Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.
Elife
Šolman, Maja M; Ligabue, Alessio A; Blaževitš, Olga O; Jaiswal, Alok A; Zhou, Yong Y; Liang, Hong H; Lectez, Benoit B; Kopra, Kari K; Guzmán, Camilo C; Härmä, Harri H; Hancock, John F JF; Aittokallio, Tero T; Abankwa, Daniel D
A novel switch region regulates H-ras membrane orientation and signal output.
The Embo Journal
Abankwa, Daniel D; Hanzal-Bayer, Michael M; Ariotti, Nicolas N; Plowman, Sarah J SJ; Gorfe, Alemayehu A AA; Parton, Robert G RG; McCammon, J Andrew JA; Hancock, John F JF