MTHFR c.236+724A>G

Variant ID: 1-11862214-T-C

NM_005957.4(MTHFR):c.236+724A>G

This variant was identified in 41 publications

View GRCh38 version.




Publications:


Interactions of SNPs in Folate Metabolism Related Genes on Prostate Cancer Aggressiveness in European Americans and African Americans.

Cancers
Lin, Hui-Yi HY; Steck, Susan E SE; Sarkar, Indrani I; Fontham, Elizabeth T H ETH; Diekman, Alan A; Rogers, Lora J LJ; Ratliff, Calvin T CT; Bensen, Jeannette T JT; Mohler, James L JL; Su, L Joseph LJ
Publication Date: 2023-03-10

Variant appearance in text: rs9651118
PubMed Link: 36980585
Variant Present in the following documents:
  • Main text
  • cancers-15-01699.pdf
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The Roles of MTRR and MTHFR Gene Polymorphisms in Colorectal Cancer Survival.

Nutrients
Wang, Yu Y; Du, Meizhi M; Vallis, Jillian J; Shariati, Matin M; Parfrey, Patrick S PS; Mclaughlin, John R JR; Wang, Peizhong Peter PP; Zhu, Yun Y
Publication Date: 2022-11-01

Variant appearance in text: rs9651118
PubMed Link: 36364857
Variant Present in the following documents:
  • nutrients-14-04594.pdf
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The NESHIE and CP Genetics Resource (NCGR): A database of genes and variants reported in neonatal encephalopathy with suspected hypoxic ischemic encephalopathy (NESHIE) and consequential cerebral palsy (CP).

Genomics
Holborn, Megan A MA; Ford, Graeme G; Turner, Sarah S; Mellet, Juanita J; van Rensburg, Jeanne J; Joubert, Fourie F; Pepper, Michael S MS
Publication Date: 2022-10-18

Variant appearance in text: rs9651118
PubMed Link: 36270382
Variant Present in the following documents:
  • mmc9.xlsx, sheet 1
  • mmc6.xlsx, sheet 1
  • mmc11.xlsx, sheet 1
  • mmc5.xlsx, sheet 1
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Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients.

Skin Health And Disease
Griffin, L L; Ho, L L; Akhurst, R J RJ; Arron, S T ST; Boggs, J M E JME; Conlon, P P; O'Kelly, P P; Toland, A E AE; Epstein, E H EH; Balmain, A A; Bastian, B C BC; Moloney, F J FJ; Murphy, G M GM; Laing, M E ME
Publication Date: 2022-06

Variant appearance in text: rs9651118
PubMed Link: 35677930
Variant Present in the following documents:
  • Main text
  • SKI2-2-e95.pdf
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Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study.

Bmc Geriatrics
Chen, Qing Q; Li, Zhi-Hao ZH; Song, Wei-Qi WQ; Yao, Yao Y; Zhang, Yu-Jie YJ; Zhong, Wen-Fang WF; Zhang, Pei-Dong PD; Liu, Dan D; Zhang, Xi-Ru XR; Huang, Qing-Mei QM; Zhao, Xiao-Yang XY; Shi, Xiao-Ming XM; Mao, Chen C
Publication Date: 2022-01-03

Variant appearance in text: rs9651118
PubMed Link: 34979947
Variant Present in the following documents:
  • Main text
  • 12877_2021_Article_2655.pdf
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Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study.

Bmc Geriatrics
Chen, Qing Q; Li, Zhi-Hao ZH; Song, Wei-Qi WQ; Yao, Yao Y; Zhang, Yu-Jie YJ; Zhong, Wen-Fang WF; Zhang, Pei-Dong PD; Liu, Dan D; Zhang, Xi-Ru XR; Huang, Qing-Mei QM; Zhao, Xiao-Yang XY; Shi, Xiao-Ming XM; Mao, Chen C
Publication Date: 2022-01-03

Variant appearance in text: rs9651118
PubMed Link: 34979947
Variant Present in the following documents:
  • Main text
  • 12877_2021_Article_2655.pdf
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RNF213 and GUCY1A3 in Moyamoya Disease: Key Regulators of Metabolism, Inflammation, and Vascular Stability.

Frontiers In Neurology
Mineharu, Yohei Y; Miyamoto, Susumu S
Publication Date: 2021

Variant appearance in text: rs9651118
PubMed Link: 34381413
Variant Present in the following documents:
  • Main text
  • fneur-12-687088.pdf
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Genetic and Proteomic Contributions to the Pathophysiology of Moyamoya Angiopathy and Related Vascular Diseases.

The Application Of Clinical Genetics
Dorschel, Kirsten B KB; Wanebo, John E JE
Publication Date: 2021

Variant appearance in text: rs9651118
PubMed Link: 33776470
Variant Present in the following documents:
  • Main text
  • tacg-14-145.pdf
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Polygenetic-Risk Scores Related to Crystallin Metabolism Are Associated with Age-Related Cataract Formation and Interact with Hyperglycemia, Hypertension, Western-Style Diet, and Na Intake.

Nutrients
Jee, Donghyun D; Kang, Suna S; Huang, ShaoKai S; Park, Sunmin S
Publication Date: 2020-11-17

Variant appearance in text: rs9651118
PubMed Link: 33213085
Variant Present in the following documents:
  • Main text
  • nutrients-12-03534.pdf
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Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.

Bioscience Reports
Liu, Shan S; Liu, Mengwei M; Li, Qian Q; Liu, Xiuping X; Wang, Yue Y; Mambiya, Michael M; Zhang, Kaili K; Yang, Luping L; Zhang, Qian Q; Shang, Mengke M; Zeng, Fanxin F; Nie, Fangfang F; Liu, Wanyang W
Publication Date: 2019-12-20

Variant appearance in text: rs9651118
PubMed Link: 31815282
Variant Present in the following documents:
  • Main text
  • bsr-39-bsr20191454.pdf
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Association between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: a case-control study.

Bioscience Reports
Zhang, Sheng S; Lin, Jing J; Jiang, Jiakai J; Chen, Yu Y; Tang, Weifeng W; Liu, Longgen L
Publication Date: 2019-11-29

Variant appearance in text: rs9651118
PubMed Link: 31694048
Variant Present in the following documents:
  • Main text
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Methylenetetrahydrofolate reductase and psychiatric diseases.

Translational Psychiatry
Wan, Lin L; Li, Yuhong Y; Zhang, Zhengrong Z; Sun, Zuoli Z; He, Yi Y; Li, Rena R
Publication Date: 2018-11-05

Variant appearance in text: rs9651118
PubMed Link: 30397195
Variant Present in the following documents:
  • Main text
  • 41398_2018_Article_276.pdf
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The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.

The American Journal Of Clinical Nutrition
Shane, Barry B; Pangilinan, Faith F; Mills, James L JL; Fan, Ruzong R; Gong, Tingting T; Cropp, Cheryl D CD; Kim, Yoonhee Y; Ueland, Per M PM; Bailey-Wilson, Joan E JE; Wilson, Alexander F AF; Brody, Lawrence C LC; Molloy, Anne M AM
Publication Date: 2018-12-01

Variant appearance in text: rs9651118
PubMed Link: 30339177
Variant Present in the following documents:
  • Main text
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Hyperhomocysteinemia in a Patient with Moyamoya Disease.

Case Reports In Neurological Medicine
Meena, Durga Shankar DS; Bohra, Gopal Krishana GK; Meena, Mahadev M; Maheshwari, Bharat Kumar BK
Publication Date: 2018

Variant appearance in text: rs9651118
PubMed Link: 29854506
Variant Present in the following documents:
  • Main text
  • CRINM2018-7806873.pdf
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Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 Chinese Han subjects.

Oncotarget
Ding, Guowen G; Wang, Yafeng Y; Chen, Yu Y; Yin, Jun J; Liu, Chao C; Fan, Yu Y; Qiu, Hao H; Tang, Weifeng W; Chen, Shuchen S
Publication Date: 2017-12-19

Variant appearance in text: rs9651118
PubMed Link: 29340069
Variant Present in the following documents:
  • Main text
  • oncotarget-08-111482.pdf
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Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of non-small cell lung cancer in eastern Chinese Han population.

Oncotarget
Ding, Hao H; Wang, Yafeng Y; Chen, Yuanmei Y; Liu, Chao C; Qiu, Hao H; Kang, Mingqiang M; Tang, Weifeng W
Publication Date: 2017-12-15

Variant appearance in text: rs9651118
PubMed Link: 29299150
Variant Present in the following documents:
  • Main text
  • oncotarget-08-110326.pdf
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Investigation of methylenetetrahydrofolate reductase tagging polymorphisms with colorectal cancer in Chinese Han population.

Oncotarget
Zhang, Sheng S; Chen, Shuchen S; Chen, Yu Y; Kang, Mingqiang M; Liu, Chao C; Qiu, Hao H; Wang, Yafeng Y; Tang, Weifeng W
Publication Date: 2017-09-08

Variant appearance in text: rs9651118
PubMed Link: 28969008
Variant Present in the following documents:
  • Main text
  • oncotarget-08-63518.pdf
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Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.

Scientific Reports
Qiu, Qi Q; Huang, Jing J; Shu, Xiaoming X; Fan, Huizheng H; Zhou, Youwen Y; Xiao, Cheng C
Publication Date: 2017-03-07

Variant appearance in text: rs9651118
PubMed Link: 28266606
Variant Present in the following documents:
  • Main text
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Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.

Plos One
Wu, Xiaohang X; Lai, Weiyi W; Lin, Haotian H; Liu, Yizhi Y
Publication Date: 2017

Variant appearance in text: rs9651118
PubMed Link: 28253266
Variant Present in the following documents:
  • Main text
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Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer.

International Journal Of Molecular Sciences
Lin, Victor C VC; Lu, Te-Ling TL; Yin, Hsin-Ling HL; Yang, Sheau-Fang SF; Lee, Yung-Chin YC; Liu, Chia-Chu CC; Huang, Chao-Yuan CY; Yu, Chia-Cheng CC; Chang, Ta-Yuan TY; Huang, Shu-Pin SP; Bao, Bo-Ying BY
Publication Date: 2016-11-29

Variant appearance in text: rs9651118
PubMed Link: 27916838
Variant Present in the following documents:
  • Main text
  • ijms-17-01996.pdf
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Polymorphisms in the MTHFR gene are associated with recurrence risk in lymph node-positive breast cancer patients.

Oncotargets And Therapy
Suner, Ali A; Buyukhatipoglu, Hakan H; Aktas, Gokmen G; Kus, Tulay T; Ulasli, Mustafa M; Oztuzcu, Serdar S; Kalender, Mehmet Emin ME; Sevinc, Alper A; Kul, Seval S; Camci, Celaletdin C
Publication Date: 2016

Variant appearance in text: rs9651118
PubMed Link: 27672331
Variant Present in the following documents:
  • Main text
  • ott-9-5603.pdf
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Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population.

International Journal Of Clinical And Experimental Medicine
Wang, Yafeng Y; Chen, Shuchen S; Kang, Mingqiang M; Tang, Weifeng W; Gu, Haiyong H; Yin, Jun J; Huang, Ziyang Z
Publication Date: 2015

Variant appearance in text: rs9651118
PubMed Link: 26770518
Variant Present in the following documents:
  • Main text
View BVdb publication page



Associations of Polymorphisms in MTHFR Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis.

Plos One
Wang, Xue-bin XB; Qiao, Chen C; Wei, Li L; Han, Ya-di YD; Cui, Ning-hua NH; Huang, Zhu-liang ZL; Li, Zu-hua ZH; Zheng, Fang F; Yan, Ming M
Publication Date: 2015

Variant appearance in text: rs9651118
PubMed Link: 26689687
Variant Present in the following documents:
  • Main text
  • pone.0145581.pdf
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Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh.

Toxicology And Applied Pharmacology
Farzan, Shohreh F SF; Karagas, Margaret R MR; Jiang, Jieying J; Wu, Fen F; Liu, Mengling M; Newman, Jonathan D JD; Jasmine, Farzana F; Kibriya, Muhammad G MG; Paul-Brutus, Rachelle R; Parvez, Faruque F; Argos, Maria M; Scannell Bryan, Molly M; Eunus, Mahbub M; Ahmed, Alauddin A; Islam, Tariqul T; Rakibuz-Zaman, Muhammad M; Hasan, Rabiul R; Sarwar, Golam G; Slavkovich, Vesna V; Graziano, Joseph J; Ahsan, Habibul H; Chen, Yu Y
Publication Date: 2015-10-01

Variant appearance in text: rs9651118
PubMed Link: 26220686
Variant Present in the following documents:
  • Main text
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Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study.

Environmental Health Perspectives
Wu, Fen F; Jasmine, Farzana F; Kibriya, Muhammad G MG; Liu, Mengling M; Cheng, Xin X; Parvez, Faruque F; Islam, Tariqul T; Ahmed, Alauddin A; Rakibuz-Zaman, Muhammad M; Jiang, Jieying J; Roy, Shantanu S; Paul-Brutus, Rachelle R; Slavkovich, Vesna V; Islam, Tariqul T; Levy, Diane D; VanderWeele, Tyler J TJ; Pierce, Brandon L BL; Graziano, Joseph H JH; Ahsan, Habibul H; Chen, Yu Y
Publication Date: 2015-05

Variant appearance in text: rs9651118
PubMed Link: 25575156
Variant Present in the following documents:
  • ehp.1307883.s001.508.pdf
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Association of tagging SNPs in the MTHFR gene with risk of type 2 diabetes mellitus and serum homocysteine levels in a Chinese population.

Disease Markers
Wang, Han H; Hu, Cong C; Xiao, Shu-Hui SH; Wan, Bin B
Publication Date: 2014

Variant appearance in text: rs9651118
PubMed Link: 25165408
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population.

International Journal Of Molecular Sciences
Zhou, Bao-Sheng BS; Bu, Guo-Yun GY; Li, Mu M; Chang, Bin-Ge BG; Zhou, Yi-Pin YP
Publication Date: 2014-05-20

Variant appearance in text: rs9651118
PubMed Link: 24853127
Variant Present in the following documents:
  • Main text
  • ijms-15-08931.pdf
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Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer.

Plos One
Swartz, Michael D MD; Peterson, Christine B CB; Lupo, Philip J PJ; Wu, Xifeng X; Forman, Michele R MR; Spitz, Margaret R MR; Hernandez, Ladia M LM; Vannucci, Marina M; Shete, Sanjay S
Publication Date: 2013

Variant appearance in text: rs9651118
PubMed Link: 23372658
Variant Present in the following documents:
  • Main text
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Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.

Plos One
Spellicy, Catherine J CJ; Northrup, Hope H; Fletcher, Jack M JM; Cirino, Paul T PT; Dennis, Maureen M; Morrison, Alanna C AC; Martinez, Carla A CA; Au, Kit Sing KS
Publication Date: 2012

Variant appearance in text: rs9651118
PubMed Link: 23227261
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gene-gene interaction analysis for the survival phenotype based on the Cox model.

Bioinformatics (Oxford, England)
Lee, Seungyeoun S; Kwon, Min-Seok MS; Oh, Jung Mi JM; Park, Taesung T
Publication Date: 2012-09-15

Variant appearance in text: rs9651118
PubMed Link: 22962485
Variant Present in the following documents:
  • Main text
  • bts415.pdf
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A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma.

Molecular Vision
Awadalla, Mona S MS; Burdon, Kathryn P KP; Thapa, Suman S SS; Hewitt, Alex W AW; Craig, Jamie E JE
Publication Date: 2012

Variant appearance in text: rs9651118
PubMed Link: 22933837
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control study.

Environmental Health : A Global Access Science Source
Beebe-Dimmer, Jennifer L JL; Iyer, Priyanka T PT; Nriagu, Jerome O JO; Keele, Greg R GR; Mehta, Shilpin S; Meliker, Jaymie R JR; Lange, Ethan M EM; Schwartz, Ann G AG; Zuhlke, Kimberly A KA; Schottenfeld, David D; Cooney, Kathleen A KA
Publication Date: 2012-06-29

Variant appearance in text: rs9651118
PubMed Link: 22747749
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variant of AMD1 is associated with obesity in urban Indian children.

Plos One
Tabassum, Rubina R; Jaiswal, Alok A; Chauhan, Ganesh G; Dwivedi, Om Prakash OP; Ghosh, Saurabh S; Marwaha, Raman K RK; Tandon, Nikhil N; Bharadwaj, Dwaipayan D
Publication Date: 2012

Variant appearance in text: rs9651118
PubMed Link: 22496743
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk.

Plos One
Gibson, Todd M TM; Brennan, Paul P; Han, Summer S; Karami, Sara S; Zaridze, David D; Janout, Vladimir V; Kollarova, Helen H; Bencko, Vladimir V; Navratilova, Marie M; Szeszenia-Dabrowska, Neonila N; Mates, Dana D; Slamova, Alena A; Pfeiffer, Ruth M RM; Stolzenberg-Solomon, Rachael Z RZ; Mayne, Susan T ST; Yeager, Meredith M; Chanock, Stephen S; Rothman, Nat N; Chow, Wong-Ho WH; Rosenberg, Philip S PS; Boffetta, Paolo P; Moore, Lee E LE
Publication Date: 2011

Variant appearance in text: rs9651118
PubMed Link: 22039442
Variant Present in the following documents:
  • Main text
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Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians.

Experimental Diabetes Research
Chauhan, Ganesh G; Kaur, Ismeet I; Tabassum, Rubina R; Dwivedi, Om Prakash OP; Ghosh, Saurabh S; Tandon, Nikhil N; Bharadwaj, Dwaipayan D
Publication Date: 2012

Variant appearance in text: rs9651118
PubMed Link: 21960995
Variant Present in the following documents:
  • Main text
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Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study.

Bmc Public Health
Marti, Franziska F; Vollenweider, Peter P; Marques-Vidal, Pedro-Manuel PM; Mooser, Vincent V; Waeber, Gérard G; Paccaud, Fred F; Bochud, Murielle M
Publication Date: 2011-09-26

Variant appearance in text: rs9651118
PubMed Link: 21943240
Variant Present in the following documents:
  • Main text
  • 1471-2458-11-733.pdf
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Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.

Cancer Causes & Control : Ccc
Metayer, Catherine C; Scélo, Ghislaine G; Chokkalingam, Anand P AP; Barcellos, Lisa F LF; Aldrich, Melinda C MC; Chang, Jeffrey S JS; Guha, Neela N; Urayama, Kevin Y KY; Hansen, Helen M HM; Block, Gladys G; Kiley, Vincent V; Wiencke, John K JK; Wiemels, Joseph L JL; Buffler, Patricia A PA
Publication Date: 2011-09

Variant appearance in text: rs9651118
PubMed Link: 21748308
Variant Present in the following documents:
  • Main text
View BVdb publication page



Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study.

Cancer Causes & Control : Ccc
Levine, A Joan AJ; Lee, Won W; Figueiredo, Jane C JC; Conti, David V DV; Vandenberg, David J DJ; Davis, Brian D BD; Edlund, Christopher K CK; Henning, Susanne M SM; Heber, David D; Stern, Mariana C MC; Haile, Robert W RW
Publication Date: 2011-04

Variant appearance in text: rs9651118
PubMed Link: 21274745
Variant Present in the following documents:
  • Main text
  • 10552_2011_Article_9726.pdf
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Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Levine, A Joan AJ; Figueiredo, Jane C JC; Lee, Won W; Poynter, Jenny N JN; Conti, David D; Duggan, David J DJ; Campbell, Peter T PT; Newcomb, Polly P; Martinez, Maria Elena ME; Hopper, John L JL; Le Marchand, Loic L; Baron, John A JA; Limburg, Paul J PJ; Ulrich, Cornelia M CM; Haile, Robert W RW
Publication Date: 2010-01

Variant appearance in text: rs9651118
PubMed Link: 20056627
Variant Present in the following documents:
  • Main text
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Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida.

American Journal Of Obstetrics And Gynecology
Martinez, Carla A CA; Northrup, Hope H; Lin, Jone-Ing JI; Morrison, Alanna C AC; Fletcher, Jack M JM; Tyerman, Gayle H GH; Au, Kit Sing KS
Publication Date: 2009-10

Variant appearance in text: rs9651118
PubMed Link: 19683694
Variant Present in the following documents:
  • Main text
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Increasing the number of SNP loci does not necessarily improve prediction power at least in the comparison of MTHFR SNP and haplotypes.

Journal Of Epidemiology
Miyaki, Koichi K; Takahashi, Yoshimitsu Y; Song, Yixuan Y; Zhang, Ling L; Muramatsu, Masaaki M; Nakayama, Takeo T
Publication Date: 2008

Variant appearance in text: rs9651118
PubMed Link: 19075497
Variant Present in the following documents:
  • Main text
  • je-18-243.pdf
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