Publications:

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Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma.

Frontiers In Immunology

Zhang, Wenjing W; Kong, Yujia Y; Li, Yuting Y; Shi, Fuyan F; Lyu, Juncheng J; Sheng, Chao C; Wang, Suzhen S; Wang, Qinghua Q

Publication Date: 2021

Variant appearance in text: NRAS: S17A

PubMed Link: 35087523

Variant Present in the following documents:

• Main text
• fimmu-12-798474.pdf

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Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.

Molecular Oncology

Yu, Le L; Zhou, Dan D; Zhang, Guiming G; Ren, Zhonglu Z; Luo, Xin X; Liu, Peng P; Plouffe, Steven W SW; Meng, Zhipeng Z; Moroishi, Toshiro T; Li, Yilei Y; Zhang, Yiyue Y; Brown, Joan Heller JH; Liu, Shuwen S; Guan, Kun-Liang KL

Publication Date: 2022-02

Variant appearance in text: NRAS: S17A

PubMed Link: 34706158

Variant Present in the following documents:

• MOL2-16-607.pdf

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Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.

Molecular Oncology

Yu, Le L; Zhou, Dan D; Zhang, Guiming G; Ren, Zhonglu Z; Luo, Xin X; Liu, Peng P; Plouffe, Steven W SW; Meng, Zhipeng Z; Moroishi, Toshiro T; Li, Yilei Y; Zhang, Yiyue Y; Brown, Joan Heller JH; Liu, Shuwen S; Guan, Kun-Liang KL

Publication Date: 2021-10-27

Variant appearance in text: NRAS: S17A

PubMed Link: 34706158

Variant Present in the following documents:

• MOL2-16-607.pdf

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Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials.

Science Translational Medicine

Lin, Ann A; Giuliano, Christopher J CJ; Palladino, Ann A; John, Kristen M KM; Abramowicz, Connor C; Yuan, Monet Lou ML; Sausville, Erin L EL; Lukow, Devon A DA; Liu, Luwei L; Chait, Alexander R AR; Galluzzo, Zachary C ZC; Tucker, Clara C; Sheltzer, Jason M JM

Publication Date: 2019-09-11

Variant appearance in text: NRAS: S17A

PubMed Link: 31511426

Variant Present in the following documents:

• Main text

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An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells.

Oncogene

Perotti, Valentina V; Baldassari, Paola P; Molla, Alessandra A; Nicolini, Gabriella G; Bersani, Ilaria I; Grazia, Giulia G; Benigni, Fabio F; Maurichi, Andrea A; Santinami, Mario M; Anichini, Andrea A; Mortarini, Roberta R

Publication Date: 2019-05

Variant appearance in text: NRAS: S17a

PubMed Link: 30710146

Variant Present in the following documents:

• Main text
• 41388_2019_Article_729.pdf

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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.

Nature Communications

Li, Xiaodun X; Francies, Hayley E HE; Secrier, Maria M; Perner, Juliane J; Miremadi, Ahmad A; Galeano-Dalmau, Núria N; Barendt, William J WJ; Letchford, Laura L; Leyden, Genevieve M GM; Goffin, Emma K EK; Barthorpe, Andrew A; Lightfoot, Howard H; Chen, Elisabeth E; Gilbert, James J; Noorani, Ayesha A; Devonshire, Ginny G; Bower, Lawrence L; Grantham, Amber A; MacRae, Shona S; Grehan, Nicola N; Wedge, David C DC; Fitzgerald, Rebecca C RC; Garnett, Mathew J MJ

Publication Date: 2018-07-30

Variant appearance in text: NRAS: S17A

PubMed Link: 30061675

Variant Present in the following documents:

• Main text

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Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.

Oncogene

Read, M L ML; Fong, J C JC; Modasia, B B; Fletcher, A A; Imruetaicharoenchoke, W W; Thompson, R J RJ; Nieto, H H; Reynolds, J J JJ; Bacon, A A; Mallick, U U; Hackshaw, A A; Watkinson, J C JC; Boelaert, K K; Turnell, A S AS; Smith, V E VE; McCabe, C J CJ

Publication Date: 2017-09-14

Variant appearance in text: NRAS: S17a

PubMed Link: 28504713

Variant Present in the following documents:

• Main text
• emss-72326.pdf

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Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.

Nature Genetics

Secrier, Maria M; Li, Xiaodun X; de Silva, Nadeera N; Eldridge, Matthew D MD; Contino, Gianmarco G; Bornschein, Jan J; MacRae, Shona S; Grehan, Nicola N; O'Donovan, Maria M; Miremadi, Ahmad A; Yang, Tsun-Po TP; Bower, Lawrence L; Chettouh, Hamza H; Crawte, Jason J; Galeano-Dalmau, Núria N; Grabowska, Anna A; Saunders, John J; Underwood, Tim T; Waddell, Nicola N; Barbour, Andrew P AP; Nutzinger, Barbara B; Achilleos, Achilleas A; Edwards, Paul A W PA; Lynch, Andy G AG; Tavaré, Simon S; Fitzgerald, Rebecca C RC; ,

Publication Date: 2016-10

Variant appearance in text: NRAS: S17A

PubMed Link: 27595477

Variant Present in the following documents:

• Main text
• emss-69691.pdf

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Synergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanoma.

Cell Death & Disease

Grazia, G G; Vegetti, C C; Benigni, F F; Penna, I I; Perotti, V V; Tassi, E E; Bersani, I I; Nicolini, G G; Canevari, S S; Carlo-Stella, C C; Gianni, A M AM; Mortarini, R R; Anichini, A A

Publication Date: 2014-10-02

Variant appearance in text: NRAS: S17a

PubMed Link: 25275595

Variant Present in the following documents:

• Main text
• cddis2014410a.pdf

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