PMID: 37018014

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

The Biochemical journal
Balmanno, Kathryn K, Kidger, Andrew M AM, Byrne, Dominic P DP, Sale, Matthew J MJ, Nassman, Nejma N, Eyers, Patrick A PA, Cook, Simon J SJ

4 variants were identified in this publication

Variant ID Gene cDNA Protein Consequence Exon Intron
11-125514092-TT-GC CHEK1 c.1030_1031delTTinsGC p.F344A Missense 10/13 -
7-140453136-A-T BRAF c.1799T>A p.V600E Missense 15/18 -
12-25398281-C-T KRAS c.38G>A p.G13D Missense 2/5 -
12-25378670-G-C KRAS c.328C>G p.P110A Missense 4/5 -