Publications:

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RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.

The Journal Of Clinical Investigation

Ren, Jian-Gang JG; Xing, Bowen B; Lv, Kaosheng K; O'Keefe, Rachel A RA; Wu, Mengfang M; Wang, Ruoxing R; Bauer, Kaylyn M KM; Ghazaryan, Arevik A; Burslem, George M GM; Zhang, Jing J; O'Connell, Ryan M RM; Pillai, Vinodh V; Hexner, Elizabeth O EO; Philips, Mark R MR; Tong, Wei W

Publication Date: 2023-06-15

Variant appearance in text: NRAS: C181S

PubMed Link: 37317963

Variant Present in the following documents:

• jci-133-165510-s055.pdf
• jci-133-165510.pdf

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Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development.

International Journal Of Biological Sciences

Qu, Mengyuan M; Zhou, Xuan X; Wang, Xiaotong X; Li, Honggang H

Publication Date: 2021

Variant appearance in text: NRAS: C181S

PubMed Link: 34803494

Variant Present in the following documents:

• Main text
• ijbsv17p4223.pdf

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Palmitoylation as a Key Regulator of Ras Localization and Function.

Frontiers In Molecular Biosciences

Busquets-Hernández, Carla C; Triola, Gemma G

Publication Date: 2021

Variant appearance in text: N-ras: C181S

PubMed Link: 33816563

Variant Present in the following documents:

• fmolb-08-659861.pdf

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NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.

Life Science Alliance

Ahearn, Ian M IM; Court, Helen R HR; Siddiqui, Farid F; Abankwa, Daniel D; Philips, Mark R MR

Publication Date: 2021-05

Variant appearance in text: NRAS: C181S

PubMed Link: 33579760

Variant Present in the following documents:

• Main text
• LSA-2020-00972.pdf

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Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.

Blood

Zambetti, Noemi A NA; Firestone, Ari J AJ; Remsberg, Jarrett R JR; Huang, Benjamin J BJ; Wong, Jasmine C JC; Long, Amanda M AM; Predovic, Marina M; Suciu, Radu M RM; Inguva, Anagha A; Kogan, Scott C SC; Haigis, Kevin M KM; Cravatt, Benjamin F BF; Shannon, Kevin K

Publication Date: 2020-05-14

Variant appearance in text: NRAS: C181S

PubMed Link: 32219446

Variant Present in the following documents:

• Main text

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KRAS4A directly regulates hexokinase 1.

Nature

Amendola, Caroline R CR; Mahaffey, James P JP; Parker, Seth J SJ; Ahearn, Ian M IM; Chen, Wei-Ching WC; Zhou, Mo M; Court, Helen H; Shi, Jie J; Mendoza, Sebastian L SL; Morten, Michael J MJ; Rothenberg, Eli E; Gottlieb, Eyal E; Wadghiri, Youssef Z YZ; Possemato, Richard R; Hubbard, Stevan R SR; Balmain, Allan A; Kimmelman, Alec C AC; Philips, Mark R MR

Publication Date: 2019-12

Variant appearance in text: NRAS: C181S

PubMed Link: 31827279

Variant Present in the following documents:

• Main text
• nihms-1541488.pdf

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Roles of palmitoylation and the KIKK membrane-targeting motif in leukemogenesis by oncogenic KRAS4A.

Journal Of Hematology & Oncology

Zhao, Huanbin H; Liu, Ping P; Zhang, Ruihong R; Wu, Min M; Li, Donghe D; Zhao, Xuemei X; Zhang, Chun C; Jiao, Bo B; Chen, Bing B; Chen, Zhu Z; Ren, Ruibao R

Publication Date: 2015-12-30

Variant appearance in text: NRAS: C181S

PubMed Link: 26715448

Variant Present in the following documents:

• 13045_2015_Article_226.pdf

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A New View of Ras Isoforms in Cancers.

Cancer Research

Nussinov, Ruth R; Tsai, Chung-Jung CJ; Chakrabarti, Mayukh M; Jang, Hyunbum H

Publication Date: 2016-01-01

Variant appearance in text: NRAS: C181S

PubMed Link: 26659836

Variant Present in the following documents:

• Main text

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Targeting oncogenic Ras signaling in hematologic malignancies.

Blood

Ward, Ashley F AF; Braun, Benjamin S BS; Shannon, Kevin M KM

Publication Date: 2012-10-25

Variant appearance in text: NRAS: C181S

PubMed Link: 22898602

Variant Present in the following documents:

• Main text

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Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Blood

Xu, Jin J; Hedberg, Christian C; Dekker, Frank J FJ; Li, Qing Q; Haigis, Kevin M KM; Hwang, Eugene E; Waldmann, Herbert H; Shannon, Kevin K

Publication Date: 2012-01-26

Variant appearance in text: NRAS: C181S

PubMed Link: 22144181

Variant Present in the following documents:

• Main text

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Palmitoylation of oncogenic NRAS is essential for leukemogenesis.

Blood

Cuiffo, Benjamin B; Ren, Ruibao R

Publication Date: 2010-04-29

Variant appearance in text: NRAS: C181S

PubMed Link: 20200357

Variant Present in the following documents:

• Main text

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Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.

The Journal Of Cell Biology

Goodwin, J Shawn JS; Drake, Kimberly R KR; Rogers, Carl C; Wright, Latasha L; Lippincott-Schwartz, Jennifer J; Philips, Mark R MR; Kenworthy, Anne K AK

Publication Date: 2005-07-18

Variant appearance in text: N-ras: C181S

PubMed Link: 16027222

Variant Present in the following documents:

• 200502063.pdf

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Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling.

Molecular And Cellular Biology

Roy, Sandrine S; Plowman, Sarah S; Rotblat, Barak B; Prior, Ian A IA; Muncke, Cornelia C; Grainger, Sarah S; Parton, Robert G RG; Henis, Yoav I YI; Kloog, Yoel Y; Hancock, John F JF

Publication Date: 2005-08

Variant appearance in text: N-ras: C181S

PubMed Link: 16024806

Variant Present in the following documents:

• Main text

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