NRAS c.557G>C ;(p.C186S)

Variant ID: 1-115251169-C-G

NM_002524.4(NRAS):c.557G>C;(p.C186S)

This variant was identified in 10 publications

View GRCh38 version.




Publications:


Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy.

International Journal Of Biological Sciences
Liu, Zhuang Z; Xiao, Mingming M; Mo, Yaqi Y; Wang, Han H; Han, Yamei Y; Zhao, Xu X; Yang, Xue X; Liu, Zhenxing Z; Xu, Bo B
Publication Date: 2022

Variant appearance in text: NRAS: Cys186Ser
PubMed Link: 35637973
Variant Present in the following documents:
  • ijbsv18p3447.pdf
View BVdb publication page



Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules.

Cell
Tulpule, Asmin A; Guan, Juan J; Neel, Dana S DS; Allegakoen, Hannah R HR; Lin, Yone Phar YP; Brown, David D; Chou, Yu-Ting YT; Heslin, Ann A; Chatterjee, Nilanjana N; Perati, Shriya S; Menon, Shruti S; Nguyen, Tan A TA; Debnath, Jayanta J; Ramirez, Alejandro D AD; Shi, Xiaoyu X; Yang, Bin B; Feng, Siyu S; Makhija, Suraj S; Huang, Bo B; Bivona, Trever G TG
Publication Date: 2021-05-13

Variant appearance in text: NRAS: C186S
PubMed Link: 33848463
Variant Present in the following documents:
  • Main text
View BVdb publication page



The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.

The Journal Of Biological Chemistry
Shimizu, Takanobu T; Nakamura, Takeshi T; Inaba, Hironori H; Iwasa, Hiroaki H; Maruyama, Junichi J; Arimoto-Matsuzaki, Kyoko K; Nakata, Takao T; Nishina, Hiroshi H; Hata, Yutaka Y
Publication Date: 2020-08-07

Variant appearance in text: NRAS: C186S
PubMed Link: 32554467
Variant Present in the following documents:
  • Main text
View BVdb publication page



KRAS4A directly regulates hexokinase 1.

Nature
Amendola, Caroline R CR; Mahaffey, James P JP; Parker, Seth J SJ; Ahearn, Ian M IM; Chen, Wei-Ching WC; Zhou, Mo M; Court, Helen H; Shi, Jie J; Mendoza, Sebastian L SL; Morten, Michael J MJ; Rothenberg, Eli E; Gottlieb, Eyal E; Wadghiri, Youssef Z YZ; Possemato, Richard R; Hubbard, Stevan R SR; Balmain, Allan A; Kimmelman, Alec C AC; Philips, Mark R MR
Publication Date: 2019-12

Variant appearance in text: NRAS: C186S
PubMed Link: 31827279
Variant Present in the following documents:
  • Main text
  • nihms-1541488.pdf
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LZTR1 is a regulator of RAS ubiquitination and signaling.

Science (New York, N.Y.)
Bigenzahn, Johannes W JW; Collu, Giovanna M GM; Kartnig, Felix F; Pieraks, Melanie M; Vladimer, Gregory I GI; Heinz, Leonhard X LX; Sedlyarov, Vitaly V; Schischlik, Fiorella F; Fauster, Astrid A; Rebsamen, Manuele M; Parapatics, Katja K; Blomen, Vincent A VA; Müller, André C AC; Winter, Georg E GE; Kralovics, Robert R; Brummelkamp, Thijn R TR; Mlodzik, Marek M; Superti-Furga, Giulio G
Publication Date: 2018-12-07

Variant appearance in text: NRAS: C186S
PubMed Link: 30442766
Variant Present in the following documents:
  • Main text
View BVdb publication page



SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.

Elife
Jing, Hui H; Zhang, Xiaoyu X; Wisner, Stephanie A SA; Chen, Xiao X; Spiegelman, Nicole A NA; Linder, Maurine E ME; Lin, Hening H
Publication Date: 2017-12-14

Variant appearance in text: NRAS: C186S
PubMed Link: 29239724
Variant Present in the following documents:
  • Main text
  • elife-32436.pdf
View BVdb publication page



Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells.

Journal Of Visualized Experiments : Jove
Zhou, Mo M; Philips, Mark R MR
Publication Date: 2017-08-18

Variant appearance in text: NRAS: C186S
PubMed Link: 28872138
Variant Present in the following documents:
  • Main text
View BVdb publication page



VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking.

The Journal Of Cell Biology
Zhou, Mo M; Wiener, Heidi H; Su, Wenjuan W; Zhou, Yong Y; Liot, Caroline C; Ahearn, Ian I; Hancock, John F JF; Philips, Mark R MR
Publication Date: 2016-08-15

Variant appearance in text: NRAS: C186S
PubMed Link: 27502489
Variant Present in the following documents:
  • Main text
  • JCB_201604061_sm.pdf
  • JCB_201604061.pdf
View BVdb publication page



Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Scientific Reports
Blaževitš, Olga O; Mideksa, Yonatan G YG; Šolman, Maja M; Ligabue, Alessio A; Ariotti, Nicholas N; Nakhaeizadeh, Hossein H; Fansa, Eyad K EK; Papageorgiou, Anastassios C AC; Wittinghofer, Alfred A; Ahmadian, Mohammad R MR; Abankwa, Daniel D
Publication Date: 2016-04-18

Variant appearance in text: N-ras: C186S
PubMed Link: 27087647
Variant Present in the following documents:
  • srep24165.pdf
View BVdb publication page



Palmitoylation of oncogenic NRAS is essential for leukemogenesis.

Blood
Cuiffo, Benjamin B; Ren, Ruibao R
Publication Date: 2010-04-29

Variant appearance in text: NRAS: C186S
PubMed Link: 20200357
Variant Present in the following documents:
  • Main text
View BVdb publication page