Integrative molecular profiling identifies two molecularly and clinically distinct subtypes of blastic plasmacytoid dendritic cell neoplasm.
Blood Cancer Journal
Künstner, Axel A; Schwarting, Julian J; Witte, Hanno M HM; Bernard, Veronica V; Stölting, Stephanie S; Kusch, Kathrin K; Nagarathinam, Kumar K; von Bubnoff, Nikolas N; Murga Penas, Eva Maria EM; Merz, Hartmut H; Busch, Hauke H; Feller, Alfred C AC; Gebauer, Niklas N
Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum.
Blood Advances
Calvo, Xavier X; Roman-Bravo, David D; Garcia-Gisbert, Nieves N; Rodriguez-Sevilla, Juan Jose JJ; Garcia-Avila, Sara S; Florensa, Lourdes L; Gibert, Joan J; Fernández-Rodríguez, Concepción C; Salido, Marta M; Puiggros, Anna A; Espinet, Blanca B; Colomo, Luis L; Bellosillo, Beatriz B; Ferrer, Ana A; Arenillas, Leonor L
Publication Date: 2022-07-12
Variant appearance in text: NRAS: 173C>T; Thr58Ile
Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.
Clinical And Translational Gastroenterology
Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD
Publication Date: 2021-11-18
Variant appearance in text: NRAS: 173C>T; Thr58Ile
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Effect of KRAS and NRAS mutations on the prognosis of patients with synchronous metastatic colorectal cancer presenting with liver-only and lung-only metastases.
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity.
Leukemia
Bueno, Clara C; Velasco-Hernandez, Talia T; Gutiérrez-Agüera, Francisco F; Zanetti, Samanta Romina SR; Baroni, Matteo L ML; Sánchez-Martínez, Diego D; Molina, Oscar O; Closa, Adria A; Agraz-Doblás, Antonio A; Marín, Pedro P; Eyras, Eduardo E; Varela, Ignacio I; Menéndez, Pablo P
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Genotype and phenotype spectrum of NRAS germline variants.
European Journal Of Human Genetics : Ejhg
Altmüller, Franziska F; Lissewski, Christina C; Bertola, Debora D; Flex, Elisabetta E; Stark, Zornitza Z; Spranger, Stephanie S; Baynam, Gareth G; Buscarilli, Michelle M; Dyack, Sarah S; Gillis, Jane J; Yntema, Helger G HG; Pantaleoni, Francesca F; van Loon, Rosa LE RL; MacKay, Sara S; Mina, Kym K; Schanze, Ina I; Tan, Tiong Yang TY; Walsh, Maie M; White, Susan M SM; Niewisch, Marena R MR; García-Miñaúr, Sixto S; Plaza, Diego D; Ahmadian, Mohammad Reza MR; Cavé, Hélène H; Tartaglia, Marco M; Zenker, Martin M
Publication Date: 2017-06
Variant appearance in text: NRAS: 173C>T; Thr58Ile
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.
Cancer Discovery
Van Allen, Eliezer M EM; Wagle, Nikhil N; Sucker, Antje A; Treacy, Daniel J DJ; Johannessen, Cory M CM; Goetz, Eva M EM; Place, Chelsea S CS; Taylor-Weiner, Amaro A; Whittaker, Steven S; Kryukov, Gregory V GV; Hodis, Eran E; Rosenberg, Mara M; McKenna, Aaron A; Cibulskis, Kristian K; Farlow, Deborah D; Zimmer, Lisa L; Hillen, Uwe U; Gutzmer, Ralf R; Goldinger, Simone M SM; Ugurel, Selma S; Gogas, Helen J HJ; Egberts, Friederike F; Berking, Carola C; Trefzer, Uwe U; Loquai, Carmen C; Weide, Benjamin B; Hassel, Jessica C JC; Gabriel, Stacey B SB; Carter, Scott L SL; Getz, Gad G; Garraway, Levi A LA; Schadendorf, Dirk D; ,
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors.
Nature Genetics
Goriely, Anne A; Hansen, Ruth M S RM; Taylor, Indira B IB; Olesen, Inge A IA; Jacobsen, Grete Krag GK; McGowan, Simon J SJ; Pfeifer, Susanne P SP; McVean, Gilean A T GA; Rajpert-De Meyts, Ewa E; Wilkie, Andrew O M AO
ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy.
Plos One
Aceves-Luquero, Clara I CI; Agarwal, Anupriya A; Callejas-Valera, Juan L JL; Arias-González, Laura L; Esparís-Ogando, Azucena A; del Peso Ovalle, Luis L; Bellón-Echeverria, Itxaso I; de la Cruz-Morcillo, Miguel A MA; Galán Moya, Eva M EM; Moreno Gimeno, Inmaculada I; Gómez, Juan C JC; Deininger, Michael W MW; Pandiella, Atanasio A; Sánchez Prieto, Ricardo R