MTHFR c.-14+141T>C

Variant ID: 1-11865804-A-G

NM_005957.5(MTHFR):c.-14+141T>C

This variant was identified in 18 publications

View GRCh38 version.




Publications:


Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications.

Genes
Changalidis, Anton I AI; Maksiutenko, Evgeniia M EM; Barbitoff, Yury A YA; Tkachenko, Alexander A AA; Vashukova, Elena S ES; Pachuliia, Olga V OV; Nasykhova, Yulia A YA; Glotov, Andrey S AS
Publication Date: 2022-11-30

Variant appearance in text: rs13306561
PubMed Link: 36553520
Variant Present in the following documents:
  • genes-13-02255.pdf
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The Roles of MTRR and MTHFR Gene Polymorphisms in Colorectal Cancer Survival.

Nutrients
Wang, Yu Y; Du, Meizhi M; Vallis, Jillian J; Shariati, Matin M; Parfrey, Patrick S PS; Mclaughlin, John R JR; Wang, Peizhong Peter PP; Zhu, Yun Y
Publication Date: 2022-11-01

Variant appearance in text: rs13306561
PubMed Link: 36364857
Variant Present in the following documents:
  • nutrients-14-04594.pdf
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Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population.

Frontiers In Genetics
Liu, Tianzi T; Momin, Mohetaboer M; Zhou, Huiyue H; Zheng, Qiwen Q; Fan, Fangfang F; Jia, Jia J; Liu, Mengyuan M; Bao, Minghui M; Li, Jianping J; Huo, Yong Y; Liu, Jialin J; Zhang, Yaning Y; Mao, Xuemei X; Han, Xiao X; Hu, Zhiyuan Z; Zeng, Changqing C; Liu, Fan F; Zhang, Yan Y
Publication Date: 2021

Variant appearance in text: rs13306561
PubMed Link: 34707639
Variant Present in the following documents:
  • Main text
  • fgene-12-717621.pdf
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Genetics of blood malignancies among Iranian population: an overview.

Diagnostic Pathology
Ghayour-Mobarhan, Majid M; Zangouei, Amir Sadra AS; Hosseinirad, Seyed Mohammad SM; Mojarrad, Majid M; Moghbeli, Meysam M
Publication Date: 2020-05-06

Variant appearance in text: rs13306561
PubMed Link: 32375828
Variant Present in the following documents:
  • Main text
  • 13000_2020_Article_968.pdf
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A multiple coefficient of determination-based method for parsing SNPs that correlate with mRNA expression.

Scientific Reports
Song, Fan F; Tao, Yu Y; Sun, Yue Y; Saffen, David D
Publication Date: 2019-12-27

Variant appearance in text: rs13306561
PubMed Link: 31882953
Variant Present in the following documents:
  • 41598_2019_56494_MOESM1_ESM.pdf
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A genome-wide association and replication study of blood pressure in Ugandan early adolescents.

Molecular Genetics & Genomic Medicine
Lule, Swaib A SA; Mentzer, Alexander J AJ; Namara, Benigna B; Muwenzi, Allan G AG; Nassanga, Beatrice B; Kizito, Dennison D; Akurut, Helen H; Lubyayi, Lawrence L; Tumusiime, Josephine J; Zziwa, Christopher C; Akello, Florence F; Gurdasani, Deept D; Sandhu, Manjinder M; Smeeth, Liam L; Elliott, Alison M AM; Webb, Emily L EL
Publication Date: 2019-10

Variant appearance in text: rs13306561
PubMed Link: 31469255
Variant Present in the following documents:
  • Main text
  • MGG3-7-e00950.pdf
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Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.

Scientific Reports
Qiu, Qi Q; Huang, Jing J; Shu, Xiaoming X; Fan, Huizheng H; Zhou, Youwen Y; Xiao, Cheng C
Publication Date: 2017-03-07

Variant appearance in text: rs13306561
PubMed Link: 28266606
Variant Present in the following documents:
  • Main text
  • srep44015.pdf
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Association between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Susceptibility to Childhood Acute Lymphoblastic Leukemia in an Iranian Population.

International Journal Of Hematology-Oncology And Stem Cell Research
Bahari, Gholamreza G; Hashemi, Mohammad M; Naderi, Majid M; Taheri, Mohsen M
Publication Date: 2016-07-01

Variant appearance in text: rs13306561
PubMed Link: 27489588
Variant Present in the following documents:
  • Main text
  • IJHOSCR-10-130.pdf
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Choline metabolites: gene by diet interactions.

Current Opinion In Lipidology
Smallwood, Tangi T; Allayee, Hooman H; Bennett, Brian J BJ
Publication Date: 2016-02

Variant appearance in text: rs13306561
PubMed Link: 26655287
Variant Present in the following documents:
  • Main text
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Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.

Nature Communications
Andiappan, Anand Kumar AK; Melchiotti, Rossella R; Poh, Tuang Yeow TY; Nah, Michelle M; Puan, Kia Joo KJ; Vigano, Elena E; Haase, Doreen D; Yusof, Nurhashikin N; San Luis, Boris B; Lum, Josephine J; Kumar, Dilip D; Foo, Shihui S; Zhuang, Li L; Vasudev, Anusha A; Irwanto, Astrid A; Lee, Bernett B; Nardin, Alessandra A; Liu, Hong H; Zhang, Furen F; Connolly, John J; Liu, Jianjun J; Mortellaro, Alessandra A; Wang, De Yun Y; Poidinger, Michael M; Larbi, Anis A; Zolezzi, Francesca F; Rotzschke, Olaf O
Publication Date: 2015-08-10

Variant appearance in text: rs13306561
PubMed Link: 26259071
Variant Present in the following documents:
  • ncomms8971-s1.pdf
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Association of tagging SNPs in the MTHFR gene with risk of type 2 diabetes mellitus and serum homocysteine levels in a Chinese population.

Disease Markers
Wang, Han H; Hu, Cong C; Xiao, Shu-Hui SH; Wan, Bin B
Publication Date: 2014

Variant appearance in text: rs13306561
PubMed Link: 25165408
Variant Present in the following documents:
  • Main text
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Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.

American Journal Of Human Genetics
Ganesh, Santhi K SK; Chasman, Daniel I DI; Larson, Martin G MG; Guo, Xiuqing X; Verwoert, Germain G; Bis, Joshua C JC; Gu, Xiangjun X; Smith, Albert V AV; Yang, Min-Lee ML; Zhang, Yan Y; Ehret, Georg G; Rose, Lynda M LM; Hwang, Shih-Jen SJ; Papanicolau, George J GJ; Sijbrands, Eric J EJ; Rice, Kenneth K; Eiriksdottir, Gudny G; Pihur, Vasyl V; Ridker, Paul M PM; Vasan, Ramachandran S RS; Newton-Cheh, Christopher C; , ; Raffel, Leslie J LJ; Amin, Najaf N; Rotter, Jerome I JI; Liu, Kiang K; Launer, Lenore J LJ; Xu, Ming M; Caulfield, Mark M; Morrison, Alanna C AC; Johnson, Andrew D AD; Vaidya, Dhananjay D; Dehghan, Abbas A; Li, Guo G; Bouchard, Claude C; Harris, Tamara B TB; Zhang, He H; Boerwinkle, Eric E; Siscovick, David S DS; Gao, Wei W; Uitterlinden, Andre G AG; Rivadeneira, Fernando F; Hofman, Albert A; Willer, Cristen J CJ; Franco, Oscar H OH; Huo, Yong Y; Witteman, Jacqueline C M JC; Munroe, Patricia B PB; Gudnason, Vilmundur V; Palmas, Walter W; van Duijn, Cornelia C; Fornage, Myriam M; Levy, Daniel D; Psaty, Bruce M BM; Chakravarti, Aravinda A
Publication Date: 2014-07-03

Variant appearance in text: rs13306561
PubMed Link: 24975945
Variant Present in the following documents:
  • Main text
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Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population.

International Journal Of Molecular Sciences
Zhou, Bao-Sheng BS; Bu, Guo-Yun GY; Li, Mu M; Chang, Bin-Ge BG; Zhou, Yi-Pin YP
Publication Date: 2014-05-20

Variant appearance in text: rs13306561
PubMed Link: 24853127
Variant Present in the following documents:
  • Main text
  • ijms-15-08931.pdf
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Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis.

Plos One
Lautner-Csorba, Orsolya O; Gézsi, András A; Erdélyi, Dániel J DJ; Hullám, Gábor G; Antal, Péter P; Semsei, Ágnes F ÁF; Kutszegi, Nóra N; Kovács, Gábor G; Falus, András A; Szalai, Csaba C
Publication Date: 2013

Variant appearance in text: rs13306561
PubMed Link: 23940529
Variant Present in the following documents:
  • Main text
  • pone.0069843.pdf
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Loci influencing blood pressure identified using a cardiovascular gene-centric array.

Human Molecular Genetics
Ganesh, Santhi K SK; Tragante, Vinicius V; Guo, Wei W; Guo, Yiran Y; Lanktree, Matthew B MB; Smith, Erin N EN; Johnson, Toby T; Castillo, Berta Almoguera BA; Barnard, John J; Baumert, Jens J; Chang, Yen-Pei Christy YP; Elbers, Clara C CC; Farrall, Martin M; Fischer, Mary E ME; Franceschini, Nora N; Gaunt, Tom R TR; Gho, Johannes M I H JM; Gieger, Christian C; Gong, Yan Y; Isaacs, Aaron A; Kleber, Marcus E ME; Mateo Leach, Irene I; McDonough, Caitrin W CW; Meijs, Matthijs F L MF; Mellander, Olle O; Molony, Cliona M CM; Nolte, Ilja M IM; Padmanabhan, Sandosh S; Price, Tom S TS; Rajagopalan, Ramakrishnan R; Shaffer, Jonathan J; Shah, Sonia S; Shen, Haiqing H; Soranzo, Nicole N; van der Most, Peter J PJ; Van Iperen, Erik P A EP; Van Setten, Jessica J; Van Setten, Jessic A JA; Vonk, Judith M JM; Zhang, Li L; Beitelshees, Amber L AL; Berenson, Gerald S GS; Bhatt, Deepak L DL; Boer, Jolanda M A JM; Boerwinkle, Eric E; Burkley, Ben B; Burt, Amber A; Chakravarti, Aravinda A; Chen, Wei W; Cooper-Dehoff, Rhonda M RM; Curtis, Sean P SP; Dreisbach, Albert A; Duggan, David D; Ehret, Georg B GB; Fabsitz, Richard R RR; Fornage, Myriam M; Fox, Ervin E; Furlong, Clement E CE; Gansevoort, Ron T RT; Hofker, Marten H MH; Hovingh, G Kees GK; Kirkland, Susan A SA; Kottke-Marchant, Kandice K; Kutlar, Abdullah A; Lacroix, Andrea Z AZ; Langaee, Taimour Y TY; Li, Yun R YR; Lin, Honghuang H; Liu, Kiang K; Maiwald, Steffi S; Malik, Rainer R; , ; Murugesan, Gurunathan G; Newton-Cheh, Christopher C; O'Connell, Jeffery R JR; Onland-Moret, N Charlotte NC; Ouwehand, Willem H WH; Palmas, Walter W; Penninx, Brenda W BW; Pepine, Carl J CJ; Pettinger, Mary M; Polak, Joseph F JF; Ramachandran, Vasan S VS; Ranchalis, Jane J; Redline, Susan S; Ridker, Paul M PM; Rose, Lynda M LM; Scharnag, Hubert H; Schork, Nicholas J NJ; Shimbo, Daichi D; Shuldiner, Alan R AR; Srinivasan, Sathanur R SR; Stolk, Ronald P RP; Taylor, Herman A HA; Thorand, Barbara B; Trip, Mieke D MD; van Duijn, Cornelia M CM; Verschuren, W Monique WM; Wijmenga, Cisca C; Winkelmann, Bernhard R BR; Wyatt, Sharon S; Young, J Hunter JH; Boehm, Bernhard O BO; Caulfield, Mark J MJ; Chasman, Daniel I DI; Davidson, Karina W KW; Doevendans, Pieter A PA; Fitzgerald, Garret A GA; Gums, John G JG; Hakonarson, Hakon H; Hillege, Hans L HL; Illig, Thomas T; Jarvik, Gail P GP; Johnson, Julie A JA; Kastelein, John J P JJ; Koenig, Wolfgang W; , ; März, Winfried W; Mitchell, Braxton D BD; Murray, Sarah S SS; Oldehinkel, Albertine J AJ; Rader, Daniel J DJ; Reilly, Muredach P MP; Reiner, Alex P AP; Schadt, Eric E EE; Silverstein, Roy L RL; Snieder, Harold H; Stanton, Alice V AV; Uitterlinden, André G AG; van der Harst, Pim P; van der Schouw, Yvonne T YT; Samani, Nilesh J NJ; Johnson, Andrew D AD; Munroe, Patricia B PB; de Bakker, Paul I W PI; Zhu, Xiaofeng X; Levy, Daniel D; Keating, Brendan J BJ; Asselbergs, Folkert W FW
Publication Date: 2013-04-15

Variant appearance in text: rs13306561
PubMed Link: 23303523
Variant Present in the following documents:
  • Main text
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Deep sequencing study of the MTHFR gene to identify variants associated with myelomeningocele.

Birth Defects Research. Part A, Clinical And Molecular Teratology
Aneji, Chiamaka N CN; Northrup, Hope H; Au, Kit Sing KS
Publication Date: 2012-02

Variant appearance in text: rs13306561
PubMed Link: 22241680
Variant Present in the following documents:
  • Main text
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Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array.

Hypertension (Dallas, Tex. : 1979)
Tomaszewski, Maciej M; Debiec, Radoslaw R; Braund, Peter S PS; Nelson, Christopher P CP; Hardwick, Robert R; Christofidou, Paraskevi P; Denniff, Matthew M; Codd, Veryan V; Rafelt, Suzanne S; van der Harst, Pim P; Waterworth, Dawn D; Song, Kijoung K; Vollenweider, Peter P; Waeber, Gerard G; Zukowska-Szczechowska, Ewa E; Burton, Paul R PR; Mooser, Vincent V; Charchar, Fadi J FJ; Thompson, John R JR; Tobin, Martin D MD; Samani, Nilesh J NJ
Publication Date: 2010-12

Variant appearance in text: rs13306561
PubMed Link: 21060006
Variant Present in the following documents:
  • Main text
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Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults.

Human Molecular Genetics
Lange, Leslie A LA; Croteau-Chonka, Damien C DC; Marvelle, Amanda F AF; Qin, Li L; Gaulton, Kyle J KJ; Kuzawa, Christopher W CW; McDade, Thomas W TW; Wang, Yunfei Y; Li, Yun Y; Levy, Shawn S; Borja, Judith B JB; Lange, Ethan M EM; Adair, Linda S LS; Mohlke, Karen L KL
Publication Date: 2010-05-15

Variant appearance in text: rs13306561
PubMed Link: 20154341
Variant Present in the following documents:
  • Main text
View BVdb publication page