Publications:

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Cutaneous sarcoidosis due to immune-checkpoint inhibition and exacerbated by a novel BRAF dimerization inhibitor.

Skin Health And Disease

Pham, J P JP; Star, P P; Wong, S S; Damian, D L DL; Saw, R P M RPM; Whitfeld, M J MJ; Menzies, A M AM; Joshua, A M AM; Smith, A A

Publication Date: 2021-12

Variant appearance in text: NRAS: Q61K

PubMed Link: 35663773

Variant Present in the following documents:

• Main text
• SKI2-1-e71.pdf

View BVdb publication page

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Corrigendum: Longitudinal Circulating Tumor DNA Profiling in Metastatic Colorectal Cancer During Anti-EGFR Therapy.

Frontiers In Oncology

Yang, Wentao W; Zou, Jianling J; Li, Ye Y; Liu, Rujiao R; Yan, Zhengqing Z; Chen, Shiqing S; Zhao, Xiaoying X; Guo, Weijian W; Huang, Mingzhu M; Li, Wenhua W; Zhu, Xiaodong X; Chen, Zhiyu Z

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35646700

Variant Present in the following documents:

• fonc-12-903586.pdf

View BVdb publication page

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HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature.

Current Oncology (Toronto, Ont.)

Mathiot, Laurent L; Herbreteau, Guillaume G; Robin, Siméon S; Fenat, Charlotte C; Bennouna, Jaafar J; Blanquart, Christophe C; Denis, Marc M; Pons-Tostivint, Elvire E

Publication Date: 2022-05-20

Variant appearance in text: NRAS: Gln61Lys

PubMed Link: 35621690

Variant Present in the following documents:

• Main text
• curroncol-29-00300.pdf

View BVdb publication page

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KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.

Cureus

Saharti, Samah S

Publication Date: 2022-04

Variant appearance in text: NRAS: Q61K

PubMed Link: 35619874

Variant Present in the following documents:

• Main text

View BVdb publication page

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A bipartite graph-based expected networks approach identifies DDR genes not associated with TMB yet predictive of immune checkpoint blockade response.

Cell Reports. Medicine

Weir, William H WH; Mucha, Peter J PJ; Kim, William Y WY

Publication Date: 2022-05-17

Variant appearance in text: NRAS: 181C>A; Gln61Lys

PubMed Link: 35584624

Variant Present in the following documents:

• mmc2.xlsx

View BVdb publication page

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DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF.

Life Science Alliance

Gutierrez-Prat, Nuria N; Zuberer, Hedwig L HL; Mangano, Luca L; Karimaddini, Zahra Z; Wolf, Luise L; Tyanova, Stefka S; Wellinger, Lisa C LC; Marbach, Daniel D; Griesser, Vera V; Pettazzoni, Piergiorgio P; Bischoff, James R JR; Rohle, Daniel D; Palladino, Chiara C; Vivanco, Igor I

Publication Date: 2022-09

Variant appearance in text: NRAS: Q61K

PubMed Link: 35580987

Variant Present in the following documents:

• LSA-2021-01235_SdataF4_FS5.pdf
• LSA-2021-01235.pdf

View BVdb publication page

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Genetic and Clinical Characteristics of ARID1A Mutated Melanoma Reveal High Tumor Mutational Load without Implications on Patient Survival.

Cancers

Thielmann, Carl Maximilian CM; Matull, Johanna J; Roth, Sebastian S; Placke, Jan-Malte JM; Chorti, Eleftheria E; Zaremba, Anne A; Lodde, Georg G; Jansen, Philipp P; Krefting, Frederik F; Kretz, Julia J; Möller, Inga I; Sucker, Antje A; Paschen, Annette A; Livingstone, Elisabeth E; Zimmer, Lisa L; Ugurel, Selma S; Schadendorf, Dirk D; Hadaschik, Eva E; Griewank, Klaus G KG

Publication Date: 2022-04-22

Variant appearance in text: NRAS: Q61K

PubMed Link: 35565222

Variant Present in the following documents:

• cancers-14-02090.pdf

View BVdb publication page

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Non-Hodgkin lymphoma mimicking acute leukemia: a report of six cases and review of the literature.

Journal Of Hematopathology

Dorfman, David M DM; Sadigh, Sam S

Publication Date: 2022-04-23

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35496359

Variant Present in the following documents:

• 12308_2022_Article_493.pdf

View BVdb publication page

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Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.

Frontiers In Oncology

Diefenbach, Russell J RJ; Lee, Jenny H JH; Stewart, Ashleigh A; Menzies, Alexander M AM; Carlino, Matteo S MS; Saw, Robyn P M RPM; Stretch, Jonathan R JR; Long, Georgina V GV; Scolyer, Richard A RA; Rizos, Helen H

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35494035

Variant Present in the following documents:

• Table_2.xlsx
• fonc-12-820510.pdf

View BVdb publication page

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Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics

Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R

Publication Date: 2022-04-25

Variant appearance in text: NRAS: Q61K

PubMed Link: 35468810

Variant Present in the following documents:

• 12920_2022_1235_MOESM3_ESM.xlsx
• 12920_2022_1235_MOESM2_ESM.xlsx

View BVdb publication page

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Preclinical Models for Acquired Resistance to Third-Generation EGFR Inhibitors in NSCLC: Functional Studies and Drug Combinations Used to Overcome Resistance.

Frontiers In Oncology

Mahfoudhi, Emna E; Ricordel, Charles C; Lecuyer, Gwendoline G; Mouric, Cécile C; Lena, Hervé H; Pedeux, Rémy R

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35463360

Variant Present in the following documents:

• fonc-12-853501.pdf

View BVdb publication page

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Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.

American Journal Of Human Genetics

Palles, Claire C; West, Hannah D HD; Chew, Edward E; Galavotti, Sara S; Flensburg, Christoffer C; Grolleman, Judith E JE; Jansen, Erik A M EAM; Curley, Helen H; Chegwidden, Laura L; Arbe-Barnes, Edward H EH; Lander, Nicola N; Truscott, Rebekah R; Pagan, Judith J; Bajel, Ashish A; Sherwood, Kitty K; Martin, Lynn L; Thomas, Huw H; Georgiou, Demetra D; Fostira, Florentia F; Goldberg, Yael Y; Adams, David J DJ; van der Biezen, Simone A M SAM; Christie, Michael M; Clendenning, Mark M; Thomas, Laura E LE; Deltas, Constantinos C; Dimovski, Aleksandar J AJ; Dymerska, Dagmara D; Lubinski, Jan J; Mahmood, Khalid K; van der Post, Rachel S RS; Sanders, Mathijs M; Weitz, Jürgen J; Taylor, Jenny C JC; Turnbull, Clare C; Vreede, Lilian L; van Wezel, Tom T; Whalley, Celina C; Arnedo-Pac, Claudia C; Caravagna, Giulio G; Cross, William W; Chubb, Daniel D; Frangou, Anna A; Gruber, Andreas J AJ; Kinnersley, Ben B; Noyvert, Boris B; Church, David D; Graham, Trevor T; Houlston, Richard R; Lopez-Bigas, Nuria N; Sottoriva, Andrea A; Wedge, David D; , ; , ; , ; Jenkins, Mark A MA; Kuiper, Roland P RP; Roberts, Andrew W AW; Cheadle, Jeremy P JP; Ligtenberg, Marjolijn J L MJL; Hoogerbrugge, Nicoline N; Koelzer, Viktor H VH; Rivas, Andres Dacal AD; Winship, Ingrid M IM; Ponte, Clara Ruiz CR; Buchanan, Daniel D DD; Power, Derek G DG; Green, Andrew A; Tomlinson, Ian P M IPM; Sampson, Julian R JR; Majewski, Ian J IJ; de Voer, Richarda M RM

Publication Date: 2022-04-20

Variant appearance in text: NRAS: Q61K

PubMed Link: 35460607

Variant Present in the following documents:

• mmc2.xlsx

View BVdb publication page

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Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P

Publication Date: 2022-04-09

Variant appearance in text: NRAS: Q61K

PubMed Link: 35456982

Variant Present in the following documents:

• ijms-23-04164.pdf

View BVdb publication page

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Organismal and Cellular Stress Responses upon Disruption of Mitochondrial Lonp1 Protease.

Cells

Taouktsi, Eirini E; Kyriakou, Eleni E; Smyrniotis, Stefanos S; Borbolis, Fivos F; Bondi, Labrina L; Avgeris, Socratis S; Trigazis, Efstathios E; Rigas, Stamatis S; Voutsinas, Gerassimos E GE; Syntichaki, Popi P

Publication Date: 2022-04-16

Variant appearance in text: N-ras: Gln61Lys

PubMed Link: 35456042

Variant Present in the following documents:

• cells-11-01363.pdf

View BVdb publication page

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Development and evaluation of ActSeq: A targeted next-generation sequencing panel for clinical oncology use.

Plos One

Shi, Zonggao Z; Lopez, Jacqueline J; Kalliney, William W; Sutton, Bobbie B; Simpson, Joyce J; Maggert, Kevin K; Liu, Sheng S; Wan, Jun J; Stack, M Sharon MS

Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35446881

Variant Present in the following documents:

• pone.0266914.pdf

View BVdb publication page

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Simultaneous monitoring of disease and microbe dynamics through plasma DNA sequencing in pediatric patients with acute lymphoblastic leukemia.

Science Advances

Barsan, Valentin V; Xia, Yuntao Y; Klein, David D; Gonzalez-Pena, Veronica V; Youssef, Sarah S; Inaba, Yuki Y; Mahmud, Ousman O; Natarajan, Sivaraman S; Agarwal, Vibhu V; Pang, Yakun Y; Autry, Robert R; Pui, Ching-Hon CH; Inaba, Hiroto H; Evans, William W; Gawad, Charles C

Publication Date: 2022-04-22

Variant appearance in text: NRAS: Q61K

PubMed Link: 35442732

Variant Present in the following documents:

• sciadv.abj1360.pdf

View BVdb publication page

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BRAF-Mutated Non-Small Cell Lung Cancer: Current Treatment Status and Future Perspective.

Frontiers In Oncology

Yan, Ningning N; Guo, Sanxing S; Zhang, Huixian H; Zhang, Ziheng Z; Shen, Shujing S; Li, Xingya X

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35433454

Variant Present in the following documents:

• fonc-12-863043.pdf

View BVdb publication page

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Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic Studies.

International Journal Of Molecular Sciences

Shetu, Shaila A SA; Bandyopadhyay, Debasish D

Publication Date: 2022-03-28

Variant appearance in text: NRAS: Q61K

PubMed Link: 35409064

Variant Present in the following documents:

• ijms-23-03706.pdf

View BVdb publication page

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Molecular Markers of Pediatric Solid Tumors-Diagnosis, Optimizing Treatments, and Determining Susceptibility: Current State and Future Directions.

Cells

Trubicka, Joanna J; Grajkowska, Wiesława W; Dembowska-Bagińska, Bożenna B

Publication Date: 2022-04-06

Variant appearance in text: NRAS: Q61K

PubMed Link: 35406801

Variant Present in the following documents:

• cells-11-01238.pdf

View BVdb publication page

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Daily Practice Assessment of KRAS Status in NSCLC Patients: A New Challenge for the Thoracic Pathologist Is Right around the Corner.

Cancers

Bontoux, Christophe C; Hofman, Véronique V; Brest, Patrick P; Ilié, Marius M; Mograbi, Baharia B; Hofman, Paul P

Publication Date: 2022-03-23

Variant appearance in text: NRAS: Q61K

PubMed Link: 35406400

Variant Present in the following documents:

• cancers-14-01628.pdf

View BVdb publication page

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Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis.

Frontiers In Oncology

Kyrochristos, Ioannis D ID; Glantzounis, Georgios K GK; Goussia, Anna A; Eliades, Alexia A; Achilleos, Achilleas A; Tsangaras, Kyriakos K; Hadjidemetriou, Irene I; Elpidorou, Marilena M; Ioannides, Marios M; Koumbaris, George G; Mitsis, Michail M; Patsalis, Philippos C PC; Roukos, Dimitrios D

Publication Date: 2022

Variant appearance in text: NRAS: 181C>A

PubMed Link: 35402285

Variant Present in the following documents:

• Table_1.xlsx

View BVdb publication page

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Partial response to dabrafenib and trametinib in relapsed BRAF V600E-Mutated multiple myeloma and possible mechanisms of resistance.

Bmj Case Reports

Ernst, Tina T; Aebi, Stefan S; Zander, Andrea A; Zander, Thilo T

Publication Date: 2022-04-08

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35396243

Variant Present in the following documents:

• bcr-2021-246264.pdf

View BVdb publication page

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Different Susceptibilities of Human Melanoma Cell Lines to G2/M Blockage and Cell Death Activation in Response to the Estrogen Receptor β agonist LY500307.

Journal Of Cancer

Pontecorvi, Giada G; Bellenghi, Maria M; Tait, Sabrina S; Tirelli, Valentina V; Matarrese, Paola P; Mattia, Gianfranco G; Carè, Alessandra A; Puglisi, Rossella R

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35371312

Variant Present in the following documents:

• jcav13p1573s1.pdf

View BVdb publication page

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PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity.

Scientific Reports

Maskin, Carolyn R CR; Raman, Renuka R; Houvras, Yariv Y

Publication Date: 2022-04-02

Variant appearance in text: NRAS: Q61K

PubMed Link: 35368039

Variant Present in the following documents:

• 41598_2022_Article_8936.pdf

View BVdb publication page

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Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.

Nature Communications

Liu, Ting T; Rao, Jianan J; Hu, Wenting W; Cui, Bowen B; Cai, Jiaoyang J; Liu, Yuhan Y; Sun, Huiying H; Chen, Xiaoxiao X; Tang, Yanjing Y; Chen, Jing J; Wang, Xiang X; Wang, Han H; Qian, Wubin W; Mao, Binchen B; Guo, Sheng S; Wang, Ronghua R; Liu, Yu Y; Shen, Shuhong S

Publication Date: 2022-03-28

Variant appearance in text: NRAS: Q61K

PubMed Link: 35347147

Variant Present in the following documents:

• 41467_2022_29336_MOESM8_ESM.xlsx

View BVdb publication page

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Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumors treated with entrectinib.

Molecular Oncology

Dziadziuszko, Rafal R; Hung, Tiffany T; Wang, Kun K; Choeurng, Voleak V; Drilon, Alexander A; Doebele, Robert C RC; Barlesi, Fabrice F; Wu, Charlie C; Dennis, Lucas L; Skoletsky, Joel J; Woodhouse, Ryan R; Li, Meijuan M; Chang, Ching-Wei CW; Simmons, Brian B; Riehl, Todd T; Wilson, Timothy R TR

Publication Date: 2022-03-26

Variant appearance in text: NRAS: Q61K

PubMed Link: 35338679

Variant Present in the following documents:

• Main text

View BVdb publication page

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Utilisation of semiconductor sequencing for the detection of predictive biomarkers in glioblastoma.

Plos One

Williams, Gareth G; Llewelyn, Alexander A; Thatcher, Robert R; Hardisty, Keeda-Marie KM; Loddo, Marco M

Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Gln61Lys

PubMed Link: 35324914

Variant Present in the following documents:

• pone.0245817.s005.pdf

View BVdb publication page

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Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming.

Frontiers In Oncology

Zuo, Sipeng S; Wang, Huixue H; Li, Lin L; Pan, Hui H; Lu, Linna L

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35311151

Variant Present in the following documents:

• fonc-12-802807.pdf

View BVdb publication page

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PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen.

Frontiers In Medicine

Xu, Jianping J; Pu, Yue Y; Lin, Rui R; Xiao, Shanshan S; Fu, Yingxue Y; Wang, Tao T

Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35308511

Variant Present in the following documents:

• fmed-09-822200.pdf

View BVdb publication page

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ZEB1 transcription factor promotes immune escape in melanoma.

Journal For Immunotherapy Of Cancer

Plaschka, Maud M; Benboubker, Valentin V; Grimont, Maxime M; Berthet, Justine J; Tonon, Laurie L; Lopez, Jonathan J; Le-Bouar, Myrtille M; Balme, Brigitte B; Tondeur, Garance G; de la Fouchardière, Arnaud A; Larue, Lionel L; Puisieux, Alain A; Grinberg-Bleyer, Yenkel Y; Bendriss-Vermare, Nathalie N; Dubois, Bertrand B; Caux, Christophe C; Dalle, Stéphane S; Caramel, Julie J

Publication Date: 2022-03

Variant appearance in text: NRAS: Q61K

PubMed Link: 35288462

Variant Present in the following documents:

• jitc-2021-003484.pdf

View BVdb publication page

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Longitudinal Circulating Tumor DNA Profiling in Metastatic Colorectal Cancer During Anti-EGFR Therapy.

Frontiers In Oncology

Yang, Wentao W; Zou, Jianling J; Li, Ye Y; Liu, Rujiao R; Yan, Zhengqing Z; Chen, Shiqing S; Zhao, Xiaoying X; Guo, Weijian W; Huang, Mingzhu M; Li, Wenhua W; Zhu, Xiaodong X; Chen, Zhiyu Z

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35280779

Variant Present in the following documents:

• fonc-12-830816.pdf

View BVdb publication page

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Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance.

Cancers

Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M

Publication Date: 2022-03-04

Variant appearance in text: NRAS: Q61K

PubMed Link: 35267628

Variant Present in the following documents:

• cancers-14-01321.pdf

View BVdb publication page

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Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies.

Frontiers In Oncology

Désage, Anne-Laure AL; Léonce, Camille C; Swalduz, Aurélie A; Ortiz-Cuaran, Sandra S

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35251972

Variant Present in the following documents:

• fonc-12-796832.pdf

View BVdb publication page

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Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models.

Therapeutic Advances In Medical Oncology

Lim, Sun Min SM; Yang, San-Duk SD; Lim, Sangbin S; Heo, Seong Gu SG; Daniel, Stetson S; Markovets, Aleksandra A; Minoo, Rafati R; Pyo, Kyoung-Ho KH; Yun, Mi Ran MR; Hong, Min Hee MH; Kim, Hye Ryun HR; Cho, Byoung Chul BC

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 35251316

Variant Present in the following documents:

• 10.1177_17588359221079125.pdf

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: NRAS: Gln61Lys

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx

View BVdb publication page

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Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.

Nature Communications

Farshidfar, Farshad F; Rhrissorrakrai, Kahn K; Levovitz, Chaya C; Peng, Cong C; Knight, James J; Bacchiocchi, Antonella A; Su, Juan J; Yin, Mingzhu M; Sznol, Mario M; Ariyan, Stephan S; Clune, James J; Olino, Kelly K; Parida, Laxmi L; Nikolaus, Joerg J; Zhang, Meiling M; Zhao, Shuang S; Wang, Yan Y; Huang, Gang G; Wan, Miaojian M; Li, Xianan X; Cao, Jian J; Yan, Qin Q; Chen, Xiang X; Newman, Aaron M AM; Halaban, Ruth R

Publication Date: 2022-02-23

Variant appearance in text: NRAS: Q61K

PubMed Link: 35197475

Variant Present in the following documents:

• 41467_2022_28566_MOESM5_ESM.xlsx

View BVdb publication page

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Discrimination of Single-Nucleotide Variants Based on an Allele-Specific Hybridization Chain Reaction and Smartphone Detection.

Acs Sensors

Lázaro, Ana A; Maquieira, Ángel Á; Tortajada-Genaro, Luis A LA

Publication Date: 2022-02-21

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35188365

Variant Present in the following documents:

• se1c02220.pdf
• se1c02220_si_001.pdf

View BVdb publication page

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Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma.

Case Reports In Surgery

Alshbib, Ayham A; Grzyb, Krzysztof K; Syversveen, Trygve T; Reims, Henrik Mikael HM; Lassen, Kristoffer K; Yaqub, Sheraz S

Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Gln61Lys

PubMed Link: 35178267

Variant Present in the following documents:

• Main text
• CRIS2022-5280884.pdf

View BVdb publication page

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Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition.

Scientific Reports

Jiri, Jungwirth J; Marketa, Urbanova U; Arnoud, Boot B; Petr, Hosek H; Petra, Bendova B; Anna, Siskova S; Jiri, Svec S; Milan, Kment K; Daniela, Tumova T; Sandra, Summerova S; Zdenek, Benes B; Tomas, Buchler B; Pavel, Kohout K; Tomas, Hucl H; Radoslav, Matej M; Ludmila, Vodickova V; Tom, van Wezel VW; Pavel, Vodicka V; Veronika, Vymetalkova V

Publication Date: 2022-02-16

Variant appearance in text: NRAS: Q61K

PubMed Link: 35173208

Variant Present in the following documents:

• 41598_2022_Article_6498.pdf

View BVdb publication page

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Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cells.

Science Advances

Filali, Liza L; Puissegur, Marie-Pierre MP; Cortacero, Kevin K; Cussat-Blanc, Sylvain S; Khazen, Roxana R; Van Acker, Nathalie N; Frenois, François-Xavier FX; Abreu, Arnaud A; Lamant, Laurence L; Meyer, Nicolas N; Vergier, Béatrice B; Müller, Sabina S; McKenzie, Brienne B; Valitutti, Salvatore S

Publication Date: 2022-02-18

Variant appearance in text: NRAS: Q61K

PubMed Link: 35171665

Variant Present in the following documents:

• sciadv.abk3234_sm.pdf

View BVdb publication page

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Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma.

Cancers

Raymond, Jérémy H JH; Aktary, Zackie Z; Larue, Lionel L; Delmas, Véronique V

Publication Date: 2022-01-29

Variant appearance in text: NRAS: Q61K

PubMed Link: 35158973

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody.

Embo Reports

Tvorogov, Denis D; Thompson-Peach, Chloe A L CAL; Foßelteder, Johannes J; Dottore, Mara M; Stomski, Frank F; Onnesha, Suraiya A SA; Lim, Kelly K; Moretti, Paul A B PAB; Pitson, Stuart M SM; Ross, David M DM; Reinisch, Andreas A; Thomas, Daniel D; Lopez, Angel F AF

Publication Date: 2022-02-14

Variant appearance in text: NRAS: Q61K

PubMed Link: 35156745

Variant Present in the following documents:

• EMBR-23-e52904.pdf

View BVdb publication page

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Acquired somatic variants in inherited myeloid malignancies.

Leukemia

Armes, Hannah H; Rio-Machin, Ana A; Krizsán, Szilvia S; Bödör, Csaba C; Kaya, Fadimana F; Bewicke-Copley, Findlay F; Alnajar, Jenna J; Walne, Amanda A; Péterffy, Borbála B; Tummala, Hemanth H; Rouault-Pierre, Kevin K; Dokal, Inderjeet I; Vulliamy, Tom T; Fitzgibbon, Jude J

Publication Date: 2022-02-09

Variant appearance in text: NRAS: Q61K

PubMed Link: 35140362

Variant Present in the following documents:

• 41375_2022_1515_MOESM4_ESM.xlsx
• 41375_2022_1515_MOESM1_ESM.pdf

View BVdb publication page

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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Cell Reports

Khan, Imran I; Koide, Akiko A; Zuberi, Mariyam M; Ketavarapu, Gayatri G; Denbaum, Eric E; Teng, Kai Wen KW; Rhett, J Matthew JM; Spencer-Smith, Russell R; Hobbs, G Aaron GA; Camp, Ernest Ramsay ER; Koide, Shohei S; O'Bryan, John P JP

Publication Date: 2022-02-08

Variant appearance in text: NRAS: Q61K

PubMed Link: 35139380

Variant Present in the following documents:

• NIHMS1778820-supplement-1.pdf

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Tumor-to-Tumor Metastasis: Lung Typical Carcinoid Metastatic to Follicular Variant of Papillary Thyroid Carcinoma.

Endocrine Pathology

Clara, Ugolini U; Rossella, Del Frate DF; Giulio, Rossi R; Gabriele, Materazzi M; Virginia, LiVolsi L

Publication Date: 2022-02-09

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35138561

Variant Present in the following documents:

• Main text
• 12022_2022_Article_9706.pdf

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Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells.

Cancer & Metabolism

Godfrey, Jason J; Riscal, Romain R; Skuli, Nicolas N; Simon, M Celeste MC

Publication Date: 2022-02-05

Variant appearance in text: NRAS: Q61K

PubMed Link: 35123542

Variant Present in the following documents:

• Main text

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Mutational profiling of melanomas in patients from the southeast coast of China.

Translational Cancer Research

Zheng, Ai-Wen AW; Jia, Dong-Dong DD; Zhou, Cheng-Cheng CC; Li, Tao T

Publication Date: 2020-08

Variant appearance in text: NRAS: Q61K

PubMed Link: 35117841

Variant Present in the following documents:

• Main text
• tcr-09-08-4781.pdf

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Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients.

Frontiers In Oncology

Zhang, Jiexia J; Tang, Shuangfeng S; Zhang, Chunning C; Li, Mingyao M; Zheng, Yating Y; Hu, Xue X; Huang, Mengli M; Cheng, Xiangyang X

Publication Date: 2021

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35087742

Variant Present in the following documents:

• Table_2.xlsx

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Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer.

Frontiers In Oncology

Iseas, Soledad S; Sendoya, Juan M JM; Robbio, Juan J; Coraglio, Mariana M; Kujaruk, Mirta M; Mikolaitis, Vanesa V; Rizzolo, Mariana M; Cabanne, Ana A; Ruiz, Gonzalo G; Salanova, Rubén R; Gualdrini, Ubaldo U; Méndez, Guillermo G; Antelo, Marina M; Carballido, Marcela M; Rotondaro, Cecilia C; Viglino, Julieta J; Eleta, Martín M; Di Sibio, Alejandro A; Podhajcer, Osvaldo L OL; Roca, Enrique E; Llera, Andrea S AS; Golubicki, Mariano M; Abba, Martín Carlos MC

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 35071006

Variant Present in the following documents:

• Table_4.xlsx

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Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab.

Frontiers In Oncology

Burgos, Remberto R; Cardona, Andrés F AF; Santoyo, Nicolas N; Ruiz-Patiño, Alejandro A; Cure-Casilimas, Juanita J; Rojas, Leonardo L; Ricaurte, Luisa L; Muñoz, Álvaro Á; Garcia-Robledo, Juan Esteban JE; Ordoñez, Camila C; Sotelo, Carolina C; Rodríguez, July J; Zatarain-Barrón, Zyanya Lucia ZL; Pineda, Diego D; Arrieta, Oscar O

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 35070950

Variant Present in the following documents:

• Main text

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Mixed odontogenic tumors: A review of the clinicopathological and molecular features and changes in the WHO classification.

World Journal Of Clinical Oncology

Sánchez-Romero, Celeste C; Paes de Almeida, Oslei O; Bologna-Molina, Ronell R

Publication Date: 2021-12-24

Variant appearance in text: NRAS: Gln61Lys

PubMed Link: 35070741

Variant Present in the following documents:

• Main text
• WJCO-12-1227.pdf

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The Molecular Pathology of Odontogenic Tumors: Expanding the Spectrum of MAPK Pathway Driven Tumors.

Frontiers In Oral Health

Guimarães, Letícia Martins LM; Coura, Bruna Pizziolo BP; Gomez, Ricardo Santiago RS; Gomes, Carolina Cavalieri CC

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 35048058

Variant Present in the following documents:

• Main text
• froh-02-740788.pdf

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The dominant TP53 hotspot mutation in -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications.

Neuro-Oncology Advances

Marker, Daniel F DF; Agnihotri, Sameer S; Amankulor, Nduka N; Murdoch, Geoffrey H GH; Pearce, Thomas M TM

Publication Date: 2022

Variant appearance in text: NRAS: 181C>A; Q61K

PubMed Link: 35047821

Variant Present in the following documents:

• vdab182_suppl_supplementary_table_s1.xlsx

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A B-Raf V600E gene signature for melanoma predicts prognosis and reveals sensitivity to targeted therapies.

Cancer Medicine

Yao, Kevin K; Zhou, Emily E; Cheng, Chao C

Publication Date: 2022-01-19

Variant appearance in text: NRAS: Q61K

PubMed Link: 35044091

Variant Present in the following documents:

• CAM4-11-1232.pdf

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Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations.

Signal Transduction And Targeted Therapy

Zhu, Huiyuan H; Bi, Dexi D; Zhang, Youhua Y; Kong, Cheng C; Du, Jiahao J; Wu, Xiawei X; Wei, Qing Q; Qin, Huanlong H

Publication Date: 2022-01-17

Variant appearance in text: NRAS: Q61K

PubMed Link: 35034957

Variant Present in the following documents:

• Main text
• 41392_2021_Article_831.pdf

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Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer.

Frontiers In Oncology

Blaquier, Juan Bautista JB; Cardona, Andrés Felipe AF; Recondo, Gonzalo G

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 35004309

Variant Present in the following documents:

• Main text
• fonc-11-787585.pdf

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Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics.

Computational And Structural Biotechnology Journal

Tripathi, Swarnendu S; Dsouza, Nikita R NR; Mathison, Angela J AJ; Leverence, Elise E; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2022

Variant appearance in text: NRAS: Q61K

PubMed Link: 34976316

Variant Present in the following documents:

• main.pdf

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Ultrasensitive analysis of genetic instability related to chemical exposure.

Journal Of Applied Genetics

Domoradzki, Tomasz T; Grochowski, Piotr P; Jaśkiewicz, Anna A; Pająk, Beata B

Publication Date: 2021-12-30

Variant appearance in text: NRAS: Q61K

PubMed Link: 34967917

Variant Present in the following documents:

• 13353_2021_Article_677.pdf

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Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.

International Journal Of Molecular Sciences

Ragab, Nada N; Bauer, Julia J; Botermann, Dominik S DS; Uhmann, Anja A; Hahn, Heidi H

Publication Date: 2021-12-13

Variant appearance in text: NRAS: Q61K

PubMed Link: 34948179

Variant Present in the following documents:

• Main text
• ijms-22-13377.pdf

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Methylation Markers in Cutaneous Melanoma: Unravelling the Potential Utility of Their Tracking by Liquid Biopsy.

Cancers

Aleotti, Valentina V; Catoni, Cristina C; Poggiana, Cristina C; Rosato, Antonio A; Facchinetti, Antonella A; Scaini, Maria Chiara MC

Publication Date: 2021-12-10

Variant appearance in text: NRAS: Q61K

PubMed Link: 34944843

Variant Present in the following documents:

• cancers-13-06217.pdf

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Development and Validation of a Targeted 'Liquid' NGS Panel for Treatment Customization in Patients with Metastatic Colorectal Cancer.

Diagnostics (Basel, Switzerland)

Kastrisiou, Myrto M; Zarkavelis, George G; Kougioumtzi, Anastasia A; Sakaloglou, Prodromos P; Kostoulas, Charilaos C; Georgiou, Ioannis I; Batistatou, Anna A; Pentheroudakis, George G; Magklara, Angeliki A

Publication Date: 2021-12-16

Variant appearance in text: NRAS: Q61K

PubMed Link: 34943612

Variant Present in the following documents:

• Main text
• diagnostics-11-02375.pdf

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Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.

Blood Advances

Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; St-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallee, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer Jg JJ; Schroeder, Kaitlin K; Koch, Victoria B VB; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D

Publication Date: 2021-12-21

Variant appearance in text: NRAS: Q61K

PubMed Link: 34933343

Variant Present in the following documents:

• advancesADV2021005634-suppl1.xlsx

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Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.

Npj Precision Oncology

Schaufler, Diana D; Ast, David F DF; Tumbrink, Hannah L HL; Abedpour, Nima N; Maas, Lukas L; Schwäbe, Ayla E AE; Spille, Inga I; Lennartz, Stefanie S; Fassunke, Jana J; Aldea, Mihaela M; Besse, Benjamin B; Planchard, David D; Nogova, Lucia L; Michels, Sebastian S; Kobe, Carsten C; Persigehl, Thorsten T; Westphal, Theresa T; Koleczko, Sophia S; Fischer, Rieke R; Weber, Jan-Phillip JP; Altmüller, Janine J; Thomas, Roman K RK; Merkelbach-Bruse, Sabine S; Gautschi, Oliver O; Mezquita, Laura L; Büttner, Reinhard R; Wolf, Jürgen J; Peifer, Martin M; Brägelmann, Johannes J; Scheffler, Matthias M; Sos, Martin L ML

Publication Date: 2021-12-17

Variant appearance in text: NRAS: Q61K

PubMed Link: 34921211

Variant Present in the following documents:

• Main text
• 41698_2021_Article_241.pdf

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Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies.

Frontiers In Oncology

Sin, Chun-Fung CF; Man, Pui-Hei Marcus PM

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 34912707

Variant Present in the following documents:

• Main text
• fonc-11-750789.pdf

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Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.

Cell Reports

McFall, Thomas T; Stites, Edward C EC

Publication Date: 2021-12-14

Variant appearance in text: NRAS: Q61K

PubMed Link: 34910921

Variant Present in the following documents:

• NIHMS1764636-supplement-1.pdf

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Intratumor heterogeneity and clonal evolution revealed in castration-resistant prostate cancer by longitudinal genomic analysis.

Translational Oncology

Zhang, Wenhui W; Wang, Tao T; Wang, Yan Y; Zhu, Feng F; Shi, Haoqing H; Zhang, Jili J; Wang, Ziwei Z; Qu, Min M; Zhang, Huaru H; Wang, Tianyi T; Qian, Yuping Y; Yang, Jinjian J; Gao, Xu X; Li, Jing J

Publication Date: 2021-12-10

Variant appearance in text: NRAS: Q61K

PubMed Link: 34902740

Variant Present in the following documents:

• mmc5.xlsx

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Analysis of Mutations and Dysregulated Pathways Unravels Carcinogenic Effect and Clinical Actionability of Mutational Processes.

Frontiers In Cell And Developmental Biology

Jiang, Zedong Z; Liao, Gaoming G; Yang, Yiran Y; Lan, Yujia Y; Xu, Liwen L; Yan, Min M; Zhou, Yao Y; Zhu, Jiali J; Liu, Wei W; Bai, Jing J; Xiao, Yun Y; Li, Xia X

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 34901014

Variant Present in the following documents:

• Main text
• fcell-09-768981.pdf

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Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers.

Frontiers In Oncology

Okuma, Hitomi Sumiyoshi HS; Yonemori, Kan K; Kojima, Yuki Y; Tanioka, Maki M; Sudo, Kazuki K; Noguchi, Emi E; Hijioka, Susumu S; Wakakuwa, Keiko K; Kato, Ken K; Hirakawa, Akihiro A; Kuchiba, Aya A; Kubo, Takashi T; Ichikawa, Hitoshi H; Yoshida, Akihiko A; Yatabe, Yasushi Y; Nakamura, Kenichi K; Mano, Hiroyuki H; Yamamoto, Noboru N; Fujiwara, Yasuhiro Y

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 34900683

Variant Present in the following documents:

• Main text
• fonc-11-732525.pdf

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Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer.

Cancers

Sunaga, Noriaki N; Miura, Yosuke Y; Kasahara, Norimitsu N; Sakurai, Reiko R

Publication Date: 2021-11-26

Variant appearance in text: NRAS: Q61K

PubMed Link: 34885068

Variant Present in the following documents:

• Main text
• cancers-13-05956.pdf

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Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value.

Frontiers In Oncology

Najem, Ahmad A; Wouters, Jasper J; Krayem, Mohammad M; Rambow, Florian F; Sabbah, Malak M; Sales, François F; Awada, Ahmad A; Aerts, Stein S; Journe, Fabrice F; Marine, Jean-Christophe JC; Ghanem, Ghanem E GE

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 34869032

Variant Present in the following documents:

• Main text
• fonc-11-780654.pdf

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Case Report: The Added Value of Liquid Biopsy in Advanced Colorectal Cancer From Clinical Case Experiences.

Frontiers In Pharmacology

Ulivi, Paola P; Passardi, Alessandro A; Marisi, Giorgia G; Chiadini, Elisa E; Molinari, Chiara C; Canale, Matteo M; Pasini, Luigi L; Ferroni, Fabio F; Frassineti, Giovanni Luca GL; Bartolini, Giulia G; Monti, Manlio M

Publication Date: 2021

Variant appearance in text: NRAS: Q61K

PubMed Link: 34858176

Variant Present in the following documents:

• Main text
• fphar-12-745701.pdf

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Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma.

Journal Of Experimental & Clinical Cancer Research : Cr

Lanzi, Cinzia C; Favini, Enrica E; Dal Bo, Laura L; Tortoreto, Monica M; Arrighetti, Noemi N; Zaffaroni, Nadia N; Cassinelli, Giuliana G

Publication Date: 2021-12-02

Variant appearance in text: NRAS: Q61K

PubMed Link: 34857011

Variant Present in the following documents:

• Main text
• 13046_2021_Article_2150.pdf

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