PMID: 36872366

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2.

Signal transduction and targeted therapy

Wang, Penglei P, Jia, Xuechao X, Lu, Bingbing B, Huang, Han H, Liu, Jialin J, Liu, Xuejiao X, Wu, Qiong Q, Hu, Yamei Y, Li, Pan P, Wei, Huifang H, Liu, Tingting T, Zhao, Dengyun D, Zhang, Lingwei L, Tian, Xueli X, Jiang, Yanan Y, Qiao, Yan Y, Nie, Wenna W, Ma, Xinli X, Bai, Ruihua R, Peng, Cong C, Dong, Zigang Z, Liu, Kangdong K

2023-03-06

12 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
3-12633276-TT-GC	RAF1	c.1123_1124delAAinsGC	p.K375A	Missense	11/17	-
15-66729228-AT-GC	MAP2K1	c.436_437delATinsGC	p.M146A	Missense	3/11	-
19-4110508-AT-GC	MAP2K2	c.448_449delATinsGC	p.M150A	Missense	3/11	-
7-55259524-T-A	EGFR	c.2582T>A	p.L861Q	Missense	21/28	-
1-115258747-C-T	NRAS	c.35G>A	p.G12D	Missense	2/7	-
15-66727573-AA-GC	MAP2K1	c.289_290delAAinsGC	p.K97A	Missense	2/11	-
7-55233046-TC-AG	EGFR	c.1796_1797delTCinsAG	p.V599E	Missense	15/28	-
19-17943483-T-A	JAK3	c.2525A>T	p.D842V	Missense	19/24	-
3-12641278-ATA-CTC	RAF1	c.1018_1020delTATinsGAG	p.Y340E	Missense	10/17	-
19-4117418-TT-GC	MAP2K2	c.301_302delAAinsGC	p.K101A	Missense	2/11	-
22-50695609-G-C	MAPK12	c.328C>G	p.P110A	Missense	4/12	-
22-29130457-G-C	CHEK2	c.253C>G	p.P85A	Missense	2/15	-