Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program.
Plos One
Huang, Rose D L RDL; Nguyen, Xuan-Mai T XT; Peloso, Gina M GM; Trinder, Mark M; Posner, Daniel C DC; Aragam, Krishna G KG; Ho, Yuk-Lam YL; Lynch, Julie A JA; Damrauer, Scott M SM; Chang, Kyong-Mi KM; Tsao, Philip S PS; Natarajan, Pradeep P; Assimes, Themistocles T; Gaziano, J Michael JM; Djousse, Luc L; Cho, Kelly K; Wilson, Peter W F PWF; Huffman, Jennifer E JE; O'Donnell, Christopher J CJ; ,
Maligłówka, Mateusz M; Kosowski, Michał M; Hachuła, Marcin M; Cyrnek, Marcin M; Bułdak, Łukasz Ł; Basiak, Marcin M; Bołdys, Aleksandra A; Machnik, Grzegorz G; Bułdak, Rafał Jakub RJ; Okopień, Bogusław B
Publication Date: 2022-03-17
Variant appearance in text: PCSK9: R46L; rs11591147
Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond.
International Journal Of Molecular Sciences
Grewal, Thomas T; Buechler, Christa C
Publication Date: 2022-01-19
Variant appearance in text: PCSK9: R46L; rs11591147
Association Between Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations and Cardiovascular Events in Cardiovascular Disease: A Systemic Review and Meta-Analysis.
Frontiers In Cardiovascular Medicine
Liu, Jiahui J; Fan, Fangfang F; Luo, Xingyu X; Ji, Wenjun W; Liu, Yaokun Y; Zhang, Yan Y; Zheng, Bo B
Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol.
Hepatology Communications
Ioannou, George N GN; Lee, Sum P SP; Linsley, Peter S PS; Gersuk, Vivian V; Yeh, Matthew M MM; Chen, Yen-Ying YY; Peng, Yi-Jen YJ; Dutta, Moumita M; Mascarinas, Gabby G; Molla, Bruk B; Cui, Julia Yue JY; Savard, Christopher C
Familial Hypercholesterolemia Genetic Variations and Long-Term Cardiovascular Outcomes in Patients with Hypercholesterolemia Who Underwent Coronary Angiography.
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.
Nature Communications
Schmidt, Amand F AF; Hunt, Nicholas B NB; Gordillo-Marañón, Maria M; Charoen, Pimphen P; Drenos, Fotios F; Kivimaki, Mika M; Lawlor, Deborah A DA; Giambartolomei, Claudia C; Papacosta, Olia O; Chaturvedi, Nishi N; Bis, Joshua C JC; O'Donnell, Christopher J CJ; Wannamethee, Goya G; Wong, Andrew A; Price, Jackie F JF; Hughes, Alun D AD; Gaunt, Tom R TR; Franceschini, Nora N; Mook-Kanamori, Dennis O DO; Zwierzyna, Magdalena M; Sofat, Reecha R; Hingorani, Aroon D AD; Finan, Chris C
Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin.
The Journal Of Biological Chemistry
Susan-Resiga, Delia D; Girard, Emmanuelle E; Essalmani, Rachid R; Roubtsova, Anna A; Marcinkiewicz, Jadwiga J; Derbali, Rabeb M RM; Evagelidis, Alexandra A; Byun, Jae H JH; Lebeau, Paul F PF; Austin, Richard C RC; Seidah, Nabil G NG
Can Clinicians Start Prescribing Inclisiran for Hypercholesterolemia Today? A Review of Clinical Studies for Internal Medicine Physicians and Endocrinologists.
Cureus
Jahangir, Abdullah A; Sahra, Syeda S; Krzyzak, Michael M
Protective lipid-lowering variants in healthy older individuals without coronary heart disease.
Open Heart
Lacaze, Paul P; Riaz, Moeen M; Sebra, Robert R; Hooper, Amanda J AJ; Pang, Jing J; Tiller, Jane J; Polekhina, Galina G; Tonkin, Andrew A; Reid, Chris C; Zoungas, Sophia S; Murray, Anne M AM; Nicholls, Stephen S; Watts, Gerald G; Schadt, Eric E; McNeil, John J JJ
Publication Date: 2021-07
Variant appearance in text: PCSK9: 137G>T; Arg46Leu; rs11591147
Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project.
Diagnostics (Basel, Switzerland)
Zamarrón-Licona, Erasmo E; Rodríguez-Pérez, José Manuel JM; Posadas-Sánchez, Rosalinda R; Vargas-Alarcón, Gilberto G; Baños-González, Manuel Alfonso MA; Borgonio-Cuadra, Verónica Marusa VM; Pérez-Hernández, Nonanzit N
Publication Date: 2021-04-26
Variant appearance in text: PCSK9: R46L; rs11591147
PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin.
International Journal Of Molecular Sciences
Lupo, Maria Giovanna MG; Marchianò, Silvia S; Adorni, Maria Pia MP; Zimetti, Francesca F; Ruscica, Massimiliano M; Greco, Maria Francesca MF; Corsini, Alberto A; Ferri, Nicola N
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.
Plos Genetics
Gormley, Mark M; Yarmolinsky, James J; Dudding, Tom T; Burrows, Kimberley K; Martin, Richard M RM; Thomas, Steven S; Tyrrell, Jessica J; Brennan, Paul P; Pring, Miranda M; Boccia, Stefania S; Olshan, Andrew F AF; Diergaarde, Brenda B; Hung, Rayjean J RJ; Liu, Geoffrey G; Legge, Danny D; Tajara, Eloiza H EH; Severino, Patricia P; Lacko, Martin M; Ness, Andrew R AR; Davey Smith, George G; Vincent, Emma E EE; Richmond, Rebecca C RC
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in aortic stenosis - Is this the light at the end of the tunnel for patients with aortic stenosis?
Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction.