	7/11	-
2-48026852-G-A	MSH6	c.1730G>A	p.R577H	Missense	4/10	-
9-139413072-A-G	NOTCH1	c.1070T>C	p.F357S	Missense	6/34	-
9-139412375-C-T	NOTCH1	c.1270G>A	p.E424K	Missense	8/34	-
17-7579418-G-A	TP53	c.269C>T	p.S90F	Missense	4/11	-
9-139412326-C-A	NOTCH1	c.1319G>T	p.C440F	Missense	8/34	-
19-47422005-G-A	ARHGAP35	c.73G>A	p.E25K	Missense	2/7	-
3-52437782-G-C	BAP1	c.1379C>G	p.S460*	Nonsense	13/17	-
17-7577143-CAGT-C	TP53	c.792_794delACT	p.L265del	InFrameDeletion	8/11	-
9-98248009-G-T	PTCH1	c.542C>A	p.S181*	Nonsense	3/24	-
3-12641689-G-A	RAF1	c.952C>T	p.R318W	Missense	9/17	-
17-7578502-A-T	TP53	c.428T>A	p.V143E	Missense	5/11	-
9-139413069-TAGA-T	NOTCH1	c.1070_1072delTCT	p.F357del	InFrameDeletion	6/34	-
9-139412245-C-A	NOTCH1	c.1400G>T	p.C467F	Missense	8/34	-
2-198263197-C-T	SF3B1	c.3122G>A	p.R1041H	Missense	21/25	-
13-32954022-CA-C	BRCA2	c.9097delA	p.T3033Lfs*29	Frameshift	23/27	-
17-7579582-CA-C	TP53	c.104delT	p.L35Cfs*9	Frameshift	4/11	-
10-123239454-C-A	FGFR2	c.2383G>T	p.D795Y	Missense	18/18	-
11-94189472-AT-A	MRE11	c.1532delA	p.N511Ifs*13	Frameshift	14/20	-
22-41574838-C-T	EP300	c.7123C>T	p.Q2375*	Nonsense	31/31	-
12-4479628-C-T	FGF23	c.637G>A	p.A213T	Missense	3/3	-
2-225339021-C-T	CUL3	c.2248G>A	p.E750K	Missense	16/16	-
4-55161371-G-A	PDGFRA	c.3202G>A	p.E1068K	Missense	23/23	-
10-89717661-C-G	PTEN	c.686C>G	p.S229*	Nonsense	7/9	-
20-31022839-T-A	ASXL1	c.2324T>A	p.L775*	Nonsense	13/13	-
2-225368395-C-T	CUL3	c.1351G>A	p.E451K	Missense	9/16	-
3-47164273-G-C	SETD2	c.1853C>G	p.S618*	Nonsense	3/21	-
9-139399276-C-T	NOTCH1	c.4867G>A	p.E1623K	Missense	26/34	-
17-7579699-C-T	TP53	c.96+1G>A	-	IntronicSNV	-	3/10
17-7576851-A-C	TP53	c.993+2T>G	-	IntronicSNV	-	9/10
17-7578249-AT-A	TP53	c.599delA	p.N200Ifs*47	Frameshift	6/11	-
9-98231084-TGA-T	PTCH1	c.2197_2198delTC	p.S733Ifs*4	Frameshift	14/24	-
7-151845693-T-C	KMT2C	c.13319A>G	p.Y4440C	Missense	52/59	-
7-148524338-G-A	EZH2	c.646C>T	p.R216W	Missense	7/20	-
9-139396497-G-A	NOTCH1	c.5428C>T	p.Q1810*	Nonsense	29/34	-
9-135776134-G-A	TSC1	c.2593C>T	p.Q865*	Nonsense	20/23	-
11-119144603-C-T	CBL	c.616C>T	p.R206*	Nonsense	4/16	-
9-139412212-C-T	NOTCH1	c.1433G>A	p.C478Y	Missense	8/34	-
19-10600376-C-G	KEAP1	c.1479G>C	p.E493D	Missense	4/6	-
17-47699375-G-A	SPOP	c.133C>T	p.R45W	Missense	3/10	-
22-42525827-C-G	CYP2D6	c.265G>C	p.E89Q	Missense	2/9	-
2-141214085-G-T	LRP1B	c.9902C>A	p.P3301H	Missense	62/91	-
19-11144808-G-A	SMARCA4	c.3883G>A	p.E1295K	Missense	28/35	-
6-27777978-C-T	H3C10	c.127C>T	p.R43W	Missense	1/1	-
6-26031973-C-T	H3C2	c.316G>A	p.E106K	Missense	1/1	-
1-11168343-C-T	MTOR	c.7529G>A	p.G2510D	Missense	57/58	-
13-32907110-C-T	BRCA2	c.1495C>T	p.Q499*	Nonsense	10/27	-
22-41566511-T-C	EP300	c.4388T>C	p.L1463P	Missense	27/31	-
22-29095918-C-T	CHEK2	c.916G>A	p.G306R	Missense	9/15	-
7-13971324-G-A	ETV1	c.605C>T	p.T202M	Missense	9/14	-
20-57484611-G-A	GNAS	c.695G>A	p.R232H	Missense	9/13	-
13-28589323-C-T	FLT3	c.2724G>A	p.M908I	Missense	22/24	-
6-26056132-C-G	H1-2	c.525G>C	p.K175N	Missense	1/1	-
7-40118378-G-A	CDK13	c.2957G>A	p.R986H	Missense	11/14	-
5-150934134-T-C	FAT2	c.3734A>G	p.K1245R	Missense	5/24	-
7-86468997-C-T	GRM3	c.2167C>T	p.R723W	Missense	4/6	-
17-7579321-C-CA	TP53	c.365dupT	p.T123Dfs*26	Frameshift	4/11	-
1-120458783-C-T	NOTCH2	c.6562G>A	p.A2188T	Missense	34/34	-
17-37881022-G-A	ERBB2	c.2351G>A	p.R784H	Missense	20/27	-
13-49030402-C-G	RB1	c.1877C>G	p.A626G	Missense	19/27	-
2-47657081-G-A	MSH2	c.1276+1G>A	-	IntronicSNV	-	7/15
3-187443336-G-C	BCL6	c.1790C>G	p.S597C	Missense	8/10	-
X-39933151-G-A	BCOR	c.1448C>T	p.P483L	Missense	4/15	-
17-37627919-C-T	CDK12	c.1834C>T	p.Q612*	Nonsense	2/14	-
12-133256768-C-T	POLE	c.326G>A	p.R109K	Missense	4/49	-
7-55224280-C-T	EGFR	c.1061C>T	p.T354M	Missense	9/28	-
17-40839754-G-A	CNTNAP1	c.1061G>A	p.R354H	Missense	8/24	-
3-89259610-G-T	EPHA3	c.754G>T	p.V252L	Missense	3/17	-
9-139412742-G-C	NOTCH1	c.1102C>G	p.L368V	Missense	7/34	-
22-41568557-T-G	EP300	c.4507T>G	p.Y1503D	Missense	28/31	-
19-2199910-G-A	DOT1L	c.679G>A	p.E227K	Missense	8/28	-
9-97879600-G-C	FANCC	c.1069C>G	p.Q357E	Missense	11/15	-
9-87636213-C-T	NTRK2	c.2378C>T	p.T793M	Missense	19/19	-
16-3786787-G-A	CREBBP	c.4424C>T	p.P1475L	Missense	27/31	-
19-11098465-C-T	SMARCA4	c.983C>T	p.P328L	Missense	6/35	-
16-2136341-G-A	TSC2	c.4810G>A	p.G1604S	Missense	37/42	-
13-48951166-C-G	RB1	c.1328C>G	p.S443*	Nonsense	13/27	-
2-141458106-G-T	LRP1B	c.6512C>A	p.A2171D	Missense	41/91	-
2-212989506-C-T	ERBB4	c.205G>A	p.E69K	Missense	2/28	-
7-140534579-A-T	BRAF	c.334T>A	p.S112T	Missense	3/18	-
3-52443892-C-T	BAP1	c.3G>A	p.M1?	Missense	1/17	-
19-11106958-C-T	SMARCA4	c.1663C>T	p.Q555*	Nonsense	10/35	-
9-139402784-C-T	NOTCH1	c.3225G>A	p.W1075*	Nonsense	20/34	-
19-2217865-C-T	DOT1L	c.2639C>T	p.P880L	Missense	22/28	-
8-51449291-G-C	SNTG1	c.603G>C	p.K201N	Missense	11/19	-
9-37015126-G-T	PAX5	c.278C>A	p.P93H	Missense	3/10	-
16-72827934-T-C	ZFHX3	c.8647A>G	p.M2883V	Missense	9/10	-
17-15961884-C-T	NCOR1	c.5911G>A	p.D1971N	Missense	38/46	-
20-36022614-C-T	SRC	c.487C>T	p.R163W	Missense	7/14	-
3-178942585-G-C	PIK3CA	c.2392G>C	p.E798Q	Missense	16/21	-
4-1808585-C-T	FGFR3	c.2198C>T	p.A733V	Missense	17/18	-
3-41266450-G-C	CTNNB1	c.247G>C	p.D83H	Missense	4/15	-
1-27023685-C-A	ARID1A	c.791C>A	p.S264*	Nonsense	1/20	-
4-187628266-G-A	FAT1	c.2716C>T	p.Q906*	Nonsense	2/27	-
5-38945824-G-A	RICTOR	c.4402C>T	p.L1468F	Missense	34/38	-
19-15276608-C-T	NOTCH3	c.5657G>A	p.G1886D	Missense	30/33	-
17-7578489-AACCC-A	TP53	c.437_440delGGGT	p.W146Lfs*23	Frameshift	5/11	-
19-11488938-C-G	EPOR	c.1249G>C	p.E417Q	Missense	8/8	-
12-113515249-C-T	DTX1	c.280C>T	p.R94C	Missense	3/10	-
3-41266891-A-G	CTNNB1	c.562A>G	p.I188V	Missense	5/15	-
7-151919142-G-T	KMT2C	c.3443C>A	p.S1148*	Nonsense	22/59	-
2-142237983-C-T	LRP1B	c.325G>A	p.E109K	Missense	3/91	-
2-198265448-C-G	SF3B1	c.2709G>C	p.Q903H	Missense	18/25	-
19-15297996-C-T	NOTCH3	c.1760G>A	p.R587H	Missense	11/33	-
9-136913405-C-T	BRD3	c.886G>A	p.G296S	Missense	6/12	-
15-88669522-C-T	NTRK3	c.1376G>A	p.R459Q	Missense	13/20	-
9-21971202-C-CA	CDKN2A	c.155dupT	p.M52Ifs*68	Frameshift	2/3	-
1-116932282-G-A	ATP1A1	c.976G>A	p.G326S	Missense	8/23	-
9-139413165-C-T	NOTCH1	c.977G>A	p.G326D	Missense	6/34	-
X-47032581-C-T	RBM10	c.487C>T	p.R163W	Missense	5/24	-
9-139418227-GC-G	NOTCH1	c.344delG	p.G115Afs*8	Frameshift	3/34	-
7-86416133-C-T	GRM3	c.1025C>T	p.P342L	Missense	3/6	-
11-77934649-G-A	GAB2	c.1376C>T	p.S459F	Missense	6/10	-
19-17945768-C-T	JAK3	c.2092G>A	p.E698K	Missense	16/24	-
10-8100507-G-T	GATA3	c.481G>T	p.V161F	Missense	3/6	-
17-47696739-C-T	SPOP	c.209G>A	p.R70Q	Missense	4/10	-
17-66521916-G-A	PRKAR1A	c.571G>A	p.A191T	Missense	7/11	-
9-139413151-C-A	NOTCH1	c.991G>T	p.D331Y	Missense	6/34	-
17-7579578-GA-G	TP53	c.109delT	p.S37Pfs*7	Frameshift	4/11	-
20-31022390-AG-A	ASXL1	c.1879delG	p.A627Rfs*76	Frameshift	13/13	-
9-8492898-G-A	PTPRD	c.2431C>T	p.R811C	Missense	27/46	-
3-89391087-C-T	EPHA3	c.1153C>T	p.R385*	Nonsense	5/17	-
2-141625798-G-A	LRP1B	c.4204C>T	p.P1402S	Missense	26/91	-
14-45605469-G-A	FANCM	c.235G>A	p.A79T	Missense	1/23	-
4-187521103-C-T	FAT1	c.12052G>A	p.A4018T	Missense	22/27	-
7-128845086-G-A	SMO	c.580G>A	p.E194K	Missense	3/12	-
1-27100922-C-T	ARID1A	c.4204C>T	p.Q1402*	Nonsense	18/20	-
16-3652140-C-T	SLX4	c.929G>A	p.R310Q	Missense	4/15	-
22-41565578-A-C	EP300	c.4244A>C	p.H1415P	Missense	26/31	-
17-29508761-G-T	NF1	c.688G>T	p.E230*	Nonsense	7/58	-
11-46917494-G-GC	LRP4	c.1123dupG	p.A375Gfs*24	Frameshift	10/38	-
17-37666007-G-A	CDK12	c.2659G>A	p.E887K	Missense	7/14	-
6-32945698-T-G	BRD2	c.1494T>G	p.D498E	Missense	9/13	-
5-150925497-G-A	FAT2	c.5191C>T	p.R1731*	Nonsense	10/24	-
2-225368470-C-A	CUL3	c.1276G>T	p.D426Y	Missense	9/16	-
19-38951082-T-A	RYR1	c.2428T>A	p.C810S	Missense	20/106	-
19-2223485-G-A	DOT1L	c.3596G>A	p.R1199Q	Missense	25/28	-
9-139396847-AC-A	NOTCH1	c.5260delG	p.V1754Cfs*44	Frameshift	28/34	-
3-52620481-G-C	PBRM1	c.3272C>G	p.S1091*	Nonsense	21/30	-
13-28980002-G-A	FLT1	c.1466C>T	p.S489F	Missense	11/30	-