Publications:

---

Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications

Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G

Publication Date: 2023-03-11

Variant appearance in text: NRAS: G60E

PubMed Link: 36906579

Variant Present in the following documents:

• 41467_2023_36922_MOESM4_ESM.xls, sheet 2

View BVdb publication page

---

KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.

International Journal Of Molecular Sciences

Martianov, Aleksandr S AS; Mitiushkina, Natalia V NV; Ershova, Anastasia N AN; Martynenko, Darya E DE; Bubnov, Mikhail G MG; Amankwah, Priscilla P; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Tiurin, Vladislav I VI; Venina, Aigul R AR; Anuskina, Aleksandra A AA; Gorgul, Yuliy A YA; Shestakova, Anna D AD; Maidin, Mikhail A MA; Belyaev, Alexey M AM; Baboshkina, Liliya S LS; Iyevleva, Aglaya G AG; Imyanitov, Evgeny N EN

Publication Date: 2023-03-02

Variant appearance in text: NRAS: G60E

PubMed Link: 36902296

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

---

First-in-human phase I dose-escalation and dose-expansion trial of the selective MEK inhibitor HL-085 in patients with advanced melanoma harboring NRAS mutations.

Bmc Medicine

Wang, Xuan X; Luo, Zhiguo Z; Chen, Jing J; Chen, Yu Y; Ji, Dongmei D; Fan, Li L; Chen, Ling L; Zhao, Qian Q; Hu, Pei P; Sun, Peng P; Jia, Zhongwei Z; Guo, Jun J; Si, Lu L

Publication Date: 2023-01-04

Variant appearance in text: NRAS: G60E

PubMed Link: 36600247

Variant Present in the following documents:

• Main text
• 12916_2022_Article_2669.pdf

View BVdb publication page

---

A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study.

The Lancet. Haematology

,

Publication Date: 2022-11-24

Variant appearance in text: NRAS: 179G>A; G60E

PubMed Link: 36436542

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

---

Identification of NRAS Diagnostic Biomarkers and Drug Targets for Endometrial Cancer-An Integrated in Silico Approach.

International Journal Of Molecular Sciences

Alessandro, Larsen L; Low, Kat-Jun Eric KE; Abushelaibi, Aisha A; Lim, Swee-Hua Erin SE; Cheng, Wan-Hee WH; Chang, Sook-Keng SK; Lai, Kok-Song KS; Sum, Yap Wai YW; Maran, Sathiya S

Publication Date: 2022-11-18

Variant appearance in text: NRAS: G60E; rs267606920

PubMed Link: 36430761

Variant Present in the following documents:

• Main text
• ijms-23-14285.pdf

View BVdb publication page

---

Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: NRAS: 179G>A; G60E

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

---

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Blood

Ansari-Pour, Naser N; Samur, Mehmet K MK; Flynt, Erin E; Gooding, Sarah S; Towfic, Fadi F; Stong, Nicholas N; Ortiz Estevez, Maria M; Mavrommatis, Konstantinos K; Walker, Brian A BA; Morgan, Gareth J GJ; Munshi, Nikhil C NC; Avet Loiseau, Herve H; Thakurta, Anjan A

Publication Date: 2022-10-12

Variant appearance in text: NRAS: G60E

PubMed Link: 36223594

Variant Present in the following documents:

• BLOOD_BLD-2022-017010-mmc2.xlsx, sheet 1

View BVdb publication page

---

Cancer-driving mutations are enriched in genic regions intolerant to germline variation.

Science Advances

Vitsios, Dimitrios D; Dhindsa, Ryan S RS; Matelska, Dorota D; Mitchell, Jonathan J; Zou, Xuequing X; Armenia, Joshua J; Hu, Fengyuan F; Wang, Quanli Q; Sidders, Ben B; Harper, Andrew R AR; Petrovski, Slavé S

Publication Date: 2022-08-26

Variant appearance in text: NRAS: Gly60Glu

PubMed Link: 36026442

Variant Present in the following documents:

• Main text
• sciadv.abo6371.pdf

View BVdb publication page

---

Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: NRAS: 179G>A; G60E

PubMed Link: 35936718

Variant Present in the following documents:

• Table_4.xlsx, sheet 2

View BVdb publication page

---

Next-generation sequencing in advanced Chinese melanoma reveals therapeutic targets and prognostic biomarkers for immunotherapy.

Scientific Reports

Huang, Fuxue F; Li, Jingjing J; Wen, Xizhi X; Zhu, Baoyan B; Liu, Wei W; Wang, Jiuhong J; Jiang, Hang H; Ding, Ya Y; Li, Dandan D; Zhang, Xiaoshi X

Publication Date: 2022-06-10

Variant appearance in text: NRAS: 179G>A; Gly60Glu; rs267606920

PubMed Link: 35688842

Variant Present in the following documents:

• 41598_2022_13391_MOESM5_ESM.xlsx, sheet 2

View BVdb publication page

---

Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.

Ebiomedicine

Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP

Publication Date: 2022-06

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 35617825

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

---

Are transient protein-protein interactions more dispensable?

Plos Computational Biology

Ghadie, Mohamed Ali MA; Xia, Yu Y

Publication Date: 2022-04

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 35404956

Variant Present in the following documents:

• pcbi.1010013.s002.xlsx, sheet 2
• pcbi.1010013.s002.xlsx, sheet 4

View BVdb publication page

---

Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia.

Blood Science (Baltimore, Md.)

Zhu, Haichuan H; Dong, Bingjie B; Zhang, Yingchi Y; Wang, Mei M; Rao, Jianan J; Cui, Bowen B; Liu, Yu Y; Jiang, Qian Q; Wang, Weitao W; Yang, Lu L; Yu, Anqi A; Li, Zongru Z; Liu, Chao C; Zhang, Leping L; Huang, Xiaojun X; Zhu, Xiaofan X; Wu, Hong H

Publication Date: 2022-01

Variant appearance in text: NRAS: G60E

PubMed Link: 35399540

Variant Present in the following documents:

• bls-4-16-s005.xlsx, sheet 2
• bls-4-16-s005.xlsx, sheet 9
• bls-4-16-s004.pdf

View BVdb publication page

---

Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia.

Frontiers In Cell And Developmental Biology

Qian, Jiabi J; Li, Zifeng Z; Pei, Kunlin K; Li, Ziping Z; Li, Chunjie C; Yan, Muxia M; Qian, Maoxiang M; Song, Yuanbin Y; Zhang, Hui H; He, Yingyi Y

Publication Date: 2022

Variant appearance in text: NRAS: G60E

PubMed Link: 35211470

Variant Present in the following documents:

• DataSheet2.xlsx, sheet 8

View BVdb publication page

---

The RASopathies: from pathogenetics to therapeutics.

Disease Models & Mechanisms

Hebron, Katie E KE; Hernandez, Edjay Ralph ER; Yohe, Marielle E ME

Publication Date: 2022-02-01

Variant appearance in text: NRAS: G60E

PubMed Link: 35178568

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: NRAS: G60E

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

---

Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: NRAS: 179G>A; G60E

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

View BVdb publication page

---

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Lin, Jessica J JJ; Choudhury, Noura J NJ; Yoda, Satoshi S; Zhu, Viola W VW; Johnson, Ted W TW; Sakhtemani, Ramin R; Dagogo-Jack, Ibiayi I; Digumarthy, Subba R SR; Lee, Charlotte C; Do, Andrew A; Peterson, Jennifer J; Prutisto-Chang, Kylie K; Malik, Wafa W; Hubbeling, Harper G HG; Langenbucher, Adam A; Schoenfeld, Adam J AJ; Falcon, Christina J CJ; Temel, Jennifer S JS; Sequist, Lecia V LV; Yeap, Beow Y BY; Lennerz, Jochen K JK; Shaw, Alice T AT; Lawrence, Michael S MS; Ou, Sai-Hong Ignatius SI; Hata, Aaron N AN; Drilon, Alexander A; Gainor, Justin F JF

Publication Date: 2021-05-15

Variant appearance in text: NRAS: G60E

PubMed Link: 33685866

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects.

Frontiers In Cell And Developmental Biology

You, Xiaona X; Ryu, Myung-Jeom MJ; Cho, Eunjin E; Sang, Yanzhi Y; Damnernsawad, Alisa A; Zhou, Yun Y; Liu, Yangang Y; Zhang, Jing J; Lee, Youngsook Y

Publication Date: 2021

Variant appearance in text: NRAS: G60E

PubMed Link: 33681212

Variant Present in the following documents:

• Main text
• fcell-09-633661.pdf

View BVdb publication page

---

KRAS Codon 12 Mutation is Associated with More Aggressive Invasiveness in Synchronous Metastatic Colorectal Cancer (mCRC): Retrospective Research.

Oncotargets And Therapy

He, Kang K; Wang, Yajing Y; Zhong, Yuejiao Y; Pan, Xiaohua X; Si, Lixiang L; Lu, Jianwei J

Publication Date: 2020

Variant appearance in text: NRAS: G60E

PubMed Link: 33335401

Variant Present in the following documents:

• Main text
• ott-13-12601.pdf

View BVdb publication page

---

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica

Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP

Publication Date: 2021-12-01

Variant appearance in text: NRAS: G60E

PubMed Link: 33147938

Variant Present in the following documents:

• 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3

View BVdb publication page

---

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica

Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP

Publication Date: 2021-12-01

Variant appearance in text: NRAS: G60E

PubMed Link: 33147938

Variant Present in the following documents:

• 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3

View BVdb publication page

---

Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types.

Genome Medicine

Bao, Riyue R; Stapor, Daniel D; Luke, Jason J JJ

Publication Date: 2020-10-27

Variant appearance in text: NRAS: G60E

PubMed Link: 33106165

Variant Present in the following documents:

• 13073_2020_787_MOESM1_ESM.xlsx, sheet 9

View BVdb publication page

---

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.

Nature Communications

Morita, Kiyomi K; Wang, Feng F; Jahn, Katharina K; Hu, Tianyuan T; Tanaka, Tomoyuki T; Sasaki, Yuya Y; Kuipers, Jack J; Loghavi, Sanam S; Wang, Sa A SA; Yan, Yuanqing Y; Furudate, Ken K; Matthews, Jairo J; Little, Latasha L; Gumbs, Curtis C; Zhang, Jianhua J; Song, Xingzhi X; Thompson, Erika E; Patel, Keyur P KP; Bueso-Ramos, Carlos E CE; DiNardo, Courtney D CD; Ravandi, Farhad F; Jabbour, Elias E; Andreeff, Michael M; Cortes, Jorge J; Bhalla, Kapil K; Garcia-Manero, Guillermo G; Kantarjian, Hagop H; Konopleva, Marina M; Nakada, Daisuke D; Navin, Nicholas N; Beerenwinkel, Niko N; Futreal, P Andrew PA; Takahashi, Koichi K

Publication Date: 2020-10-21

Variant appearance in text: NRAS: G60E

PubMed Link: 33087716

Variant Present in the following documents:

• Main text
• 41467_2020_19119_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

---

Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: NRAS: G60E

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

---

The effects of mutant Ras proteins on the cell signalome.

Cancer Metastasis Reviews

Takács, Tamás T; Kudlik, Gyöngyi G; Kurilla, Anita A; Szeder, Bálint B; Buday, László L; Vas, Virag V

Publication Date: 2020-12

Variant appearance in text: NRAS: G60E

PubMed Link: 32648136

Variant Present in the following documents:

• Main text
• 10555_2020_Article_9912.pdf

View BVdb publication page

---

Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Dunnett-Kane, V V; Burkitt-Wright, E E; Blackhall, F H FH; Malliri, A A; Evans, D G DG; Lindsay, C R CR

Publication Date: 2020-07

Variant appearance in text: NRAS: G60E

PubMed Link: 32240795

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks.

Scientific Reports

Zimmerman, Lior L; Zelichov, Ori O; Aizenmann, Arie A; Barbash, Zohar Z; Vidne, Michael M; Tarcic, Gabi G

Publication Date: 2020-03-06

Variant appearance in text: NRAS: G60E

PubMed Link: 32144301

Variant Present in the following documents:

• Main text
• 41598_2020_Article_61173.pdf

View BVdb publication page

---

Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: NRAS: G60E

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

---

Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes.

Nature Communications

Nagata, Yasunobu Y; Makishima, Hideki H; Kerr, Cassandra M CM; Przychodzen, Bartlomiej P BP; Aly, Mai M; Goyal, Abhinav A; Awada, Hassan H; Asad, Mohammad Fahad MF; Kuzmanovic, Teodora T; Suzuki, Hiromichi H; Yoshizato, Tetsuichi T; Yoshida, Kenichi K; Chiba, Kenichi K; Tanaka, Hiroko H; Shiraishi, Yuichi Y; Miyano, Satoru S; Mukherjee, Sudipto S; LaFramboise, Thomas T; Nazha, Aziz A; Sekeres, Mikkael A MA; Radivoyevitch, Tomas T; Haferlach, Torsten T; Ogawa, Seishi S; Maciejewski, Jaroslaw P JP

Publication Date: 2019-11-26

Variant appearance in text: NRAS: G60E

PubMed Link: 31772163

Variant Present in the following documents:

• 41467_2019_13001_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

---

A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology

Muñoz-Maldonado, Carmen C; Zimmer, Yitzhak Y; Medová, Michaela M

Publication Date: 2019

Variant appearance in text: NRAS: G60E

PubMed Link: 31681616

Variant Present in the following documents:

• Main text
• fonc-09-01088.pdf

View BVdb publication page

---

Prospective evaluation of two screening methods for molecular testing of metastatic melanoma: Diagnostic performance of BRAF V600E immunohistochemistry and of a NRAS-BRAF fully automated real-time PCR-based assay.

Plos One

Vallée, Audrey A; Denis-Musquer, Marie M; Herbreteau, Guillaume G; Théoleyre, Sandrine S; Bossard, Céline C; Denis, Marc G MG

Publication Date: 2019

Variant appearance in text: NRAS: G60E

PubMed Link: 31415669

Variant Present in the following documents:

• Main text

View BVdb publication page

---

RAS-associated Autoimmune Leukoproliferative disease (RALD) manifested with early-onset SLE-like syndrome: a case series of RALD in Chinese children.

Pediatric Rheumatology Online Journal

Wang, Wei W; Zhou, Yu Y; Zhong, Linqing L; Wang, Lin L; Tang, Xiaoyan X; Ma, Mingsheng M; Li, Ji J; Song, Hongmei H

Publication Date: 2019-08-14

Variant appearance in text: NRAS: G60E

PubMed Link: 31412876

Variant Present in the following documents:

• Main text
• 12969_2019_Article_346.pdf

View BVdb publication page

---

Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer.

Journal Of Translational Medicine

Isnaldi, Edoardo E; Garuti, Anna A; Cirmena, Gabriella G; Scabini, Stefano S; Rimini, Edoardo E; Ferrando, Lorenzo L; Lia, Michela M; Murialdo, Roberto R; Tixi, Lucia L; Carminati, Enrico E; Panaro, Andrea A; Gallo, Maurizio M; Grillo, Federica F; Mastracci, Luca L; Repetto, Lazzaro L; Fiocca, Roberto R; Romairone, Emanuele E; Zoppoli, Gabriele G; Ballestrero, Alberto A

Publication Date: 2019-04-29

Variant appearance in text: NRAS: G60E

PubMed Link: 31036005

Variant Present in the following documents:

• Main text
• 12967_2019_Article_1879.pdf

View BVdb publication page

---

Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting.

American Journal Of Human Genetics

Wright, Caroline F CF; West, Ben B; Tuke, Marcus M; Jones, Samuel E SE; Patel, Kashyap K; Laver, Thomas W TW; Beaumont, Robin N RN; Tyrrell, Jessica J; Wood, Andrew R AR; Frayling, Timothy M TM; Hattersley, Andrew T AT; Weedon, Michael N MN

Publication Date: 2019-02-07

Variant appearance in text: NRAS: G60E

PubMed Link: 30665703

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

---

Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients.

Heliyon

Deng, Qinfang Q; Xie, Boxiong B; Wu, Leilei L; Ji, Xianxiu X; Li, Chao C; Feng, Li L; Fang, Qiyu Q; Bao, Yuchen Y; Li, Jialu J; Jin, Shengnan S; Ding, Chunming C; Li, Yixue Y; Zhou, Songwen S

Publication Date: 2018-12

Variant appearance in text: NRAS: G60E

PubMed Link: 30603682

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

---

Clinical validation of coexisting driver mutations in colorectal cancers.

Human Pathology

Zheng, Gang G; Tseng, Li-Hui LH; Haley, Lisa L; Ibrahim, Junaid J; Bynum, Jennifer J; Xian, Rena R; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2019-04

Variant appearance in text: NRAS: G60E

PubMed Link: 30481508

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: NRAS: G60E

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 2
• pone.0196434.s001.xlsx, sheet 3

View BVdb publication page

---

Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Schrock, Alexa B AB; Pavlick, Dean D; Klempner, Samuel J SJ; Chung, Jon H JH; Forcier, Brady B; Welsh, Allison A; Young, Lauren L; Leyland-Jones, Bryan B; Bordoni, Rodolfo R; Carvajal, Richard D RD; Chao, Joseph J; Kurzrock, Razelle R; Sicklick, Jason K JK; Ross, Jeffrey S JS; Stephens, Philip J PJ; Devoe, Craig C; Braiteh, Fadi F; Ali, Siraj M SM; Miller, Vincent A VA

Publication Date: 2018-04-15

Variant appearance in text: NRAS: G60E

PubMed Link: 29363525

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications

Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ

Publication Date: 2017-08-04

Variant appearance in text: NRAS: 179G>A; G60E

PubMed Link: 28775315

Variant Present in the following documents:

• 41467_2017_289_MOESM7_ESM.xlsx, sheet 1

View BVdb publication page

---

Genotype and phenotype spectrum of NRAS germline variants.

European Journal Of Human Genetics : Ejhg

Altmüller, Franziska F; Lissewski, Christina C; Bertola, Debora D; Flex, Elisabetta E; Stark, Zornitza Z; Spranger, Stephanie S; Baynam, Gareth G; Buscarilli, Michelle M; Dyack, Sarah S; Gillis, Jane J; Yntema, Helger G HG; Pantaleoni, Francesca F; van Loon, Rosa LE RL; MacKay, Sara S; Mina, Kym K; Schanze, Ina I; Tan, Tiong Yang TY; Walsh, Maie M; White, Susan M SM; Niewisch, Marena R MR; García-Miñaúr, Sixto S; Plaza, Diego D; Ahmadian, Mohammad Reza MR; Cavé, Hélène H; Tartaglia, Marco M; Zenker, Martin M

Publication Date: 2017-06

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 28594414

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics

Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S

Publication Date: 2017-10

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 28569743

Variant Present in the following documents:

• gim201760x7.xlsx, sheet 2

View BVdb publication page

---

Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.

Plos One

Giannoulatou, Eleni E; Maher, Geoffrey J GJ; Ding, Zhihao Z; Gillis, Ad J M AJM; Dorssers, Lambert C J LCJ; Hoischen, Alexander A; Rajpert-De Meyts, Ewa E; , ; McVean, Gilean G; Wilkie, Andrew O M AOM; Looijenga, Leendert H J LHJ; Goriely, Anne A

Publication Date: 2017

Variant appearance in text: NRAS: G60E

PubMed Link: 28542371

Variant Present in the following documents:

• Main text
• pone.0178169.pdf

View BVdb publication page

---

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: NRAS: G60E; rs267606920

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

View BVdb publication page

---

Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing.

Oncotarget

Youssef, Omar O; Knuuttila, Aija A; Piirilä, Päivi P; Böhling, Tom T; Sarhadi, Virinder V; Knuutila, Sakari S

Publication Date: 2017-03-14

Variant appearance in text: NRAS: G60E

PubMed Link: 28199989

Variant Present in the following documents:

• Main text
• oncotarget-08-18166.pdf

View BVdb publication page

---

Juvenile myelomonocytic leukemia-associated variants are associated with neo-natal lethal Noonan syndrome.

European Journal Of Human Genetics : Ejhg

Mason-Suares, Heather H; Toledo, Diana D; Gekas, Jean J; Lafferty, Katherine A KA; Meeks, Naomi N; Pacheco, M Cristina MC; Sharpe, David D; Mullen, Thomas E TE; Lebo, Matthew S MS

Publication Date: 2017-04

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 28098151

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.

Oncotarget

Lindqvist, C Mårten CM; Lundmark, Anders A; Nordlund, Jessica J; Freyhult, Eva E; Ekman, Diana D; Carlsson Almlöf, Jonas J; Raine, Amanda A; Övernäs, Elin E; Abrahamsson, Jonas J; Frost, Britt-Marie BM; Grandér, Dan D; Heyman, Mats M; Palle, Josefine J; Forestier, Erik E; Lönnerholm, Gudmar G; Berglund, Eva C EC; Syvänen, Ann-Christine AC

Publication Date: 2016-09-27

Variant appearance in text: NRAS: G60E

PubMed Link: 27590521

Variant Present in the following documents:

• oncotarget-07-64071-s002.xlsx, sheet 4

View BVdb publication page

---

1p13.2 deletion displays clinical features overlapping Noonan syndrome, likely related to NRAS gene haploinsufficiency.

Genetics And Molecular Biology

Linhares, Natália Duarte ND; Freire, Maíra Cristina Menezes MC; Cardenas, Raony Guimarães Corrêa do Carmo Lisboa RG; Pena, Heloisa Barbosa HB; Lachlan, Katherine K; Dallapiccola, Bruno B; Bacino, Carlos C; Delobel, Bruno B; James, Paul P; Thuresson, Ann-Charlotte AC; Annerén, Göran G; Pena, Sérgio D J SD

Publication Date: 2016

Variant appearance in text: NRAS: Gly60Glu

PubMed Link: 27561113

Variant Present in the following documents:

• Main text
• 1415-4757-gmb-1678-4685-GMB-2016-0049.pdf

View BVdb publication page

---

Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies.

The Journal Of Molecular Diagnostics : Jmd

Fisher, Kevin E KE; Zhang, Linsheng L; Wang, Jason J; Smith, Geoffrey H GH; Newman, Scott S; Schneider, Thomas M TM; Pillai, Rathi N RN; Kudchadkar, Ragini R RR; Owonikoko, Taofeek K TK; Ramalingam, Suresh S SS; Lawson, David H DH; Delman, Keith A KA; El-Rayes, Bassel F BF; Wilson, Malania M MM; Sullivan, H Clifford HC; Morrison, Annie S AS; Balci, Serdar S; Adsay, N Volkan NV; Gal, Anthony A AA; Sica, Gabriel L GL; Saxe, Debra F DF; Mann, Karen P KP; Hill, Charles E CE; Khuri, Fadlo R FR; Rossi, Michael R MR

Publication Date: 2016-03

Variant appearance in text: NRAS: G60E

PubMed Link: 26801070

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutation in NRAS in familial Noonan syndrome--case report and review of the literature.

Bmc Medical Genetics

Ekvall, Sara S; Wilbe, Maria M; Dahlgren, Jovanna J; Legius, Eric E; van Haeringen, Arie A; Westphal, Otto O; Annerén, Göran G; Bondeson, Marie-Louise ML

Publication Date: 2015-10-14

Variant appearance in text: NRAS: G60E

PubMed Link: 26467218

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth.

Jama

Mody, Rajen J RJ; Wu, Yi-Mi YM; Lonigro, Robert J RJ; Cao, Xuhong X; Roychowdhury, Sameek S; Vats, Pankaj P; Frank, Kevin M KM; Prensner, John R JR; Asangani, Irfan I; Palanisamy, Nallasivam N; Dillman, Jonathan R JR; Rabah, Raja M RM; Kunju, Laxmi Priya LP; Everett, Jessica J; Raymond, Victoria M VM; Ning, Yu Y; Su, Fengyun F; Wang, Rui R; Stoffel, Elena M EM; Innis, Jeffrey W JW; Roberts, J Scott JS; Robertson, Patricia L PL; Yanik, Gregory G; Chamdin, Aghiad A; Connelly, James A JA; Choi, Sung S; Harris, Andrew C AC; Kitko, Carrie C; Rao, Rama Jasty RJ; Levine, John E JE; Castle, Valerie P VP; Hutchinson, Raymond J RJ; Talpaz, Moshe M; Robinson, Dan R DR; Chinnaiyan, Arul M AM

Publication Date: 2015-09-01

Variant appearance in text: NRAS: G60E

PubMed Link: 26325560

Variant Present in the following documents:

• Main text

View BVdb publication page

---

GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: NRAS: G60E

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 2

View BVdb publication page

---

RASopathies: unraveling mechanisms with animal models.

Disease Models & Mechanisms

Jindal, Granton A GA; Goyal, Yogesh Y; Burdine, Rebecca D RD; Rauen, Katherine A KA; Shvartsman, Stanislav Y SY

Publication Date: 2015-08-01

Variant appearance in text: NRAS: G60E

PubMed Link: 26203125

Variant Present in the following documents:

• supp_8.8.769_DMM020339supp.pdf

View BVdb publication page

---

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One

Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M

Publication Date: 2015

Variant appearance in text: NRAS: G60E

PubMed Link: 26010451

Variant Present in the following documents:

• pone.0127146.s014.xlsx, sheet 3

View BVdb publication page

---

An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.

American Journal Of Medical Genetics. Part A

Gripp, Karen W KW; Sol-Church, Katia K; Smpokou, Patroula P; Graham, Gail E GE; Stevenson, David A DA; Hanson, Heather H; Viskochil, David H DH; Baker, Laura C LC; Russo, Bridget B; Gardner, Nick N; Stabley, Deborah L DL; Kolbe, Verena V; Rosenberger, Georg G

Publication Date: 2015-09

Variant appearance in text: NRAS: 179G>A; Gly60Glu

PubMed Link: 25914166

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.

The Journal Of Investigative Dermatology

Siroy, Alan E AE; Boland, Genevieve M GM; Milton, Denái R DR; Roszik, Jason J; Frankian, Silva S; Malke, Jared J; Haydu, Lauren L; Prieto, Victor G VG; Tetzlaff, Michael M; Ivan, Doina D; Wang, Wei-Lien WL; Torres-Cabala, Carlos C; Curry, Jonathan J; Roy-Chowdhuri, Sinchita S; Broaddus, Russell R; Rashid, Asif A; Stewart, John J; Gershenwald, Jeffrey E JE; Amaria, Rodabe N RN; Patel, Sapna P SP; Papadopoulos, Nicholas E NE; Bedikian, Agop A; Hwu, Wen-Jen WJ; Hwu, Patrick P; Diab, Adi A; Woodman, Scott E SE; Aldape, Kenneth D KD; Luthra, Rajyalakshmi R; Patel, Keyur P KP; Shaw, Kenna R KR; Mills, Gordon B GB; Mendelsohn, John J; Meric-Bernstam, Funda F; Kim, Kevin B KB; Routbort, Mark J MJ; Lazar, Alexander J AJ; Davies, Michael A MA

Publication Date: 2015-02

Variant appearance in text: NRAS: 179G>A; G60E

PubMed Link: 25148578

Variant Present in the following documents:

• NIHMS622327-supplement-supplement_1.pdf

View BVdb publication page

---