Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.
Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
KRAS, NRAS, and BRAF mutation prevalence, clinicopathological association, and their application in a predictive model in Mexican patients with metastatic colorectal cancer: A retrospective cohort study.
Plos One
Sanchez-Ibarra, Hector Eduardo HE; Jiang, Xianli X; Gallegos-Gonzalez, Elena Yareli EY; Cavazos-González, Adriana Carolina AC; Chen, Yenho Y; Morcos, Faruck F; Barrera-Saldaña, Hugo Alberto HA
Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.
Scientific Reports
Del Carmen, Sofía S; Corchete, Luís Antonio LA; Gervas, Ruth R; Rodriguez, Alba A; Garcia, María M; Álcazar, José Antonio JA; García, Jacinto J; Bengoechea, Oscar O; Muñoz-Bellvis, Luis L; Sayagués, José María JM; Abad, Mar M
Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel.
Cancers
Froyen, Guy G; Le Mercier, Marie M; Lierman, Els E; Vandepoele, Karl K; Nollet, Friedel F; Boone, Elke E; Van der Meulen, Joni J; Jacobs, Koen K; Lambin, Suzan S; Vander Borght, Sara S; Van Valckenborgh, Els E; Antoniou, Aline A; Hébrant, Aline A
A large peptidome dataset improves HLA class I epitope prediction across most of the human population.
Nature Biotechnology
Sarkizova, Siranush S; Klaeger, Susan S; Le, Phuong M PM; Li, Letitia W LW; Oliveira, Giacomo G; Keshishian, Hasmik H; Hartigan, Christina R CR; Zhang, Wandi W; Braun, David A DA; Ligon, Keith L KL; Bachireddy, Pavan P; Zervantonakis, Ioannis K IK; Rosenbluth, Jennifer M JM; Ouspenskaia, Tamara T; Law, Travis T; Justesen, Sune S; Stevens, Jonathan J; Lane, William J WJ; Eisenhaure, Thomas T; Lan Zhang, Guang G; Clauser, Karl R KR; Hacohen, Nir N; Carr, Steven A SA; Wu, Catherine J CJ; Keskin, Derin B DB
Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation.
Plos One
Gilson, Pauline P; Franczak, Claire C; Dubouis, Ludovic L; Husson, Marie M; Rouyer, Marie M; Demange, Jessica J; Perceau, Marie M; Leroux, Agnès A; Merlin, Jean-Louis JL; Harlé, Alexandre A
Publication Date: 2019
Variant appearance in text: NRAS: 351G>T; Lys117Asn
Clinical Validation of Newly Developed Multiplex Kit Using Luminex xMAP Technology for Detecting Simultaneous RAS and BRAF Mutations in Colorectal Cancer: Results of the RASKET-B Study.
Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach.
Oncotarget
Del Carmen, Sofía S; Sayagués, José María JM; Bengoechea, Oscar O; Anduaga, María Fernanda MF; Alcazar, Jose Antonio JA; Gervas, Ruth R; García, Jacinto J; Orfao, Alberto A; Bellvis, Luis Muñoz LM; Sarasquete, María Eugenia ME; Del Mar Abad, María M
Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.
Cell Reports
Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS
Clinical performance evaluation of the Idylla NRAS-BRAF mutation test on retrospectively collected formalin-fixed paraffin-embedded colorectal cancer tissue.
Journal Of Clinical Pathology
Johnston, Louise L; Power, Michael M; Sloan, Philip P; Long, Anna A; Silmon, Angela A; Chaffey, Ben B; Lisgo, Andrea Jane AJ; Little, Liam L; Vercauteren, Ellen E; Steiniche, Torben T; Meyer, Tine T; Simpson, John J
Publication Date: 2018-04
Variant appearance in text: NRAS: 351G>T; Lys117Asn
The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab.
British Journal Of Cancer
Demurtas, Laura L; Puzzoni, Marco M; Giampieri, Riccardo R; Ziranu, Pina P; Pusceddu, Valeria V; Mandolesi, Alessandra A; Cremolini, Chiara C; Masi, Gianluca G; Gelsomino, Fabio F; Antoniotti, Carlotta C; Loretelli, Cristian C; Meriggi, Fausto F; Zaniboni, Alberto A; Falcone, Alfredo A; Cascinu, Stefano S; Scartozzi, Mario M
Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing.
Molecular Oncology
Schmiegel, Wolff W; Scott, Rodney J RJ; Dooley, Susan S; Lewis, Wendy W; Meldrum, Cliff J CJ; Pockney, Peter P; Draganic, Brian B; Smith, Steve S; Hewitt, Chelsee C; Philimore, Hazel H; Lucas, Amanda A; Shi, Elva E; Namdarian, Kateh K; Chan, Timmy T; Acosta, Danilo D; Ping-Chang, Su S; Tannapfel, Andrea A; Reinacher-Schick, Anke A; Uhl, Waldemar W; Teschendorf, Christian C; Wolters, Heiner H; Stern, Josef J; Viebahn, Richard R; Friess, Helmut H; Janssen, Klaus-Peter KP; Nitsche, Ulrich U; Slotta-Huspenina, Julia J; Pohl, Michael M; Vangala, Deepak D; Baraniskin, Alexander A; Dockhorn-Dworniczak, Barbara B; Hegewisch-Becker, Susanne S; Ronga, Philippe P; Edelstein, Daniel L DL; Jones, Frederick S FS; Hahn, Stephan S; Fox, Stephen B SB
Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer.
Cancer Research And Treatment
Kim, Dalyong D; Hong, Yong Sang YS; Kim, Jeong Eun JE; Kim, Kyu-Pyo KP; Lee, Jae-Lyun JL; Chun, Sung-Min SM; Kim, Jihun J; Jang, Se Jin SJ; Kim, Tae Won TW
Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients.
Blood Cancer Journal
Kortuem, K M KM; Braggio, E E; Bruins, L L; Barrio, S S; Shi, C S CS; Zhu, Y X YX; Tibes, R R; Viswanatha, D D; Votruba, P P; Ahmann, G G; Fonseca, R R; Jedlowski, P P; Schlam, I I; Kumar, S S; Bergsagel, P L PL; Stewart, A K AK