PMID: 37018014

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

The Biochemical journal

Balmanno, Kathryn K, Kidger, Andrew M AM, Byrne, Dominic P DP, Sale, Matthew J MJ, Nassman, Nejma N, Eyers, Patrick A PA, Cook, Simon J SJ

2023-04-05

4 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
7-140453136-A-T	BRAF	c.1799T>A	p.V600E	Missense	15/18	-
12-25398281-C-T	KRAS	c.38G>A	p.G13D	Missense	2/5	-
11-125514092-TT-GC	CHEK1	c.1030_1031delTTinsGC	p.F344A	Missense	10/13	-
12-25378670-G-C	KRAS	c.328C>G	p.P110A	Missense	4/5	-