Publications:

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Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter.

Nature Communications

Turney, Toby S TS; Li, Vivian V; Brohawn, Stephen G SG

Publication Date: 2022-06-09

Variant appearance in text: KCNK1: I293A

PubMed Link: 35680900

Variant Present in the following documents:

• Main text
• 41467_2022_Article_30853.pdf

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The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism.

The Journal Of General Physiology

Riel, Elena B EB; Jürs, Björn C BC; Cordeiro, Sönke S; Musinszki, Marianne M; Schewe, Marcus M; Baukrowitz, Thomas T

Publication Date: 2022-02-07

Variant appearance in text: TWIK-1: I293A

PubMed Link: 34928298

Variant Present in the following documents:

• Main text
• JGP_202112989.pdf

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A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.

Slas Discovery : Advancing Life Sciences R & D

McCoull, David D; Ococks, Emma E; Large, Jonathan M JM; Tickle, David C DC; Mathie, Alistair A; Jerman, Jeffrey J; Wright, Paul D PD

Publication Date: 2021-03

Variant appearance in text: TWIK-1: I293A

PubMed Link: 33375888

Variant Present in the following documents:

• Main text
• 10.1177_2472555220976126.pdf

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Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel.

The Journal Of Biological Chemistry

Nematian-Ardestani, Ehsan E; Abd-Wahab, Firdaus F; Chatelain, Franck C FC; Sun, Han H; Schewe, Marcus M; Baukrowitz, Thomas T; Tucker, Stephen J SJ

Publication Date: 2020-01-10

Variant appearance in text: TWIK-1: I293A

PubMed Link: 31806709

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The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ye, Wenlei W; Chang, Rui B RB; Bushman, Jeremy D JD; Tu, Yu-Hsiang YH; Mulhall, Eric M EM; Wilson, Courtney E CE; Cooper, Alexander J AJ; Chick, Wallace S WS; Hill-Eubanks, David C DC; Nelson, Mark T MT; Kinnamon, Sue C SC; Liman, Emily R ER

Publication Date: 2016-01-12

Variant appearance in text: KCNK1: I293A

PubMed Link: 26627720

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A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

Nature Communications

Aryal, Prafulla P; Abd-Wahab, Firdaus F; Bucci, Giovanna G; Sansom, Mark S P MS; Tucker, Stephen J SJ

Publication Date: 2014-07-08

Variant appearance in text: TWIK-1: I293A

PubMed Link: 25001086

Variant Present in the following documents:

• Main text
• ncomms5377-s1.pdf
• ncomms5377.pdf

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Silent TWIK-1 potassium channels conduct monovalent cation currents.

Biophysical Journal

Ma, Liqun L; Xie, Yu-Ping YP; Zhou, Min M; Chen, Haijun H

Publication Date: 2012-04-18

Variant appearance in text: TWIK-1: I293A

PubMed Link: 22768960

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