PMID: 37026591

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal of medicinal chemistry
Harnden, Alice C AC, Davis, Owen A OA, Box, Gary M GM, Hayes, Angela A, Johnson, Louise D LD, Henley, Alan T AT, de Haven Brandon, Alexis K AK, Valenti, Melanie M, Cheung, Kwai-Ming J KJ, Brennan, Alfie A, Huckvale, Rosemary R, Pierrat, Olivier A OA, Talbot, Rachel R, Bright, Michael D MD, Akpinar, Hafize Aysin HA, Miller, Daniel S J DSJ, Tarantino, Dalia D, Gowan, Sharon S, de Klerk, Selby S, McAndrew, Peter Craig PC, Le Bihan, Yann-Vaï YV, Meniconi, Mirco M, Burke, Rosemary R, Kirkin, Vladimir V, van Montfort, Rob L M RLM, Raynaud, Florence I FI, Rossanese, Olivia W OW, Bellenie, Benjamin R BR, Hoelder, Swen S
2023-04-07

60 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-55242473-GAGA-G EGFR c.2246_2248delAAG p.E749del InFrameDeletion 19/28 -
3-178936082-G-A PIK3CA c.1624G>A p.E542K Missense 10/21 -
7-55242505-AATC-A EGFR c.2275_2277delATC p.I759del InFrameDeletion 19/28 -
7-55242487-C-T EGFR c.2257C>T p.P753S Missense 19/28 -
7-55249071-C-T EGFR c.2369C>T p.T790M Missense 20/28 -
7-140453136-A-T BRAF c.1799T>A p.V600E Missense 15/18 -
7-55259524-T-A EGFR c.2582T>A p.L861Q Missense 21/28 -
7-55259515-T-G EGFR c.2573T>G p.L858R Missense 21/28 -
7-55242478-G-C EGFR c.2248G>C p.A750P Missense 19/28 -
4-55599321-A-T KIT c.2447A>T p.D816V Missense 17/21 -
9-133748283-C-T ABL1 c.944C>T p.T315I Missense 6/11 -
7-55242476-AAGC-A EGFR c.2248_2250delGCA p.A750del InFrameDeletion 19/28 -
7-55242484-ATCT-A EGFR c.2254_2256delTCT p.S752del InFrameDeletion 19/28 -
7-55241707-G-A EGFR c.2155G>A p.G719S Missense 18/28 -
7-55242478-GCAA-G EGFR c.2251_2253delACA p.T751del InFrameDeletion 19/28 -
13-28592644-C-T FLT3 c.2501G>A p.R834Q Missense 20/24 -
13-28592642-C-A FLT3 c.2503G>T p.D835Y Missense 20/24 -
12-40734202-G-A LRRK2 c.6055G>A p.G2019S Missense 41/51 -
3-178936091-G-A PIK3CA c.1633G>A p.E545K Missense 10/21 -
7-55241707-G-T EGFR c.2155G>T p.G719C Missense 18/28 -
10-43617416-T-C RET c.2753T>C p.M918T Missense 16/20 -
10-43614996-G-C RET c.2410G>C p.V804L Missense 14/20 -
10-43614996-G-T RET c.2410G>T p.V804L Missense 14/20 -
10-43614996-G-A RET c.2410G>A p.V804M Missense 14/20 -
9-133738358-A-T ABL1 c.758A>T p.Y253F Missense 4/11 -
9-133738363-G-A ABL1 c.763G>A p.E255K Missense 4/11 -
4-55593661-T-C KIT c.1727T>C p.L576P Missense 11/21 -
4-55599320-G-C KIT c.2446G>C p.D816H Missense 17/21 -
3-178936092-A-C PIK3CA c.1634A>C p.E545A Missense 10/21 -
13-28592641-T-A FLT3 c.2504A>T p.D835V Missense 20/24 -
7-116423474-T-C MET c.3749T>C p.M1250T Missense 19/21 -
13-28592642-C-G FLT3 c.2503G>C p.D835H Missense 20/24 -
4-55593610-T-A KIT c.1676T>A p.V559D Missense 11/21 -
4-1808331-G-T FGFR3 c.2089G>T p.G697C Missense 16/18 -
3-178936094-C-A PIK3CA c.1636C>A p.Q546K Missense 10/21 -
3-178952085-A-T PIK3CA c.3140A>T p.H1047L Missense 21/21 -
3-178952084-C-T PIK3CA c.3139C>T p.H1047Y Missense 21/21 -
7-116423428-T-G MET c.3703T>G p.Y1235D Missense 19/21 -
9-133738356-G-T ABL1 c.756G>T p.Q252H Missense 4/11 -
9-133738356-G-C ABL1 c.756G>C p.Q252H Missense 4/11 -
9-133748288-T-C ABL1 c.949T>C p.F317L Missense 6/11 -
9-133748391-T-C ABL1 c.1052T>C p.M351T Missense 6/11 -
9-133748290-C-A ABL1 c.951C>A p.F317L Missense 6/11 -
9-133748290-C-G ABL1 c.951C>G p.F317L Missense 6/11 -
3-178927980-T-C PIK3CA c.1258T>C p.C420R Missense 8/21 -
3-178952074-G-C PIK3CA c.3129G>C p.M1043I Missense 21/21 -
3-178952074-G-A PIK3CA c.3129G>A p.M1043I Missense 21/21 -
3-178952074-G-T PIK3CA c.3129G>T p.M1043I Missense 21/21 -
2-29443631-G-T ALK c.3586C>A p.L1196M Missense 23/29 -
13-28601361-A-G FLT3 c.2071T>C p.F691L Missense 17/24 -
13-28601359-A-T FLT3 c.2073T>A p.F691L Missense 17/24 -
13-28601359-A-C FLT3 c.2073T>G p.F691L Missense 17/24 -
9-133748288-T-A ABL1 c.949T>A p.F317I Missense 6/11 -
2-29445258-C-T ALK c.3467G>A p.C1156Y Missense 22/29 -
3-178942591-A-C PIK3CA c.2398A>C p.I800L Missense 16/21 -
9-133750356-A-C ABL1 c.1187A>C p.H396P Missense 7/11 -
15-91438741-A-G FES c.2422A>G p.S808G Missense 19/19 -
13-28592623-T-A FLT3 c.2522A>T p.N841I Missense 20/24 -
13-28602381-T-G FLT3 c.1987A>C p.K663Q Missense 16/24 -
4-55602664-G-C KIT c.2485G>C p.A829P Missense 18/21 -