PMID: 36910641

Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

Frontiers in oncology

He, Ping P, Liu, Jie J, Xu, Qingyuan Q, Ma, Huaijun H, Niu, Beifang B, Huang, Gang G, Wu, Wei W

2023

1347 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
17-7577570-C-A	TP53	c.711G>T	p.M237I	Missense	7/11	-
7-55259524-T-A	EGFR	c.2582T>A	p.L861Q	Missense	21/28	-
7-55242470-T-C	EGFR	c.2240T>C	p.L747S	Missense	19/28	-
13-32914814-C-T	BRCA2	c.6322C>T	p.R2108C	Missense	11/27	-
7-55249005-G-T	EGFR	c.2303G>T	p.S768I	Missense	20/28	-
17-7577547-C-T	TP53	c.734G>A	p.G245D	Missense	7/11	-
12-25398284-C-G	KRAS	c.35G>C	p.G12A	Missense	2/5	-
17-7577534-C-A	TP53	c.747G>T	p.R249S	Missense	7/11	-
17-7577121-G-A	TP53	c.817C>T	p.R273C	Missense	8/11	-
17-7579312-C-T	TP53	c.375G>A	p.T125=	Synonymous	4/11	-
17-7579312-C-A	TP53	c.375G>T	p.T125=	Synonymous	4/11	-
17-7579312-C-G	TP53	c.375G>C	p.T125=	Synonymous	4/11	-
7-55241677-G-A	EGFR	c.2125G>A	p.E709K	Missense	18/28	-
5-112174669-C-G	APC	c.3378C>G	p.S1126R	Missense	16/16	-
17-7578403-C-A	TP53	c.527G>T	p.C176F	Missense	5/11	-
17-7577539-G-A	TP53	c.742C>T	p.R248W	Missense	7/11	-
7-55241708-G-C	EGFR	c.2156G>C	p.G719A	Missense	18/28	-
16-2130243-C-T	TSC2	c.3475C>T	p.R1159W	Missense	30/42	-
13-32906558-T-A	BRCA2	c.943T>A	p.C315S	Missense	10/27	-
19-15298126-G-A	NOTCH3	c.1630C>T	p.R544C	Missense	11/33	-
17-7577548-C-T	TP53	c.733G>A	p.G245S	Missense	7/11	-
17-7577506-C-A	TP53	c.775G>T	p.D259Y	Missense	7/11	-
7-55242465-AGGAATTAAGAGAAGC-A	EGFR	c.2235_2249del15	p.E746_A750del	InFrameDeletion	19/28	-
7-55242466-GGAATTAAGAGAAGCA-G	EGFR	c.2236_2250del15	p.E746_A750del	InFrameDeletion	19/28	-
13-32914277-A-G	BRCA2	c.5785A>G	p.I1929V	Missense	11/27	-
17-7577120-C-A	TP53	c.818G>T	p.R273L	Missense	8/11	-
22-41573672-C-T	EP300	c.5957C>T	p.P1986L	Missense	31/31	-
22-29121242-G-A	CHEK2	c.433C>T	p.R145W	Missense	3/15	-
7-55242467-AATTAAGAGAAGCAAC-A	EGFR	c.2240_2254del15	p.L747_T751del	InFrameDeletion	19/28	-
7-55242470-TTAAGAGAAGCAACATCTC-T	EGFR	c.2240_2257del18	p.L747_P753delinsS	MultiAAMissense	19/28	-
17-7577550-C-T	TP53	c.731G>A	p.G244D	Missense	7/11	-
7-55259434-G-A	EGFR	c.2492G>A	p.R831H	Missense	21/28	-
17-7578263-G-A	TP53	c.586C>T	p.R196*	Nonsense	6/11	-
7-116339770-T-G	MET	c.632T>G	p.L211W	Missense	2/21	-
6-162206876-A-G	PRKN	c.799T>C	p.Y267H	Missense	7/12	-
17-7577106-G-A	TP53	c.832C>T	p.P278S	Missense	8/11	-
17-7577548-C-A	TP53	c.733G>T	p.G245C	Missense	7/11	-
7-55268884-G-A	EGFR	c.2950G>A	p.D984N	Missense	25/28	-
11-108098555-A-G	ATM	c.125A>G	p.H42R	Missense	3/63	-
12-49434689-C-A	KMT2D	c.6864G>T	p.K2288N	Missense	32/55	-
2-48030639-AC-A	MSH6	c.3261delC	p.F1088Sfs*2	Frameshift	5/10	-
12-49444829-C-A	KMT2D	c.2637G>T	p.E879D	Missense	11/55	-
7-81350103-A-C	HGF	c.1229T>G	p.L410R	Missense	10/18	-
10-123324028-T-C	FGFR2	c.442A>G	p.S148G	Missense	4/18	-
17-7579705-C-T	TP53	c.91G>A	p.V31I	Missense	3/11	-
19-1221301-CG-C	STK11	c.827delG	p.G276Afs*11	Frameshift	6/10	-
19-10265416-G-A	DNMT1	c.1678C>T	p.R560C	Missense	21/41	-
12-49425230-G-A	KMT2D	c.13258C>T	p.R4420W	Missense	40/55	-
12-49434507-G-A	KMT2D	c.7046C>T	p.P2349L	Missense	32/55	-
12-49434517-C-T	KMT2D	c.7036G>A	p.G2346S	Missense	32/55	-
12-49446767-C-T	KMT2D	c.1043G>A	p.R348H	Missense	9/55	-
12-49446777-G-C	KMT2D	c.1033C>G	p.L345V	Missense	9/55	-
12-49426003-C-T	KMT2D	c.12485G>A	p.R4162Q	Missense	40/55	-
22-36690220-G-A	MYH9	c.3755C>T	p.A1252V	Missense	28/41	-
12-49427347-C-T	KMT2D	c.11141G>A	p.R3714K	Missense	40/55	-
4-1805473-G-A	FGFR3	c.985G>A	p.V329I	Missense	8/18	-
19-10251537-A-C	DNMT1	c.3443T>G	p.I1148R	Missense	32/41	-
7-116339988-A-G	MET	c.850A>G	p.I284V	Missense	2/21	-
15-66727455-G-T	MAP2K1	c.171G>T	p.K57N	Missense	2/11	-
10-101595975-G-A	ABCC2	c.3542G>A	p.R1181Q	Missense	25/32	-
7-55249007-G-T	EGFR	c.2305G>T	p.V769L	Missense	20/28	-
17-7577551-C-A	TP53	c.730G>T	p.G244C	Missense	7/11	-
17-37868208-C-T	ERBB2	c.929C>T	p.S310F	Missense	8/27	-
10-89685281-C-G	PTEN	c.176C>G	p.S59*	Nonsense	3/9	-
7-55249012-C-CGGT	EGFR	c.2310_2311insGGT	p.D770_N771insG	InFrameInsertion	20/28	-
7-55242465-GGAATTAAGAGAAGCAAC-AAT	EGFR	c.2235_2252delinsAAT	p.E746_T751delinsI	MultiAAMissense	19/28	-
7-55242467-AATTAAGAGAAGCAACATC-T	EGFR	c.2237_2255delinsT	p.E746_S752delinsV	MultiAAMissense	19/28	-
6-150001395-G-A	LATS1	c.2209C>T	p.R737*	Nonsense	5/8	-
11-108224493-G-A	ATM	c.8672G>A	p.G2891D	Missense	60/63	-
16-23619239-G-A	PALB2	c.3296C>T	p.T1099M	Missense	12/13	-
7-142460750-G-C	PRSS1	c.623G>C	p.G208A	Missense	5/5	-
17-7578454-G-T	TP53	c.476C>A	p.A159D	Missense	5/11	-
6-37139063-G-A	PIM1	c.403G>A	p.E135K	Missense	4/6	-
3-47098379-C-T	SETD2	c.6895G>A	p.G2299R	Missense	15/21	-
5-44388714-AAGC-A	FGF10	c.68_70delGCT	p.C23del	InFrameDeletion	1/3	-
3-47103754-GTC-G	SETD2	c.6190_6191delGA	p.D2064Pfs*8	Frameshift	14/21	-
17-56435160-AC-A	RNF43	c.1976delG	p.G659Vfs*41	Frameshift	9/10	-
20-31023472-A-G	ASXL1	c.2957A>G	p.N986S	Missense	13/13	-
13-29012441-C-T	FLT1	c.430G>A	p.E144K	Missense	4/30	-
17-7577018-C-A	TP53	c.919+1G>T	-	IntronicSNV	-	8/10
16-67063336-G-A	CBFB	c.26G>A	p.R9K	Missense	1/6	-
5-131931451-TA-T	RAD50	c.2165delA	p.K722Rfs*14	Frameshift	13/25	-
10-96702012-G-A	CYP2C9	c.395G>A	p.R132Q	Missense	3/9	-
1-27105700-C-T	ARID1A	c.5311C>T	p.P1771S	Missense	20/20	-
1-156851285-C-T	NTRK1	c.2242C>T	p.R748W	Missense	17/17	-
5-56178098-A-G	MAP3K1	c.3071A>G	p.K1024R	Missense	14/20	-
19-11138550-C-G	SMARCA4	c.3306C>G	p.F1102L	Missense	24/35	-
17-7577569-A-G	TP53	c.712T>C	p.C238R	Missense	7/11	-
17-7577099-C-A	TP53	c.839G>T	p.R280I	Missense	8/11	-
17-7578177-C-A	TP53	c.672G>T	p.E224D	Missense	6/11	-
2-128046943-CTCT-C	ERCC3	c.789_791delAGA	p.E264del	InFrameDeletion	6/15	-
11-108098605-G-T	ATM	c.175G>T	p.A59S	Missense	3/63	-
8-41798419-GCTC-G	KAT6A	c.2977_2979delGAG	p.E993del	InFrameDeletion	15/17	-
8-128750604-CCAG-C	MYC	c.154_156delCAG	p.Q52del	InFrameDeletion	2/3	-
2-203395591-G-A	BMPR2	c.1042G>A	p.V348I	Missense	8/13	-
1-46546408-G-A	PIK3R3	c.121C>T	p.P41S	Missense	2/10	-
22-29885580-AAGGCCAAGTCCCCAGAGAAGGAAG-A	NEFH	c.1965_1988del24	p.E658_K665del	InFrameDeletion	4/4	-
6-106536272-A-T	PRDM1	c.239A>T	p.E80V	Missense	2/7	-
3-73114232-C-T	PPP4R2	c.868C>T	p.R290C	Missense	8/9	-
10-43610089-C-G	RET	c.2041C>G	p.Q681E	Missense	11/20	-
20-46279836-ACAG-A	NCOA3	c.3789_3791delGCA	p.Q1276del	InFrameDeletion	20/23	-
2-29416380-T-C	ALK	c.4573A>G	p.K1525E	Missense	29/29	-
16-89838136-T-C	FANCA	c.2101A>G	p.K701E	Missense	23/43	-
10-76781905-GGAA-G	KAT6B	c.3310_3312delGAA	p.E1104del	InFrameDeletion	16/18	-
2-29449820-G-A	ALK	c.3035C>T	p.T1012M	Missense	18/29	-
6-32548032-T-G	HLA-DRB1	c.779A>C	p.Q260P	Missense	5/6	-
17-29653227-A-G	NF1	c.5225A>G	p.N1742S	Missense	37/58	-
5-149512332-G-A	PDGFRB	c.1108C>T	p.R370C	Missense	7/23	-
7-151842355-T-C	KMT2C	c.14057A>G	p.N4686S	Missense	54/59	-
7-55259442-G-T	EGFR	c.2500G>T	p.V834L	Missense	21/28	-
16-2218138-C-G	TRAF7	c.200C>G	p.A67G	Missense	4/21	-
19-41727077-C-T	AXL	c.335C>T	p.T112M	Missense	3/20	-
17-29559887-A-G	NF1	c.3484A>G	p.M1162V	Missense	26/58	-
17-38567951-C-T	TOP2A	c.909G>A	p.M303I	Missense	8/35	-
17-29553484-C-T	NF1	c.2033C>T	p.P678L	Missense	18/58	-
2-209113119-T-C	IDH1	c.388A>G	p.I130V	Missense	4/10	-
1-162731077-G-A	DDR2	c.932G>A	p.S311N	Missense	9/18	-
16-23646208-G-T	PALB2	c.1659C>A	p.H553Q	Missense	4/13	-
12-133256117-G-A	POLE	c.544C>T	p.H182Y	Missense	6/49	-
16-23649269-G-A	PALB2	c.113C>T	p.A38V	Missense	3/13	-
1-156845315-C-T	NTRK1	c.1358C>T	p.P453L	Missense	12/17	-
12-56487317-G-A	ERBB3	c.1463G>A	p.R488Q	Missense	12/28	-
16-3900336-C-T	CREBBP	c.760G>A	p.A254T	Missense	2/31	-
7-55259560-G-A	EGFR	c.2618G>A	p.G873E	Missense	21/28	-
3-47163843-C-T	SETD2	c.2283G>A	p.M761I	Missense	3/21	-
13-32929042-C-G	BRCA2	c.7052C>G	p.A2351G	Missense	14/27	-
16-2220713-CGAG-C	TRAF7	c.343_345delGAG	p.E115del	InFrameDeletion	5/21	-
9-101909965-T-C	TGFBR1	c.1285T>C	p.Y429H	Missense	8/9	-
8-90965508-G-T	NBN	c.1809C>A	p.F603L	Missense	11/16	-
11-108098564-G-A	ATM	c.134G>A	p.R45Q	Missense	3/63	-
13-32907183-A-G	BRCA2	c.1568A>G	p.H523R	Missense	10/27	-
22-29091846-G-A	CHEK2	c.1111C>T	p.H371Y	Missense	11/15	-
22-29083920-T-C	CHEK2	c.1597A>G	p.T533A	Missense	15/15	-
22-29090043-C-T	CHEK2	c.1438G>A	p.A480T	Missense	13/15	-
1-11272529-G-A	MTOR	c.3401C>T	p.A1134V	Missense	23/58	-
16-23646813-C-G	PALB2	c.1054G>C	p.E352Q	Missense	4/13	-
11-119156088-C-T	CBL	c.1753C>T	p.R585C	Missense	11/16	-
17-7578496-A-T	TP53	c.434T>A	p.L145Q	Missense	5/11	-
3-37053562-C-T	MLH1	c.649C>T	p.R217C	Missense	8/19	-
17-41244585-G-A	BRCA1	c.2963C>T	p.S988L	Missense	10/23	-
7-41729740-TTTC-T	INHBA	c.786_788delGAA	p.K263del	InFrameDeletion	3/3	-
3-37089020-C-T	MLH1	c.1742C>T	p.P581L	Missense	16/19	-
2-47637371-A-G	MSH2	c.505A>G	p.I169V	Missense	3/16	-
2-47698132-A-G	MSH2	c.1690A>G	p.T564A	Missense	11/16	-
2-47705625-G-A	MSH2	c.2425G>A	p.E809K	Missense	14/16	-
11-61205535-G-A	SDHAF2	c.320G>A	p.R107H	Missense	3/4	-
3-49723321-AGCGCTG-A	MST1	c.1216_1221delCAGCGC	p.Q406_R407del	InFrameDeletion	10/18	-
19-1220707-G-T	STK11	c.725G>T	p.G242V	Missense	5/10	-
9-80537095-G-T	GNAQ	c.303C>A	p.Y101*	Nonsense	2/7	-
11-119149377-G-A	CBL	c.1385G>A	p.R462Q	Missense	9/16	-
1-226595617-G-C	PARP1	c.14C>G	p.S5W	Missense	1/23	-
X-66765161-A-T	AR	c.173A>T	p.Q58L	Missense	1/8	-
6-26056053-C-T	H1-2	c.604G>A	p.V202I	Missense	1/1	-
2-48026217-G-T	MSH6	c.1095G>T	p.W365C	Missense	4/10	-
19-11141507-G-T	SMARCA4	c.3484G>T	p.G1162C	Missense	25/35	-
17-40379552-G-A	STAT5B	c.280C>T	p.L94F	Missense	3/19	-
9-139396503-C-T	NOTCH1	c.5422G>A	p.D1808N	Missense	29/34	-
2-212495294-T-A	ERBB4	c.1972A>T	p.I658F	Missense	17/28	-
7-151874147-CT-C	KMT2C	c.8390delA	p.K2797Rfs*26	Frameshift	38/59	-
5-176518103-C-T	FGFR4	c.601C>T	p.R201W	Missense	5/18	-
3-30691871-G-GA	TGFBR2	c.383_383dupA	p.P129Afs*3	Frameshift	3/7	-
19-4090636-C-T	MAP2K2	c.1163G>A	p.R388Q	Missense	11/11	-
19-1207064-TG-T	STK11	c.157delG	p.D53Tfs*11	Frameshift	1/10	-
15-93545433-G-GA	CHD2	c.4173_4173dupA	p.Q1392Tfs*17	Frameshift	33/39	-
5-180045911-G-A	FLT4	c.2860C>T	p.P954S	Missense	21/30	-
19-1207054-A-T	STK11	c.142A>T	p.K48*	Nonsense	1/10	-
2-209113210-T-C	IDH1	c.297A>G	p.I99M	Missense	4/10	-
2-48033920-A-C	MSH6	c.4004A>C	p.E1335A	Missense	10/10	-
19-1220715-C-T	STK11	c.733C>T	p.L245F	Missense	5/10	-
3-189607233-A-G	TP63	c.1612A>G	p.T538A	Missense	12/14	-
1-85736510-AT-A	BCL10	c.136delA	p.I46Yfs*24	Frameshift	2/3	-
9-21968732-G-A	CDKN2A	c.458-491C>T	-	IntronicSNV	-	2/2
17-41243952-G-A	BRCA1	c.3596C>T	p.A1199V	Missense	10/23	-
3-134968200-C-T	EPHB1	c.2713C>T	p.R905C	Missense	15/16	-
9-98231061-G-A	PTCH1	c.2222C>T	p.A741V	Missense	14/24	-
16-16276741-G-A	ABCC6	c.1990C>T	p.P664S	Missense	16/31	-
19-17942173-G-A	JAK3	c.2842C>T	p.R948C	Missense	21/24	-
17-33428027-A-T	RAD51D	c.932T>A	p.I311N	Missense	10/10	-
14-81563048-C-T	TSHR	c.611C>T	p.A204V	Missense	7/10	-
17-37864776-G-A	ERBB2	c.428G>A	p.R143Q	Missense	3/27	-
15-88799324-C-A	NTRK3	c.61G>T	p.V21F	Missense	3/20	-
17-7579882-C-T	TP53	c.31G>A	p.E11K	Missense	2/11	-
2-203421006-G-A	BMPR2	c.2618G>A	p.R873Q	Missense	12/13	-
6-106554373-A-G	PRDM1	c.1901A>G	p.Q634R	Missense	6/7	-
16-341266-C-T	AXIN1	c.2218G>A	p.A740T	Missense	9/11	-
6-134583262-T-A	SGK1	c.94A>T	p.M32L	Missense	2/14	-
17-33428245-G-A	RAD51D	c.878C>T	p.A293V	Missense	9/10	-
17-59924502-T-C	BRIP1	c.587A>G	p.N196S	Missense	6/20	-
17-59878736-G-A	BRIP1	c.1018C>T	p.L340F	Missense	8/20	-
17-59870989-C-T	BRIP1	c.1442G>A	p.G481D	Missense	10/20	-
7-6017269-G-A	PMS2	c.2395C>T	p.R799W	Missense	14/15	-
20-54961562-G-A	AURKA	c.70C>T	p.R24C	Missense	3/9	-
1-36941179-G-C	CSF3R	c.160C>G	p.H54D	Missense	4/17	-
X-76931741-GTCA-G	ATRX	c.3786_3788delTGA	p.D1264del	InFrameDeletion	10/35	-
12-21628620-T-C	RECQL	c.1088A>G	p.N363S	Missense	9/15	-
12-21626550-T-C	RECQL	c.1382A>G	p.H461R	Missense	12/15	-
19-15281582-A-T	NOTCH3	c.4791T>A	p.N1597K	Missense	26/33	-
11-125503112-G-A	CHEK1	c.479G>A	p.R160H	Missense	6/13	-
17-7578218-T-G	TP53	c.631A>C	p.T211P	Missense	6/11	-
17-46804175-C-A	HOXB13	c.832G>T	p.V278L	Missense	2/2	-
16-23641001-C-G	PALB2	c.2474G>C	p.R825T	Missense	5/13	-
5-112151233-G-C	APC	c.876G>C	p.L292F	Missense	9/16	-
19-13054393-G-A	CALR	c.1003G>A	p.D335N	Missense	8/9	-
14-81606063-G-A	TSHR	c.733G>A	p.G245S	Missense	9/10	-
12-133240977-C-T	POLE	c.2540G>A	p.R847Q	Missense	22/49	-
4-187584610-C-G	FAT1	c.3423G>C	p.E1141D	Missense	3/27	-
9-98224163-C-T	PTCH1	c.2678G>A	p.R893H	Missense	16/24	-
19-17945798-T-A	JAK3	c.2062A>T	p.I688F	Missense	16/24	-
10-63850704-G-GA	ARID5B	c.1489_1489dupA	p.I497Nfs*31	Frameshift	10/10	-
3-37070322-C-T	MLH1	c.1457C>T	p.S486F	Missense	13/19	-
16-9858774-A-G	GRIN2A	c.2627T>C	p.I876T	Missense	13/13	-
17-37884176-C-A	ERBB2	c.3647C>A	p.A1216D	Missense	27/27	-
15-41797609-C-T	LTK	c.1817G>A	p.R606Q	Missense	14/20	-
6-112386180-C-CA	CCN6	c.624_624dupA	p.S191Kfs*9	Frameshift	3/5	-
12-121432117-G-GC	HNF1A	c.872dupC	p.G292Rfs*25	Frameshift	4/10	-
5-79970914-CA-C	MSH3	c.1148delA	p.K383Rfs*32	Frameshift	7/24	-
15-91304138-G-GA	BLM	c.1544_1544dupA	p.N515Kfs*2	Frameshift	7/22	-
5-131931451-T-TA	RAD50	c.2157_2157dupA	p.E723Gfs*5	Frameshift	13/25	-
2-141473606-G-A	LRP1B	c.5959C>T	p.R1987C	Missense	37/91	-
17-70120403-A-G	SOX9	c.1405A>G	p.M469V	Missense	3/3	-
4-55561861-C-T	KIT	c.251C>T	p.T84M	Missense	2/21	-
4-1980601-C-T	NSD2	c.4063C>T	p.R1355W	Missense	22/22	-
12-120784045-C-T	MSI1	c.940G>A	p.G314S	Missense	13/15	-
1-40366502-G-A	MYCL	c.496+109C>T	-	IntronicSNV	-	1/1
13-41134072-G-A	FOXO1	c.1556C>T	p.P519L	Missense	2/3	-
10-104375107-G-A	SUFU	c.1105G>A	p.V369I	Missense	9/12	-
12-58143021-G-A	CDK4	c.763C>T	p.R255C	Missense	7/8	-
15-42058948-G-A	MGA	c.8668G>A	p.V2890I	Missense	24/24	-
1-32798325-AAGG-A	HDAC1	c.1402_1404delGAG	p.E468del	InFrameDeletion	13/14	-
15-42058969-A-G	MGA	c.8689A>G	p.I2897V	Missense	24/24	-
15-42059392-C-T	MGA	c.9112C>T	p.R3038W	Missense	24/24	-
19-50138891-G-A	RRAS	c.599C>T	p.P200L	Missense	6/6	-
14-36986635-C-T	NKX2-1	c.1054G>A	p.G352S	Missense	3/3	-
3-149245654-T-G	WWTR1	c.874A>C	p.T292P	Missense	5/7	-
19-11032327-C-T	CARM1	c.1721C>T	p.T574M	Missense	16/16	-
16-9857047-G-A	GRIN2A	c.4354C>T	p.R1452C	Missense	13/13	-
17-30326014-A-C	SUZ12	c.2212A>C	p.K738Q	Missense	16/16	-
2-29416431-C-T	ALK	c.4522G>A	p.G1508S	Missense	29/29	-
17-37687514-G-A	CDK12	c.4418G>A	p.R1473Q	Missense	14/14	-
22-29885644-C-A	NEFH	c.2015C>A	p.A672E	Missense	4/4	-
22-41574794-A-G	EP300	c.7079A>G	p.E2360G	Missense	31/31	-
3-149245702-G-C	WWTR1	c.826C>G	p.Q276E	Missense	5/7	-
19-13054704-G-A	CALR	c.1231G>A	p.G411S	Missense	9/9	-
22-29885638-T-A	NEFH	c.2009T>A	p.V670E	Missense	4/4	-
22-41574859-A-G	EP300	c.7144A>G	p.M2382V	Missense	31/31	-
2-128016886-A-G	ERCC3	c.2203T>C	p.S735P	Missense	14/15	-
6-152129480-G-A	ESR1	c.433G>A	p.G145S	Missense	1/8	-
4-55161415-C-A	PDGFRA	c.3246C>A	p.D1082E	Missense	23/23	-
5-176722419-G-A	NSD1	c.8050G>A	p.A2684T	Missense	23/23	-
8-32621424-G-A	NRG1	c.1427G>A	p.R476K	Missense	12/12	-
5-44305114-T-C	FGF10	c.610A>G	p.M204V	Missense	3/3	-
6-20488470-G-A	E2F3	c.1126G>A	p.A376T	Missense	6/7	-
5-170832369-G-C	NPM1	c.733G>C	p.E245Q	Missense	9/11	-
8-37699715-GAGA-G	ADGRA2	c.3862_3864delAAG	p.K1288del	InFrameDeletion	19/19	-
19-1627417-C-T	TCF3	c.307G>A	p.G103S	Missense	6/19	-
7-100414918-C-T	EPHB4	c.1484G>A	p.R495Q	Missense	8/17	-
5-176638587-A-G	NSD1	c.3187A>G	p.T1063A	Missense	5/23	-
13-103524611-G-GA	ERCC5	c.2751dupA	p.L918Ifs*12	Frameshift	13/15	-
5-35867500-G-A	IL7R	c.314G>A	p.S105N	Missense	3/8	-
11-17741592-A-G	MYOD1	c.263A>G	p.H88R	Missense	1/3	-
14-81609317-T-A	TSHR	c.915T>A	p.S305R	Missense	10/10	-
4-55143618-G-A	PDGFRA	c.1850G>A	p.R617Q	Missense	13/23	-
1-228612837-G-A	H3-4	c.190C>T	p.R64C	Missense	1/1	-
1-120539661-C-T	NOTCH2	c.710G>A	p.R237Q	Missense	4/34	-
1-228612869-C-T	HIST3H3	c.158G>A	p.R53H	Missense	1/1	-
1-228612939-C-T	HIST3H3	c.88G>A	p.A30T	Missense	1/1	-
1-226553720-T-C	PARP1	c.2440A>G	p.I814V	Missense	18/23	-
4-187549766-G-C	FAT1	c.4475C>G	p.T1492S	Missense	8/27	-
17-7577090-C-A	TP53	c.848G>T	p.R283L	Missense	8/11	-
9-35075738-G-C	FANCG	c.1157C>G	p.P386R	Missense	10/14	-
9-35074206-G-C	FANCG	c.1768C>G	p.P590A	Missense	14/14	-
5-131911469-G-A	RAD50	c.214G>A	p.V72I	Missense	3/25	-
13-26975608-CCAG-C	CDK8	c.1129_1131delCAG	p.Q377del	InFrameDeletion	12/13	-
15-91298125-G-A	BLM	c.1044G>A	p.M348I	Missense	5/22	-
2-25464430-C-T	DNMT3A	c.2082+1G>A	-	IntronicSNV	-	17/22
13-32914707-C-T	BRCA2	c.6215C>T	p.S2072F	Missense	11/27	-
19-50905089-T-C	POLD1	c.371T>C	p.V124A	Missense	4/27	-
15-88799237-C-T	NTRK3	c.148G>A	p.D50N	Missense	3/20	-
2-47635594-T-C	MSH2	c.266T>C	p.V89A	Missense	2/16	-
16-2090156-C-T	NTHL1	c.793G>A	p.A257T	Missense	5/6	-
20-52193658-C-T	ZNF217	c.1645G>A	p.A549T	Missense	4/6	-
1-11863038-G-A	MTHFR	c.136C>T	p.R46W	Missense	2/12	-
5-37000609-C-T	NIPBL	c.3439C>T	p.R1147*	Nonsense	12/47	-
3-10116221-C-T	FANCD2	c.2723C>T	p.T908I	Missense	29/44	-
17-62007646-T-G	CD79B	c.218A>C	p.N73T	Missense	3/6	-
6-138202223-C-T	TNFAIP3	c.2140C>T	p.P714S	Missense	9/9	-
16-72832153-C-T	ZFHX3	c.4428G>A	p.M1476I	Missense	9/10	-
5-180048821-C-T	FLT4	c.1741G>A	p.D581N	Missense	13/30	-
22-41546053-A-C	EP300	c.2668A>C	p.T890P	Missense	14/31	-
8-128750631-GC-G	MYC	c.173delC	p.P58Rfs*60	Frameshift	2/3	-
7-148524338-G-A	EZH2	c.646C>T	p.R216W	Missense	7/20	-
7-2979543-C-T	CARD11	c.704G>A	p.R235Q	Missense	6/25	-
10-104597087-G-A	CYP17A1	c.32C>T	p.T11I	Missense	1/8	-
1-241680556-C-T	FH	c.193G>A	p.D65N	Missense	2/10	-
5-233687-G-A	SDHA	c.991G>A	p.A331T	Missense	8/15	-
4-187541475-C-T	FAT1	c.6265G>A	p.V2089I	Missense	10/27	-
9-135781505-G-C	TSC1	c.1460C>G	p.S487C	Missense	15/23	-
5-131944381-CA-C	RAD50	c.2801delA	p.N934Ifs*6	Frameshift	17/25	-
16-2138319-G-A	TSC2	c.5252G>A	p.R1751H	Missense	41/42	-
X-76918997-T-C	ATRX	c.3994A>G	p.K1332E	Missense	12/35	-
12-21644546-C-CT	RECQL	c.120_120dupA	p.V41Sfs*14	Frameshift	3/15	-
9-128206872-C-T	MAPKAP1	c.1351G>A	p.A451T	Missense	11/12	-
2-190719350-C-T	PMS1	c.1352C>T	p.T451M	Missense	9/13	-
10-8100406-C-A	GATA3	c.380C>A	p.P127Q	Missense	3/6	-
6-106553435-C-T	PRDM1	c.1400C>T	p.P467L	Missense	5/7	-
7-151874709-C-T	KMT2C	c.7829G>A	p.R2610Q	Missense	38/59	-
12-123875223-C-T	KMT5A	c.179C>T	p.P60L	Missense	3/8	-
7-55227873-C-T	EGFR	c.1340C>T	p.S447F	Missense	12/28	-
19-36211133-G-A	KMT2B	c.884G>A	p.R295H	Missense	3/37	-
3-178927486-G-C	PIK3CA	c.1249G>C	p.E417Q	Missense	7/21	-
2-178095985-C-T	NFE2L2	c.1346G>A	p.R449H	Missense	5/5	-
22-42526720-C-T	CYP2D6	c.74G>A	p.R25Q	Missense	1/9	-
1-158631190-A-C	SPTA1	c.2474T>G	p.L825R	Missense	18/52	-
6-26031885-C-G	H3C2	c.404G>C	p.R135T	Missense	1/1	-
16-72821322-G-T	ZFHX3	c.10853C>A	p.P3618Q	Missense	10/10	-
9-27204923-G-A	TEK	c.2224G>A	p.G742R	Missense	14/23	-
17-56440903-C-T	RNF43	c.434G>A	p.R145Q	Missense	4/10	-
2-128051291-T-C	ERCC3	c.32A>G	p.K11R	Missense	2/15	-
6-27839921-G-A	H3C11	c.173C>T	p.S58L	Missense	1/1	-
3-37092035-A-G	MLH1	c.2162A>G	p.Y721C	Missense	19/19	-
8-128751158-C-T	MYC	c.695C>T	p.S232F	Missense	2/3	-
2-29519901-C-T	ALK	c.1670G>A	p.R557H	Missense	9/29	-
17-78899254-C-T	RPTOR	c.2893C>T	p.R965C	Missense	24/34	-
10-89720738-G-T	PTEN	c.889G>T	p.D297Y	Missense	8/9	-
5-67569269-C-T	PIK3R1	c.386C>T	p.P129L	Missense	3/16	-
1-45798308-G-A	MUTYH	c.544C>T	p.Q182*	Nonsense	8/16	-
7-151877980-A-G	KMT2C	c.6965T>C	p.V2322A	Missense	36/59	-
17-7579466-G-A	TP53	c.221C>T	p.A74V	Missense	4/11	-
19-10610685-C-T	KEAP1	c.25G>A	p.G9R	Missense	2/6	-
1-120056870-G-A	HSD3B1	c.724G>A	p.D242N	Missense	4/4	-
22-29095918-C-T	CHEK2	c.916G>A	p.G306R	Missense	9/15	-
X-47045136-C-T	RBM10	c.2377C>T	p.R793*	Nonsense	21/24	-
19-45868176-C-T	ERCC2	c.514G>A	p.A172T	Missense	7/23	-
14-68353784-G-A	RAD51B	c.619G>A	p.V207M	Missense	7/11	-
13-29008200-C-T	FLT1	c.671G>A	p.R224Q	Missense	5/30	-
16-72822363-G-A	ZFHX3	c.9812C>T	p.T3271M	Missense	10/10	-
2-141291668-G-A	LRP1B	c.7684C>T	p.R2562C	Missense	47/91	-
2-112740556-A-G	MERTK	c.1282A>G	p.S428G	Missense	8/19	-
1-16254855-A-G	SPEN	c.2120A>G	p.E707G	Missense	11/15	-
5-180058747-CG-C	FLT4	c.89delC	p.P30Rfs*3	Frameshift	2/30	-
10-63845621-GA-G	ARID5B	c.1365delA	p.E456Kfs*23	Frameshift	9/10	-
1-162749975-C-T	DDR2	c.2507C>T	p.T836M	Missense	18/18	-
11-2154241-TG-T	IGF2	c.518delC	p.P173Qfs*27	Frameshift	4/4	-
22-23653975-T-TCCGG	BCR	c.3275_3278dup	p.V1094Rfs*17	Frameshift	19/23	-
3-9934760-C-G	JAGN1	c.251C>G	p.P84R	Missense	2/2	-
2-141356360-A-C	LRP1B	c.7034T>G	p.M2345R	Missense	43/91	-
7-142651300-A-C	KEL	c.895T>G	p.F299V	Missense	8/19	-
19-35832405-T-G	CD22	c.1667T>G	p.L556R	Missense	8/14	-
19-45867709-C-T	ERCC2	c.691G>A	p.V231M	Missense	8/23	-
2-227659803-A-G	IRS1	c.3652T>C	p.S1218P	Missense	1/2	-
13-26975740-TATC-T	CDK8	c.1251_1253delCAT	p.I417del	InFrameDeletion	12/13	-
1-16258026-A-C	SPEN	c.5291A>C	p.Q1764P	Missense	11/15	-
17-40854956-G-A	EZH1	c.2122C>T	p.R708W	Missense	20/21	-
19-54649671-CT-C	CNOT3	c.729delT	p.S245Afs*90	Frameshift	9/18	-
17-40489825-G-A	STAT3	c.601C>T	p.Q201*	Nonsense	7/24	-
19-15290911-C-T	NOTCH3	c.3299G>A	p.R1100H	Missense	20/33	-
16-89357538-C-G	ANKRD11	c.280G>C	p.A94P	Missense	5/13	-
16-23646629-G-T	PALB2	c.1238C>A	p.T413K	Missense	4/13	-
7-2962848-G-A	CARD11	c.2060C>T	p.A687V	Missense	16/25	-
1-156844184-C-T	NTRK1	c.1187C>T	p.S396L	Missense	9/17	-
16-89348713-C-T	ANKRD11	c.4237G>A	p.E1413K	Missense	9/13	-
6-26056289-G-A	H1-2	c.368C>T	p.A123V	Missense	1/1	-
12-133201570-T-C	POLE	c.6668A>G	p.K2223R	Missense	48/49	-
16-2103448-G-T	TSC2	c.331G>T	p.G111W	Missense	4/42	-
2-109384469-A-G	RANBP2	c.7474A>G	p.T2492A	Missense	20/29	-
17-33445587-C-T	RAD51D	c.196G>A	p.V66M	Missense	3/10	-
6-35423591-C-T	FANCE	c.316C>T	p.R106W	Missense	2/10	-
4-20620616-C-T	SLIT2	c.4574C>T	p.T1525M	Missense	37/37	-
2-111881707-A-C	BCL2L11	c.385A>C	p.S129R	Missense	2/4	-
15-38641674-G-A	SPRED1	c.634G>A	p.V212I	Missense	6/7	-
22-24143309-G-A	SMARCB1	c.500+41G>A	-	IntronicSNV	-	4/8
17-15983379-C-G	NCOR1	c.3401-1G>C	-	IntronicSNV	-	25/45
5-121736798-G-T	SNCAIP	c.58-2690G>T	-	IntronicSNV	-	2/10
17-7574034-C-G	TP53	c.994-1G>C	-	IntronicSNV	-	9/10
17-7574034-C-T	TP53	c.994-1G>A	-	IntronicSNV	-	9/10
19-11150137-A-G	SMARCA4	c.4171-1846A>G	-	IntronicSNV	-	29/34
17-17124829-G-A	FLCN	c.871+22C>T	-	IntronicSNV	-	8/13
17-17124829-G-T	FLCN	c.871+22C>A	-	IntronicSNV	-	8/13
3-142278091-A-G	ATR	c.1732+2T>C	-	IntronicSNV	-	7/46
19-15299158-AGCCTGGGGCAGGGAATAGGGCTTAGGAAAGCGGGGGCTACCCTATGGTGTGAACGGGGT-A	NOTCH3	c.1372_1380del649	-	Multi:SpliceDonorDeletion,SpliceAcceptorDeletion	9/33	8/32
4-106158550-G-T	TET2	c.3409+42G>T	-	IntronicSNV	-	3/10
3-30664732-A-C	TGFBR2	c.94+16263A>C	-	IntronicSNV	-	1/6
6-37138299-C-T	PIM1	c.1-53C>T	-	5-UTRSNV	1/6	-
8-26150763-A-G	PPP2R2A	c.8-419A>G	-	IntronicSNV	-	1/9
1-179087721-C-A	ABL2	c.1223+1G>T	-	IntronicSNV	-	7/11
19-1612427-G-A	TCF3	c.1823-579C>T	-	IntronicSNV	-	18/18
16-89836265-A-T	FANCA	c.2484T>A	p.D828E	Missense	26/43	-
19-45868311-G-A	ERCC2	c.466C>T	p.R156*	Nonsense	6/23	-
7-41729711-C-T	INHBA	c.818G>A	p.G273D	Missense	3/3	-
X-47039636-T-A	RBM10	c.1088T>A	p.L363Q	Missense	11/24	-
1-228612929-G-C	H3-4	c.98C>G	p.T33S	Missense	1/1	-
5-180030223-C-T	FLT4	c.4061G>A	p.R1354H	Missense	30/30	-
6-26020922-C-T	H3C1	c.205C>T	p.Q69*	Nonsense	1/1	-
7-151860599-T-C	KMT2C	c.10063A>G	p.I3355V	Missense	43/59	-
9-128206796-T-C	MAPKAP1	c.1427A>G	p.N476S	Missense	11/12	-
12-49433059-C-T	KMT2D	c.8312G>A	p.R2771Q	Missense	34/55	-
12-133257806-G-C	POLE	c.122C>G	p.T41R	Missense	2/49	-
13-28626691-T-C	FLT3	c.605A>G	p.Q202R	Missense	5/24	-
16-14014063-C-A	ERCC4	c.41C>A	p.P14Q	Missense	1/11	-
9-135797283-G-C	TSC1	c.586C>G	p.P196A	Missense	7/23	-
1-28599212-G-T	SESN2	c.658G>T	p.G220W	Missense	5/10	-
4-187541915-G-A	FAT1	c.5825C>T	p.T1942I	Missense	10/27	-
6-150005674-G-C	LATS1	c.551C>G	p.S184C	Missense	4/8	-
7-151843698-G-A	KMT2C	c.14017C>T	p.R4673C	Missense	53/59	-
11-67200905-A-T	RPS6KB2	c.893A>T	p.D298V	Missense	10/15	-
15-91352395-G-T	BLM	c.3780G>T	p.L1260F	Missense	20/22	-
16-3639021-C-T	SLX4	c.4618G>A	p.E1540K	Missense	12/15	-
6-150016303-T-C	LATS1	c.403A>G	p.I135V	Missense	3/8	-
13-48916774-T-C	RB1	c.304T>C	p.C102R	Missense	3/27	-
3-10183811-G-A	VHL	c.280G>A	p.E94K	Missense	1/3	-
5-112170769-A-G	APC	c.1865A>G	p.Y622C	Missense	15/16	-
10-63817034-G-T	ARID5B	c.1005G>T	p.R335S	Missense	6/10	-
1-2491274-G-A	TNFRSF14	c.317G>A	p.R106H	Missense	4/8	-
1-9770518-C-T	PIK3CD	c.5C>T	p.P2L	Missense	3/24	-
1-17349159-G-A	SDHB	c.709C>T	p.P237S	Missense	7/8	-
2-112722824-G-A	MERTK	c.814G>A	p.V272M	Missense	5/19	-
3-73114061-C-T	PPP4R2	c.697C>T	p.P233S	Missense	8/9	-
6-134583141-T-C	SGK1	c.215A>G	p.H72R	Missense	2/14	-
4-55979488-G-A	KDR	c.959C>T	p.T320I	Missense	7/30	-
11-108139218-G-T	ATM	c.2720G>T	p.C907F	Missense	18/63	-
13-28913359-G-A	FLT1	c.2434C>T	p.R812W	Missense	17/30	-
13-29001366-C-T	FLT1	c.1366G>A	p.A456T	Missense	10/30	-
17-63554570-G-A	AXIN2	c.169C>T	p.R57W	Missense	2/11	-
17-66518934-G-T	PRKAR1A	c.215G>T	p.G72V	Missense	3/11	-
1-28599295-C-A	SESN2	c.741C>A	p.N247K	Missense	5/10	-
1-16261134-C-T	SPEN	c.8399C>T	p.A2800V	Missense	11/15	-
2-242795024-C-T	PDCD1	c.185G>A	p.S62N	Missense	2/5	-
9-8504321-G-A	PTPRD	c.1762C>T	p.R588C	Missense	23/46	-
12-111885302-G-A	SH2B3	c.1190G>A	p.R397Q	Missense	6/8	-
14-30046661-T-C	PRKD1	c.2522A>G	p.D841G	Missense	18/18	-
17-40362464-T-A	STAT5B	c.1732A>T	p.M578L	Missense	14/19	-
2-141214137-A-G	LRP1B	c.9850T>C	p.C3284R	Missense	62/91	-
8-68864697-T-A	PREX2	c.68T>A	p.L23Q	Missense	1/40	-
17-16068454-G-A	NCOR1	c.457C>T	p.H153Y	Missense	5/46	-
22-23626222-T-C	BCR	c.2174T>C	p.L725P	Missense	9/23	-
6-151687411-T-C	ZBTB2	c.790A>G	p.T264A	Missense	3/3	-
12-416120-C-T	KDM5A	c.4066G>A	p.D1356N	Missense	24/28	-
12-472157-G-A	KDM5A	c.644C>T	p.P215L	Missense	5/28	-
5-56167853-TCAA-T	MAP3K1	c.1418_1420delCAA	p.S473_I474delinsF	MultiAAMissense	7/20	-
22-41513324-CTAAACATAAACA-C	EP300	c.228_239del12	p.K77_Q80del	InFrameDeletion	2/31	-
17-63533732-ATGG-A	AXIN2	c.1419_1421delCCA	p.H474del	InFrameDeletion	6/11	-
5-137801673-GGCGGCAGCAACAGCA-G	EGR1	c.226_240del15	p.G76_S80del	InFrameDeletion	1/2	-
17-7573976-T-TA	TP53	c.1050_1051insT	p.K351*	Nonsense	10/11	-
15-88576252-TCAC-T	NTRK3	c.1418_1420delGTG	p.G473del	InFrameDeletion	14/20	-
5-56155726-G-A	MAP3K1	c.818G>A	p.R273K	Missense	3/20	-
5-180046321-T-C	FLT4	c.2693A>G	p.K898R	Missense	19/30	-
3-73114232-C-G	PPP4R2	c.868C>G	p.R290G	Missense	8/9	-
15-43724624-A-G	TP53BP1	c.3443T>C	p.L1148S	Missense	17/28	-
7-100405190-G-A	EPHB4	c.2131C>T	p.Q711*	Nonsense	13/17	-
6-20481568-G-A	E2F3	c.637G>A	p.V213M	Missense	3/7	-
7-142641420-T-A	KEL	c.1481A>T	p.E494V	Missense	13/19	-
7-151878022-G-C	KMT2C	c.6923C>G	p.S2308C	Missense	36/59	-
9-139564387-G-A	EGFL7	c.335G>A	p.R112Q	Missense	7/11	-
11-111958583-C-G	SDHD	c.55C>G	p.L19V	Missense	2/4	-
11-119146766-C-T	CBL	c.929C>T	p.A310V	Missense	6/16	-
13-32913177-A-C	BRCA2	c.4685A>C	p.Q1562P	Missense	11/27	-
13-49050891-C-A	RB1	c.2575C>A	p.L859I	Missense	25/27	-
16-81957108-G-T	PLCG2	c.2326G>T	p.A776S	Missense	22/33	-
5-80109478-T-G	MSH3	c.2731T>G	p.L911V	Missense	20/24	-
21-36259286-C-G	RUNX1	c.205G>C	p.G69R	Missense	4/9	-
4-187541639-G-T	FAT1	c.6101C>A	p.T2034N	Missense	10/27	-
5-180057674-T-C	FLT4	c.281A>G	p.K94R	Missense	3/30	-
8-38205494-G-A	NSD3	c.196C>T	p.L66F	Missense	2/24	-
8-55371781-C-A	SOX17	c.471C>A	p.H157Q	Missense	2/2	-
12-46244334-G-C	ARID2	c.2428G>C	p.A810P	Missense	15/21	-
4-187628563-G-A	FAT1	c.2419C>T	p.L807F	Missense	2/27	-
X-48650368-G-T	GATA1	c.338G>T	p.R113L	Missense	3/6	-
2-58456972-C-T	FANCL	c.193G>A	p.G65R	Missense	3/14	-
2-141680541-C-A	LRP1B	c.3312G>T	p.W1104C	Missense	21/91	-
7-81336665-G-T	HGF	c.1557C>A	p.C519*	Nonsense	14/18	-
7-142640005-A-G	KEL	c.1898T>C	p.L633S	Missense	17/19	-
7-142649704-C-A	KEL	c.1095G>T	p.M365I	Missense	10/19	-
9-139403348-G-A	NOTCH1	c.3145C>T	p.Q1049*	Nonsense	19/34	-
17-70120209-C-T	SOX9	c.1211C>T	p.P404L	Missense	3/3	-
X-63410730-C-A	AMER1	c.2437G>T	p.D813Y	Missense	2/2	-
1-16255121-A-T	SPEN	c.2386A>T	p.T796S	Missense	11/15	-
2-111881374-C-T	BCL2L11	c.52C>T	p.Q18*	Nonsense	2/4	-
4-1905965-G-A	NSD2	c.620G>A	p.C207Y	Missense	3/22	-
4-187539275-A-G	FAT1	c.8465T>C	p.L2822P	Missense	10/27	-
7-152345974-A-G	XRCC2	c.596T>C	p.M199T	Missense	3/3	-
13-21549473-G-A	LATS2	c.2803C>T	p.P935S	Missense	8/8	-
15-43749251-T-C	TP53BP1	c.1555A>G	p.K519E	Missense	12/28	-
18-39550376-A-T	PIK3C3	c.487A>T	p.T163S	Missense	4/25	-
2-141242996-G-T	LRP1B	c.9341C>A	p.S3114Y	Missense	59/91	-
11-85961458-A-G	EED	c.235A>G	p.K79E	Missense	2/12	-
11-94910967-T-C	SESN3	c.1163A>G	p.N388S	Missense	8/10	-
12-123889451-A-C	KMT5A	c.678A>C	p.K226N	Missense	7/8	-
4-187557833-T-C	FAT1	c.3878A>G	p.D1293G	Missense	5/27	-
15-88679781-C-T	NTRK3	c.682G>A	p.V228I	Missense	8/20	-
15-91333894-A-G	BLM	c.2839A>G	p.I947V	Missense	15/22	-
22-29095911-T-C	CHEK2	c.923A>G	p.E308G	Missense	9/15	-
2-25467166-C-A	DNMT3A	c.1709G>T	p.G570V	Missense	15/23	-
16-23646905-A-C	PALB2	c.962T>G	p.L321*	Nonsense	4/13	-
22-21337335-G-A	LZTR1	c.220G>A	p.V74M	Missense	2/21	-
16-72822008-TTGC-T	ZFHX3	c.10164_10166delGCA	p.Q3389del	InFrameDeletion	10/10	-
X-63412978-CTTGCCACCAAAGAGT-C	AMER1	c.174_188del15	p.L59_K63del	InFrameDeletion	2/2	-
1-72163773-CC-GA	NEGR1	c.584_585delGGinsTC	p.R195I	Missense	4/7	-
1-16255154-C-T	SPEN	c.2419C>T	p.R807C	Missense	11/15	-
8-41845004-T-G	KAT6A	c.678A>C	p.E226D	Missense	3/17	-
1-246027147-T-G	SMYD3	c.855A>C	p.E285D	Missense	9/12	-
6-20488374-G-A	E2F3	c.1030G>A	p.G344R	Missense	6/7	-
6-20488374-G-C	E2F3	c.1030G>C	p.G344R	Missense	6/7	-
15-43749236-T-C	TP53BP1	c.1570A>G	p.T524A	Missense	12/28	-
2-227660259-G-A	IRS1	c.3196C>T	p.P1066S	Missense	1/2	-
5-57752401-T-A	PLK2	c.1172A>T	p.E391V	Missense	9/14	-
3-72866527-A-G	SHQ1	c.736T>C	p.S246P	Missense	7/11	-
5-161116112-A-G	GABRA6	c.383A>G	p.N128S	Missense	4/9	-
5-176721790-A-C	NSD1	c.7421A>C	p.Q2474P	Missense	23/23	-
8-69129903-G-A	PREX2	c.4657G>A	p.G1553R	Missense	38/40	-
10-63851054-C-T	ARID5B	c.1832C>T	p.T611M	Missense	10/10	-
12-50483727-G-A	SMARCD1	c.832G>A	p.V278M	Missense	7/13	-
15-73995322-G-A	CD276	c.628G>A	p.V210M	Missense	4/10	-
5-176637372-T-A	NSD1	c.1972T>A	p.S658T	Missense	5/23	-
16-72993698-G-A	ZFHX3	c.347C>T	p.T116I	Missense	2/10	-
17-37618391-C-T	CDK12	c.67C>T	p.P23S	Missense	1/14	-
19-15272087-G-A	NOTCH3	c.6352C>T	p.P2118S	Missense	33/33	-
X-47038888-A-G	RBM10	c.895A>G	p.N299D	Missense	9/24	-
13-32910839-G-A	BRCA2	c.2347G>A	p.V783I	Missense	11/27	-
7-100416166-G-C	EPHB4	c.1398C>G	p.D466E	Missense	7/17	-
4-187584746-C-T	FAT1	c.3287G>A	p.R1096Q	Missense	3/27	-
8-41839364-T-C	KAT6A	c.818A>G	p.K273R	Missense	4/17	-
5-39002683-T-C	RICTOR	c.346A>G	p.I116V	Missense	5/38	-
6-161771220-G-C	PRKN	c.1309C>G	p.P437A	Missense	12/12	-
7-77797349-T-A	MAGI2	c.2480A>T	p.Y827F	Missense	15/22	-
9-27202937-C-A	TEK	c.2029C>A	p.Q677K	Missense	13/23	-
12-69968460-A-G	FRS2	c.1252A>G	p.T418A	Missense	9/9	-
12-133226047-G-A	POLE	c.3850C>T	p.R1284W	Missense	31/49	-
13-103528245-A-G	ERCC5	c.3553A>G	p.K1185E	Missense	15/15	-
19-41727911-C-T	AXL	c.536C>T	p.P179L	Missense	4/20	-
17-37866080-C-G	ERBB2	c.589C>G	p.P197A	Missense	5/27	-
20-54961381-A-G	AURKA	c.251T>C	p.V84A	Missense	3/9	-
22-24145495-G-A	SMARCB1	c.514G>A	p.D172N	Missense	5/9	-
19-41725307-C-T	AXL	c.10C>T	p.R4W	Missense	1/20	-
X-39934211-C-T	BCOR	c.388G>A	p.E130K	Missense	4/15	-
4-187584498-T-C	FAT1	c.3535A>G	p.T1179A	Missense	3/27	-
2-141526806-C-T	LRP1B	c.5734G>A	p.A1912T	Missense	35/91	-
15-42035256-G-A	MGA	c.5098G>A	p.V1700M	Missense	15/24	-
2-141777624-G-A	LRP1B	c.1837C>T	p.L613F	Missense	12/91	-
3-156413700-A-C	TIPARP	c.1133A>C	p.E378A	Missense	4/6	-
6-35423973-G-C	FANCE	c.698G>C	p.R233T	Missense	2/10	-
1-120056718-A-T	HSD3B1	c.572A>T	p.Y191F	Missense	4/4	-
4-55133832-T-G	PDGFRA	c.1045T>G	p.W349G	Missense	7/23	-
19-18965420-T-G	UPF1	c.1167T>G	p.D389E	Missense	9/24	-
7-142658493-AAGG-A	KEL	c.174_176delCCT	p.L59del	InFrameDeletion	3/19	-
22-21346036-ACAACACGCTGCCCAACGAGCTGCACTG-A	LZTR1	c.913_939del27	p.N305_C313del	InFrameDeletion	9/21	-
19-41748890-TCCA-T	AXL	c.1418_1420delACC	p.H473del	InFrameDeletion	11/20	-
7-55210118-TTTCCTTCTTAAA-T	EGFR	c.228_239del12	p.S77_K80del	SpliceDonorDeletion	2/28	-
7-55210072-T-TGCAGCA	EGFR	c.182_183insGCAGCA	p.V61_L62insQH	InFrameInsertion	2/28	-
17-62007623-CCTG-C	CD79B	c.238_240delCAG	p.Q80del	InFrameDeletion	3/6	-
17-16024381-G-A	NCOR1	c.1837C>T	p.P613S	Missense	16/46	-
X-47040781-AGGG-A	RBM10	c.1418_1420delGGG	p.G473del	InFrameDeletion	13/24	-
2-109357057-A-G	RANBP2	c.895A>G	p.K299E	Missense	7/29	-
15-73996332-G-A	CD276	c.1066G>A	p.V356M	Missense	5/10	-
15-73996332-G-C	CD276	c.1066G>C	p.V356L	Missense	5/10	-
3-72428487-C-T	RYBP	c.433G>A	p.V145I	missense_variant	2/4	-
17-17965216-G-A	GID4	c.766G>A	p.G256R	Missense	5/6	-
X-47044845-C-A	RBM10	c.2171C>A	p.P724H	Missense	20/24	-
X-47041648-G-T	RBM10	c.1873G>T	p.G625*	Nonsense	17/24	-
3-47061265-T-G	SETD2	c.7416A>C	p.E2472D	Missense	19/21	-
4-55136880-C-A	PDGFRA	c.1202C>A	p.A401D	Missense	8/23	-
4-187540634-G-A	FAT1	c.7106C>T	p.T2369M	Missense	10/27	-
6-134492047-T-C	SGK1	c.1330A>G	p.I444V	Missense	13/14	-
8-145739467-G-A	RECQL4	c.1903C>T	p.H635Y	Missense	12/22	-
11-100998657-G-A	PGR	c.1145C>T	p.P382L	Missense	1/8	-
13-103515168-G-A	ERCC5	c.1669G>A	p.D557N	Missense	8/15	-
19-4099265-C-T	MAP2K2	c.853G>A	p.D285N	Missense	7/11	-
20-57478734-T-G	GNAS	c.320T>G	p.V107G	Missense	5/13	-
19-10262196-C-G	DNMT1	c.2143G>C	p.A715P	Missense	24/41	-
19-50140175-T-A	RRAS	c.250A>T	p.T84S	Missense	3/6	-
8-145739869-T-C	RECQL4	c.1661A>G	p.H554R	Missense	10/22	-
11-100998685-C-T	PGR	c.1117G>A	p.A373T	Missense	1/8	-
12-111885999-C-T	SH2B3	c.1621C>T	p.H541Y	Missense	8/8	-
16-3828751-C-A	CREBBP	c.1891G>T	p.A631S	Missense	9/31	-
17-16029465-G-C	NCOR1	c.1565C>G	p.A522G	Missense	15/46	-
19-5223251-C-T	PTPRS	c.2552G>A	p.R851H	Missense	18/38	-
20-46251047-A-G	NCOA3	c.56A>G	p.K19R	Missense	3/23	-
16-72830355-T-C	ZFHX3	c.6226A>G	p.I2076V	Missense	9/10	-
11-108126971-T-G	ATM	c.2154T>G	p.C718W	Missense	14/63	-
20-57478743-T-A	GNAS	c.329T>A	p.M110K	Missense	5/13	-
19-10602845-C-T	KEAP1	c.733G>A	p.V245I	Missense	3/6	-
6-26056410-C-G	H1-2	c.247G>C	p.G83R	Missense	1/1	-
2-141819811-C-T	LRP1B	c.1045G>A	p.A349T	Missense	8/91	-
7-151877813-T-C	KMT2C	c.7132A>G	p.T2378A	Missense	36/59	-
9-8636826-C-A	PTPRD	c.83G>T	p.R28L	Missense	13/46	-
13-21557391-C-A	LATS2	c.2454G>T	p.W818C	Missense	5/8	-
15-91308640-T-A	BLM	c.2189T>A	p.L730*	Nonsense	9/22	-
17-46804391-G-T	HOXB13	c.616C>A	p.H206N	Missense	2/2	-
19-10602760-C-T	KEAP1	c.818G>A	p.C273Y	Missense	3/6	-
1-162742033-G-A	DDR2	c.1724G>A	p.G575E	Missense	13/18	-
1-226568835-T-C	PARP1	c.1234A>G	p.I412V	Missense	9/23	-
2-58392880-T-C	FANCL	c.670A>G	p.T224A	Missense	8/14	-
2-109384800-C-T	RANBP2	c.7805C>T	p.T2602M	Missense	20/29	-
2-109347264-G-T	RANBP2	c.175G>T	p.D59Y	Missense	3/29	-
9-139564131-G-A	EGFL7	c.271G>A	p.G91S	Missense	6/11	-
12-21628504-C-T	RECQL	c.1114G>A	p.V372I	Missense	10/15	-
12-56491590-C-T	ERBB3	c.2482C>T	p.H828Y	Missense	21/28	-
1-158581148-G-T	SPTA1	c.7166C>A	p.A2389D	Missense	52/52	-
2-225370710-A-T	CUL3	c.1169T>A	p.L390*	Nonsense	8/16	-
18-19751694-A-C	GATA6	c.589A>C	p.M197L	Missense	2/7	-
7-86415875-A-T	GRM3	c.767A>T	p.Y256F	Missense	3/6	-
17-63533618-C-A	AXIN2	c.1536G>T	p.K512N	Missense	6/11	-
11-108121610-A-C	ATM	c.1418A>C	p.E473A	Missense	10/63	-
1-40366656-G-A	MYCL	c.451C>T	p.P151S	Missense	1/2	-
2-39262577-C-T	SOS1	c.929G>A	p.R310H	Missense	7/23	-
5-79950739-G-C	MSH3	c.193G>C	p.A65P	Missense	1/24	-
5-161116274-C-A	GABRA6	c.461C>A	p.A154D	Missense	5/9	-
4-187517748-A-T	FAT1	c.12946T>A	p.S4316T	Missense	25/27	-
2-109371654-G-A	RANBP2	c.2405G>A	p.R802Q	Missense	17/29	-
2-128036890-C-T	ERCC3	c.1589G>A	p.R530Q	Missense	10/15	-
X-63412570-C-A	AMER1	c.597G>T	p.R199S	Missense	2/2	-
2-227661057-A-G	IRS1	c.2398T>C	p.Y800H	Missense	1/2	-
2-227663105-G-A	IRS1	c.350C>T	p.A117V	Missense	1/2	-
7-2968298-A-T	CARD11	c.1688T>A	p.I563N	Missense	13/25	-
11-118360946-G-A	KMT2A	c.4678G>A	p.A1560T	Missense	13/36	-
13-73349353-C-T	DIS3	c.983G>A	p.R328Q	Missense	6/21	-
16-30128020-C-T	MAPK3	c.1109G>A	p.R370H	Missense	8/9	-
11-32456484-AGGC-A	WT1	c.405_407delGCC	p.P141del	InFrameDeletion	1/10	-
1-27023144-GGCGGCGGCGGAGCCGGCA-G	ARID1A	c.261_278del18	p.A88_G93del	InFrameDeletion	1/20	-
3-149260193-TCTG-T	WWTR1	c.697_699delCAG	p.Q233del	InFrameDeletion	4/7	-
2-30143176-G-A	ALK	c.350C>T	p.P117L	Missense	1/29	-
2-109352078-C-T	RANBP2	c.496C>T	p.H166Y	Missense	5/29	-
1-156837904-C-T	NTRK1	c.437C>T	p.S146L	Missense	5/17	-
2-225371576-T-C	CUL3	c.1028A>G	p.Q343R	Missense	7/16	-
12-56481805-G-A	ERBB3	c.733G>A	p.A245T	Missense	7/28	-
1-162743380-A-G	DDR2	c.1850A>G	p.N617S	Missense	14/18	-
11-64135956-A-G	RPS6KA4	c.1217A>G	p.Q406R	Missense	11/17	-
3-73113180-C-T	PPP4R2	c.521C>T	p.P174L	Missense	7/9	-
6-20488470-G-T	E2F3	c.1126G>T	p.A376S	Missense	6/7	-
17-17118350-G-A	FLCN	c.1487C>T	p.S496F	Missense	13/14	-
16-89838116-G-T	FANCA	c.2121C>A	p.N707K	Missense	23/43	-
4-55964435-T-C	KDR	c.2378A>G	p.N793S	Missense	17/30	-
17-56448309-C-T	RNF43	c.338G>A	p.R113Q	Missense	3/10	-
20-50408232-T-C	SALL4	c.790A>G	p.M264V	Missense	2/4	-
11-9595749-A-G	WEE1	c.269A>G	p.E90G	Missense	1/11	-
18-48584825-C-G	SMAD4	c.903C>G	p.Y301*	Nonsense	7/12	-
2-111431788-C-T	BUB1	c.100G>A	p.V34I	Missense	3/25	-
1-162731124-G-A	DDR2	c.979G>A	p.V327I	Missense	9/18	-
22-41566480-C-T	EP300	c.4357C>T	p.P1453S	Missense	27/31	-
8-27634207-G-A	ESCO2	c.382G>A	p.G128R	Missense	3/11	-
6-152419991-G-A	ESR1	c.1678G>A	p.V560M	Missense	8/8	-
3-47165816-G-T	SETD2	c.310C>A	p.P104T	Missense	3/21	-
16-3651028-C-T	SLX4	c.1115G>A	p.R372Q	Missense	5/15	-
8-55371882-G-T	SOX17	c.572G>T	p.G191V	Missense	2/2	-
10-76781905-GGAAGAA-G	KAT6B	c.3307_3312delGAAGAA	p.E1103_E1104del	InFrameDeletion	16/18	-
1-158606499-C-T	SPTA1	c.5242G>A	p.V1748I	Missense	37/52	-
2-227660487-T-C	IRS1	c.2968A>G	p.M990V	Missense	1/2	-
5-112177922-G-A	APC	c.6631G>A	p.G2211S	Missense	16/16	-
20-54961408-T-G	AURKA	c.224A>C	p.K75T	Missense	3/9	-
1-7737712-T-G	CAMTA1	c.2833T>G	p.S945A	Missense	11/23	-
22-41533700-A-G	EP300	c.1666A>G	p.M556V	Missense	8/31	-
20-54945677-G-A	AURKA	c.893C>T	p.P298L	Missense	8/9	-
7-13946197-T-C	ETV1	c.968A>G	p.Y323C	Missense	12/14	-
5-176637243-T-G	NSD1	c.1843T>G	p.C615G	Missense	5/23	-
10-32311107-C-A	KIF5B	c.1993G>T	p.D665Y	Missense	17/26	-
6-43550160-C-T	POLH	c.104C>T	p.A35V	Missense	2/11	-
5-38952520-C-T	RICTOR	c.2905G>A	p.V969I	Missense	30/38	-
17-58725406-C-G	PPM1D	c.980C>G	p.S327*	Nonsense	4/6	-
2-216296629-A-C	FN1	c.474T>G	p.H158Q	Missense	4/46	-
1-22176542-G-A	HSPG2	c.7438C>T	p.R2480W	Missense	57/97	-
5-176517812-G-A	FGFR4	c.422G>A	p.S141N	Missense	4/18	-
8-103289337-T-A	UBR5	c.6372A>T	p.E2124D	Missense	45/59	-
8-145738801-C-T	RECQL4	c.2264G>A	p.R755Q	Missense	14/22	-
13-32890608-G-C	BRCA2	c.11G>C	p.G4A	Missense	2/27	-
22-30035184-C-T	NF2	c.346C>T	p.H116Y	Missense	3/16	-
17-7579446-TAGG-T	TP53	c.238_240delCCT	p.P80del	InFrameDeletion	4/11	-
18-48603117-GGAT-G	SMAD4	c.1418_1420delGAT	p.G473_S474delinsA	MultiAAMissense	11/12	-
X-70360623-ACAG-A	MED12	c.6198_6200delGCA	p.Q2076del	InFrameDeletion	42/45	-
5-37063924-TGAA-T	NIPBL	c.7907_7909delAAG	p.E2636del	InFrameDeletion	46/47	-
2-96919780-ATGC-A	TMEM127	c.480_482delGCA	p.Q160del	InFrameDeletion	4/4	-
12-49426753-AGTTGCT-A	KMT2D	c.11729_11734delAGCAAC	p.Q3910_Q3911del	InFrameDeletion	40/55	-
20-57478616-AAAC-A	GNAS	c.292_294delAAC	p.N98del	InFrameDeletion	4/13	-
22-23596120-GGCAGCC-G	BCR	c.1416_1421delCAGCCG	p.S473_R474del	InFrameDeletion	2/23	-
8-128752807-A-G	MYC	c.968A>G	p.N323S	Missense	3/3	-
1-22222420-CTGG-C	HSPG2	c.237_239delCCA	p.F79_Q80delinsL	MultiAAMissense	3/97	-
10-76729508-GCCT-G	KAT6B	c.821_823delCCT	p.A274_C275delinsG	MultiAAMissense	5/18	-
11-103128425-G-A	DYNC2H1	c.10550G>A	p.R3517H	Missense	69/89	-
1-25229100-G-A	RUNX3	c.761C>T	p.T254M	Missense	5/5	-
1-25229100-G-C	RUNX3	c.761C>G	p.T254R	Missense	5/5	-
19-3532641-A-G	FZR1	c.1235A>G	p.N412S	Missense	11/14	-
6-137528167-T-C	IFNGR1	c.133A>G	p.I45V	Missense	2/7	-
11-108106462-A-G	ATM	c.397A>G	p.N133D	Missense	5/63	-
19-2226490-G-A	DOT1L	c.3970G>A	p.A1324T	Missense	27/28	-
6-26056197-T-C	H1-2	c.460A>G	p.T154A	Missense	1/1	-
2-109381529-G-T	RANBP2	c.4534G>T	p.A1512S	Missense	20/29	-
21-42866388-A-C	TMPRSS2	c.133T>G	p.Y45D	Missense	3/14	-
2-58392939-A-T	FANCL	c.611T>A	p.M204K	Missense	8/14	-
3-49927997-T-A	MST1R	c.3731A>T	p.H1244L	Missense	18/20	-
7-55221750-C-G	EGFR	c.794C>G	p.P265R	Missense	7/28	-
X-63412839-C-T	AMER1	c.328G>A	p.V110I	Missense	2/2	-
3-10116292-G-T	FANCD2	c.2794G>T	p.V932F	Missense	29/44	-
8-90993741-T-C	NBN	c.182A>G	p.D61G	Missense	3/16	-
10-63845597-C-T	ARID5B	c.1336C>T	p.H446Y	Missense	9/10	-
15-42042493-A-G	MGA	c.6688A>G	p.I2230V	Missense	17/24	-
15-73994770-A-G	CD276	c.254A>G	p.Q85R	Missense	3/10	-
16-14029153-A-G	ERCC4	c.1364A>G	p.K455R	Missense	8/11	-
17-17942830-C-T	GID4	c.52C>T	p.P18S	Missense	1/6	-
X-47028847-C-T	RBM10	c.151C>T	p.Q51*	Nonsense	3/24	-
3-156421304-A-C	TIPARP	c.1339A>C	p.N447H	Missense	5/6	-
6-134492280-C-T	SGK1	c.1204G>A	p.D402N	Missense	12/14	-
7-151846114-A-G	KMT2C	c.12898T>C	p.S4300P	Missense	52/59	-
8-145737580-G-A	RECQL4	c.3184C>T	p.R1062W	Missense	19/22	-
11-22647274-G-C	FANCF	c.83C>G	p.P28R	Missense	1/1	-
17-78914341-G-A	RPTOR	c.2965G>A	p.E989K	Missense	25/34	-
21-45649954-G-A	ICOSLG	c.881C>T	p.P294L	Missense	6/7	-
12-49438033-C-G	KMT2D	c.5138G>C	p.G1713A	Missense	22/55	-
1-17355193-T-A	SDHB	c.325A>T	p.N109Y	Missense	4/8	-
4-1932441-C-T	NSD2	c.1499C>T	p.A500V	Missense	6/22	-
7-81350116-T-G	HGF	c.1216A>C	p.T406P	Missense	10/18	-
1-28599897-C-T	SESN2	c.779C>T	p.A260V	Missense	6/10	-
1-43804956-C-T	MPL	c.406C>T	p.P136S	Missense	4/12	-
1-120548096-G-C	NOTCH2	c.271C>G	p.R91G	Missense	3/34	-
15-43748365-C-A	TP53BP1	c.2441G>T	p.S814I	Missense	12/28	-
2-29541235-C-T	ALK	c.1582G>A	p.A528T	Missense	8/29	-
7-2984019-C-T	CARD11	c.511G>A	p.V171M	Missense	5/25	-
8-37697076-C-T	ADGRA2	c.2447C>T	p.A816V	Missense	16/19	-
16-89347486-C-T	ANKRD11	c.5464G>A	p.D1822N	Missense	9/13	-
19-36211552-C-G	KMT2B	c.1303C>G	p.P435A	Missense	3/37	-
X-70601761-T-A	TAF1	c.1589T>A	p.L510H	Missense	9/38	-
1-43803899-C-T	MPL	c.209C>T	p.P70L	Missense	2/12	-
1-158632656-C-T	SPTA1	c.2300G>A	p.R767K	Missense	17/52	-
6-20402746-G-T	E2F3	c.283G>T	p.A95S	Missense	1/7	-
9-8465633-C-A	PTPRD	c.3547G>T	p.G1183W	Missense	32/46	-
17-29527483-G-T	NF1	c.932G>T	p.G311V	Missense	9/58	-
19-17953253-G-C	JAK3	c.733C>G	p.L245V	Missense	6/24	-
1-158648261-G-A	SPTA1	c.742C>T	p.R248C	Missense	6/52	-
9-8485851-G-A	PTPRD	c.2966C>T	p.T989I	Missense	28/46	-
6-149997769-G-A	LATS1	c.2698C>T	p.R900C	Missense	6/8	-
7-6022456-C-T	PMS2	c.2173G>A	p.A725T	Missense	12/15	-
8-145737580-G-C	RECQL4	c.3184C>G	p.R1062G	Missense	19/22	-
7-151848636-C-T	KMT2C	c.12557G>A	p.G4186D	Missense	50/59	-
9-139794069-C-T	TRAF2	c.212C>T	p.A71V	Missense	3/11	-
16-3640215-A-G	SLX4	c.3424T>C	p.S1142P	Missense	12/15	-
19-18943209-G-T	UPF1	c.191G>T	p.G64V	Missense	1/24	-
20-46279830-GCAGCAA-G	NCOA3	c.3762_3767delACAGCA	p.Q1275_Q1276del	InFrameDeletion	20/23	-
7-151845153-ATGGCCTTGTTCC-A	KMT2C	c.13848_13859del12	p.Q4618_E4621del	InFrameDeletion	52/59	-
19-15289635-CTGGGCA-C	NOTCH3	c.3831_3836delTGCCCA	p.C1277_Q1279delinsW	SpliceDonorDeletion	23/33	-
20-46266441-G-A	NCOA3	c.2426G>A	p.S809N	Missense	13/23	-
17-17965244-C-G	GID4	c.794C>G	p.S265*	Nonsense	5/6	-
15-41988548-C-T	MGA	c.1340C>T	p.P447L	Missense	3/24	-
X-39911390-C-G	BCOR	c.5240G>C	p.S1747T	Missense	15/15	-
15-43748365-C-T	TP53BP1	c.2441G>A	p.S814N	Missense	12/28	-
17-78931492-G-A	RPTOR	c.3439G>A	p.V1147I	Missense	29/34	-
17-63533865-C-T	AXIN2	c.1289G>A	p.S430N	Missense	6/11	-
15-91354582-C-T	BLM	c.4022C>T	p.A1341V	Missense	21/22	-
1-98058883-G-A	DPYD	c.1019C>T	p.A340V	Missense	10/23	-
11-44129444-G-A	EXT2	c.182G>A	p.R61H	Missense	2/14	-
1-22150672-G-A	HSPG2	c.12841C>T	p.R4281C	Missense	95/97	-
14-75514070-C-A	MLH3	c.2289G>T	p.K763N	Missense	2/13	-
8-96057801-G-T	NDUFAF6	c.506G>T	p.R169L	Missense	5/9	-
22-41543949-C-T	EP300	c.2240C>T	p.P747L	Missense	12/31	-
3-37042462-T-C	MLH1	c.224T>C	p.I75T	Missense	3/19	-
16-3658668-T-C	SLX4	c.298A>G	p.T100A	Missense	2/15	-
17-40948193-G-C	WNK4	c.3484G>C	p.D1162H	Missense	17/19	-
8-41790541-C-A	KAT6A	c.5197G>T	p.E1733*	Nonsense	17/17	-
12-49445821-A-T	KMT2D	c.1645T>A	p.F549I	Missense	11/55	-
14-68878231-C-G	RAD51B	c.944C>G	p.S315*	Nonsense	9/11	-
1-158626443-G-T	SPTA1	c.2809C>A	p.L937I	Missense	20/52	-
2-17955667-C-T	GEN1	c.1201C>T	p.R401*	Nonsense	11/14	-
17-46805405-C-A	HOXB13	c.551G>T	p.C184F	Missense	1/2	-
5-131927015-C-G	RAD50	c.1552C>G	p.L518V	Missense	10/25	-
1-22204732-G-A	HSPG2	c.2632C>T	p.R878C	Missense	21/97	-
7-103207075-C-T	RELN	c.4720G>A	p.A1574T	Missense	32/65	-
1-182555531-C-G	RNASEL	c.411G>C	p.K137N	Missense	2/7	-
14-81610468-T-G	TSHR	c.2066T>G	p.V689G	Missense	10/10	-
10-31750149-A-G	ZEB1	c.242A>G	p.N81S	Missense	2/9	-
2-141945994-C-G	LRP1B	c.1009G>C	p.A337P	Missense	7/91	-
7-103202089-C-T	RELN	c.5419G>A	p.D1807N	Missense	36/65	-
8-41798955-T-C	KAT6A	c.2444A>G	p.K815R	Missense	15/17	-
3-128628975-C-A	ACAD9	c.1675C>A	p.R559S	Missense	16/18	-
2-128044317-C-A	ERCC3	c.1304G>T	p.W435L	Missense	8/15	-
16-89815141-C-T	FANCA	c.3274G>A	p.G1092S	Missense	33/43	-
9-86592621-T-C	HNRNPK	c.139A>G	p.I47V	Missense	4/17	-
18-53128314-C-T	TCF4	c.240G>A	p.M80I	Missense	5/20	-
10-76789182-A-C	KAT6B	c.4600A>C	p.T1534P	Missense	18/18	-
16-16251549-C-T	ABCC6	c.3853G>A	p.V1285M	Missense	27/31	-
1-179100604-C-T	ABL2	c.233G>A	p.R78H	Missense	3/12	-
1-22176880-T-C	HSPG2	c.7270A>G	p.I2424V	Missense	56/97	-
8-41906092-A-C	KAT6A	c.404T>G	p.F135C	Missense	2/17	-
19-11151986-A-G	SMARCA4	c.4174A>G	p.I1392V	Missense	30/35	-
1-193119450-C-G	CDC73	c.845C>G	p.T282S	Missense	9/17	-
1-27023450-AGCG-A	ARID1A	c.567_569delCGG	p.G191del	InFrameDeletion	1/20	-
3-128627857-GTTGGCCGGAGGCTTCGGGACT-G	ACAD9	c.1400_1420del21	p.V467_S474delinsA	MultiAAMissense	14/18	-
3-128603564-CCGTGGAAAAATTCTTCACTGA-C	ACAD9	c.219_239del21	p.V74_E80del	InFrameDeletion	2/18	-
12-25380217-CACA-C	KRAS	c.238_240delTGT	p.C80del	InFrameDeletion	3/5	-
1-27023140-TGGC-T	ARID1A	c.258_260delCGG	p.G87del	InFrameDeletion	1/20	-
17-42940135-TC-AA	EFTUD2	c.1552_1553delinsTT	p.D518F	Missense	16/28	-
17-63554515-A-G	AXIN2	c.224T>C	p.L75P	Missense	2/11	-
2-47641532-C-G	MSH2	c.917C>G	p.A306G	Missense	5/16	-
20-40710573-G-C	PTPRT	c.4221C>G	p.F1407L	Missense	30/31	-
19-50919693-C-T	POLD1	c.2861C>T	p.T954M	Missense	23/27	-
7-55223550-C-G	EGFR	c.917C>G	p.S306W	Missense	8/28	-
2-111425146-C-G	BUB1	c.757G>C	p.E253Q	Missense	8/25	-
1-28595739-G-A	SESN2	c.136G>A	p.A46T	Missense	2/10	-
1-156834527-G-A	NTRK1	c.295G>A	p.V99M	Missense	3/17	-
2-178096105-G-A	NFE2L2	c.1226C>T	p.P409L	Missense	5/5	-
5-180045875-G-A	FLT4	c.2896C>T	p.L966F	Missense	21/30	-
9-139564629-G-A	EGFL7	c.418G>A	p.E140K	Missense	8/11	-
11-119156011-G-A	CBL	c.1676G>A	p.R559Q	Missense	11/16	-
6-149997819-G-C	LATS1	c.2648C>G	p.S883*	Nonsense	6/8	-
11-71948538-G-T	INPPL1	c.3250G>T	p.E1084*	Nonsense	26/28	-
2-25982385-C-T	ASXL2	c.905G>A	p.R302Q	Missense	9/13	-
2-141771224-T-C	LRP1B	c.2281A>G	p.I761V	Missense	14/91	-
10-63852760-T-C	ARID5B	c.3538T>C	p.S1180P	Missense	10/10	-
11-102199650-C-A	BIRC3	c.1055C>A	p.P352Q	Missense	5/9	-
17-38568013-C-T	TOP2A	c.847G>A	p.G283S	Missense	8/35	-
19-5212381-G-A	PTPRS	c.4736C>T	p.P1579L	Missense	31/38	-
19-5273546-G-C	PTPRS	c.286C>G	p.L96V	Missense	4/38	-
13-103514062-A-T	ERCC5	c.878A>T	p.K293I	Missense	7/15	-
13-110435328-G-C	IRS2	c.3073C>G	p.P1025A	Missense	1/2	-
12-49445351-TGAGTCCTCAGGTGGTGGGGATGTGGGG-T	KMT2D	c.2088_2114del27	p.T698_P706del	InFrameDeletion	11/55	-
6-20402833-AGCG-A	E2F3	c.385_387delGGC	p.G129del	InFrameDeletion	1/7	-
19-10597476-G-T	KEAP1	c.1727C>A	p.T576K	Missense	6/6	-
14-81528545-T-C	TSHR	c.224T>C	p.L75P	Missense	2/10	-
12-111856235-C-G	SH2B3	c.286C>G	p.P96A	Missense	2/8	-
15-43700191-G-C	TP53BP1	c.5696C>G	p.T1899S	Missense	27/28	-
13-102378986-G-T	FGF14	c.583C>A	p.H195N	Missense	4/5	-
1-226568883-G-C	PARP1	c.1186C>G	p.L396V	Missense	9/23	-
2-109381471-T-G	RANBP2	c.4476T>G	p.N1492K	Missense	20/29	-
2-227660220-G-A	IRS1	c.3235C>T	p.P1079S	Missense	1/2	-
3-185165671-A-G	MAP3K13	c.946A>G	p.T316A	Missense	5/14	-
3-49722469-G-C	MST1	c.1598C>G	p.T533S	Missense	14/18	-
3-72873654-A-T	SHQ1	c.648T>A	p.N216K	Missense	6/11	-
5-180053001-G-A	FLT4	c.1289C>T	p.S430F	Missense	10/30	-
7-142659292-A-G	KEL	c.2T>C	p.M1?	Missense	1/19	-
12-69967885-G-A	FRS2	c.677G>A	p.S226N	Missense	9/9	-
19-15298066-C-T	NOTCH3	c.1690G>A	p.A564T	Missense	11/33	-
7-140449124-C-A	BRAF	c.1955G>T	p.G652V	Missense	16/18	-
3-72891463-G-T	SHQ1	c.299C>A	p.S100Y	Missense	3/11	-
16-72821642-ACCGCCG-A	ZFHX3	c.10527_10532delCGGCGG	p.G3511_G3512del	InFrameDeletion	10/10	-
19-15303289-GTCCTCCAGCTGA-G	NOTCH3	c.228_239del12	p.Q77_D80del	InFrameDeletion	3/33	-
19-15308324-C-CCTGCTG	NOTCH3	c.183_184insCAGCAG	p.R61_E62insQQ	InFrameInsertion	2/33	-
8-117864216-C-T	RAD21	c.1441G>A	p.G481R	Missense	11/14	-
8-117864216-C-G	RAD21	c.1441G>C	p.G481R	Missense	11/14	-
5-131923318-GCCT-G	RAD50	c.821_823delCCT	p.A274_L275delinsV	MultiAAMissense	6/25	-
7-151879666-T-C	KMT2C	c.5279A>G	p.K1760R	Missense	36/59	-
15-43749151-T-C	TP53BP1	c.1655A>G	p.D552G	Missense	12/28	-
3-185184675-A-G	MAP3K13	c.1567A>G	p.I523V	Missense	10/14	-
1-228612824-A-T	HIST3H3	c.203T>A	p.F68Y	Missense	1/1	-
1-45798488-C-A	MUTYH	c.439G>T	p.A147S	Missense	7/16	-
1-45798488-C-G	MUTYH	c.439G>C	p.A147P	Missense	7/16	-
19-14627367-T-C	DNAJB1	c.703A>G	p.I235V	Missense	2/3	-
17-37880984-37880985---TACGTGATGGCT	ERBB2	c.2314_2325dup	p.Y772_A775dup	inframe_insertion	20/27	-
17-37880981-37880982---GCATACGTGATG	ERBB2	c.2313_2324dup	p.Y772_A775dup	inframe_insertion	20/27	-
20-31024810-C-G	ASXL1	c.4295C>G	p.S1432C	Missense	13/13	-
X-47426758-G-A	ARAF	c.1003G>A	p.V335M	Missense	10/16	-
2-109352660-C-T	RANBP2	c.737C>T	p.T246M	Missense	6/29	-
3-12422872-A-T	PPARG	c.278A>T	p.Q91L	Missense	4/8	-
5-67576804-A-G	PIK3R1	c.886A>G	p.T296A	Missense	7/16	-
5-176520262-C-T	FGFR4	c.1181C>T	p.A394V	Missense	9/18	-
13-28611358-C-T	FLT3	c.1273G>A	p.A425T	Missense	10/24	-
15-43700206-G-C	TP53BP1	c.5681C>G	p.S1894C	Missense	27/28	-
16-347839-C-T	AXIN1	c.1667G>A	p.R556H	Missense	6/11	-
16-3646303-G-A	SLX4	c.1775C>T	p.T592I	Missense	8/15	-
1-158597415-C-G	SPTA1	c.5664G>C	p.K1888N	Missense	40/52	-
2-39241945-A-T	SOS1	c.1901T>A	p.F634Y	Missense	11/23	-
12-12022865-C-T	ETV6	c.971C>T	p.P324L	Missense	5/8	-
14-30108013-G-C	PRKD1	c.794C>G	p.S265C	Missense	5/18	-
X-47041720-C-T	RBM10	c.1945C>T	p.Q649*	Nonsense	17/24	-
17-41610670-C-A	ETV4	c.430G>T	p.G144C	Missense	7/13	-
3-142172064-G-C	ATR	c.7667C>G	p.T2556S	Missense	46/47	-
4-187549736-A-G	FAT1	c.4505T>C	p.L1502P	Missense	8/27	-
7-14027731-T-C	ETV1	c.113A>G	p.D38G	Missense	4/14	-
8-38162787-C-G	NSD3	c.2419G>C	p.D807H	Missense	13/24	-
10-70405575-A-G	TET1	c.3089A>G	p.N1030S	Missense	4/12	-
12-57864355-G-A	GLI1	c.1832G>A	p.R611Q	Missense	12/12	-
14-95584087-T-A	DICER1	c.1381A>T	p.I461L	Missense	9/27	-
16-3900567-T-C	CREBBP	c.529A>G	p.M177V	Missense	2/31	-
17-17119805-C-A	FLCN	c.1189G>T	p.V397L	Missense	11/14	-
17-37872185-C-G	ERBB2	c.1506C>G	p.D502E	Missense	12/27	-
15-42041927-G-A	MGA	c.6122G>A	p.G2041D	Missense	17/24	-
16-396226-A-C	AXIN1	c.800T>G	p.L267R	Missense	2/11	-
17-56440960-G-A	RNF43	c.377C>T	p.A126V	Missense	4/10	-
20-46271051-A-T	NCOA3	c.3175A>T	p.T1059S	Missense	17/23	-
1-206943179-T-G	IL10	c.439A>C	p.N147H	Missense	4/5	-
17-15961337-G-A	NCOR1	c.6052C>T	p.R2018*	Nonsense	39/46	-
1-201983019-G-A	ELF3	c.868G>A	p.E290K	Missense	8/9	-
5-223642-G-A	SDHA	c.109G>A	p.V37I	Missense	2/15	-
17-29486049-GAAAAAAATTTAT-G	NF1	c.228_239del12	p.E76_Y80delinsD	MultiAAMissense	3/58	-
2-26022303-ACTG-A	ASXL2	c.351_353delCAG	p.S118del	InFrameDeletion	5/13	-
15-66782894-C-A	MAP2K1	c.1123C>A	p.L375I	Missense	11/11	-
16-81944317-G-C	PLCG2	c.1926G>C	p.E642D	Missense	18/33	-
19-18966027-A-G	UPF1	c.1520A>G	p.Y507C	Missense	11/24	-
20-52198735-T-C	ZNF217	c.631A>G	p.I211V	Missense	2/6	-
X-47044721-G-T	RBM10	c.2121G>T	p.Q707H	Missense	19/24	-
2-109382140-C-A	RANBP2	c.5145C>A	p.S1715R	Missense	20/29	-
3-189456493-C-T	TP63	c.254C>T	p.A85V	Missense	3/14	-
5-112174667-A-G	APC	c.3376A>G	p.S1126G	Missense	16/16	-
6-89793532-C-A	PNRC1	c.601C>A	p.H201N	Missense	2/2	-
10-112724451-T-C	SHOC2	c.335T>C	p.I112T	Missense	2/9	-
12-6709736-G-A	CHD4	c.1027C>T	p.R343C	Missense	8/40	-
18-19751256-G-A	GATA6	c.151G>A	p.E51K	Missense	2/7	-
9-8499712-T-A	PTPRD	c.2257A>T	p.R753W	Missense	25/46	-
2-128030511-T-C	ERCC3	c.1757A>G	p.Q586R	Missense	11/15	-
4-187542461-T-C	FAT1	c.5279A>G	p.D1760G	Missense	10/27	-
12-498170-T-C	KDM5A	c.88A>G	p.T30A	Missense	1/28	-
14-30100188-T-G	PRKD1	c.1432A>C	p.K478Q	Missense	10/18	-
17-78858937-A-T	RPTOR	c.1972A>T	p.M658L	Missense	17/34	-
12-133233799-T-C	POLE	c.3505A>G	p.K1169E	Missense	29/49	-
7-100417341-A-G	EPHB4	c.1135T>C	p.F379L	Missense	6/17	-
3-119582406-C-T	GSK3B	c.956G>A	p.R319H	Missense	9/11	-
6-43746655-A-G	VEGFA	c.962A>G	p.K321R	Missense	5/8	-
15-43749166-T-C	TP53BP1	c.1640A>G	p.N547S	Missense	12/28	-
16-56867142-C-T	NUP93	c.1361C>T	p.T454M	Missense	13/22	-
6-112015659-C-G	FYN	c.1192G>C	p.V398L	Missense	12/14	-
11-111958617-A-C	SDHD	c.89A>C	p.H30P	Missense	2/4	-
16-72992112-A-T	ZFHX3	c.1933T>A	p.C645S	Missense	2/10	-
1-158653225-G-A	SPTA1	c.326C>T	p.S109F	Missense	3/52	-
20-52198817-C-A	ZNF217	c.549G>T	p.G183=	Synonymous	2/6	-
16-72993299-C-G	ZFHX3	c.746G>C	p.G249A	Missense	2/10	-
19-15281580-T-A	NOTCH3	c.4793A>T	p.D1598V	Missense	26/33	-
16-72821343-T-G	ZFHX3	c.10832A>C	p.H3611P	Missense	10/10	-
18-19752100-A-C	GATA6	c.995A>C	p.H332P	Missense	2/7	-
3-30686280-A-C	TGFBR2	c.136A>C	p.K46Q	Missense	2/7	-
5-38950118-A-G	RICTOR	c.3832T>C	p.S1278P	Missense	31/38	-
2-141812727-T-A	LRP1B	c.1510A>T	p.R504W	Missense	10/91	-
8-37691603-T-C	ADGRA2	c.1565T>C	p.I522T	Missense	11/19	-
16-89839690-C-A	FANCA	c.2003G>T	p.S668I	Missense	22/43	-
19-50906399-G-T	POLD1	c.1060G>T	p.A354S	Missense	9/27	-
7-2946463-G-A	CARD11	c.3274C>T	p.R1092*	Nonsense	25/25	-
19-6590945-C-A	CD70	c.69G>T	p.L23F	Missense	1/3	-
2-141083426-C-T	LRP1B	c.12245G>A	p.S4082N	Missense	80/91	-
3-49936338-G-A	MST1R	c.1510C>T	p.R504C	Missense	3/20	-
3-49934990-A-C	MST1R	c.2009T>G	p.V670G	Missense	6/20	-
5-86675607-T-C	RASA1	c.2543T>C	p.L848P	Missense	19/25	-
2-47612335-T-G	EPCAM	c.889T>G	p.Y297D	Missense	8/9	-
7-100421477-G-A	EPHB4	c.200C>T	p.P67L	Missense	3/17	-
7-100421460-G-C	EPHB4	c.217C>G	p.L73V	Missense	3/17	-
10-90770309-A-G	FAS	c.457A>G	p.I153V	Missense	5/9	-
11-108114780-T-G	ATM	c.597T>G	p.C199W	Missense	6/63	-
12-49445089-C-T	KMT2D	c.2377G>A	p.E793K	Missense	11/55	-
12-49448725-C-T	KMT2D	c.134G>A	p.S45N	Missense	3/55	-
19-11015725-G-A	CARM1	c.319G>A	p.V107I	Missense	2/16	-
11-118376161-C-T	KMT2A	c.9554C>T	p.S3185L	Missense	27/36	-
2-48032061-G-T	MSH6	c.3451G>T	p.A1151S	Missense	6/10	-
5-180057053-C-T	FLT4	c.566G>A	p.R189Q	Missense	5/30	-
6-94066470-A-G	EPHA7	c.1289T>C	p.L430P	Missense	5/17	-
17-7578201-CACACTATGTCGA-C	TP53	c.636_647del12	p.F212_V216delinsL	MultiAAMissense	6/11	-
7-55242467-AATTAAGAGAAGCAACAT-TTG	EGFR	c.2237_2254delinsTTG	p.E746_S752delinsVA	MultiAAMissense	19/28	-
9-21971182-AC-TT	CDKN2A	c.175_176delinsAA	p.V59K	Missense	2/3	-
3-49725208-G-C	MST1	c.217C>G	p.R73G	Missense	2/18	-
15-42019398-G-T	MGA	c.3451G>T	p.E1151*	Nonsense	10/24	-
20-52193094-G-A	ZNF217	c.2209C>T	p.P737S	Missense	4/6	-
17-33433432-C-A	RAD51D	c.549G>T	p.Q183H	Missense	6/10	-
14-20823933-C-T	PARP2	c.925C>T	p.R309W	Missense	10/16	-
8-145738094-G-A	RECQL4	c.2816C>T	p.A939V	missense_variant	17/22	-
X-76939822-T-C	ATRX	c.926A>G	p.Y309C	Missense	9/35	-
1-193181207-G-T	CDC73	c.1043G>T	p.R348I	Missense	12/17	-
5-112173554-A-G	APC	c.2263A>G	p.R755G	Missense	16/16	-
6-150001517-T-C	LATS1	c.2087A>G	p.K696R	Missense	5/8	-
7-128843429-C-T	SMO	c.536C>T	p.T179M	Missense	2/12	-
9-110249774-C-G	KLF4	c.901G>C	p.A301P	Missense	3/5	-
12-15722382-A-G	PTPRO	c.2779A>G	p.I927V	Missense	19/27	-
13-29041087-G-T	FLT1	c.341C>A	p.T114N	Missense	3/30	-
8-38273437-G-T	FGFR1	c.1805C>A	p.S602Y	Missense	13/18	-
16-30134511-T-A	MAPK3	c.20A>T	p.Q7L	Missense	1/9	-
19-5246020-A-T	PTPRS	c.755T>A	p.M252K	Missense	10/38	-
1-120054205-C-G	HSD3B1	c.225C>G	p.D75E	Missense	3/4	-
1-158631174-C-G	SPTA1	c.2490G>C	p.K830N	Missense	18/52	-
8-41805294-C-G	KAT6A	c.1877G>C	p.C626S	Missense	11/17	-
8-69031688-T-G	PREX2	c.3443T>G	p.V1148G	Missense	28/40	-
10-8105963-G-T	GATA3	c.786G>T	p.R262S	Missense	4/6	-
11-118377037-C-A	KMT2A	c.10430C>A	p.S3477Y	Missense	27/36	-
13-28913392-G-C	FLT1	c.2401C>G	p.P801A	Missense	17/30	-
15-41803485-C-T	LTK	c.874G>A	p.E292K	Missense	7/20	-
16-67662454-G-T	CTCF	c.1700G>T	p.R567L	Missense	9/12	-
18-60985745-T-A	BCL2	c.155A>T	p.Q52L	Missense	2/3	-
19-50920313-G-A	POLD1	c.3079G>A	p.E1027K	Missense	25/27	-
21-45651283-T-A	ICOSLG	c.742A>T	p.S248C	Missense	5/7	-
22-38379668-G-T	SOX10	c.124C>A	p.L42M	Missense	2/4	-
1-243716188-T-C	AKT3	c.1006A>G	p.M336V	Missense	11/14	-
14-75516166-C-G	MLH3	c.193G>C	p.D65H	Missense	2/13	-
7-2969678-G-T	CARD11	c.1601C>A	p.A534D	Missense	12/25	-
7-2969679-C-T	CARD11	c.1600G>A	p.A534T	Missense	12/25	-
16-72830410-C-A	ZFHX3	c.6171G>T	p.Q2057H	Missense	9/10	-
16-3789622-G-A	CREBBP	c.4237C>T	p.H1413Y	Missense	25/31	-
16-3639377-A-C	SLX4	c.4262T>G	p.I1421S	Missense	12/15	-
2-29754893-C-T	ALK	c.1042G>A	p.A348T	Missense	4/29	-
2-227661669-C-G	IRS1	c.1786G>C	p.G596R	Missense	1/2	-
5-176520202-C-T	FGFR4	c.1121C>T	p.A374V	Missense	9/18	-
12-69968445-C-T	FRS2	c.1237C>T	p.R413W	Missense	9/9	-
16-14041752-T-C	ERCC4	c.2299T>C	p.F767L	Missense	11/11	-
17-7980421-C-T	ALOX12B	c.1162G>A	p.A388T	Missense	9/15	-
11-71942228-C-T	INPPL1	c.1492C>T	p.R498C	Missense	12/28	-
1-2491358-A-G	TNFRSF14	c.401A>G	p.H134R	Missense	4/8	-
15-91293039-A-G	BLM	c.541A>G	p.S181G	Missense	3/22	-
3-12475561-C-G	PPARG	c.1351C>G	p.Q449E	Missense	8/8	-
3-169953071-A-G	PRKCI	c.155A>G	p.N52S	Missense	2/18	-
4-1806195-G-T	FGFR3	c.1214G>T	p.G405V	Missense	9/18	-
6-134494479-T-G	SGK1	c.635A>C	p.H212P	Missense	7/14	-
12-49445732-C-G	KMT2D	c.1734G>C	p.E578D	Missense	11/55	-
8-37688342-G-A	ADGRA2	c.833G>A	p.R278H	Missense	7/19	-
9-5069154-C-T	JAK2	c.1459C>T	p.R487C	Missense	11/25	-
9-35075730-G-C	FANCG	c.1165C>G	p.P389A	Missense	10/14	-
11-118373677-C-G	KMT2A	c.7070C>G	p.P2357R	Missense	27/36	-
12-21644468-C-T	RECQL	c.199G>A	p.A67T	Missense	3/15	-
16-23649402-C-T	PALB2	c.97G>A	p.A33T	Missense	2/13	-
21-45655232-C-T	ICOSLG	c.620G>A	p.R207Q	Missense	4/7	-
7-55087058-G-C	EGFR	c.88G>C	p.V30L	Missense	1/28	-
5-149497346-C-T	PDGFRB	c.2972G>A	p.R991H	Missense	22/23	-
7-6027012-T-C	PMS2	c.1384A>G	p.I462V	Missense	11/15	-
9-93606448-C-A	SYK	c.268C>A	p.H90N	Missense	2/14	-
9-97876934-T-G	FANCC	c.1131A>C	p.E377D	Missense	12/15	-
9-93606269-T-C	SYK	c.89T>C	p.V30A	Missense	2/14	-
11-108196135-T-C	ATM	c.6671T>C	p.M2224T	Missense	46/63	-
7-6026969-C-T	PMS2	c.1427G>A	p.S476N	Missense	11/15	-
17-7989447-GTCCTTGGGGAAGAAGGCGTAC-G	ALOX12B	c.219_239del21	p.Y74_D80del	InFrameDeletion	2/15	-
19-18965834-CTCAACCACT-C	UPF1	c.1412_1420delTCAACCACT	p.L471_S474delinsP	MultiAAMissense	10/24	-
4-55984811-CC-AT	KDR	c.317_318delinsAT	p.R106H	Missense	3/30	-
5-176518043-A-G	FGFR4	c.541A>G	p.T181A	Missense	5/18	-
3-52661320-T-A	PBRM1	c.1510A>T	p.T504S	Missense	14/30	-
16-14014110-G-C	ERCC4	c.88G>C	p.D30H	Missense	1/11	-
9-137300095-T-C	RXRA	c.380T>C	p.M127T	Missense	3/10	-
2-242794121-T-TGGCTCC	PDCD1	c.601_606dup	p.G201_A202dup	InFrameInsertion	4/5	-
3-12475471-C-G	PPARG	c.1261C>G	p.L421V	Missense	8/8	-
5-176520430-C-G	FGFR4	c.1275C>G	p.S425=	Synonymous	10/18	-
5-176520430-C-T	FGFR4	c.1275C>T	p.S425=	Synonymous	10/18	-
17-55704620-G-A	MSI2	c.683G>A	p.R228H	Missense	10/14	-
15-41797609-C-A	LTK	c.1817G>T	p.R606L	Missense	14/20	-
12-92538121-G-C	BTG1	c.251C>G	p.A84G	Missense	2/2	-
1-22181855-G-A	HSPG2	c.5939C>T	p.A1980V	Missense	47/97	-
2-29754914-T-C	ALK	c.1021A>G	p.S341G	Missense	4/29	-
7-92244520-C-A	CDK6	c.915G>T	p.R305S	Missense	8/8	-
10-50686456-G-A	ERCC6	c.2230C>T	p.R744W	Missense	11/21	-
5-36976408-G-A	NIPBL	c.1399G>A	p.D467N	Missense	9/47	-
2-30143525-T-C	ALK	c.1A>G	p.M1?	Missense	1/29	-
19-15303035-C-T	NOTCH3	c.415G>A	p.D139N	Missense	4/33	-
1-22207013-C-T	HSPG2	c.2038G>A	p.A680T	Missense	16/97	-
X-47041678-G-T	RBM10	c.1903G>T	p.E635*	Nonsense	17/24	-
13-21562631-T-G	LATS2	c.1288A>C	p.N430H	Missense	4/8	-
16-3640872-T-A	SLX4	c.2767A>T	p.M923L	Missense	12/15	-
17-48276804-C-T	COL1A1	c.344G>A	p.G115E	Missense	4/51	-
18-61323100-C-T	SERPINB3	c.964G>A	p.G322S	Missense	8/8	-
12-4479733-T-G	FGF23	c.532A>C	p.T178P	Missense	3/3	-
2-190719076-C-T	PMS1	c.1078C>T	p.L360F	Missense	9/13	-
8-56882302-G-A	LYN	c.1000G>A	p.D334N	Missense	10/13	-
9-133759429-G-C	ABL1	c.1752G>C	p.L584=	Synonymous	11/11	-
11-108115597-A-G	ATM	c.745A>G	p.I249V	Missense	7/63	-
15-67473585-A-G	SMAD3	c.665A>G	p.Q222R	Missense	6/9	-
16-341269-G-A	AXIN1	c.2215C>T	p.R739C	Missense	9/11	-
3-72799483-G-T	SHQ1	c.1686C>A	p.N562K	Missense	11/11	-
4-20544150-G-A	SLIT2	c.2177G>A	p.R726H	Missense	21/37	-
5-161117341-C-T	GABRA6	c.808C>T	p.P270S	Missense	7/9	-
9-127923140-C-T	PPP6C	c.217G>A	p.D73N	Missense	3/7	-
21-39755737-T-C	ERG	c.1028A>G	p.D343G	Missense	10/10	-
10-76781878-GGAAGAGGAT-G	KAT6B	c.3270_3278delTGAAGAGGA	p.D1090_E1092del	InFrameDeletion	16/18	-
4-41748118-CCCG-C	PHOX2B	c.648_650delCGG	p.G217del	InFrameDeletion	3/3	-
9-20365693-AAGCTGG-A	MLLT3	c.1169_1174delCCAGCT	p.S390_S391del	InFrameDeletion	6/11	-
9-87338523-ACTGTGGAGGAAGGAAAGT-A	NTRK2	c.622_639del18	p.V208_S213del	InFrameDeletion	7/19	-
16-3778400-TTGC-T	CREBBP	c.6645_6647delGCA	p.Q2216del	InFrameDeletion	31/31	-
10-101544518-A-AAGC	ABCC2	c.188_189insGCA	p.K63_L64insQ	InFrameInsertion	2/32	-
16-72821615-GCCACCG-A	ZFHX3	c.10554_10560delinsT	p.G3526_G3527del	InFrameDeletion	10/10	-
4-41747944-GGGA-G	PHOX2B	c.822_824delTCC	p.P275del	InFrameDeletion	3/3	-
11-125497673-TCCA-T	CHEK1	c.237_239delCCA	p.Q80del	InFrameDeletion	3/13	-
1-22206925-T-C	HSPG2	c.2126A>G	p.D709G	Missense	16/97	-
8-26149336-A-G	PPP2R2A	c.1A>G	p.M1?	Missense	1/10	-
16-359996-G-A	AXIN1	c.1093C>T	p.R365W	Missense	4/11	-
9-133759372-G-C	ABL1	c.1695G>C	p.E565D	Missense	11/11	-
19-35831891-C-T	CD22	c.1357C>T	p.R453W	Missense	7/14	-
2-109381515-A-C	RANBP2	c.4520A>C	p.K1507T	Missense	20/29	-
2-109380129-C-T	RANBP2	c.3134C>T	p.T1045M	Missense	20/29	-
6-32487258-C-A	HLA-DRB5	c.541G>T	p.D181Y	Missense	3/6	-
6-32634287-C-A	HLA-DQB1	c.98G>T	p.R33I	Missense	1/5	-
11-17743020-G-A	MYOD1	c.928G>A	p.G310S	Missense	3/3	-
13-110436411-C-A	IRS2	c.1990G>T	p.G664C	Missense	1/2	-
2-212251704-C-T	ERBB4	c.3355G>A	p.V1119I	Missense	27/28	-
2-234669547-C-T	UGT1A1	c.614C>T	p.T205I	Missense	1/5	-
2-212488723-T-C	ERBB4	c.2126A>G	p.Q709R	Missense	18/28	-
8-145741388-C-G	RECQL4	c.1115G>C	p.R372T	Missense	5/22	-
11-94178990-A-G	MRE11	c.1853T>C	p.M618T	Missense	16/20	-
16-31146744-A-C	PRSS8	c.76T>G	p.S26A	Missense	1/6	-
12-430171-C-T	KDM5A	c.2531G>A	p.R844Q	Missense	18/28	-
12-57860171-C-T	GLI1	c.911C>T	p.T304M	Missense	8/12	-
16-3656667-G-A	SLX4	c.568C>T	p.P190S	Missense	3/15	-
19-15288568-C-G	NOTCH3	c.4171G>C	p.A1391P	Missense	24/33	-
4-187541170-C-A	FAT1	c.6570G>T	p.E2190D	Missense	10/27	-
14-38061141-C-A	FOXA1	c.848G>T	p.G283V	Missense	2/2	-
X-47041563-T-G	RBM10	c.1788T>G	p.Y596*	Nonsense	17/24	-
10-123324026-A-T	FGFR2	c.444T>A	p.S148R	Missense	4/18	-
12-123874060-A-T	KMT5A	c.91A>T	p.M31L	Missense	2/8	-
6-35420365-G-C	FANCE	c.43G>C	p.E15Q	Missense	1/10	-
3-47165554-G-A	SETD2	c.572C>T	p.P191L	Missense	3/21	-
7-151860142-C-T	KMT2C	c.10520G>A	p.R3507Q	Missense	43/59	-
12-1040408-C-T	RAD52	c.164G>A	p.R55H	Missense	3/12	-
12-56490398-G-A	ERBB3	c.2167G>A	p.V723M	Missense	18/28	-
22-29091827-T-G	CHEK2	c.1130A>C	p.E377A	Missense	11/15	-
22-30057255-C-G	NF2	c.737C>G	p.P246R	Missense	8/16	-
X-47035920-C-T	RBM10	c.598C>T	p.Q200*	Nonsense	7/24	-
17-40371414-T-G	STAT5B	c.749A>C	p.D250A	Missense	7/19	-
12-123874064-T-G	KMT5A	c.95T>G	p.V32G	Missense	2/8	-
16-72863756-C-A	ZFHX3	c.3451G>T	p.E1151*	Nonsense	5/10	-
9-21818170-G-A	MTAP	c.316G>A	p.D106N	Missense	4/8	-
12-475204-G-A	KDM5A	c.433C>T	p.R145C	Missense	4/28	-
15-93496765-G-A	CHD2	c.1681G>A	p.V561I	Missense	14/39	-
20-52193112-G-C	ZNF217	c.2191C>G	p.L731V	Missense	4/6	-
1-16257012-T-C	SPEN	c.4277T>C	p.L1426S	Missense	11/15	-
9-5549514-C-T	PDCD1LG2	c.541C>T	p.R181C	Missense	4/7	-
12-133237641-C-T	POLE	c.2974G>A	p.A992T	Missense	25/49	-
2-141946077-A-G	LRP1B	c.926T>C	p.V309A	Missense	7/91	-
9-87482334-A-C	NTRK2	c.1621A>C	p.K541Q	Missense	14/19	-
14-30066702-T-G	PRKD1	c.2429A>C	p.H810P	Missense	16/18	-
17-7216752-T-G	GPS2	c.671A>C	p.Q224P	Missense	8/11	-
17-37619085-A-C	CDK12	c.761A>C	p.H254P	Missense	1/14	-
19-42753064-G-C	ERF	c.1200C>G	p.D400E	Missense	4/4	-
1-149785140-T-C	H3C13	c.97A>G	p.T33A	Missense	1/1	-
2-215645591-C-T	BARD1	c.1007G>A	p.C336Y	Missense	4/11	-
9-27197397-C-T	TEK	c.1709C>T	p.S570L	Missense	12/23	-
11-100999132-C-T	PGR	c.670G>A	p.E224K	Missense	1/8	-
18-56390435-C-T	MALT1	c.1174C>T	p.R392C	Missense	10/17	-
12-49431305-TTGC-T	KMT2D	c.9831_9833delGCA	p.Q3282del	InFrameDeletion	35/55	-
22-30032859-CAAG-C	NF2	c.238_240delAAG	p.K80del	SpliceDonorDeletion	2/16	-
22-30032797-G-GAGCAGCAGCAGC	NF2	c.173_174insGCAGCAGCAGCA	p.E58_T59insQQQQ	InFrameInsertion	2/16	-
4-106155335-CACA-C	TET2	c.238_240delCAA	p.Q80del	InFrameDeletion	3/11	-
9-27157973-A-G	TEK	c.197A>G	p.N66S	Missense	2/23	-
10-123244937-C-T	FGFR2	c.2167G>A	p.D723N	Missense	16/18	-
12-49447349-T-G	KMT2D	c.749A>C	p.H250P	Missense	7/55	-
7-151877845-G-T	KMT2C	c.7100C>A	p.T2367K	Missense	36/59	-
10-63850916-C-A	ARID5B	c.1694C>A	p.T565N	Missense	10/10	-
12-49425206-C-T	KMT2D	c.13282G>A	p.A4428T	Missense	40/55	-
16-89371740-C-T	ANKRD11	c.100G>A	p.V34I	Missense	4/13	-
16-3779076-G-A	CREBBP	c.5972C>T	p.P1991L	Missense	31/31	-
17-37864680-A-G	ERBB2	c.332A>G	p.N111S	Missense	3/27	-
1-118166506-G-A	TENT5C	c.1016G>A	p.R339H	Missense	2/2	-
2-112722768-G-T	MERTK	c.758G>T	p.G253V	Missense	5/19	-
7-128829133-C-A	SMO	c.141C>A	p.S47R	Missense	1/12	-
13-21620048-C-A	LATS2	c.118G>T	p.G40*	Nonsense	2/8	-
20-9624949-C-A	PAK5	c.28G>T	p.E10*	Nonsense	3/10	-
1-51439914-G-C	CDKN2C	c.479G>C	p.G160A	Missense	2/2	-
2-26022318-G-C	ASXL2	c.339C>G	p.N113K	Missense	5/13	-
2-47630391-C-T	MSH2	c.61C>T	p.R21C	Missense	1/16	-
3-51977429-C-G	PARP3	c.79C>G	p.R20G	Missense	2/11	-
5-176637082-C-G	NSD1	c.1682C>G	p.S561C	Missense	5/23	-
7-142643310-G-A	KEL	c.1298C>T	p.P433L	Missense	11/19	-
8-145738862-G-A	RECQL4	c.2203C>T	p.R735C	Missense	14/22	-
16-3647516-G-A	SLX4	c.1547C>T	p.A516V	Missense	7/15	-
19-1219396-G-A	STK11	c.448G>A	p.V150M	Missense	3/10	-
1-162745495-T-C	DDR2	c.1910T>C	p.I637T	Missense	15/18	-
1-246093200-G-A	SMYD3	c.571C>T	p.Q191*	Nonsense	6/12	-
4-20618542-G-T	SLIT2	c.3857G>T	p.G1286V	Missense	35/37	-
7-81386539-G-T	HGF	c.448C>A	p.Q150K	Missense	4/18	-
8-37690548-G-A	ADGRA2	c.1118G>A	p.G373D	Missense	9/19	-
10-104592955-C-A	CYP17A1	c.764G>T	p.R255L	Missense	5/8	-
11-102094429-T-A	YAP1	c.1109T>A	p.M370K	Missense	7/9	-
14-38061009-C-A	FOXA1	c.980G>T	p.G327V	Missense	2/2	-
17-29509630-G-C	NF1	c.835G>C	p.E279Q	Missense	8/58	-
17-29541493-A-G	NF1	c.1417A>G	p.T473A	Missense	13/58	-
20-41385221-C-A	PTPRT	c.740G>T	p.R247L	Missense	6/31	-
X-47424197-C-T	ARAF	c.202C>T	p.R68*	Nonsense	4/16	-
5-112176292-T-G	APC	c.5001T>G	p.N1667K	Missense	16/16	-
2-48025766-T-G	MSH6	c.644T>G	p.V215G	Missense	4/10	-
3-189526270-C-A	TP63	c.534C>A	p.D178E	Missense	4/14	-
16-23632749-A-G	PALB2	c.3047T>C	p.F1016S	Missense	10/13	-
4-55129932-G-A	PDGFRA	c.466G>A	p.E156K	Missense	4/23	-
10-63852251-G-A	ARID5B	c.3029G>A	p.R1010Q	Missense	10/10	-
11-17741787-C-G	MYOD1	c.458C>G	p.A153G	Missense	1/3	-
13-113887594-G-A	CUL4A	c.616G>A	p.G206S	Missense	6/20	-
14-30100011-G-T	PRKD1	c.1609C>A	p.Q537K	Missense	10/18	-
12-120784095-G-A	MSI1	c.890C>T	p.P297L	Missense	13/15	-
12-133241898-T-G	POLE	c.2458A>C	p.M820L	Missense	21/49	-
1-228612974-C-T	H3-4	c.53G>A	p.R18H	Missense	1/1	-
12-49435770-C-A	KMT2D	c.6113G>T	p.W2038L	Missense	30/55	-
1-156851267-C-T	NTRK1	c.2224C>T	p.Q742*	Nonsense	17/17	-
7-151879084-G-C	KMT2C	c.5861C>G	p.S1954C	Missense	36/59	-
11-111965590-G-T	SDHD	c.376G>T	p.A126S	Missense	4/4	-
2-25973044-A-C	ASXL2	c.1381T>G	p.S461A	Missense	12/13	-
2-25973050-T-C	ASXL2	c.1375A>G	p.T459A	Missense	12/13	-
2-26068408-G-C	ASXL2	c.82C>G	p.P28A	Missense	2/13	-
15-43748774-C-A	TP53BP1	c.2032G>T	p.E678*	Nonsense	12/28	-
12-1025806-G-C	RAD52	c.724C>G	p.R242G	Missense	8/12	-
20-46255875-G-A	NCOA3	c.487G>A	p.E163K	Missense	6/23	-
20-57478608-G-A	GNAS	c.280G>A	p.D94N	Missense	4/13	-
4-20568902-A-G	SLIT2	c.2743A>G	p.I915V	Missense	27/37	-
X-39933151-G-A	BCOR	c.1448C>T	p.P483L	Missense	4/15	-
X-48649728-A-G	GATA1	c.212A>G	p.H71R	Missense	2/6	-
2-25966378-G-C	ASXL2	c.2828C>G	p.T943S	Missense	13/13	-
17-30323835-G-T	SUZ12	c.1813G>T	p.D605Y	Missense	15/16	-
2-47705619-A-C	MSH2	c.2419A>C	p.T807P	Missense	14/16	-
11-118390417-G-A	KMT2A	c.11231G>A	p.R3744Q	Missense	32/36	-
3-10128885-A-C	FANCD2	c.3403A>C	p.I1135L	Missense	34/44	-
11-118342838-T-G	KMT2A	c.964T>G	p.S322A	Missense	3/36	-
9-133759851-G-T	ABL1	c.2174G>T	p.G725V	Missense	11/11	-
9-133759718-T-C	ABL1	c.2041T>C	p.F681L	Missense	11/11	-
5-176517436-C-T	FGFR4	c.137C>T	p.T46I	Missense	3/18	-
7-55224510-G-A	EGFR	c.1192G>A	p.V398I	Missense	10/28	-
8-41906039-G-C	KAT6A	c.457C>G	p.R153G	Missense	2/17	-
16-3779022-C-G	CREBBP	c.6026G>C	p.S2009T	Missense	31/31	-
16-72829040-G-A	ZFHX3	c.7541C>T	p.T2514I	Missense	9/10	-
17-29483115-A-C	NF1	c.175A>C	p.T59P	Missense	2/58	-
2-227660807-GGCT-G	IRS1	c.2645_2647delAGC	p.Q882del	InFrameDeletion	1/2	-
10-63851054-CGGA-C	ARID5B	c.1836_1838delGGA	p.E612del	InFrameDeletion	10/10	-
10-63850633-CAAGAAAAAG-C	ARID5B	c.1414_1422delGAAAAAGAA	p.E472_E474del	InFrameDeletion	10/10	-
X-110406205-GGAA-G	PAK3	c.546_548delAGA	p.E182del	InFrameDeletion	9/18	-
15-42003382-ACAG-A	MGA	c.2931_2933delGCA	p.Q981del	InFrameDeletion	8/24	-
22-29130529-T-TCTGCTG	CHEK2	c.180_181insCAGCAG	p.L60_S61insQQ	InFrameInsertion	2/15	-
12-49445425-A-G	KMT2D	c.2041T>C	p.S681P	Missense	11/55	-
2-25978959-A-C	ASXL2	c.964T>G	p.L322V	Missense	10/13	-
15-41796358-A-G	LTK	c.2431T>C	p.S811P	Missense	20/20	-
1-156851285-C-A	NTRK1	c.2242C>A	p.R748=	Synonymous	17/17	-
9-133759794-G-T	ABL1	c.2117G>T	p.G706V	Missense	11/11	-
7-55248998-A-ATGGCCAGCG	EGFR	c.2300_2308dup	p.A767_V769dup	InFrameInsertion	20/28	-
1-45799120-C-A	MUTYH	c.229G>T	p.D77Y	Missense	3/16	-
1-45799120-C-G	MUTYH	c.229G>C	p.D77H	Missense	3/16	-
1-45799120-C-T	MUTYH	c.229G>A	p.D77N	Missense	3/16	-
2-141946086-C-A	LRP1B	c.917G>T	p.R306L	Missense	7/91	-
2-212566725-C-A	ERBB4	c.1456G>T	p.V486L	Missense	12/28	-
3-10084285-G-T	FANCD2	c.826G>T	p.E276*	Nonsense	11/44	-
3-38180417-G-A	MYD88	c.265G>A	p.D76N	Missense	1/5	-
3-52621446-C-A	PBRM1	c.2971G>T	p.E991*	Nonsense	20/30	-
4-55976869-A-T	KDR	c.1043T>A	p.V348D	Missense	8/30	-
5-57750553-C-G	PLK2	c.1915G>C	p.E639Q	Missense	14/14	-
5-176637159-G-T	NSD1	c.1759G>T	p.G587C	Missense	5/23	-
5-180055994-G-T	FLT4	c.991C>A	p.P331T	Missense	8/30	-
7-81388023-G-T	HGF	c.352C>A	p.L118I	Missense	3/18	-
7-92355028-T-C	CDK6	c.449A>G	p.N150S	Missense	4/8	-
7-100410605-C-A	EPHB4	c.1882G>T	p.E628*	Nonsense	12/17	-
8-37692838-G-T	ADGRA2	c.1755G>T	p.E585D	Missense	12/19	-
5-180030278-C-T	FLT4	c.4006G>A	p.E1336K	Missense	30/30	-
7-81355326-G-A	HGF	c.1048C>T	p.R350*	Nonsense	9/18	-
9-27190589-A-C	TEK	c.1390A>C	p.N464H	Missense	10/23	-
14-95582861-T-C	DICER1	c.1681A>G	p.I561V	Missense	10/27	-
16-23619239-G-T	PALB2	c.3296C>A	p.T1099K	Missense	12/13	-
17-58678032-C-T	PPM1D	c.257C>T	p.P86L	Missense	1/6	-
19-50919036-G-A	POLD1	c.2773G>A	p.V925M	Missense	22/27	-
15-43784559-C-T	TP53BP1	c.115G>A	p.D39N	Missense	2/28	-
1-120491725-G-A	NOTCH2	c.2504C>T	p.A835V	Missense	16/34	-
16-89877354-G-C	FANCA	c.409C>G	p.L137V	Missense	4/43	-
19-15276653-G-A	NOTCH3	c.5612C>T	p.S1871L	Missense	30/33	-
15-93485147-T-G	CHD2	c.788T>G	p.I263S	Missense	8/39	-
16-72821636-ACTG-A	ZFHX3	c.10536_10538delCAG	p.S3513del	InFrameDeletion	10/10	-
16-72993868-CTCA-C	ZFHX3	c.174_176delTGA	p.N58_E59delinsK	MultiAAMissense	2/10	-
7-55268955-GGACGACGTGGTGGAT-G	EGFR	c.3023_3037del15	p.D1008_D1012del	InFrameDeletion	25/28	-
19-18273784-GG-CT	PIK3R2	c.1117_1118delGGinsCT	p.G373L	Missense	10/16	-
10-104596877-AGCT-A	CYP17A1	c.239_241delAGC	p.Q80del	InFrameDeletion	1/8	-
19-10292734-C-T	DNMT1	c.100G>A	p.D34N	Missense	2/41	-
1-246078897-G-A	SMYD3	c.748C>T	p.R250W	Missense	8/12	-
1-246078897-G-T	SMYD3	c.748C>A	p.R250=	Synonymous	8/12	-
3-134851697-G-A	EPHB1	c.1103G>A	p.R368Q	Missense	5/16	-
8-68982089-G-A	PREX2	c.1463G>A	p.R488H	Missense	13/40	-
17-70120442-G-A	SOX9	c.1444G>A	p.D482N	Missense	3/3	-
X-70343020-C-T	MED12	c.1561C>T	p.R521C	Missense	11/45	-
9-80537225-T-A	GNAQ	c.173A>T	p.Q58L	Missense	2/7	-
2-242794872-C-T	PDCD1	c.337G>A	p.A113T	Missense	2/5	-
16-81957157-G-A	PLCG2	c.2375G>A	p.R792H	Missense	22/33	-
17-59871023-C-T	BRIP1	c.1408G>A	p.G470R	Missense	10/20	-
19-1627410-C-T	TCF3	c.314G>A	p.R105Q	Missense	6/19	-
19-13049543-C-G	CALR	c.50C>G	p.A17G	Missense	1/9	-
19-1621879-A-G	TCF3	c.913T>C	p.S305P	Missense	11/19	-
2-215645691-C-T	BARD1	c.907G>A	p.V303I	Missense	4/11	-
4-187541859-C-T	FAT1	c.5881G>A	p.G1961S	Missense	10/27	-
5-176518758-G-A	FGFR4	c.676G>A	p.V226I	Missense	6/18	-
7-151878479-T-C	KMT2C	c.6466A>G	p.T2156A	Missense	36/59	-
6-37138784-C-G	PIM1	c.217C>G	p.R73G	Missense	3/6	-
15-38643531-G-A	SPRED1	c.1001G>A	p.R334H	Missense	7/7	-
15-41988350-T-C	MGA	c.1142T>C	p.I381T	Missense	3/24	-
16-3633395-G-A	SLX4	c.4856C>T	p.P1619L	Missense	14/15	-
6-37138981-G-A	PIM1	c.321G>A	p.L107=	Synonymous	4/6	-
17-7983555-G-C	ALOX12B	c.752C>G	p.S251C	Missense	6/15	-
1-27106106-G-C	ARID1A	c.5717G>C	p.R1906P	Missense	20/20	-
6-89793584-A-G	PNRC1	c.653A>G	p.Y218C	Missense	2/2	-
8-37689078-G-A	ADGRA2	c.1070G>A	p.R357H	Missense	8/19	-
9-93627330-G-C	SYK	c.797G>C	p.G266A	Missense	6/14	-
16-89350760-C-A	ANKRD11	c.2190G>T	p.R730S	Missense	9/13	-
17-29653164-A-G	NF1	c.5162A>G	p.H1721R	Missense	37/58	-
1-27107009-A-T	ARID1A	c.6620A>T	p.Q2207L	Missense	20/20	-
2-16082915-G-T	MYCN	c.729G>T	p.Q243H	Missense	2/3	-
2-25505459-T-A	DNMT3A	c.299A>T	p.Q100L	Missense	4/23	-
2-215674179-C-T	BARD1	c.115G>A	p.A39T	Missense	1/11	-
3-52582216-C-G	PBRM1	c.4612G>C	p.E1538Q	Missense	30/30	-
4-106155177-G-T	TET2	c.78G>T	p.Q26H	Missense	3/11	-
6-150001155-C-T	LATS1	c.2449G>A	p.E817K	Missense	5/8	-
7-86416031-G-C	GRM3	c.923G>C	p.S308T	Missense	3/6	-
9-98231266-G-A	PTCH1	c.2017C>T	p.H673Y	Missense	14/24	-
10-63810730-A-G	ARID5B	c.817A>G	p.N273D	Missense	5/10	-
12-57861831-T-A	GLI1	c.1132T>A	p.S378T	Missense	10/12	-
13-28622416-A-G	FLT3	c.1201T>C	p.Y401H	Missense	9/24	-
13-29001378-G-T	FLT1	c.1354C>A	p.L452M	Missense	10/30	-
13-32910747-A-T	BRCA2	c.2255A>T	p.D752V	Missense	11/27	-
16-81934373-G-T	PLCG2	c.1350G>T	p.K450N	Missense	14/33	-
4-41748004-CGCTGCCGCCGCCGCCGCTGCCGCGGCCGCCGCCGCTGCT-C	PHOX2B	c.726_764del39	p.A248_A260del	InFrameDeletion	3/3	-
19-45854930-CTCT-C	ERCC2	c.2238_2240delAGA	p.E748del	InFrameDeletion	23/23	-
19-45872195-AATC-A	ERCC2	c.237_239delGAT	p.E79_I80delinsD	MultiAAMissense	4/23	-
3-51979069-CGAGGCCTTG-C	PARP3	c.717_725delCTTGGAGGC	p.A235_E237del	InFrameDeletion	6/11	-
3-51981876-TTCG-T	PARP3	c.1418_1420delTCG	p.F466_D467delinsY	MultiAAMissense	10/11	-
7-55242468-ATTAAGAGAAGCAACATCT-GCAA	EGFR	c.2238_2256delinsGCAA	p.L747_S752delinsQ	MultiAAMissense	19/28	-
17-30264502-TCCA-T	SUZ12	c.237_239delCCA	p.Q80del	InFrameDeletion	1/16	-
9-87475976-GGGA-G	NTRK2	c.1418_1420delGGA	p.G473_K474delinsE	MultiAAMissense	13/19	-
19-1622199-C-T	TCF3	c.676G>A	p.E226K	Missense	10/19	-
19-13050265-C-G	CALR	c.217C>G	p.R73G	Missense	3/9	-
5-176517620-G-A	FGFR4	c.321G>A	p.M107I	Missense	3/18	-
12-133212597-C-G	POLE	c.5692G>C	p.E1898Q	Missense	42/49	-
2-212248635-G-A	ERBB4	c.3632C>T	p.T1211I	Missense	28/28	-
5-112175007-G-A	APC	c.3716G>A	p.R1239K	Missense	16/16	-
11-77043849-T-C	PAK1	c.1477A>G	p.I493V	Missense	14/15	-
14-95593000-A-C	DICER1	c.820T>G	p.L274V	Missense	7/27	-
15-42035253-G-A	MGA	c.5095G>A	p.V1699I	Missense	15/24	-
16-81946269-G-A	PLCG2	c.2002G>A	p.A668T	Missense	19/33	-
19-2211146-T-C	DOT1L	c.1400T>C	p.V467A	Missense	15/28	-
19-42383204-C-G	CD79A	c.224C>G	p.T75R	Missense	2/5	-
7-140449206-T-G	BRAF	c.1873A>C	p.I625L	Missense	16/18	-
9-87317319-G-T	NTRK2	c.344G>T	p.S115I	Missense	4/19	-
2-141143489-T-C	LRP1B	c.10504A>G	p.S3502G	Missense	67/91	-
1-150551373-T-C	MCL1	c.634A>G	p.T212A	Missense	1/3	-
13-73337683-AT-A	DIS3	c.2032delA	p.I678Ffs*59	Frameshift	16/21	-
19-45854937-C-A	ERCC2	c.2233G>T	p.E745*	Nonsense	23/23	-
19-18943167-GC-G	UPF1	c.153delC	p.G52Afs*42	Frameshift	1/24	-
19-1207064-T-TG	STK11	c.157_157dup	p.D53Gfs*110	Frameshift	1/10	-
X-47045664-CG-C	RBM10	c.2545delG	p.E849Sfs*37	Frameshift	23/24	-
1-120458389-CG-C	NOTCH2	c.6956delC	p.A2319Gfs*39	Frameshift	34/34	-
5-67589575-G-GA	PIK3R1	c.1344_1344dup	p.L449Ifs*3	Frameshift	11/16	-
17-40370235-TG-T	STAT5B	c.1102delC	p.Q368Rfs*2	Frameshift	9/19	-
6-112386180-CA-C	CCN6	c.625delA	p.S191Afs*41	Frameshift	3/5	-
7-142658485-G-GA	KEL	c.184_184dup	p.S62Ffs*17	Frameshift	3/19	-
X-47044927-AG-A	RBM10	c.2253delG	p.K752Sfs*50	Frameshift	20/24	-
16-72822591-G-GA	ZFHX3	c.9583_9584insT	p.P3195Lfs*44	Frameshift	10/10	-
16-72822586-G-GCT	ZFHX3	c.9588_9589insAG	p.Q3197Sfs*45	Frameshift	10/10	-
11-125505377-G-GA	CHEK1	c.676_676dup	p.T226Nfs*19	Frameshift	7/13	-
2-220439653-TG-T	INHA	c.509delG	p.G170Afs*20	Frameshift	2/2	-
12-57860073-C-CT	GLI1	c.814_814dup	p.W272Lfs*35	Frameshift	8/12	-
7-13975472-TG-T	ETV1	c.414delC	p.T139Hfs*116	Frameshift	8/14	-
11-118344185-AC-A	KMT2A	c.2318delC	p.P773Rfs*8	Frameshift	3/36	-
5-79970914-C-CA	MSH3	c.1148_1148dup	p.N385Qfs*19	Frameshift	7/24	-
12-21644546-CT-C	RECQL	c.120delA	p.V41Sfs*2	Frameshift	3/15	-
7-41730027-TG-T	INHBA	c.501delC	p.R168Gfs*30	Frameshift	3/3	-
7-116403235-T-TC	MET	c.2497_2497dup	p.L833Pfs*6	Frameshift	11/21	-
16-72991350-TG-T	ZFHX3	c.2694delC	p.M899Wfs*4	Frameshift	2/10	-
10-123239508-CGA-C	FGFR2	c.2327_2328delTC	p.L776Rfs*6	Frameshift	18/18	-
1-27023830-CG-C	ARID1A	c.941delG	p.G314Afs*49	Frameshift	1/20	-
12-49420203-G-GC	KMT2D	c.15545_15545dup	p.L5183Pfs*16	Frameshift	49/55	-
17-38546380-C-CT	TOP2A	c.4303_4303dup	p.R1435Kfs*8	Frameshift	34/35	-
5-112177176-TG-T	APC	c.5885delG	p.C1962Sfs*8	Frameshift	16/16	-
10-101578637-CCT-C	ABCC2	c.2362_2363delCT	p.L788Vfs*13	Frameshift	18/32	-
17-38512368-CCGGGGGGTGGGGGGCGGGA-C	RARA	c.1286_1304del19	p.G429Vfs*208	Frameshift	9/9	-
7-55242467-GAA-G	EGFR	c.2237_2238delAA	p.E746Vfs*16	Frameshift	19/28	-
3-49927458-GT-G	MST1R	c.3846delA	p.R1283Gfs*37	Frameshift	19/20	-
1-36937051-AC-A	CSF3R	c.1267delG	p.V423Sfs*10	Frameshift	10/17	-
3-142188348-TCTGTGATAAC-T	ATR	c.6373_6382delGTTATCACAG	p.V2125Sfs*6	Frameshift	38/47	-
3-10084281-A-AT	FANCD2	c.824_824dup	p.L275Ffs*22	Frameshift	11/44	-
X-47039288-TGCGCAACCTGAACCCACACA-T	RBM10	c.914_933del20	p.R305Hfs*69	Frameshift	10/24	-
2-141128388-CCTTACATTCAGTCACACAG-C	LRP1B	c.10881_10899del19	p.D3627Efs*123	Frameshift	71/91	-
2-227661663-GC-G	IRS1	c.1791delG	p.H598Tfs*38	Frameshift	1/2	-
2-227661663-G-GC	IRS1	c.1791_1791dup	p.H598Afs*13	Frameshift	1/2	-
17-41610700-TG-T	ETV4	c.399delC	p.R134Dfs*30	Frameshift	7/13	-
12-121416708-AG-A	HNF1A	c.142delG	p.E48Sfs*107	Frameshift	1/10	-
7-151848069-CCT-C	KMT2C	c.12688_12689delAG	p.R4230Gfs*9	Frameshift	51/59	-
5-131944381-C-CA	RAD50	c.2801_2801dup	p.N934Kfs*10	Frameshift	17/25	-
8-68992720-G-GT	PREX2	c.1693_1693dup	p.S565Ffs*3	Frameshift	16/40	-
7-151874147-C-CT	KMT2C	c.8390_8390dup	p.E2798Gfs*11	Frameshift	38/59	-
12-21644546-C-CA	RECQL	c.120_121insT	p.V41Cfs*14	Frameshift	3/15	-