Publications:

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Dynamic ctDNA Mutational Complexity in Patients with Melanoma Receiving Immunotherapy.

Molecular Diagnosis & Therapy

Fitzgerald, Sandra S; Blenkiron, Cherie C; Stephens, Rosalie R; Mathy, Jon A JA; Somers-Edgar, Tiffany T; Rolfe, Gill G; Martin, Richard R; Jackson, Christopher C; Eccles, Michael M; Robb, Tamsin T; Rodger, Euan E; Lawrence, Ben B; Guilford, Parry P; Lasham, Annette A; Print, Cristin G CG

Publication Date: 2023-04-26

Variant appearance in text: NRAS: 203G>C; R68T

PubMed Link: 37099071

Variant Present in the following documents:

• 40291_2023_651_MOESM1_ESM.xlsx, sheet 2

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Anti-CLL1-based CAR T-cells with 4-1-BB or CD28/CD27 stimulatory domains in treating childhood refractory/relapsed acute myeloid leukemia.

Cancer Medicine

Pei, Kunlin K; Xu, Haoyu H; Wang, Pengfei P; Gan, Wening W; Hu, Zhengbin Z; Su, Xiaoling X; Zhang, Hui H; He, Yingyi Y

Publication Date: 2023-04-09

Variant appearance in text: NRAS: R68T

PubMed Link: 37031462

Variant Present in the following documents:

• Main text

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Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics

Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R

Publication Date: 2022-04-25

Variant appearance in text: NRAS: 203G>C

PubMed Link: 35468810

Variant Present in the following documents:

• 12920_2022_1235_MOESM3_ESM.xlsx, sheet 1
• 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research

Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H

Publication Date: 2022-01

Variant appearance in text: NRAS: R68T

PubMed Link: 34963661

Variant Present in the following documents:

• supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3

View BVdb publication page

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Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Mudianto, Tenny T; Campbell, Katie M KM; Webb, Jason J; Zolkind, Paul P; Skidmore, Zachary L ZL; Riley, Rachel R; Barnell, Erica K EK; Ozgenc, Ibrahim I; Giri, Tusar T; Dunn, Gavin P GP; Adkins, Douglas R DR; Griffith, Malachi M; Egloff, Ann Marie AM; Griffith, Obi L OL; Uppaluri, Ravindra R

Publication Date: 2021-04-15

Variant appearance in text: NRAS: R68T

PubMed Link: 33547198

Variant Present in the following documents:

• Main text

View BVdb publication page

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Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics

Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM

Publication Date: 2020-12

Variant appearance in text: NRAS: 203G>C; R68T

PubMed Link: 33230298

Variant Present in the following documents:

• NIHMS1637640-supplement-SuppData1.xlsx, sheet 1

View BVdb publication page

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Valproic Acid Synergizes With Cisplatin and Cetuximab in vitro and in vivo in Head and Neck Cancer by Targeting the Mechanisms of Resistance.

Frontiers In Cell And Developmental Biology

Iannelli, Federica F; Zotti, Andrea Ilaria AI; Roca, Maria Serena MS; Grumetti, Laura L; Lombardi, Rita R; Moccia, Tania T; Vitagliano, Carlo C; Milone, Maria Rita MR; Ciardiello, Chiara C; Bruzzese, Francesca F; Leone, Alessandra A; Cavalcanti, Ernesta E; De Cecio, Rossella R; Iachetta, Giuseppina G; Valiante, Salvatore S; Ionna, Franco F; Caponigro, Francesco F; Di Gennaro, Elena E; Budillon, Alfredo A

Publication Date: 2020

Variant appearance in text: NRAS: R68T

PubMed Link: 33015030

Variant Present in the following documents:

• Data_Sheet_1.pdf

View BVdb publication page

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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports

Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS

Publication Date: 2018-04-03

Variant appearance in text: NRAS: 203G>C

PubMed Link: 29617658

Variant Present in the following documents:

• NIHMS958974-supplement-6.xlsx, sheet 1
• NIHMS958974-supplement-5.xlsx, sheet 1

View BVdb publication page

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: N-ras: 203G>C

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics.

Molecular Oncology

Cirenajwis, Helena H; Lauss, Martin M; Ekedahl, Henrik H; Törngren, Therese T; Kvist, Anders A; Saal, Lao H LH; Olsson, Håkan H; Staaf, Johan J; Carneiro, Ana A; Ingvar, Christian C; Harbst, Katja K; Hayward, Nicholas K NK; Jönsson, Göran G

Publication Date: 2017-04

Variant appearance in text: NRAS: 203G>C; R68T

PubMed Link: 28267273

Variant Present in the following documents:

• MOL2-11-438-s003.xls, sheet 1

View BVdb publication page

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p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis.

Genes & Development

Brichkina, Anna A; Bertero, Thomas T; Loh, Hui Mun HM; Nguyen, Nguyet Thi Minh NT; Emelyanov, Alexander A; Rigade, Sidwell S; Ilie, Marius M; Hofman, Paul P; Gaggioli, Cedric C; Bulavin, Dmitry V DV

Publication Date: 2016-12-01

Variant appearance in text: NRAS: R68T

PubMed Link: 28007785

Variant Present in the following documents:

• Main text
• 2623.pdf

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: NRAS: 203G>C; R68T

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 3

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The role of the RAS pathway in iAMP21-ALL.

Leukemia

Ryan, S L SL; Matheson, E E; Grossmann, V V; Sinclair, P P; Bashton, M M; Schwab, C C; Towers, W W; Partington, M M; Elliott, A A; Minto, L L; Richardson, S S; Rahman, T T; Keavney, B B; Skinner, R R; Bown, N N; Haferlach, T T; Vandenberghe, P P; Haferlach, C C; Santibanez-Koref, M M; Moorman, A V AV; Kohlmann, A A; Irving, J A E JA; Harrison, C J CJ

Publication Date: 2016-09

Variant appearance in text: NRAS: R68T

PubMed Link: 27168466

Variant Present in the following documents:

• leu201680x1.pdf
• leu201680x2.xlsx, sheet 5

View BVdb publication page

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LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics

Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L

Publication Date: 2016-02-09

Variant appearance in text: NRAS: R68T

PubMed Link: 26860319

Variant Present in the following documents:

• 12859_2016_935_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics

Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2015-12

Variant appearance in text: NRAS: 203G>C; R68T

PubMed Link: 26502337

Variant Present in the following documents:

• NIHMS65345-supplement-Supplementary_table_1.xlsx, sheet 1
• NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2

View BVdb publication page

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Protein domain-level landscape of cancer-type-specific somatic mutations.

Plos Computational Biology

Yang, Fan F; Petsalaki, Evangelia E; Rolland, Thomas T; Hill, David E DE; Vidal, Marc M; Roth, Frederick P FP

Publication Date: 2015-03

Variant appearance in text: NRAS: R68T

PubMed Link: 25794154

Variant Present in the following documents:

• pcbi.1004147.s001.xlsx, sheet 1

View BVdb publication page

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Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer.

Bmc Pharmacology & Toxicology

Nichols, Anthony C AC; Black, Morgan M; Yoo, John J; Pinto, Nicole N; Fernandes, Andrew A; Haibe-Kains, Benjamin B; Boutros, Paul C PC; Barrett, John W JW

Publication Date: 2014-11-27

Variant appearance in text: NRAS: R68T

PubMed Link: 25428177

Variant Present in the following documents:

• 40360_2014_350_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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A highly recurrent RPS27 5'UTR mutation in melanoma.

Oncotarget

Dutton-Regester, Ken K; Gartner, Jared J JJ; Emmanuel, Rafi R; Qutob, Nouar N; Davies, Michael A MA; Gershenwald, Jeffrey E JE; Robinson, William W; Robinson, Steven S; Rosenberg, Steven A SA; Scolyer, Richard A RA; Mann, Graham J GJ; Thompson, John F JF; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2014-05-30

Variant appearance in text: NRAS: 203G>C; R68T

PubMed Link: 24913145

Variant Present in the following documents:

• oncotarget-05-2912-s003.xlsx, sheet 1

View BVdb publication page

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: NRAS: R68T

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

View BVdb publication page

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Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib.

Clinical And Translational Science

Hickinson, D Mark DM; Marshall, Gayle B GB; Beran, Garry J GJ; Varella-Garcia, Marileila M; Mills, Elizabeth A EA; South, Marie C MC; Cassidy, Andrew M AM; Acheson, Kerry L KL; McWalter, Gael G; McCormack, Rose M RM; Bunn, Paul A PA; French, Tim T; Graham, Alex A; Holloway, Brian R BR; Hirsch, Fred R FR; Speake, Georgina G

Publication Date: 2009-06

Variant appearance in text: NRAS: R68T

PubMed Link: 20443891

Variant Present in the following documents:

• Main text

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B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.

Plos One

Ugurel, Selma S; Thirumaran, Ranjit K RK; Bloethner, Sandra S; Gast, Andreas A; Sucker, Antje A; Mueller-Berghaus, Jan J; Rittgen, Werner W; Hemminki, Kari K; Becker, Jürgen C JC; Kumar, Rajiv R; Schadendorf, Dirk D

Publication Date: 2007-02-21

Variant appearance in text: NRAS: R68T

PubMed Link: 17311103

Variant Present in the following documents:

• pone.0000236.pdf

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