NRAS c.436G>C ;(p.A146P)

Variant ID: 1-115252204-C-G

NM_002524.4(NRAS):c.436G>C;(p.A146P)

This variant was identified in 22 publications

View GRCh38 version.




Publications:


Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.

Cancer Medicine
Montes-Rodríguez, Ingrid M IM; Centeno-Girona, Hilmaris H; Rivera-Lynch, Camila C; Rivera, Noridza N; Cruz-Correa, Marcia M
Publication Date: 2023-04-11

Variant appearance in text: NRAS: A146P
PubMed Link: 37039257
Variant Present in the following documents:
  • CAM4-12-11686-s002.xlsx, sheet 1
View BVdb publication page



Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer.

Archives Of Medical Science : Ams
Bożyk, Aleksandra A; Krawczyk, Paweł P; Reszka, Katarzyna K; Krukowska, Kinga K; Kolak, Agnieszka A; Mańdziuk, Sławomir S; Wojas-Krawczyk, Kamila K; Ramlau, Rodryg R; Milanowski, Janusz J
Publication Date: 2022

Variant appearance in text: NRAS: 436G>C
PubMed Link: 36160343
Variant Present in the following documents:
  • AMS-18-5-109170.pdf
View BVdb publication page



Analysis of KRAS, NRAS, and BRAF Mutations, Microsatellite Instability, and Relevant Prognosis Effects in Patients With Early Colorectal Cancer: A Cohort Study in East Asia.

Frontiers In Oncology
Li, Yang Y; Xiao, Jun J; Zhang, Tiancheng T; Zheng, Yanying Y; Jin, Hailin H
Publication Date: 2022

Variant appearance in text: NRAS: A146P
PubMed Link: 35837115
Variant Present in the following documents:
  • fonc-12-897548.pdf
View BVdb publication page



Concordance of acquired mutations between metastatic lesions and liquid biopsy in metastatic colorectal cancer.

Future Science Oa
Taniguchi, Fumitaka F; Nyuya, Akihiro A; Toshima, Toshiaki T; Yasui, Kazuya K; Mori, Yoshiko Y; Okawaki, Makoto M; Kishimoto, Hiroyuki H; Umeda, Yuzo Y; Fujiwara, Toshiyoshi T; Tanioka, Hiroaki H; Yamaguchi, Yoshiyuki Y; Goel, Ajay A; Nagasaka, Takeshi T
Publication Date: 2021-12

Variant appearance in text: NRAS: A146P
PubMed Link: 34840814
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutation status and prognostic value of KRAS and NRAS mutations in Moroccan colon cancer patients: A first report.

Plos One
El Agy, Fatima F; El Bardai, Sanae S; El Otmani, Ihsane I; Benbrahim, Zineb Z; Karim, Ibn Majdoub Hassani MH; Mazaz, Khalid K; Benjelloun, El Bachir EB; Ousadden, Abdelmalek A; El Abkari, Mohammed M; Ibrahimi, Sidi Adil SA; Chbani, Laila L
Publication Date: 2021

Variant appearance in text: NRAS: 436G>C
PubMed Link: 33784337
Variant Present in the following documents:
  • pone.0248522.pdf
View BVdb publication page



Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers.

Frontiers In Oncology
Ortiz-Cuaran, Sandra S; Bouaoud, Jebrane J; Karabajakian, Andy A; Fayette, Jérôme J; Saintigny, Pierre P
Publication Date: 2021

Variant appearance in text: NRAS: A146P
PubMed Link: 33718169
Variant Present in the following documents:
  • Main text
View BVdb publication page



KRAS, NRAS, and BRAF mutation prevalence, clinicopathological association, and their application in a predictive model in Mexican patients with metastatic colorectal cancer: A retrospective cohort study.

Plos One
Sanchez-Ibarra, Hector Eduardo HE; Jiang, Xianli X; Gallegos-Gonzalez, Elena Yareli EY; Cavazos-González, Adriana Carolina AC; Chen, Yenho Y; Morcos, Faruck F; Barrera-Saldaña, Hugo Alberto HA
Publication Date: 2020

Variant appearance in text: NRAS: A146P
PubMed Link: 32628708
Variant Present in the following documents:
  • Main text
  • pone.0235490.pdf
View BVdb publication page



RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International
Zhu, Liuying L; Wang, Yuanhe Y; Zhou, Yang Y; Dong, Qian Q; Liu, Yunpeng Y; Zhang, Jingdong J
Publication Date: 2020

Variant appearance in text: NRAS: A146P
PubMed Link: 32351996
Variant Present in the following documents:
  • BMRI2020-5419634.pdf
View BVdb publication page



KRAS, NRAS, and BRAF mutations are highly enriched in trisomy 12 chronic lymphocytic leukemia and are associated with shorter treatment-free survival.

Leukemia
Vendramini, Elena E; Bomben, Riccardo R; Pozzo, Federico F; Benedetti, Dania D; Bittolo, Tamara T; Rossi, Francesca Maria FM; Dal Bo, Michele M; Rabe, Kari G KG; Pozzato, Gabriele G; Zaja, Francesco F; Chiarenza, Annalisa A; Di Raimondo, Francesco F; Braggio, Esteban E; Parikh, Sameer A SA; Kay, Neil E NE; Shanafelt, Tait D TD; Del Poeta, Giovanni G; Gattei, Valter V; Zucchetto, Antonella A
Publication Date: 2019-08

Variant appearance in text: NRAS: 436G>C; A146P
PubMed Link: 30872781
Variant Present in the following documents:
  • 41375_2019_444_MOESM1_ESM.pdf
View BVdb publication page



Clinical relevance of circulating tumor DNA assessed through deep sequencing in patients with metastatic colorectal cancer.

Cancer Medicine
Osumi, Hiroki H; Shinozaki, Eiji E; Takeda, Yoshinori Y; Wakatsuki, Takeru T; Ichimura, Takashi T; Saiura, Akio A; Yamaguchi, Kensei K; Takahashi, Shunji S; Noda, Tetsuo T; Zembutsu, Hitoshi H
Publication Date: 2019-01

Variant appearance in text: NRAS: A146P
PubMed Link: 30575318
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical Validation of Newly Developed Multiplex Kit Using Luminex xMAP Technology for Detecting Simultaneous RAS and BRAF Mutations in Colorectal Cancer: Results of the RASKET-B Study.

Neoplasia (New York, N.Y.)
Taniguchi, Hiroya H; Okamoto, Wataru W; Muro, Kei K; Akagi, Kiwamu K; Hara, Hiroki H; Nishina, Tomohiro T; Kajiwara, Takeshi T; Denda, Tadamichi T; Hironaka, Shuichi S; Kudo, Toshihiro T; Satoh, Taroh T; Yamanaka, Takeharu T; Abe, Yukiko Y; Fukushima, Yoshiyuki Y; Yoshino, Takayuki T
Publication Date: 2018-12

Variant appearance in text: NRAS: A146P
PubMed Link: 30412858
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

The Lancet. Gastroenterology & Hepatology
Domingo, Enric E; Camps, Carme C; Kaisaki, Pamela J PJ; Parsons, Marie J MJ; Mouradov, Dmitri D; Pentony, Melissa M MM; Makino, Seiko S; Palmieri, Michelle M; Ward, Robyn L RL; Hawkins, Nicholas J NJ; Gibbs, Peter P; Askautrud, Hanne H; Oukrif, Dahmane D; Wang, Haitao H; Wood, Joe J; Tomlinson, Evie E; Bark, Yasmine Y; Kaur, Kulvinder K; Johnstone, Elaine C EC; Palles, Claire C; Church, David N DN; Novelli, Marco M; Danielsen, Havard E HE; Sherlock, Jon J; Kerr, David D; Kerr, Rachel R; Sieber, Oliver O; Taylor, Jenny C JC; Tomlinson, Ian I
Publication Date: 2018-09

Variant appearance in text: NRAS: A146P
PubMed Link: 30042065
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Integrated Molecular Characterization of Testicular Germ Cell Tumors.

Cell Reports
Shen, Hui H; Shih, Juliann J; Hollern, Daniel P DP; Wang, Linghua L; Bowlby, Reanne R; Tickoo, Satish K SK; Thorsson, Vésteinn V; Mungall, Andrew J AJ; Newton, Yulia Y; Hegde, Apurva M AM; Armenia, Joshua J; Sánchez-Vega, Francisco F; Pluta, John J; Pyle, Louise C LC; Mehra, Rohit R; Reuter, Victor E VE; Godoy, Guilherme G; Jones, Jeffrey J; Shelley, Carl S CS; Feldman, Darren R DR; Vidal, Daniel O DO; Lessel, Davor D; Kulis, Tomislav T; Cárcano, Flavio M FM; Leraas, Kristen M KM; Lichtenberg, Tara M TM; Brooks, Denise D; Cherniack, Andrew D AD; Cho, Juok J; Heiman, David I DI; Kasaian, Katayoon K; Liu, Minwei M; Noble, Michael S MS; Xi, Liu L; Zhang, Hailei H; Zhou, Wanding W; ZenKlusen, Jean C JC; Hutter, Carolyn M CM; Felau, Ina I; Zhang, Jiashan J; Schultz, Nikolaus N; Getz, Gad G; Meyerson, Matthew M; Stuart, Joshua M JM; , ; Akbani, Rehan R; Wheeler, David A DA; Laird, Peter W PW; Nathanson, Katherine L KL; Cortessis, Victoria K VK; Hoadley, Katherine A KA
Publication Date: 2018-06-12

Variant appearance in text: NRAS: A146P
PubMed Link: 29898407
Variant Present in the following documents:
  • NIHMS977848-supplement-2.xlsx, sheet 1
View BVdb publication page



Combined assessment of the TNM stage and BRAF mutational status at diagnosis in sporadic colorectal cancer patients.

Oncotarget
Sayagués, José María JM; Del Carmen, Sofía S; Del Mar Abad, María M; Corchete, Luís Antonio LA; Bengoechea, Oscar O; Anduaga, María Fernanda MF; Baldeón, María Jesús MJ; Cruz, Juan Jesús JJ; Alcazar, Jose Antonio JA; Angoso, María M; González, Marcos M; García, Jacinto J; Muñoz-Bellvis, Luís L; Orfao, Alberto A; Sarasquete, María Eugenia ME
Publication Date: 2018-05-08

Variant appearance in text: NRAS: A146P
PubMed Link: 29844874
Variant Present in the following documents:
  • oncotarget-09-24081.pdf
View BVdb publication page



Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.

Scientific Reports
Guo, Fang F; Gong, Hai H; Zhao, Huanhuan H; Chen, Jing J; Zhang, Yiming Y; Zhang, Lihua L; Shi, Xin X; Zhang, Aifeng A; Jin, Hui H; Zhang, Jianqiong J; He, Youji Y
Publication Date: 2018-04-17

Variant appearance in text: NRAS: A146P
PubMed Link: 29666387
Variant Present in the following documents:
  • 41598_2018_Article_24306.pdf
View BVdb publication page



Extreme assay sensitivity in molecular diagnostics further unveils intratumour heterogeneity in metastatic colorectal cancer as well as artifactual low-frequency mutations in the KRAS gene.

British Journal Of Cancer
Mariani, Sara S; Bertero, Luca L; Osella-Abate, Simona S; Di Bello, Cristiana C; Francia di Celle, Paola P; Coppola, Vittoria V; Sapino, Anna A; Cassoni, Paola P; Marchiò, Caterina C
Publication Date: 2017-07-25

Variant appearance in text: NRAS: A146P
PubMed Link: 28618430
Variant Present in the following documents:
  • bjc2017170a.pdf
View BVdb publication page



Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis.

British Journal Of Cancer
Furlan, Daniela D; Trapani, Davide D; Berrino, Enrico E; Debernardi, Carla C; Panero, Mara M; Libera, Laura L; Sahnane, Nora N; Riva, Cristina C; Tibiletti, Maria Grazia MG; Sessa, Fausto F; Sapino, Anna A; Venesio, Tiziana T
Publication Date: 2017-03-14

Variant appearance in text: NRAS: A146P
PubMed Link: 28141798
Variant Present in the following documents:
  • bjc20179x1.pdf
View BVdb publication page



Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

Oncotarget
Braig, Friederike F; Voigtlaender, Minna M; Schieferdecker, Aneta A; Busch, Chia-Jung CJ; Laban, Simon S; Grob, Tobias T; Kriegs, Malte M; Knecht, Rainald R; Bokemeyer, Carsten C; Binder, Mascha M
Publication Date: 2016-07-12

Variant appearance in text: NRAS: A146P
PubMed Link: 27119512
Variant Present in the following documents:
  • Main text
  • oncotarget-07-42988.pdf
View BVdb publication page



Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study.

Ebiomedicine
Yoshino, Takayuki T; Muro, Kei K; Yamaguchi, Kensei K; Nishina, Tomohiro T; Denda, Tadamichi T; Kudo, Toshihiro T; Okamoto, Wataru W; Taniguchi, Hiroya H; Akagi, Kiwamu K; Kajiwara, Takeshi T; Hironaka, Shuichi S; Satoh, Taroh T
Publication Date: 2015-04

Variant appearance in text: NRAS: A146P
PubMed Link: 26137573
Variant Present in the following documents:
  • Main text
View BVdb publication page



BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection.

British Journal Of Cancer
Schirripa, M M; Bergamo, F F; Cremolini, C C; Casagrande, M M; Lonardi, S S; Aprile, G G; Yang, D D; Marmorino, F F; Pasquini, G G; Sensi, E E; Lupi, C C; De Maglio, G G; Borrelli, N N; Pizzolitto, S S; Fasola, G G; Bertorelle, R R; Rugge, M M; Fontanini, G G; Zagonel, V V; Loupakis, F F; Falcone, A A
Publication Date: 2015-06-09

Variant appearance in text: NRAS: A146P
PubMed Link: 25942399
Variant Present in the following documents:
View BVdb publication page



Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Wilson, Melissa A MA; Zhao, Fengmin F; Letrero, Richard R; D'Andrea, Kurt K; Rimm, David L DL; Kirkwood, John M JM; Kluger, Harriet M HM; Lee, Sandra J SJ; Schuchter, Lynn M LM; Flaherty, Keith T KT; Nathanson, Katherine L KL
Publication Date: 2014-06-15

Variant appearance in text: NRAS: A146P
PubMed Link: 24714776
Variant Present in the following documents:
  • Main text
View BVdb publication page