NRAS c.173C>T ;(p.T58I)

Variant ID: 1-115256538-G-A

NM_002524.4(NRAS):c.173C>T;(p.T58I)

This variant was identified in 21 publications

View GRCh38 version.




Publications:


Integrative proteogenomic characterization of early esophageal cancer.

Nature Communications
Li, Lingling L; Jiang, Dongxian D; Zhang, Qiao Q; Liu, Hui H; Xu, Fujiang F; Guo, Chunmei C; Qin, Zhaoyu Z; Wang, Haixing H; Feng, Jinwen J; Liu, Yang Y; Chen, Weijie W; Zhang, Xue X; Bai, Lin L; Tian, Sha S; Tan, Subei S; Xu, Chen C; Song, Qi Q; Liu, Yalan Y; Zhong, Yunshi Y; Chen, Tianyin T; Zhou, Pinghong P; Zhao, Jian-Yuan JY; Hou, Yingyong Y; Ding, Chen C
Publication Date: 2023-03-25

Variant appearance in text: NRAS: T58I
PubMed Link: 36966136
Variant Present in the following documents:
  • 41467_2023_37440_MOESM4_ESM.xlsx, sheet 2
View BVdb publication page



Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Cheng, Wen-Yan WY; Li, Jian-Feng JF; Zhu, Yong-Mei YM; Lin, Xiang-Jie XJ; Wen, Li-Jun LJ; Zhang, Fan F; Zhang, Yu-Liang YL; Zhao, Ming M; Fang, Hai H; Wang, Sheng-Yue SY; Lin, Xiao-Jing XJ; Qiao, Niu N; Yin, Wei W; Zhang, Jia-Nan JN; Dai, Yu-Ting YT; Jiang, Lu L; Sun, Xiao-Jian XJ; Xu, Yi Y; Zhang, Tong-Tong TT; Chen, Su-Ning SN; Zhu, Hong-Hu HH; Chen, Zhu Z; Jin, Jie J; Wu, De-Pei DP; Shen, Yang Y; Chen, Sai-Juan SJ
Publication Date: 2022-12-06

Variant appearance in text: NRAS: 173C>T; Thr58Ile
PubMed Link: 36442087
Variant Present in the following documents:
  • pnas.2211429119.sd02.xlsx, sheet 1
View BVdb publication page



Integrative molecular profiling identifies two molecularly and clinically distinct subtypes of blastic plasmacytoid dendritic cell neoplasm.

Blood Cancer Journal
Künstner, Axel A; Schwarting, Julian J; Witte, Hanno M HM; Bernard, Veronica V; Stölting, Stephanie S; Kusch, Kathrin K; Nagarathinam, Kumar K; von Bubnoff, Nikolas N; Murga Penas, Eva Maria EM; Merz, Hartmut H; Busch, Hauke H; Feller, Alfred C AC; Gebauer, Niklas N
Publication Date: 2022-07-04

Variant appearance in text: NRAS: T58I
PubMed Link: 35788129
Variant Present in the following documents:
  • 41408_2022_699_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum.

Blood Advances
Calvo, Xavier X; Roman-Bravo, David D; Garcia-Gisbert, Nieves N; Rodriguez-Sevilla, Juan Jose JJ; Garcia-Avila, Sara S; Florensa, Lourdes L; Gibert, Joan J; Fernández-Rodríguez, Concepción C; Salido, Marta M; Puiggros, Anna A; Espinet, Blanca B; Colomo, Luis L; Bellosillo, Beatriz B; Ferrer, Ana A; Arenillas, Leonor L
Publication Date: 2022-07-12

Variant appearance in text: NRAS: 173C>T; Thr58Ile
PubMed Link: 35709473
Variant Present in the following documents:
  • advancesADV2022007359-suppl1.pdf
View BVdb publication page



Potential Biomarkers of Skin Melanoma Resistance to Targeted Therapy-Present State and Perspectives.

Cancers
Olbryt, Magdalena M
Publication Date: 2022-05-06

Variant appearance in text: NRAS: T58I
PubMed Link: 35565444
Variant Present in the following documents:
  • Main text
  • cancers-14-02315.pdf
View BVdb publication page



Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research
Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL
Publication Date: 2022-05

Variant appearance in text: NRAS: T58I
PubMed Link: 35229492
Variant Present in the following documents:
  • PCMR-35-369-s002.pdf
View BVdb publication page



Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.

Clinical And Translational Gastroenterology
Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD
Publication Date: 2021-11-18

Variant appearance in text: NRAS: 173C>T; Thr58Ile
PubMed Link: 34797250
Variant Present in the following documents:
  • ct9-12-e00431-s006.xlsx, sheet 1
  • ct9-12-e00431-s005.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: NRAS: T58I
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



A flexible computational pipeline for research analyses of unsolved clinical exome cases.

Npj Genomic Medicine
Lassmann, Timo T; Francis, Richard W RW; Weeks, Alexia A; Tang, Dave D; Jamieson, Sarra E SE; Broley, Stephanie S; Dawkins, Hugh J S HJS; Dreyer, Lauren L; Goldblatt, Jack J; Groza, Tudor T; Kamien, Benjamin B; Kiraly-Borri, Cathy C; McKenzie, Fiona F; Murphy, Lesley L; Pachter, Nicholas N; Pathak, Gargi G; Poulton, Cathryn C; Samanek, Amanda A; Skoss, Rachel R; Slee, Jennie J; Townshend, Sharron S; Ward, Michelle M; Baynam, Gareth S GS; Blackwell, Jenefer M JM
Publication Date: 2020-12-10

Variant appearance in text: NRAS: Thr58Ile
PubMed Link: 33303739
Variant Present in the following documents:
  • Main text
  • 41525_2020_161_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies.

Peerj
Prieto-Potin, Iván I; Carvajal, Nerea N; Plaza-Sánchez, Jenifer J; Manso, Rebeca R; Aúz-Alexandre, Carmen Laura CL; Chamizo, Cristina C; Zazo, Sandra S; López-Sánchez, Almudena A; Rodríguez-Pinilla, Socorro María SM; Camacho, Laura L; Longarón, Raquel R; Bellosillo, Beatriz B; Somoza, Rosa R; Hernández-Losa, Javier J; Fernández-Soria, Víctor Manuel VM; Ramos-Ruiz, Ricardo R; Cristóbal, Ion I; García-Foncillas, Jesús J; Rojo, Federico F
Publication Date: 2020

Variant appearance in text: NRAS: 173C>T; Thr58Ile
PubMed Link: 33083132
Variant Present in the following documents:
  • peerj-08-10069-s013.xlsx, sheet 1
  • peerj-08-10069-s012.xlsx, sheet 1
  • peerj-08-10069-s010.xlsx, sheet 1
  • peerj-08-10069-s009.xlsx, sheet 1
View BVdb publication page



Effect of KRAS and NRAS mutations on the prognosis of patients with synchronous metastatic colorectal cancer presenting with liver-only and lung-only metastases.

Oncology Letters
Chuang, Shih-Chang SC; Huang, Ching-Wen CW; Chen, Yi-Ting YT; Ma, Cheng-Jen CJ; Tsai, Hsiang-Lin HL; Chang, Tsung-Kun TK; Su, Wei-Chih WC; Hsu, Wen-Hung WH; Kuo, Chao-Hung CH; Wang, Jaw-Yuan JY
Publication Date: 2020-09

Variant appearance in text: NRAS: T58I
PubMed Link: 32782529
Variant Present in the following documents:
  • Main text
  • ol-20-03-2119.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: NRAS: T58I
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity.

Leukemia
Bueno, Clara C; Velasco-Hernandez, Talia T; Gutiérrez-Agüera, Francisco F; Zanetti, Samanta Romina SR; Baroni, Matteo L ML; Sánchez-Martínez, Diego D; Molina, Oscar O; Closa, Adria A; Agraz-Doblás, Antonio A; Marín, Pedro P; Eyras, Eduardo E; Varela, Ignacio I; Menéndez, Pablo P
Publication Date: 2019-08

Variant appearance in text: NRAS: T58I
PubMed Link: 30778134
Variant Present in the following documents:
  • 41375_2019_Article_418.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: NRAS: T58I
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Genotype and phenotype spectrum of NRAS germline variants.

European Journal Of Human Genetics : Ejhg
Altmüller, Franziska F; Lissewski, Christina C; Bertola, Debora D; Flex, Elisabetta E; Stark, Zornitza Z; Spranger, Stephanie S; Baynam, Gareth G; Buscarilli, Michelle M; Dyack, Sarah S; Gillis, Jane J; Yntema, Helger G HG; Pantaleoni, Francesca F; van Loon, Rosa LE RL; MacKay, Sara S; Mina, Kym K; Schanze, Ina I; Tan, Tiong Yang TY; Walsh, Maie M; White, Susan M SM; Niewisch, Marena R MR; García-Miñaúr, Sixto S; Plaza, Diego D; Ahmadian, Mohammad Reza MR; Cavé, Hélène H; Tartaglia, Marco M; Zenker, Martin M
Publication Date: 2017-06

Variant appearance in text: NRAS: 173C>T; Thr58Ile
PubMed Link: 28594414
Variant Present in the following documents:
  • Main text
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: N-ras: 173C>T
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



TERT promoter mutations in melanoma survival.

International Journal Of Cancer
Nagore, Eduardo E; Heidenreich, Barbara B; Rachakonda, Sívaramakrishna S; Garcia-Casado, Zaida Z; Requena, Celia C; Soriano, Virtudes V; Frank, Christoph C; Traves, Victor V; Quecedo, Esther E; Sanjuan-Gimenez, Josefa J; Hemminki, Kari K; Landi, Maria Teresa MT; Kumar, Rajiv R
Publication Date: 2016-07-01

Variant appearance in text: NRAS: T58I
PubMed Link: 26875008
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology
Kiel, Christina C; Serrano, Luis L
Publication Date: 2014-05-06

Variant appearance in text: NRAS: T58I
PubMed Link: 24803665
Variant Present in the following documents:
  • Main text
View BVdb publication page



The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.

Cancer Discovery
Van Allen, Eliezer M EM; Wagle, Nikhil N; Sucker, Antje A; Treacy, Daniel J DJ; Johannessen, Cory M CM; Goetz, Eva M EM; Place, Chelsea S CS; Taylor-Weiner, Amaro A; Whittaker, Steven S; Kryukov, Gregory V GV; Hodis, Eran E; Rosenberg, Mara M; McKenna, Aaron A; Cibulskis, Kristian K; Farlow, Deborah D; Zimmer, Lisa L; Hillen, Uwe U; Gutzmer, Ralf R; Goldinger, Simone M SM; Ugurel, Selma S; Gogas, Helen J HJ; Egberts, Friederike F; Berking, Carola C; Trefzer, Uwe U; Loquai, Carmen C; Weide, Benjamin B; Hassel, Jessica C JC; Gabriel, Stacey B SB; Carter, Scott L SL; Getz, Gad G; Garraway, Levi A LA; Schadendorf, Dirk D; ,
Publication Date: 2014-01

Variant appearance in text: NRAS: T58I
PubMed Link: 24265153
Variant Present in the following documents:
  • Main text
View BVdb publication page



Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors.

Nature Genetics
Goriely, Anne A; Hansen, Ruth M S RM; Taylor, Indira B IB; Olesen, Inge A IA; Jacobsen, Grete Krag GK; McGowan, Simon J SJ; Pfeifer, Susanne P SP; McVean, Gilean A T GA; Rajpert-De Meyts, Ewa E; Wilkie, Andrew O M AO
Publication Date: 2009-11

Variant appearance in text: NRAS: T58I
PubMed Link: 19855393
Variant Present in the following documents:
  • NIHMS27834-supplement-2.xls, sheet 1
View BVdb publication page



ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy.

Plos One
Aceves-Luquero, Clara I CI; Agarwal, Anupriya A; Callejas-Valera, Juan L JL; Arias-González, Laura L; Esparís-Ogando, Azucena A; del Peso Ovalle, Luis L; Bellón-Echeverria, Itxaso I; de la Cruz-Morcillo, Miguel A MA; Galán Moya, Eva M EM; Moreno Gimeno, Inmaculada I; Gómez, Juan C JC; Deininger, Michael W MW; Pandiella, Atanasio A; Sánchez Prieto, Ricardo R
Publication Date: 2009-07-01

Variant appearance in text: NRAS: T58I
PubMed Link: 19568437
Variant Present in the following documents:
  • Main text
  • pone.0006124.pdf
View BVdb publication page