The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Nature Communications
Pan, Min M; Wright, William C WC; Chapple, Richard H RH; Zubair, Asif A; Sandhu, Manbir M; Batchelder, Jake E JE; Huddle, Brandt C BC; Low, Jonathan J; Blankenship, Kaley B KB; Wang, Yingzhe Y; Gordon, Brittney B; Archer, Payton P; Brady, Samuel W SW; Natarajan, Sivaraman S; Posgai, Matthew J MJ; Schuetz, John J; Miller, Darcie D; Kalathur, Ravi R; Chen, Siquan S; Connelly, Jon Patrick JP; Babu, M Madan MM; Dyer, Michael A MA; Pruett-Miller, Shondra M SM; Freeman, Burgess B BB; Chen, Taosheng T; Godley, Lucy A LA; Blanchard, Scott C SC; Stewart, Elizabeth E; Easton, John J; Geeleher, Paul P