DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF.
Life Science Alliance
Gutierrez-Prat, Nuria N; Zuberer, Hedwig L HL; Mangano, Luca L; Karimaddini, Zahra Z; Wolf, Luise L; Tyanova, Stefka S; Wellinger, Lisa C LC; Marbach, Daniel D; Griesser, Vera V; Pettazzoni, Piergiorgio P; Bischoff, James R JR; Rohle, Daniel D; Palladino, Chiara C; Vivanco, Igor I
Genetic and Clinical Characteristics of ARID1A Mutated Melanoma Reveal High Tumor Mutational Load without Implications on Patient Survival.
Cancers
Thielmann, Carl Maximilian CM; Matull, Johanna J; Roth, Sebastian S; Placke, Jan-Malte JM; Chorti, Eleftheria E; Zaremba, Anne A; Lodde, Georg G; Jansen, Philipp P; Krefting, Frederik F; Kretz, Julia J; Möller, Inga I; Sucker, Antje A; Paschen, Annette A; Livingstone, Elisabeth E; Zimmer, Lisa L; Ugurel, Selma S; Schadendorf, Dirk D; Hadaschik, Eva E; Griewank, Klaus G KG
Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.
Frontiers In Oncology
Diefenbach, Russell J RJ; Lee, Jenny H JH; Stewart, Ashleigh A; Menzies, Alexander M AM; Carlino, Matteo S MS; Saw, Robyn P M RPM; Stretch, Jonathan R JR; Long, Georgina V GV; Scolyer, Richard A RA; Rizos, Helen H
Preclinical Models for Acquired Resistance to Third-Generation EGFR Inhibitors in NSCLC: Functional Studies and Drug Combinations Used to Overcome Resistance.
Frontiers In Oncology
Mahfoudhi, Emna E; Ricordel, Charles C; Lecuyer, Gwendoline G; Mouric, Cécile C; Lena, Hervé H; Pedeux, Rémy R
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.
American Journal Of Human Genetics
Palles, Claire C; West, Hannah D HD; Chew, Edward E; Galavotti, Sara S; Flensburg, Christoffer C; Grolleman, Judith E JE; Jansen, Erik A M EAM; Curley, Helen H; Chegwidden, Laura L; Arbe-Barnes, Edward H EH; Lander, Nicola N; Truscott, Rebekah R; Pagan, Judith J; Bajel, Ashish A; Sherwood, Kitty K; Martin, Lynn L; Thomas, Huw H; Georgiou, Demetra D; Fostira, Florentia F; Goldberg, Yael Y; Adams, David J DJ; van der Biezen, Simone A M SAM; Christie, Michael M; Clendenning, Mark M; Thomas, Laura E LE; Deltas, Constantinos C; Dimovski, Aleksandar J AJ; Dymerska, Dagmara D; Lubinski, Jan J; Mahmood, Khalid K; van der Post, Rachel S RS; Sanders, Mathijs M; Weitz, Jürgen J; Taylor, Jenny C JC; Turnbull, Clare C; Vreede, Lilian L; van Wezel, Tom T; Whalley, Celina C; Arnedo-Pac, Claudia C; Caravagna, Giulio G; Cross, William W; Chubb, Daniel D; Frangou, Anna A; Gruber, Andreas J AJ; Kinnersley, Ben B; Noyvert, Boris B; Church, David D; Graham, Trevor T; Houlston, Richard R; Lopez-Bigas, Nuria N; Sottoriva, Andrea A; Wedge, David D; , ; , ; , ; Jenkins, Mark A MA; Kuiper, Roland P RP; Roberts, Andrew W AW; Cheadle, Jeremy P JP; Ligtenberg, Marjolijn J L MJL; Hoogerbrugge, Nicoline N; Koelzer, Viktor H VH; Rivas, Andres Dacal AD; Winship, Ingrid M IM; Ponte, Clara Ruiz CR; Buchanan, Daniel D DD; Power, Derek G DG; Green, Andrew A; Tomlinson, Ian P M IPM; Sampson, Julian R JR; Majewski, Ian J IJ; de Voer, Richarda M RM
Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.
International Journal Of Molecular Sciences
Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P
Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis.
Frontiers In Oncology
Kyrochristos, Ioannis D ID; Glantzounis, Georgios K GK; Goussia, Anna A; Eliades, Alexia A; Achilleos, Achilleas A; Tsangaras, Kyriakos K; Hadjidemetriou, Irene I; Elpidorou, Marilena M; Ioannides, Marios M; Koumbaris, George G; Mitsis, Michail M; Patsalis, Philippos C PC; Roukos, Dimitrios D
Different Susceptibilities of Human Melanoma Cell Lines to G2/M Blockage and Cell Death Activation in Response to the Estrogen Receptor β agonist LY500307.
Journal Of Cancer
Pontecorvi, Giada G; Bellenghi, Maria M; Tait, Sabrina S; Tirelli, Valentina V; Matarrese, Paola P; Mattia, Gianfranco G; Carè, Alessandra A; Puglisi, Rossella R
PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity.
Scientific Reports
Maskin, Carolyn R CR; Raman, Renuka R; Houvras, Yariv Y
Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumors treated with entrectinib.
Molecular Oncology
Dziadziuszko, Rafal R; Hung, Tiffany T; Wang, Kun K; Choeurng, Voleak V; Drilon, Alexander A; Doebele, Robert C RC; Barlesi, Fabrice F; Wu, Charlie C; Dennis, Lucas L; Skoletsky, Joel J; Woodhouse, Ryan R; Li, Meijuan M; Chang, Ching-Wei CW; Simmons, Brian B; Riehl, Todd T; Wilson, Timothy R TR
Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody.
Embo Reports
Tvorogov, Denis D; Thompson-Peach, Chloe A L CAL; Foßelteder, Johannes J; Dottore, Mara M; Stomski, Frank F; Onnesha, Suraiya A SA; Lim, Kelly K; Moretti, Paul A B PAB; Pitson, Stuart M SM; Ross, David M DM; Reinisch, Andreas A; Thomas, Daniel D; Lopez, Angel F AF
Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.
Cell Reports
Khan, Imran I; Koide, Akiko A; Zuberi, Mariyam M; Ketavarapu, Gayatri G; Denbaum, Eric E; Teng, Kai Wen KW; Rhett, J Matthew JM; Spencer-Smith, Russell R; Hobbs, G Aaron GA; Camp, Ernest Ramsay ER; Koide, Shohei S; O'Bryan, John P JP
Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer.
Frontiers In Oncology
Iseas, Soledad S; Sendoya, Juan M JM; Robbio, Juan J; Coraglio, Mariana M; Kujaruk, Mirta M; Mikolaitis, Vanesa V; Rizzolo, Mariana M; Cabanne, Ana A; Ruiz, Gonzalo G; Salanova, Rubén R; Gualdrini, Ubaldo U; Méndez, Guillermo G; Antelo, Marina M; Carballido, Marcela M; Rotondaro, Cecilia C; Viglino, Julieta J; Eleta, Martín M; Di Sibio, Alejandro A; Podhajcer, Osvaldo L OL; Roca, Enrique E; Llera, Andrea S AS; Golubicki, Mariano M; Abba, Martín Carlos MC
Development and Validation of a Targeted 'Liquid' NGS Panel for Treatment Customization in Patients with Metastatic Colorectal Cancer.
Diagnostics (Basel, Switzerland)
Kastrisiou, Myrto M; Zarkavelis, George G; Kougioumtzi, Anastasia A; Sakaloglou, Prodromos P; Kostoulas, Charilaos C; Georgiou, Ioannis I; Batistatou, Anna A; Pentheroudakis, George G; Magklara, Angeliki A
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.
Blood Advances
Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; St-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallee, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer Jg JJ; Schroeder, Kaitlin K; Koch, Victoria B VB; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D
Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.
Npj Precision Oncology
Schaufler, Diana D; Ast, David F DF; Tumbrink, Hannah L HL; Abedpour, Nima N; Maas, Lukas L; Schwäbe, Ayla E AE; Spille, Inga I; Lennartz, Stefanie S; Fassunke, Jana J; Aldea, Mihaela M; Besse, Benjamin B; Planchard, David D; Nogova, Lucia L; Michels, Sebastian S; Kobe, Carsten C; Persigehl, Thorsten T; Westphal, Theresa T; Koleczko, Sophia S; Fischer, Rieke R; Weber, Jan-Phillip JP; Altmüller, Janine J; Thomas, Roman K RK; Merkelbach-Bruse, Sabine S; Gautschi, Oliver O; Mezquita, Laura L; Büttner, Reinhard R; Wolf, Jürgen J; Peifer, Martin M; Brägelmann, Johannes J; Scheffler, Matthias M; Sos, Martin L ML
Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value.
Frontiers In Oncology
Najem, Ahmad A; Wouters, Jasper J; Krayem, Mohammad M; Rambow, Florian F; Sabbah, Malak M; Sales, François F; Awada, Ahmad A; Aerts, Stein S; Journe, Fabrice F; Marine, Jean-Christophe JC; Ghanem, Ghanem E GE