Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.
Leukemia
Kollmann, K K; Warsch, W W; Gonzalez-Arias, C C; Nice, F L FL; Avezov, E E; Milburn, J J; Li, J J; Dimitropoulou, D D; Biddie, S S; Wang, M M; Poynton, E E; Colzani, M M; Tijssen, M R MR; Anand, S S; McDermott, U U; Huntly, B B; Green, T T