RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
The Journal Of Clinical Investigation
Ren, Jian-Gang JG; Xing, Bowen B; Lv, Kaosheng K; O'Keefe, Rachel A RA; Wu, Mengfang M; Wang, Ruoxing R; Bauer, Kaylyn M KM; Ghazaryan, Arevik A; Burslem, George M GM; Zhang, Jing J; O'Connell, Ryan M RM; Pillai, Vinodh V; Hexner, Elizabeth O EO; Philips, Mark R MR; Tong, Wei W
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Blood
Zambetti, Noemi A NA; Firestone, Ari J AJ; Remsberg, Jarrett R JR; Huang, Benjamin J BJ; Wong, Jasmine C JC; Long, Amanda M AM; Predovic, Marina M; Suciu, Radu M RM; Inguva, Anagha A; Kogan, Scott C SC; Haigis, Kevin M KM; Cravatt, Benjamin F BF; Shannon, Kevin K
Amendola, Caroline R CR; Mahaffey, James P JP; Parker, Seth J SJ; Ahearn, Ian M IM; Chen, Wei-Ching WC; Zhou, Mo M; Court, Helen H; Shi, Jie J; Mendoza, Sebastian L SL; Morten, Michael J MJ; Rothenberg, Eli E; Gottlieb, Eyal E; Wadghiri, Youssef Z YZ; Possemato, Richard R; Hubbard, Stevan R SR; Balmain, Allan A; Kimmelman, Alec C AC; Philips, Mark R MR
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.
The Journal Of Cell Biology
Goodwin, J Shawn JS; Drake, Kimberly R KR; Rogers, Carl C; Wright, Latasha L; Lippincott-Schwartz, Jennifer J; Philips, Mark R MR; Kenworthy, Anne K AK
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling.
Molecular And Cellular Biology
Roy, Sandrine S; Plowman, Sarah S; Rotblat, Barak B; Prior, Ian A IA; Muncke, Cornelia C; Grainger, Sarah S; Parton, Robert G RG; Henis, Yoav I YI; Kloog, Yoel Y; Hancock, John F JF