Publications:

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Cancer Research

Steffen, Jamin D JD; Tholey, Renee M RM; Langelier, Marie-France MF; Planck, Jamie L JL; Schiewer, Matthew J MJ; Lal, Shruti S; Bildzukewicz, Nikolai A NA; Yeo, Charles J CJ; Knudsen, Karen E KE; Brody, Jonathan R JR; Pascal, John M JM

Publication Date: 2014-01-01

Variant appearance in text: PARP: W318A

PubMed Link: 24189460

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The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.

The Journal Of Biological Chemistry

Langelier, Marie-France MF; Ruhl, Donald D DD; Planck, Jamie L JL; Kraus, W Lee WL; Pascal, John M JM

Publication Date: 2010-06-11

Variant appearance in text: PARP: W318A

PubMed Link: 20388712

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