Variant ID: 1-115256530-G-T

NM_002524.4(NRAS):c.181C>A;(p.Q61K)

This variant was identified in 1093 publications

View GRCh38 version.




Publications:


Cutaneous sarcoidosis due to immune-checkpoint inhibition and exacerbated by a novel BRAF dimerization inhibitor.

Skin Health And Disease
Pham, J P JP; Star, P P; Wong, S S; Damian, D L DL; Saw, R P M RPM; Whitfeld, M J MJ; Menzies, A M AM; Joshua, A M AM; Smith, A A
Publication Date: 2021-12

Variant appearance in text: NRAS: Q61K
PubMed Link: 35663773
Variant Present in the following documents:
  • Main text
  • SKI2-1-e71.pdf
View BVdb publication page



Corrigendum: Longitudinal Circulating Tumor DNA Profiling in Metastatic Colorectal Cancer During Anti-EGFR Therapy.

Frontiers In Oncology
Yang, Wentao W; Zou, Jianling J; Li, Ye Y; Liu, Rujiao R; Yan, Zhengqing Z; Chen, Shiqing S; Zhao, Xiaoying X; Guo, Weijian W; Huang, Mingzhu M; Li, Wenhua W; Zhu, Xiaodong X; Chen, Zhiyu Z
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35646700
Variant Present in the following documents:
  • fonc-12-903586.pdf
View BVdb publication page



HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature.

Current Oncology (Toronto, Ont.)
Mathiot, Laurent L; Herbreteau, Guillaume G; Robin, Siméon S; Fenat, Charlotte C; Bennouna, Jaafar J; Blanquart, Christophe C; Denis, Marc M; Pons-Tostivint, Elvire E
Publication Date: 2022-05-20

Variant appearance in text: NRAS: Gln61Lys
PubMed Link: 35621690
Variant Present in the following documents:
  • Main text
  • curroncol-29-00300.pdf
View BVdb publication page



KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.

Cureus
Saharti, Samah S
Publication Date: 2022-04

Variant appearance in text: NRAS: Q61K
PubMed Link: 35619874
Variant Present in the following documents:
  • Main text
View BVdb publication page



A bipartite graph-based expected networks approach identifies DDR genes not associated with TMB yet predictive of immune checkpoint blockade response.

Cell Reports. Medicine
Weir, William H WH; Mucha, Peter J PJ; Kim, William Y WY
Publication Date: 2022-05-17

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PubMed Link: 35584624
Variant Present in the following documents:
  • mmc2.xlsx
View BVdb publication page



DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF.

Life Science Alliance
Gutierrez-Prat, Nuria N; Zuberer, Hedwig L HL; Mangano, Luca L; Karimaddini, Zahra Z; Wolf, Luise L; Tyanova, Stefka S; Wellinger, Lisa C LC; Marbach, Daniel D; Griesser, Vera V; Pettazzoni, Piergiorgio P; Bischoff, James R JR; Rohle, Daniel D; Palladino, Chiara C; Vivanco, Igor I
Publication Date: 2022-09

Variant appearance in text: NRAS: Q61K
PubMed Link: 35580987
Variant Present in the following documents:
  • LSA-2021-01235_SdataF4_FS5.pdf
  • LSA-2021-01235.pdf
View BVdb publication page



Genetic and Clinical Characteristics of ARID1A Mutated Melanoma Reveal High Tumor Mutational Load without Implications on Patient Survival.

Cancers
Thielmann, Carl Maximilian CM; Matull, Johanna J; Roth, Sebastian S; Placke, Jan-Malte JM; Chorti, Eleftheria E; Zaremba, Anne A; Lodde, Georg G; Jansen, Philipp P; Krefting, Frederik F; Kretz, Julia J; Möller, Inga I; Sucker, Antje A; Paschen, Annette A; Livingstone, Elisabeth E; Zimmer, Lisa L; Ugurel, Selma S; Schadendorf, Dirk D; Hadaschik, Eva E; Griewank, Klaus G KG
Publication Date: 2022-04-22

Variant appearance in text: NRAS: Q61K
PubMed Link: 35565222
Variant Present in the following documents:
  • cancers-14-02090.pdf
View BVdb publication page



Non-Hodgkin lymphoma mimicking acute leukemia: a report of six cases and review of the literature.

Journal Of Hematopathology
Dorfman, David M DM; Sadigh, Sam S
Publication Date: 2022-04-23

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35496359
Variant Present in the following documents:
  • 12308_2022_Article_493.pdf
View BVdb publication page



Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.

Frontiers In Oncology
Diefenbach, Russell J RJ; Lee, Jenny H JH; Stewart, Ashleigh A; Menzies, Alexander M AM; Carlino, Matteo S MS; Saw, Robyn P M RPM; Stretch, Jonathan R JR; Long, Georgina V GV; Scolyer, Richard A RA; Rizos, Helen H
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35494035
Variant Present in the following documents:
  • Table_2.xlsx
  • fonc-12-820510.pdf
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: NRAS: Q61K
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM3_ESM.xlsx
  • 12920_2022_1235_MOESM2_ESM.xlsx
View BVdb publication page



Preclinical Models for Acquired Resistance to Third-Generation EGFR Inhibitors in NSCLC: Functional Studies and Drug Combinations Used to Overcome Resistance.

Frontiers In Oncology
Mahfoudhi, Emna E; Ricordel, Charles C; Lecuyer, Gwendoline G; Mouric, Cécile C; Lena, Hervé H; Pedeux, Rémy R
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35463360
Variant Present in the following documents:
  • fonc-12-853501.pdf
View BVdb publication page



Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.

American Journal Of Human Genetics
Palles, Claire C; West, Hannah D HD; Chew, Edward E; Galavotti, Sara S; Flensburg, Christoffer C; Grolleman, Judith E JE; Jansen, Erik A M EAM; Curley, Helen H; Chegwidden, Laura L; Arbe-Barnes, Edward H EH; Lander, Nicola N; Truscott, Rebekah R; Pagan, Judith J; Bajel, Ashish A; Sherwood, Kitty K; Martin, Lynn L; Thomas, Huw H; Georgiou, Demetra D; Fostira, Florentia F; Goldberg, Yael Y; Adams, David J DJ; van der Biezen, Simone A M SAM; Christie, Michael M; Clendenning, Mark M; Thomas, Laura E LE; Deltas, Constantinos C; Dimovski, Aleksandar J AJ; Dymerska, Dagmara D; Lubinski, Jan J; Mahmood, Khalid K; van der Post, Rachel S RS; Sanders, Mathijs M; Weitz, Jürgen J; Taylor, Jenny C JC; Turnbull, Clare C; Vreede, Lilian L; van Wezel, Tom T; Whalley, Celina C; Arnedo-Pac, Claudia C; Caravagna, Giulio G; Cross, William W; Chubb, Daniel D; Frangou, Anna A; Gruber, Andreas J AJ; Kinnersley, Ben B; Noyvert, Boris B; Church, David D; Graham, Trevor T; Houlston, Richard R; Lopez-Bigas, Nuria N; Sottoriva, Andrea A; Wedge, David D; , ; , ; , ; Jenkins, Mark A MA; Kuiper, Roland P RP; Roberts, Andrew W AW; Cheadle, Jeremy P JP; Ligtenberg, Marjolijn J L MJL; Hoogerbrugge, Nicoline N; Koelzer, Viktor H VH; Rivas, Andres Dacal AD; Winship, Ingrid M IM; Ponte, Clara Ruiz CR; Buchanan, Daniel D DD; Power, Derek G DG; Green, Andrew A; Tomlinson, Ian P M IPM; Sampson, Julian R JR; Majewski, Ian J IJ; de Voer, Richarda M RM
Publication Date: 2022-04-20

Variant appearance in text: NRAS: Q61K
PubMed Link: 35460607
Variant Present in the following documents:
  • mmc2.xlsx
View BVdb publication page



Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences
Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P
Publication Date: 2022-04-09

Variant appearance in text: NRAS: Q61K
PubMed Link: 35456982
Variant Present in the following documents:
  • ijms-23-04164.pdf
View BVdb publication page



Organismal and Cellular Stress Responses upon Disruption of Mitochondrial Lonp1 Protease.

Cells
Taouktsi, Eirini E; Kyriakou, Eleni E; Smyrniotis, Stefanos S; Borbolis, Fivos F; Bondi, Labrina L; Avgeris, Socratis S; Trigazis, Efstathios E; Rigas, Stamatis S; Voutsinas, Gerassimos E GE; Syntichaki, Popi P
Publication Date: 2022-04-16

Variant appearance in text: N-ras: Gln61Lys
PubMed Link: 35456042
Variant Present in the following documents:
  • cells-11-01363.pdf
View BVdb publication page



Development and evaluation of ActSeq: A targeted next-generation sequencing panel for clinical oncology use.

Plos One
Shi, Zonggao Z; Lopez, Jacqueline J; Kalliney, William W; Sutton, Bobbie B; Simpson, Joyce J; Maggert, Kevin K; Liu, Sheng S; Wan, Jun J; Stack, M Sharon MS
Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35446881
Variant Present in the following documents:
  • pone.0266914.pdf
View BVdb publication page



Simultaneous monitoring of disease and microbe dynamics through plasma DNA sequencing in pediatric patients with acute lymphoblastic leukemia.

Science Advances
Barsan, Valentin V; Xia, Yuntao Y; Klein, David D; Gonzalez-Pena, Veronica V; Youssef, Sarah S; Inaba, Yuki Y; Mahmud, Ousman O; Natarajan, Sivaraman S; Agarwal, Vibhu V; Pang, Yakun Y; Autry, Robert R; Pui, Ching-Hon CH; Inaba, Hiroto H; Evans, William W; Gawad, Charles C
Publication Date: 2022-04-22

Variant appearance in text: NRAS: Q61K
PubMed Link: 35442732
Variant Present in the following documents:
  • sciadv.abj1360.pdf
View BVdb publication page



BRAF-Mutated Non-Small Cell Lung Cancer: Current Treatment Status and Future Perspective.

Frontiers In Oncology
Yan, Ningning N; Guo, Sanxing S; Zhang, Huixian H; Zhang, Ziheng Z; Shen, Shujing S; Li, Xingya X
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35433454
Variant Present in the following documents:
  • fonc-12-863043.pdf
View BVdb publication page



Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic Studies.

International Journal Of Molecular Sciences
Shetu, Shaila A SA; Bandyopadhyay, Debasish D
Publication Date: 2022-03-28

Variant appearance in text: NRAS: Q61K
PubMed Link: 35409064
Variant Present in the following documents:
  • ijms-23-03706.pdf
View BVdb publication page



Molecular Markers of Pediatric Solid Tumors-Diagnosis, Optimizing Treatments, and Determining Susceptibility: Current State and Future Directions.

Cells
Trubicka, Joanna J; Grajkowska, Wiesława W; Dembowska-Bagińska, Bożenna B
Publication Date: 2022-04-06

Variant appearance in text: NRAS: Q61K
PubMed Link: 35406801
Variant Present in the following documents:
  • cells-11-01238.pdf
View BVdb publication page



Daily Practice Assessment of KRAS Status in NSCLC Patients: A New Challenge for the Thoracic Pathologist Is Right around the Corner.

Cancers
Bontoux, Christophe C; Hofman, Véronique V; Brest, Patrick P; Ilié, Marius M; Mograbi, Baharia B; Hofman, Paul P
Publication Date: 2022-03-23

Variant appearance in text: NRAS: Q61K
PubMed Link: 35406400
Variant Present in the following documents:
  • cancers-14-01628.pdf
View BVdb publication page



Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis.

Frontiers In Oncology
Kyrochristos, Ioannis D ID; Glantzounis, Georgios K GK; Goussia, Anna A; Eliades, Alexia A; Achilleos, Achilleas A; Tsangaras, Kyriakos K; Hadjidemetriou, Irene I; Elpidorou, Marilena M; Ioannides, Marios M; Koumbaris, George G; Mitsis, Michail M; Patsalis, Philippos C PC; Roukos, Dimitrios D
Publication Date: 2022

Variant appearance in text: NRAS: 181C>A
PubMed Link: 35402285
Variant Present in the following documents:
  • Table_1.xlsx
View BVdb publication page



Partial response to dabrafenib and trametinib in relapsed BRAF V600E-Mutated multiple myeloma and possible mechanisms of resistance.

Bmj Case Reports
Ernst, Tina T; Aebi, Stefan S; Zander, Andrea A; Zander, Thilo T
Publication Date: 2022-04-08

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35396243
Variant Present in the following documents:
  • bcr-2021-246264.pdf
View BVdb publication page



Different Susceptibilities of Human Melanoma Cell Lines to G2/M Blockage and Cell Death Activation in Response to the Estrogen Receptor β agonist LY500307.

Journal Of Cancer
Pontecorvi, Giada G; Bellenghi, Maria M; Tait, Sabrina S; Tirelli, Valentina V; Matarrese, Paola P; Mattia, Gianfranco G; Carè, Alessandra A; Puglisi, Rossella R
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35371312
Variant Present in the following documents:
  • jcav13p1573s1.pdf
View BVdb publication page



PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity.

Scientific Reports
Maskin, Carolyn R CR; Raman, Renuka R; Houvras, Yariv Y
Publication Date: 2022-04-02

Variant appearance in text: NRAS: Q61K
PubMed Link: 35368039
Variant Present in the following documents:
  • 41598_2022_Article_8936.pdf
View BVdb publication page



Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.

Nature Communications
Liu, Ting T; Rao, Jianan J; Hu, Wenting W; Cui, Bowen B; Cai, Jiaoyang J; Liu, Yuhan Y; Sun, Huiying H; Chen, Xiaoxiao X; Tang, Yanjing Y; Chen, Jing J; Wang, Xiang X; Wang, Han H; Qian, Wubin W; Mao, Binchen B; Guo, Sheng S; Wang, Ronghua R; Liu, Yu Y; Shen, Shuhong S
Publication Date: 2022-03-28

Variant appearance in text: NRAS: Q61K
PubMed Link: 35347147
Variant Present in the following documents:
  • 41467_2022_29336_MOESM8_ESM.xlsx
View BVdb publication page



Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumors treated with entrectinib.

Molecular Oncology
Dziadziuszko, Rafal R; Hung, Tiffany T; Wang, Kun K; Choeurng, Voleak V; Drilon, Alexander A; Doebele, Robert C RC; Barlesi, Fabrice F; Wu, Charlie C; Dennis, Lucas L; Skoletsky, Joel J; Woodhouse, Ryan R; Li, Meijuan M; Chang, Ching-Wei CW; Simmons, Brian B; Riehl, Todd T; Wilson, Timothy R TR
Publication Date: 2022-03-26

Variant appearance in text: NRAS: Q61K
PubMed Link: 35338679
Variant Present in the following documents:
  • Main text
View BVdb publication page



Utilisation of semiconductor sequencing for the detection of predictive biomarkers in glioblastoma.

Plos One
Williams, Gareth G; Llewelyn, Alexander A; Thatcher, Robert R; Hardisty, Keeda-Marie KM; Loddo, Marco M
Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PubMed Link: 35324914
Variant Present in the following documents:
  • pone.0245817.s005.pdf
View BVdb publication page



Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming.

Frontiers In Oncology
Zuo, Sipeng S; Wang, Huixue H; Li, Lin L; Pan, Hui H; Lu, Linna L
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35311151
Variant Present in the following documents:
  • fonc-12-802807.pdf
View BVdb publication page



PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen.

Frontiers In Medicine
Xu, Jianping J; Pu, Yue Y; Lin, Rui R; Xiao, Shanshan S; Fu, Yingxue Y; Wang, Tao T
Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35308511
Variant Present in the following documents:
  • fmed-09-822200.pdf
View BVdb publication page



ZEB1 transcription factor promotes immune escape in melanoma.

Journal For Immunotherapy Of Cancer
Plaschka, Maud M; Benboubker, Valentin V; Grimont, Maxime M; Berthet, Justine J; Tonon, Laurie L; Lopez, Jonathan J; Le-Bouar, Myrtille M; Balme, Brigitte B; Tondeur, Garance G; de la Fouchardière, Arnaud A; Larue, Lionel L; Puisieux, Alain A; Grinberg-Bleyer, Yenkel Y; Bendriss-Vermare, Nathalie N; Dubois, Bertrand B; Caux, Christophe C; Dalle, Stéphane S; Caramel, Julie J
Publication Date: 2022-03

Variant appearance in text: NRAS: Q61K
PubMed Link: 35288462
Variant Present in the following documents:
  • jitc-2021-003484.pdf
View BVdb publication page



Longitudinal Circulating Tumor DNA Profiling in Metastatic Colorectal Cancer During Anti-EGFR Therapy.

Frontiers In Oncology
Yang, Wentao W; Zou, Jianling J; Li, Ye Y; Liu, Rujiao R; Yan, Zhengqing Z; Chen, Shiqing S; Zhao, Xiaoying X; Guo, Weijian W; Huang, Mingzhu M; Li, Wenhua W; Zhu, Xiaodong X; Chen, Zhiyu Z
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35280779
Variant Present in the following documents:
  • fonc-12-830816.pdf
View BVdb publication page



Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance.

Cancers
Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M
Publication Date: 2022-03-04

Variant appearance in text: NRAS: Q61K
PubMed Link: 35267628
Variant Present in the following documents:
  • cancers-14-01321.pdf
View BVdb publication page



Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies.

Frontiers In Oncology
Désage, Anne-Laure AL; Léonce, Camille C; Swalduz, Aurélie A; Ortiz-Cuaran, Sandra S
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35251972
Variant Present in the following documents:
  • fonc-12-796832.pdf
View BVdb publication page



Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models.

Therapeutic Advances In Medical Oncology
Lim, Sun Min SM; Yang, San-Duk SD; Lim, Sangbin S; Heo, Seong Gu SG; Daniel, Stetson S; Markovets, Aleksandra A; Minoo, Rafati R; Pyo, Kyoung-Ho KH; Yun, Mi Ran MR; Hong, Min Hee MH; Kim, Hye Ryun HR; Cho, Byoung Chul BC
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 35251316
Variant Present in the following documents:
  • 10.1177_17588359221079125.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: NRAS: Gln61Lys
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx
View BVdb publication page



Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.

Nature Communications
Farshidfar, Farshad F; Rhrissorrakrai, Kahn K; Levovitz, Chaya C; Peng, Cong C; Knight, James J; Bacchiocchi, Antonella A; Su, Juan J; Yin, Mingzhu M; Sznol, Mario M; Ariyan, Stephan S; Clune, James J; Olino, Kelly K; Parida, Laxmi L; Nikolaus, Joerg J; Zhang, Meiling M; Zhao, Shuang S; Wang, Yan Y; Huang, Gang G; Wan, Miaojian M; Li, Xianan X; Cao, Jian J; Yan, Qin Q; Chen, Xiang X; Newman, Aaron M AM; Halaban, Ruth R
Publication Date: 2022-02-23

Variant appearance in text: NRAS: Q61K
PubMed Link: 35197475
Variant Present in the following documents:
  • 41467_2022_28566_MOESM5_ESM.xlsx
View BVdb publication page



Discrimination of Single-Nucleotide Variants Based on an Allele-Specific Hybridization Chain Reaction and Smartphone Detection.

Acs Sensors
Lázaro, Ana A; Maquieira, Ángel Á; Tortajada-Genaro, Luis A LA
Publication Date: 2022-02-21

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35188365
Variant Present in the following documents:
  • se1c02220.pdf
  • se1c02220_si_001.pdf
View BVdb publication page



Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma.

Case Reports In Surgery
Alshbib, Ayham A; Grzyb, Krzysztof K; Syversveen, Trygve T; Reims, Henrik Mikael HM; Lassen, Kristoffer K; Yaqub, Sheraz S
Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PubMed Link: 35178267
Variant Present in the following documents:
  • Main text
  • CRIS2022-5280884.pdf
View BVdb publication page



Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition.

Scientific Reports
Jiri, Jungwirth J; Marketa, Urbanova U; Arnoud, Boot B; Petr, Hosek H; Petra, Bendova B; Anna, Siskova S; Jiri, Svec S; Milan, Kment K; Daniela, Tumova T; Sandra, Summerova S; Zdenek, Benes B; Tomas, Buchler B; Pavel, Kohout K; Tomas, Hucl H; Radoslav, Matej M; Ludmila, Vodickova V; Tom, van Wezel VW; Pavel, Vodicka V; Veronika, Vymetalkova V
Publication Date: 2022-02-16

Variant appearance in text: NRAS: Q61K
PubMed Link: 35173208
Variant Present in the following documents:
  • 41598_2022_Article_6498.pdf
View BVdb publication page



Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cells.

Science Advances
Filali, Liza L; Puissegur, Marie-Pierre MP; Cortacero, Kevin K; Cussat-Blanc, Sylvain S; Khazen, Roxana R; Van Acker, Nathalie N; Frenois, François-Xavier FX; Abreu, Arnaud A; Lamant, Laurence L; Meyer, Nicolas N; Vergier, Béatrice B; Müller, Sabina S; McKenzie, Brienne B; Valitutti, Salvatore S
Publication Date: 2022-02-18

Variant appearance in text: NRAS: Q61K
PubMed Link: 35171665
Variant Present in the following documents:
  • sciadv.abk3234_sm.pdf
View BVdb publication page



Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma.

Cancers
Raymond, Jérémy H JH; Aktary, Zackie Z; Larue, Lionel L; Delmas, Véronique V
Publication Date: 2022-01-29

Variant appearance in text: NRAS: Q61K
PubMed Link: 35158973
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody.

Embo Reports
Tvorogov, Denis D; Thompson-Peach, Chloe A L CAL; Foßelteder, Johannes J; Dottore, Mara M; Stomski, Frank F; Onnesha, Suraiya A SA; Lim, Kelly K; Moretti, Paul A B PAB; Pitson, Stuart M SM; Ross, David M DM; Reinisch, Andreas A; Thomas, Daniel D; Lopez, Angel F AF
Publication Date: 2022-02-14

Variant appearance in text: NRAS: Q61K
PubMed Link: 35156745
Variant Present in the following documents:
  • EMBR-23-e52904.pdf
View BVdb publication page



Acquired somatic variants in inherited myeloid malignancies.

Leukemia
Armes, Hannah H; Rio-Machin, Ana A; Krizsán, Szilvia S; Bödör, Csaba C; Kaya, Fadimana F; Bewicke-Copley, Findlay F; Alnajar, Jenna J; Walne, Amanda A; Péterffy, Borbála B; Tummala, Hemanth H; Rouault-Pierre, Kevin K; Dokal, Inderjeet I; Vulliamy, Tom T; Fitzgibbon, Jude J
Publication Date: 2022-02-09

Variant appearance in text: NRAS: Q61K
PubMed Link: 35140362
Variant Present in the following documents:
  • 41375_2022_1515_MOESM4_ESM.xlsx
  • 41375_2022_1515_MOESM1_ESM.pdf
View BVdb publication page



Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Cell Reports
Khan, Imran I; Koide, Akiko A; Zuberi, Mariyam M; Ketavarapu, Gayatri G; Denbaum, Eric E; Teng, Kai Wen KW; Rhett, J Matthew JM; Spencer-Smith, Russell R; Hobbs, G Aaron GA; Camp, Ernest Ramsay ER; Koide, Shohei S; O'Bryan, John P JP
Publication Date: 2022-02-08

Variant appearance in text: NRAS: Q61K
PubMed Link: 35139380
Variant Present in the following documents:
  • NIHMS1778820-supplement-1.pdf
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Tumor-to-Tumor Metastasis: Lung Typical Carcinoid Metastatic to Follicular Variant of Papillary Thyroid Carcinoma.

Endocrine Pathology
Clara, Ugolini U; Rossella, Del Frate DF; Giulio, Rossi R; Gabriele, Materazzi M; Virginia, LiVolsi L
Publication Date: 2022-02-09

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35138561
Variant Present in the following documents:
  • Main text
  • 12022_2022_Article_9706.pdf
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Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells.

Cancer & Metabolism
Godfrey, Jason J; Riscal, Romain R; Skuli, Nicolas N; Simon, M Celeste MC
Publication Date: 2022-02-05

Variant appearance in text: NRAS: Q61K
PubMed Link: 35123542
Variant Present in the following documents:
  • Main text
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Mutational profiling of melanomas in patients from the southeast coast of China.

Translational Cancer Research
Zheng, Ai-Wen AW; Jia, Dong-Dong DD; Zhou, Cheng-Cheng CC; Li, Tao T
Publication Date: 2020-08

Variant appearance in text: NRAS: Q61K
PubMed Link: 35117841
Variant Present in the following documents:
  • Main text
  • tcr-09-08-4781.pdf
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Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients.

Frontiers In Oncology
Zhang, Jiexia J; Tang, Shuangfeng S; Zhang, Chunning C; Li, Mingyao M; Zheng, Yating Y; Hu, Xue X; Huang, Mengli M; Cheng, Xiangyang X
Publication Date: 2021

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35087742
Variant Present in the following documents:
  • Table_2.xlsx
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Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer.

Frontiers In Oncology
Iseas, Soledad S; Sendoya, Juan M JM; Robbio, Juan J; Coraglio, Mariana M; Kujaruk, Mirta M; Mikolaitis, Vanesa V; Rizzolo, Mariana M; Cabanne, Ana A; Ruiz, Gonzalo G; Salanova, Rubén R; Gualdrini, Ubaldo U; Méndez, Guillermo G; Antelo, Marina M; Carballido, Marcela M; Rotondaro, Cecilia C; Viglino, Julieta J; Eleta, Martín M; Di Sibio, Alejandro A; Podhajcer, Osvaldo L OL; Roca, Enrique E; Llera, Andrea S AS; Golubicki, Mariano M; Abba, Martín Carlos MC
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 35071006
Variant Present in the following documents:
  • Table_4.xlsx
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Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab.

Frontiers In Oncology
Burgos, Remberto R; Cardona, Andrés F AF; Santoyo, Nicolas N; Ruiz-Patiño, Alejandro A; Cure-Casilimas, Juanita J; Rojas, Leonardo L; Ricaurte, Luisa L; Muñoz, Álvaro Á; Garcia-Robledo, Juan Esteban JE; Ordoñez, Camila C; Sotelo, Carolina C; Rodríguez, July J; Zatarain-Barrón, Zyanya Lucia ZL; Pineda, Diego D; Arrieta, Oscar O
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 35070950
Variant Present in the following documents:
  • Main text
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Mixed odontogenic tumors: A review of the clinicopathological and molecular features and changes in the WHO classification.

World Journal Of Clinical Oncology
Sánchez-Romero, Celeste C; Paes de Almeida, Oslei O; Bologna-Molina, Ronell R
Publication Date: 2021-12-24

Variant appearance in text: NRAS: Gln61Lys
PubMed Link: 35070741
Variant Present in the following documents:
  • Main text
  • WJCO-12-1227.pdf
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The Molecular Pathology of Odontogenic Tumors: Expanding the Spectrum of MAPK Pathway Driven Tumors.

Frontiers In Oral Health
Guimarães, Letícia Martins LM; Coura, Bruna Pizziolo BP; Gomez, Ricardo Santiago RS; Gomes, Carolina Cavalieri CC
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 35048058
Variant Present in the following documents:
  • Main text
  • froh-02-740788.pdf
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The dominant TP53 hotspot mutation in -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications.

Neuro-Oncology Advances
Marker, Daniel F DF; Agnihotri, Sameer S; Amankulor, Nduka N; Murdoch, Geoffrey H GH; Pearce, Thomas M TM
Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Q61K
PubMed Link: 35047821
Variant Present in the following documents:
  • vdab182_suppl_supplementary_table_s1.xlsx
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A B-Raf V600E gene signature for melanoma predicts prognosis and reveals sensitivity to targeted therapies.

Cancer Medicine
Yao, Kevin K; Zhou, Emily E; Cheng, Chao C
Publication Date: 2022-01-19

Variant appearance in text: NRAS: Q61K
PubMed Link: 35044091
Variant Present in the following documents:
  • CAM4-11-1232.pdf
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Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations.

Signal Transduction And Targeted Therapy
Zhu, Huiyuan H; Bi, Dexi D; Zhang, Youhua Y; Kong, Cheng C; Du, Jiahao J; Wu, Xiawei X; Wei, Qing Q; Qin, Huanlong H
Publication Date: 2022-01-17

Variant appearance in text: NRAS: Q61K
PubMed Link: 35034957
Variant Present in the following documents:
  • Main text
  • 41392_2021_Article_831.pdf
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Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer.

Frontiers In Oncology
Blaquier, Juan Bautista JB; Cardona, Andrés Felipe AF; Recondo, Gonzalo G
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 35004309
Variant Present in the following documents:
  • Main text
  • fonc-11-787585.pdf
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Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics.

Computational And Structural Biotechnology Journal
Tripathi, Swarnendu S; Dsouza, Nikita R NR; Mathison, Angela J AJ; Leverence, Elise E; Urrutia, Raul R; Zimmermann, Michael T MT
Publication Date: 2022

Variant appearance in text: NRAS: Q61K
PubMed Link: 34976316
Variant Present in the following documents:
  • main.pdf
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Ultrasensitive analysis of genetic instability related to chemical exposure.

Journal Of Applied Genetics
Domoradzki, Tomasz T; Grochowski, Piotr P; Jaśkiewicz, Anna A; Pająk, Beata B
Publication Date: 2021-12-30

Variant appearance in text: NRAS: Q61K
PubMed Link: 34967917
Variant Present in the following documents:
  • 13353_2021_Article_677.pdf
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Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.

International Journal Of Molecular Sciences
Ragab, Nada N; Bauer, Julia J; Botermann, Dominik S DS; Uhmann, Anja A; Hahn, Heidi H
Publication Date: 2021-12-13

Variant appearance in text: NRAS: Q61K
PubMed Link: 34948179
Variant Present in the following documents:
  • Main text
  • ijms-22-13377.pdf
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Methylation Markers in Cutaneous Melanoma: Unravelling the Potential Utility of Their Tracking by Liquid Biopsy.

Cancers
Aleotti, Valentina V; Catoni, Cristina C; Poggiana, Cristina C; Rosato, Antonio A; Facchinetti, Antonella A; Scaini, Maria Chiara MC
Publication Date: 2021-12-10

Variant appearance in text: NRAS: Q61K
PubMed Link: 34944843
Variant Present in the following documents:
  • cancers-13-06217.pdf
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Development and Validation of a Targeted 'Liquid' NGS Panel for Treatment Customization in Patients with Metastatic Colorectal Cancer.

Diagnostics (Basel, Switzerland)
Kastrisiou, Myrto M; Zarkavelis, George G; Kougioumtzi, Anastasia A; Sakaloglou, Prodromos P; Kostoulas, Charilaos C; Georgiou, Ioannis I; Batistatou, Anna A; Pentheroudakis, George G; Magklara, Angeliki A
Publication Date: 2021-12-16

Variant appearance in text: NRAS: Q61K
PubMed Link: 34943612
Variant Present in the following documents:
  • Main text
  • diagnostics-11-02375.pdf
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Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.

Blood Advances
Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; St-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallee, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer Jg JJ; Schroeder, Kaitlin K; Koch, Victoria B VB; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D
Publication Date: 2021-12-21

Variant appearance in text: NRAS: Q61K
PubMed Link: 34933343
Variant Present in the following documents:
  • advancesADV2021005634-suppl1.xlsx
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Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.

Npj Precision Oncology
Schaufler, Diana D; Ast, David F DF; Tumbrink, Hannah L HL; Abedpour, Nima N; Maas, Lukas L; Schwäbe, Ayla E AE; Spille, Inga I; Lennartz, Stefanie S; Fassunke, Jana J; Aldea, Mihaela M; Besse, Benjamin B; Planchard, David D; Nogova, Lucia L; Michels, Sebastian S; Kobe, Carsten C; Persigehl, Thorsten T; Westphal, Theresa T; Koleczko, Sophia S; Fischer, Rieke R; Weber, Jan-Phillip JP; Altmüller, Janine J; Thomas, Roman K RK; Merkelbach-Bruse, Sabine S; Gautschi, Oliver O; Mezquita, Laura L; Büttner, Reinhard R; Wolf, Jürgen J; Peifer, Martin M; Brägelmann, Johannes J; Scheffler, Matthias M; Sos, Martin L ML
Publication Date: 2021-12-17

Variant appearance in text: NRAS: Q61K
PubMed Link: 34921211
Variant Present in the following documents:
  • Main text
  • 41698_2021_Article_241.pdf
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Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies.

Frontiers In Oncology
Sin, Chun-Fung CF; Man, Pui-Hei Marcus PM
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 34912707
Variant Present in the following documents:
  • Main text
  • fonc-11-750789.pdf
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Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.

Cell Reports
McFall, Thomas T; Stites, Edward C EC
Publication Date: 2021-12-14

Variant appearance in text: NRAS: Q61K
PubMed Link: 34910921
Variant Present in the following documents:
  • NIHMS1764636-supplement-1.pdf
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Intratumor heterogeneity and clonal evolution revealed in castration-resistant prostate cancer by longitudinal genomic analysis.

Translational Oncology
Zhang, Wenhui W; Wang, Tao T; Wang, Yan Y; Zhu, Feng F; Shi, Haoqing H; Zhang, Jili J; Wang, Ziwei Z; Qu, Min M; Zhang, Huaru H; Wang, Tianyi T; Qian, Yuping Y; Yang, Jinjian J; Gao, Xu X; Li, Jing J
Publication Date: 2021-12-10

Variant appearance in text: NRAS: Q61K
PubMed Link: 34902740
Variant Present in the following documents:
  • mmc5.xlsx
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Analysis of Mutations and Dysregulated Pathways Unravels Carcinogenic Effect and Clinical Actionability of Mutational Processes.

Frontiers In Cell And Developmental Biology
Jiang, Zedong Z; Liao, Gaoming G; Yang, Yiran Y; Lan, Yujia Y; Xu, Liwen L; Yan, Min M; Zhou, Yao Y; Zhu, Jiali J; Liu, Wei W; Bai, Jing J; Xiao, Yun Y; Li, Xia X
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 34901014
Variant Present in the following documents:
  • Main text
  • fcell-09-768981.pdf
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Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers.

Frontiers In Oncology
Okuma, Hitomi Sumiyoshi HS; Yonemori, Kan K; Kojima, Yuki Y; Tanioka, Maki M; Sudo, Kazuki K; Noguchi, Emi E; Hijioka, Susumu S; Wakakuwa, Keiko K; Kato, Ken K; Hirakawa, Akihiro A; Kuchiba, Aya A; Kubo, Takashi T; Ichikawa, Hitoshi H; Yoshida, Akihiko A; Yatabe, Yasushi Y; Nakamura, Kenichi K; Mano, Hiroyuki H; Yamamoto, Noboru N; Fujiwara, Yasuhiro Y
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 34900683
Variant Present in the following documents:
  • Main text
  • fonc-11-732525.pdf
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Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer.

Cancers
Sunaga, Noriaki N; Miura, Yosuke Y; Kasahara, Norimitsu N; Sakurai, Reiko R
Publication Date: 2021-11-26

Variant appearance in text: NRAS: Q61K
PubMed Link: 34885068
Variant Present in the following documents:
  • Main text
  • cancers-13-05956.pdf
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Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value.

Frontiers In Oncology
Najem, Ahmad A; Wouters, Jasper J; Krayem, Mohammad M; Rambow, Florian F; Sabbah, Malak M; Sales, François F; Awada, Ahmad A; Aerts, Stein S; Journe, Fabrice F; Marine, Jean-Christophe JC; Ghanem, Ghanem E GE
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 34869032
Variant Present in the following documents:
  • Main text
  • fonc-11-780654.pdf
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Case Report: The Added Value of Liquid Biopsy in Advanced Colorectal Cancer From Clinical Case Experiences.

Frontiers In Pharmacology
Ulivi, Paola P; Passardi, Alessandro A; Marisi, Giorgia G; Chiadini, Elisa E; Molinari, Chiara C; Canale, Matteo M; Pasini, Luigi L; Ferroni, Fabio F; Frassineti, Giovanni Luca GL; Bartolini, Giulia G; Monti, Manlio M
Publication Date: 2021

Variant appearance in text: NRAS: Q61K
PubMed Link: 34858176
Variant Present in the following documents:
  • Main text
  • fphar-12-745701.pdf
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Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma.

Journal Of Experimental & Clinical Cancer Research : Cr
Lanzi, Cinzia C; Favini, Enrica E; Dal Bo, Laura L; Tortoreto, Monica M; Arrighetti, Noemi N; Zaffaroni, Nadia N; Cassinelli, Giuliana G
Publication Date: 2021-12-02

Variant appearance in text: NRAS: Q61K
PubMed Link: 34857011
Variant Present in the following documents:
  • Main text
  • 13046_2021_Article_2150.pdf
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