PMID: 35610705

Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics.

Immunity & ageing : I & A

Uddin, Md Mesbah MM, Zhou, Ying Y, Bick, Alexander G AG, Burugula, Bala Bharathi BB, Jaiswal, Siddhartha S, Desai, Pinkal P, Honigberg, Michael C MC, Love, Shelly-Ann SA, Barac, Ana A, Hayden, Kathleen M KM, Manson, JoAnn E JE, Whitsel, Eric A EA, Kooperberg, Charles C, Natarajan, Pradeep P, Reiner, Alexander P AP, Kitzman, Jacob O JO

2022-05-24

275 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
11-119148919-T-C	CBL	c.1139T>C	p.L380P	Missense	8/16	-
11-119148930-T-C	CBL	c.1150T>C	p.C384R	Missense	8/16	-
11-119149251-G-A	CBL	c.1259G>A	p.R420Q	Missense	9/16	-
15-90631935-G-A	IDH2	c.418C>T	p.R140W	Missense	4/11	-
2-25457243-G-A	DNMT3A	c.2644C>T	p.R882C	Missense	23/23	-
2-25457176-G-A	DNMT3A	c.2711C>T	p.P904L	Missense	23/23	-
21-44514777-T-G	U2AF1	c.470A>C	p.Q157P	Missense	6/8	-
21-44514777-T-C	U2AF1	c.470A>G	p.Q157R	Missense	6/8	-
2-198267359-C-G	SF3B1	c.1998G>C	p.K666N	Missense	14/25	-
2-198267359-C-A	SF3B1	c.1998G>T	p.K666N	Missense	14/25	-
2-25457269-T-C	DNMT3A	c.2618A>G	p.H873R	Missense	23/23	-
4-106180783-T-TG	TET2	c.3812_3812dupG	p.C1271Wfs*29	Frameshift	7/11	-
2-25468888-C-T	DNMT3A	c.1474+1G>A	-	IntronicSNV	-	12/22
4-106158509-G-A	TET2	c.3409+1G>A	-	IntronicSNV	-	3/10
20-31022592-C-T	ASXL1	c.2077C>T	p.R693*	Nonsense	13/13	-
2-198266611-C-T	SF3B1	c.2225G>A	p.G742D	Missense	16/25	-
2-198267360-T-C	SF3B1	c.1997A>G	p.K666R	Missense	14/25	-
2-25463307-C-T	DNMT3A	c.2186G>A	p.R729Q	Missense	19/23	-
2-25463286-C-T	DNMT3A	c.2207G>A	p.R736H	Missense	19/23	-
17-58740529-C-A	PPM1D	c.1434C>A	p.C478*	Nonsense	6/6	-
11-119148991-G-A	CBL	c.1211G>A	p.C404Y	Missense	8/16	-
2-25463310-C-A	DNMT3A	c.2183G>T	p.G728V	Missense	19/23	-
17-58740749-C-T	PPM1D	c.1654C>T	p.R552*	Nonsense	6/6	-
17-58740432-C-G	PPM1D	c.1337C>G	p.S446*	Nonsense	6/6	-
4-106164772-C-T	TET2	c.3640C>T	p.R1214W	Missense	6/11	-
2-25463229-A-G	DNMT3A	c.2264T>C	p.F755S	Missense	19/23	-
2-25463287-G-A	DNMT3A	c.2206C>T	p.R736C	Missense	19/23	-
2-25464537-C-T	DNMT3A	c.1976G>A	p.R659H	Missense	17/23	-
2-25464544-C-T	DNMT3A	c.1969G>A	p.V657M	Missense	17/23	-
2-25470498-G-A	DNMT3A	c.976C>T	p.R326C	Missense	8/23	-
2-25464451-G-A	DNMT3A	c.2062C>T	p.R688C	Missense	17/23	-
2-25466800-G-A	DNMT3A	c.1903C>T	p.R635W	Missense	16/23	-
2-25470497-C-T	DNMT3A	c.977G>A	p.R326H	Missense	8/23	-
4-106197269-C-T	TET2	c.5602C>T	p.H1868Y	Missense	11/11	-
1-1747229-T-C	GNB1	c.169A>G	p.K57E	Missense	5/12	-
4-106197140-C-T	TET2	c.5473C>T	p.Q1825*	Nonsense	11/11	-
4-106197317-A-G	TET2	c.5650A>G	p.T1884A	Missense	11/11	-
11-119148967-G-A	CBL	c.1187G>A	p.C396Y	Missense	8/16	-
4-106197378-A-G	TET2	c.5711A>G	p.H1904R	Missense	11/11	-
17-7572990-CT-C	TP53	c.1118delA	p.K373Rfs*49	Frameshift	11/11	-
2-25462009-CG-C	DNMT3A	c.2397delC	p.G800Vfs*2	Frameshift	20/23	-
4-106155921-TC-T	TET2	c.822delC	p.N275Ifs*18	Frameshift	3/11	-
2-25463170-C-T	DNMT3A	c.2322+1G>A	-	IntronicSNV	-	19/22
4-106197285-T-C	TET2	c.5618T>C	p.I1873T	Missense	11/11	-
4-106193931-C-T	TET2	c.4393C>T	p.R1465*	Nonsense	10/11	-
4-106196213-C-T	TET2	c.4546C>T	p.R1516*	Nonsense	11/11	-
4-106180865-G-A	TET2	c.3893G>A	p.C1298Y	Missense	7/11	-
4-106164830-G-A	TET2	c.3698G>A	p.W1233*	Nonsense	6/11	-
4-106164831-G-A	TET2	c.3699G>A	p.W1233*	Nonsense	6/11	-
2-25463247-C-T	DNMT3A	c.2246G>A	p.R749H	Missense	19/23	-
2-25463554-A-T	DNMT3A	c.2128T>A	p.C710S	Missense	18/23	-
2-25463553-C-G	DNMT3A	c.2129G>C	p.C710S	Missense	18/23	-
2-25463536-C-T	DNMT3A	c.2146G>A	p.V716I	Missense	18/23	-
2-25463289-T-C	DNMT3A	c.2204A>G	p.Y735C	Missense	19/23	-
20-31022286-T-TA	ASXL1	c.1772dupA	p.Y591*	Nonsense	13/13	-
4-106158157-C-T	TET2	c.3058C>T	p.Q1020*	Nonsense	3/11	-
2-25463586-C-T	DNMT3A	c.2096G>A	p.G699D	Missense	18/23	-
2-25463293-A-G	DNMT3A	c.2200T>C	p.F734L	Missense	19/23	-
2-25463291-G-T	DNMT3A	c.2202C>A	p.F734L	Missense	19/23	-
2-25463291-G-C	DNMT3A	c.2202C>G	p.F734L	Missense	19/23	-
2-25457185-A-C	DNMT3A	c.2702T>G	p.L901R	Missense	23/23	-
2-25463308-G-A	DNMT3A	c.2185C>T	p.R729W	Missense	19/23	-
17-58740432-C-A	PPM1D	c.1337C>A	p.S446*	Nonsense	6/6	-
4-106158187-C-T	TET2	c.3088C>T	p.Q1030*	Nonsense	3/11	-
4-106157527-C-T	TET2	c.2428C>T	p.Q810*	Nonsense	3/11	-
2-25464487-G-A	DNMT3A	c.2026C>T	p.R676W	Missense	17/23	-
2-25458595-A-G	DNMT3A	c.2578T>C	p.W860R	Missense	22/23	-
2-25470573-G-A	DNMT3A	c.901C>T	p.R301W	Missense	8/23	-
2-25467072-C-T	DNMT3A	c.1803G>A	p.W601*	Nonsense	15/23	-
2-25463289-T-G	DNMT3A	c.2204A>C	p.Y735S	Missense	19/23	-
4-106155931-C-T	TET2	c.832C>T	p.Q278*	Nonsense	3/11	-
2-25470560-C-T	DNMT3A	c.914G>A	p.W305*	Nonsense	8/23	-
2-25470559-C-T	DNMT3A	c.915G>A	p.W305*	Nonsense	8/23	-
2-25470588-C-T	DNMT3A	c.886G>A	p.V296M	Missense	8/23	-
17-58740380-AG-A	PPM1D	c.1288delG	p.V430*	Frameshift	6/6	-
17-58740505-TC-T	PPM1D	c.1412delC	p.P471Qfs*12	Frameshift	6/6	-
20-31024371-C-T	ASXL1	c.3856C>T	p.Q1286*	Nonsense	13/13	-
2-25463298-A-G	DNMT3A	c.2195T>C	p.F732S	Missense	19/23	-
2-25458594-C-T	DNMT3A	c.2579G>A	p.W860*	Nonsense	22/23	-
2-25458593-C-T	DNMT3A	c.2580G>A	p.W860*	Nonsense	22/23	-
17-58740527-TGC-T	PPM1D	c.1435_1436delGC	p.A479*	Frameshift	6/6	-
4-106158446-T-TA	TET2	c.3348_3348dupA	p.N1118Kfs*12	Frameshift	3/11	-
2-25464490-C-T	DNMT3A	c.2023G>A	p.V675M	Missense	17/23	-
2-25468186-C-T	DNMT3A	c.1490G>A	p.C497Y	Missense	13/23	-
2-25470512-G-A	DNMT3A	c.962C>T	p.A321V	Missense	8/23	-
2-25457255-A-G	DNMT3A	c.2632T>C	p.S878P	Missense	23/23	-
20-31022853-C-T	ASXL1	c.2338C>T	p.Q780*	Nonsense	13/13	-
4-106190803-G-T	TET2	c.4081G>T	p.G1361C	Missense	9/11	-
4-106162586-G-A	TET2	c.3500G>A	p.R1167K	Missense	4/11	-
4-106164913-C-A	TET2	c.3781C>A	p.R1261S	Missense	6/11	-
4-106180845-G-C	TET2	c.3873G>C	p.W1291C	Missense	7/11	-
4-106190882-A-G	TET2	c.4160A>G	p.N1387S	Missense	9/11	-
4-106197255-C-T	TET2	c.5588C>T	p.A1863V	Missense	11/11	-
4-106197379-T-G	TET2	c.5712T>G	p.H1904Q	Missense	11/11	-
4-106156423-AAC-A	TET2	c.1328_1329delCA	p.T443Nfs*11	Frameshift	3/11	-
2-25467151-G-A	DNMT3A	c.1724C>T	p.A575V	Missense	15/23	-
4-106180839-T-G	TET2	c.3867T>G	p.C1289W	Missense	7/11	-
2-25466799-C-T	DNMT3A	c.1904G>A	p.R635Q	Missense	16/23	-
20-31022598-C-T	ASXL1	c.2083C>T	p.Q695*	Nonsense	13/13	-
2-25463562-C-T	DNMT3A	c.2120G>A	p.G707D	Missense	18/23	-
2-25466800-G-C	DNMT3A	c.1903C>G	p.R635G	Missense	16/23	-
20-31022277-C-T	ASXL1	c.1762C>T	p.Q588*	Nonsense	13/13	-
4-106157404-C-T	TET2	c.2305C>T	p.Q769*	Nonsense	3/11	-
2-25469529-G-GC	DNMT3A	c.1238_1238dup	p.F414Lfs*7	Frameshift	10/23	-
2-25470473-C-T	DNMT3A	c.1001G>A	p.G334D	Missense	8/23	-
2-25470905-C-T	DNMT3A	c.855+1G>A	-	IntronicSNV	-	7/22
2-25467408-C-T	DNMT3A	c.1667+1G>A	-	IntronicSNV	-	14/22
4-106157329-C-T	TET2	c.2230C>T	p.Q744*	Nonsense	3/11	-
20-31022382-C-T	ASXL1	c.1867C>T	p.Q623*	Nonsense	13/13	-
4-106157700-T-A	TET2	c.2601T>A	p.Y867*	Nonsense	3/11	-
4-106157914-C-T	TET2	c.2815C>T	p.Q939*	Nonsense	3/11	-
4-106180785-C-A	TET2	c.3813C>A	p.C1271*	Nonsense	7/11	-
20-31022432-TGCCATCGGAGG-T	ASXL1	c.1919_1929del11	p.A640Gfs*14	Frameshift	13/13	-
4-106180774-AG-A	TET2	c.3804delG	p.R1269Efs*94	Frameshift	7/11	-
2-25467428-C-T	DNMT3A	c.1648G>A	p.G550R	Missense	14/23	-
11-119149241-C-T	CBL	c.1249C>T	p.P417S	Missense	9/16	-
2-25471001-C-T	DNMT3A	c.760G>A	p.A254T	Missense	7/23	-
2-25469641-G-A	DNMT3A	c.1127C>T	p.A376V	Missense	10/23	-
2-25467133-C-T	DNMT3A	c.1742G>A	p.W581*	Nonsense	15/23	-
2-25467132-C-T	DNMT3A	c.1743G>A	p.W581*	Nonsense	15/23	-
2-25467073-C-T	DNMT3A	c.1802G>A	p.W601*	Nonsense	15/23	-
2-25462068-A-G	DNMT3A	c.2339T>C	p.I780T	Missense	20/23	-
2-25469633-G-A	DNMT3A	c.1135C>T	p.R379C	Missense	10/23	-
2-25467023-C-T	DNMT3A	c.1851+1G>A	-	IntronicSNV	-	15/22
2-25464450-C-T	DNMT3A	c.2063G>A	p.R688H	Missense	17/23	-
2-25462077-G-C	DNMT3A	c.2330C>G	p.P777R	Missense	20/23	-
4-106197379-T-A	TET2	c.5712T>A	p.H1904Q	Missense	11/11	-
4-106156048-C-T	TET2	c.949C>T	p.Q317*	Nonsense	3/11	-
4-106190798-G-A	TET2	c.4076G>A	p.R1359H	Missense	9/11	-
2-25469150-G-T	DNMT3A	c.1308C>A	p.Y436*	Nonsense	11/23	-
17-7573925-A-G	TP53	c.1100+2T>C	-	IntronicSNV	-	10/10
17-7573926-C-T	TP53	c.1100+1G>A	-	IntronicSNV	-	10/10
4-106156651-AT-A	TET2	c.1557delT	p.F519Lfs*14	Frameshift	3/11	-
2-25469945-C-T	DNMT3A	c.1097G>A	p.R366H	Missense	9/23	-
4-106157317-C-T	TET2	c.2218C>T	p.Q740*	Nonsense	3/11	-
2-25469529-GC-G	DNMT3A	c.1238delG	p.G413Afs*238	Frameshift	10/23	-
17-58740665-C-T	PPM1D	c.1570C>T	p.Q524*	Nonsense	6/6	-
2-25466766-C-T	DNMT3A	c.1936+1G>A	-	IntronicSNV	-	16/22
2-25461997-A-G	DNMT3A	c.2408+2T>C	-	IntronicSNV	-	20/22
2-25467436-A-T	DNMT3A	c.1640T>A	p.L547H	Missense	14/23	-
4-106157416-G-T	TET2	c.2317G>T	p.G773*	Nonsense	3/11	-
11-119148501-G-A	CBL	c.1042G>A	p.D348N	Missense	7/16	-
2-25470968-C-T	DNMT3A	c.793G>A	p.V265M	Missense	7/23	-
2-25470581-C-T	DNMT3A	c.893G>A	p.G298E	Missense	8/23	-
2-25464439-G-A	DNMT3A	c.2074C>T	p.Q692*	Nonsense	17/23	-
17-58740446-G-T	PPM1D	c.1351G>T	p.E451*	Nonsense	6/6	-
2-25468194-G-T	DNMT3A	c.1482C>A	p.C494*	Nonsense	13/23	-
4-106197287-G-T	TET2	c.5620G>T	p.E1874*	Nonsense	11/11	-
2-25470583-C-A	DNMT3A	c.891G>T	p.W297C	Missense	8/23	-
2-25470583-C-G	DNMT3A	c.891G>C	p.W297C	Missense	8/23	-
17-58740737-A-T	PPM1D	c.1642A>T	p.K548*	Nonsense	6/6	-
2-25467126-G-T	DNMT3A	c.1749C>A	p.C583*	Nonsense	15/23	-
2-25463575-G-C	DNMT3A	c.2107C>G	p.L703V	Missense	18/23	-
2-25463565-C-T	DNMT3A	c.2117G>A	p.G706E	Missense	18/23	-
2-25462024-A-T	DNMT3A	c.2383T>A	p.W795R	Missense	20/23	-
2-25462024-A-G	DNMT3A	c.2383T>C	p.W795R	Missense	20/23	-
2-25463248-G-C	DNMT3A	c.2245C>G	p.R749G	Missense	19/23	-
4-106157700-T-G	TET2	c.2601T>G	p.Y867*	Nonsense	3/11	-
2-25466805-G-A	DNMT3A	c.1898C>T	p.P633L	Missense	16/23	-
4-106197293-G-A	TET2	c.5626G>A	p.A1876T	Missense	11/11	-
4-106156935-TG-T	TET2	c.1842delG	p.L615Sfs*24	Frameshift	3/11	-
2-25505508-C-T	DNMT3A	c.250G>A	p.A84T	Missense	4/23	-
2-25463176-G-T	DNMT3A	c.2317C>A	p.L773I	Missense	19/23	-
2-25457265-A-T	DNMT3A	c.2622T>A	p.Y874*	Nonsense	23/23	-
20-31023083-C-A	ASXL1	c.2568C>A	p.C856*	Nonsense	13/13	-
4-106190812-G-T	TET2	c.4090G>T	p.E1364*	Nonsense	9/11	-
2-25469150-G-C	DNMT3A	c.1308C>G	p.Y436*	Nonsense	11/23	-
2-25467485-C-T	DNMT3A	c.1591G>A	p.D531N	Missense	14/23	-
2-25467428-C-G	DNMT3A	c.1648G>C	p.G550R	Missense	14/23	-
2-25463242-AG-A	DNMT3A	c.2250delC	p.F751Sfs*28	Frameshift	19/23	-
2-25467447-G-GC	DNMT3A	c.1628dupG	p.R544Pfs*2	Frameshift	14/23	-
2-25467113-GC-G	DNMT3A	c.1761delG	p.H588Tfs*63	Frameshift	15/23	-
4-106156878-AC-A	TET2	c.1782delC	p.N595Ifs*6	Frameshift	3/11	-
2-25467163-GC-G	DNMT3A	c.1711delG	p.A571Lfs*80	Frameshift	15/23	-
2-25469990-CA-C	DNMT3A	c.1051delT	p.C351Afs*56	Frameshift	9/23	-
4-106158260-TA-T	TET2	c.3165delA	p.V1056Lfs*10	Frameshift	3/11	-
2-25497814-CT-C	DNMT3A	c.634delA	p.R212Gfs*13	Frameshift	6/23	-
4-106162523-CT-C	TET2	c.3442delT	p.Y1148Ifs*4	Frameshift	4/11	-
4-106197434-GA-G	TET2	c.5772delA	p.A1925Pfs*25	Frameshift	11/11	-
4-106197424-CA-C	TET2	c.5761delA	p.M1921Wfs*29	Frameshift	11/11	-
20-31024425-CT-C	ASXL1	c.3915delT	p.F1305Lfs*145	Frameshift	13/13	-
4-106157366-T-TA	TET2	c.2268dupA	p.L757Tfs*12	Frameshift	3/11	-
4-106180919-C-T	TET2	c.3947C>T	p.P1316L	Missense	7/11	-
4-106197528-C-T	TET2	c.5861C>T	p.A1954V	Missense	11/11	-
2-25470480-C-A	DNMT3A	c.994G>T	p.G332*	Nonsense	8/23	-
2-25469924-AG-A	DNMT3A	c.1117delC	p.L373Cfs*34	Frameshift	9/23	-
4-106196323-TCAGA-T	TET2	c.4661_4664delCAGA	p.T1554Sfs*16	Frameshift	11/11	-
2-25470971-G-A	DNMT3A	c.790C>T	p.P264S	Missense	7/23	-
2-25463302-A-T	DNMT3A	c.2191T>A	p.F731I	Missense	19/23	-
4-106182981-T-TG	TET2	c.4021_4021dupG	p.A1341Gfs*3	Frameshift	8/11	-
4-106162544-C-T	TET2	c.3458C>T	p.A1153V	Missense	4/11	-
2-25466845-G-A	DNMT3A	c.1858C>T	p.P620S	Missense	16/23	-
2-25463185-A-C	DNMT3A	c.2308T>G	p.S770A	Missense	19/23	-
2-25463266-G-C	DNMT3A	c.2227C>G	p.P743A	Missense	19/23	-
2-25464470-TG-T	DNMT3A	c.2043delC	p.M682Cfs*23	Frameshift	17/23	-
4-106155202-C-T	TET2	c.103C>T	p.Q35*	Nonsense	3/11	-
4-106180845-G-T	TET2	c.3873G>T	p.W1291C	Missense	7/11	-
2-25457265-A-C	DNMT3A	c.2622T>G	p.Y874*	Nonsense	23/23	-
2-25458627-G-T	DNMT3A	c.2546C>A	p.P849H	Missense	22/23	-
2-25459821-T-C	DNMT3A	c.2462A>G	p.H821R	Missense	21/23	-
2-25463583-G-T	DNMT3A	c.2099C>A	p.P700Q	Missense	18/23	-
2-25464486-C-A	DNMT3A	c.2027G>T	p.R676L	Missense	17/23	-
2-25469082-T-A	DNMT3A	c.1376A>T	p.K459M	Missense	11/23	-
2-25470002-A-T	DNMT3A	c.1040T>A	p.L347Q	Missense	9/23	-
2-25470615-C-T	DNMT3A	c.859G>A	p.G287S	Missense	8/23	-
4-106156606-G-T	TET2	c.1507G>T	p.E503*	Nonsense	3/11	-
17-58740532-TA-T	PPM1D	c.1440delA	p.A481Pfs*2	Frameshift	6/6	-
2-25463240-GA-G	DNMT3A	c.2252delT	p.F751Sfs*28	Frameshift	19/23	-
4-106156900-AC-A	TET2	c.1803delC	p.S602Pfs*37	Frameshift	3/11	-
2-25470940-G-A	DNMT3A	c.821C>T	p.A274V	Missense	7/23	-
4-106158014-CT-C	TET2	c.2917delT	p.C973Afs*34	Frameshift	3/11	-
20-31024098-C-T	ASXL1	c.3583C>T	p.Q1195*	Nonsense	13/13	-
2-25467407-A-G	DNMT3A	c.1667+2T>C	-	IntronicSNV	-	14/22
2-25457171-T-A	DNMT3A	c.2716A>T	p.K906*	Nonsense	23/23	-
2-25523007-C-T	DNMT3A	c.177+1G>A	-	IntronicSNV	-	3/22
6-43336704-C-T	ZNF318	c.399+1G>A	-	IntronicSNV	-	1/9
20-31019484-T-C	ASXL1	c.979+2T>C	-	IntronicSNV	-	10/12
4-106197527-G-A	TET2	c.5860G>A	p.A1954T	Missense	11/11	-
17-58740842-A-T	PPM1D	c.1747A>T	p.R583*	Nonsense	6/6	-
2-25505421-C-T	DNMT3A	c.337G>A	p.G113R	Missense	4/23	-
2-25505421-C-G	DNMT3A	c.337G>C	p.G113R	Missense	4/23	-
2-25505463-G-A	DNMT3A	c.295C>T	p.P99S	Missense	4/23	-
4-106180775-GGAGAACTTGCGCCT-G	TET2	c.3805_3818del14	p.R1269Sfs*26	SpliceAcceptorDeletion	7/11	-
2-25469492-C-A	DNMT3A	c.1276G>T	p.E426*	Nonsense	10/23	-
6-43320121-G-A	ZNF318	c.2764C>T	p.Q922*	Nonsense	5/10	-
2-25463295-CTCA-C	DNMT3A	c.2196_2198delTGA	p.F732_E733delinsL	MultiAAMissense	19/23	-
2-198267447-G-T	SF3B1	c.1910C>A	p.S637Y	Missense	14/25	-
6-43325061-G-A	ZNF318	c.991C>T	p.R331*	Nonsense	3/10	-
4-106197297-A-G	TET2	c.5630A>G	p.K1877R	Missense	11/11	-
4-106182971-A-T	TET2	c.4010A>T	p.Y1337F	Missense	8/11	-
2-25470608-C-A	DNMT3A	c.866G>T	p.G289V	Missense	8/23	-
4-106190809-A-T	TET2	c.4087A>T	p.K1363*	Nonsense	9/11	-
6-43325379-G-A	ZNF318	c.673C>T	p.R225*	Nonsense	3/10	-
4-106197493-G-T	TET2	c.5826G>T	p.Q1942H	Missense	11/11	-
4-106197493-G-C	TET2	c.5826G>C	p.Q1942H	Missense	11/11	-
4-106197471-A-C	TET2	c.5804A>C	p.Y1935S	Missense	11/11	-
20-31023843-C-T	ASXL1	c.3328C>T	p.Q1110*	Nonsense	13/13	-
4-106156746-CA-C	TET2	c.1647delA	p.R550Efs*11	Frameshift	3/11	-
2-25469071-TCCGCTGTGCTC-T	DNMT3A	c.1377_1387del11	p.S460Efs*9	Frameshift	11/23	-
20-31022987-GA-G	ASXL1	c.2475delA	p.G826Efs*12	Frameshift	13/13	-
2-25469975-CT-C	DNMT3A	c.1067delA	p.Q356Rfs*51	Frameshift	9/23	-
4-106155941-ACT-A	TET2	c.845_846delCT	p.S282*	Frameshift	3/11	-
20-31022987-GAA-G	ASXL1	c.2474_2475delAA	p.K825Rfs*7	Frameshift	13/13	-
6-43325228-CG-C	ZNF318	c.823delC	p.R275Vfs*6	Frameshift	3/10	-
4-106197202-G-GATCGGCGCGTTAGAAGACA	TET2	c.5535_5536insATCGGCGCGTTAGAAGACA	p.V1846Ifs*19	Frameshift	11/11	-
2-25466782-CA-C	DNMT3A	c.1920delT	p.F640Lfs*11	Frameshift	16/23	-
4-106157413-AG-A	TET2	c.2314delG	p.E772Kfs*41	Frameshift	3/11	-
4-106155857-ACAGT-A	TET2	c.762_765delTCAG	p.S254Rfs*38	Frameshift	3/11	-
20-31022925-GGACCCACCGTTCCTGCA-G	ASXL1	c.2414_2430del17	p.P805Qfs*11	Frameshift	13/13	-
4-106157355-TA-T	TET2	c.2259delA	p.E754Rfs*59	Frameshift	3/11	-
2-25466828-AG-A	DNMT3A	c.1874delC	p.P625Lfs*26	Frameshift	16/23	-
4-106156342-G-GT	TET2	c.1244_1244dupT	p.P416Sfs*27	Frameshift	3/11	-
4-106156784-CCAGGATGGATTGAA-C	TET2	c.1685_1698del14	p.P562Lfs*16	Frameshift	3/11	-
2-25471036-GGCCTCCTCCAC-G	DNMT3A	c.715_725del11	p.V239Qfs*10	Frameshift	7/23	-
4-106156094-G-GC	TET2	c.996_996dupC	p.S334Ifs*6	Frameshift	3/11	-
20-31023004-GC-G	ASXL1	c.2489delC	p.A830Vfs*8	Frameshift	13/13	-
4-106193893-CG-C	TET2	c.4355delG	p.R1452Qfs*6	Frameshift	10/11	-
20-31023425-CAATGGCAGTT-C	ASXL1	c.2912_2921delATGGCAGTTA	p.N971Tfs*10	Frameshift	13/13	-
2-25467048-CG-C	DNMT3A	c.1827delC	p.F609Lfs*42	Frameshift	15/23	-
4-106182990-T-TG	TET2	c.4030_4030dupG	p.A1344Gfs*3	Frameshift	8/11	-
20-31023698-TC-T	ASXL1	c.3185delC	p.P1062Lfs*47	Frameshift	13/13	-
20-31022670-G-GA	ASXL1	c.2156_2156dupA	p.D720Gfs*54	Frameshift	13/13	-
6-43305379-GC-G	ZNF318	c.6356delG	p.G2119Afs*2	Frameshift	10/10	-
4-106155876-G-GT	TET2	c.778_778dupT	p.L260Ffs*4	Frameshift	3/11	-
4-106197497-TC-T	TET2	c.5833delC	p.H1945Mfs*5	Frameshift	11/11	-
2-25470018-TCA-T	DNMT3A	c.1023_1024delTG	p.K343Afs*49	Frameshift	9/23	-
2-25467054-AC-A	DNMT3A	c.1821delG	p.M607Ifs*44	Frameshift	15/23	-
2-25467120-AC-A	DNMT3A	c.1755delG	p.M585Ifs*66	Frameshift	15/23	-
2-25463564-CCCCAA-C	DNMT3A	c.2114_2118delTTGGG	p.I705Rfs*6	Frameshift	18/23	-
4-106196484-GGTTCA-G	TET2	c.4817_4821delGTTCA	p.G1606Vfs*6	Frameshift	11/11	-
17-58740611-CA-C	PPM1D	c.1516delA	p.T506Lfs*8	Frameshift	6/6	-
4-106157688-T-TG	TET2	c.2589_2590insG	p.H864Afs*8	Frameshift	3/11	-
4-106182955-CT-C	TET2	c.3996delT	p.M1333Wfs*30	Frameshift	8/11	-
4-106162523-CTT-C	TET2	c.3441_3442delTT	p.F1147Lfs*9	Frameshift	4/11	-
5-137803645-C-CGTTA	EGR1	c.1507_1508insGTTA	p.P503Rfs*40	Frameshift	2/2	-