Publications:

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The Emerging Roles of Intracellular PCSK9 and Their Implications in Endoplasmic Reticulum Stress and Metabolic Diseases.

Metabolites

Lebeau, Paul F PF; Platko, Khrystyna K; Byun, Jae Hyun JH; Makda, Yumna Y; Austin, Richard C RC

Publication Date: 2022-02-26

Variant appearance in text: PCSK9: R104C

PubMed Link: 35323658

Variant Present in the following documents:

• metabolites-12-00215.pdf

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Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications.

Frontiers In Cardiovascular Medicine

Xia, Xiao-Dan XD; Peng, Zhong-Sheng ZS; Gu, Hong-Mei HM; Wang, Maggie M; Wang, Gui-Qing GQ; Zhang, Da-Wei DW

Publication Date: 2021

Variant appearance in text: PCSK9: R104C

PubMed Link: 34782856

Variant Present in the following documents:

• Main text
• fcvm-08-764038.pdf

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PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.

Stem Cell Reports

Roudaut, Meryl M; Idriss, Salam S; Caillaud, Amandine A; Girardeau, Aurore A; Rimbert, Antoine A; Champon, Benoite B; David, Amandine A; Lévêque, Antoine A; Arnaud, Lucie L; Pichelin, Matthieu M; Prieur, Xavier X; Prat, Annik A; Seidah, Nabil G NG; Zibara, Kazem K; Le May, Cedric C; Cariou, Bertrand B; Si-Tayeb, Karim K

Publication Date: 2021-10-26

Variant appearance in text: PCSK9: R104C

PubMed Link: 34739847

Variant Present in the following documents:

• Main text
• mmc3.pdf
• main.pdf
• mmc1.pdf

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Protective lipid-lowering variants in healthy older individuals without coronary heart disease.

Open Heart

Lacaze, Paul P; Riaz, Moeen M; Sebra, Robert R; Hooper, Amanda J AJ; Pang, Jing J; Tiller, Jane J; Polekhina, Galina G; Tonkin, Andrew A; Reid, Chris C; Zoungas, Sophia S; Murray, Anne M AM; Nicholls, Stephen S; Watts, Gerald G; Schadt, Eric E; McNeil, John J JJ

Publication Date: 2021-07

Variant appearance in text: PCSK9: Arg104Cys

PubMed Link: 34341098

Variant Present in the following documents:

• openhrt-2021-001710supp001.xlsx

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Urine-derived induced pluripotent/neural stem cells for modeling neurological diseases.

Cell & Bioscience

Shi, Tianyuan T; Cheung, Martin M

Publication Date: 2021-05-13

Variant appearance in text: PCSK9: R104C

PubMed Link: 33985584

Variant Present in the following documents:

• Main text
• 13578_2021_Article_594.pdf

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New Insights Into the Regulation of Lipoprotein Metabolism by PCSK9: Lessons From Stable Isotope Tracer Studies in Human Subjects.

Frontiers In Physiology

Ying, Qidi Q; Chan, Dick C DC; Watts, Gerald F GF

Publication Date: 2021

Variant appearance in text: PCSK9: R104C

PubMed Link: 33643062

Variant Present in the following documents:

• Main text
• fphys-12-603910.pdf

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PCSK9 Variants in Familial Hypercholesterolemia: A Comprehensive Synopsis.

Frontiers In Genetics

Guo, Qianyun Q; Feng, Xunxun X; Zhou, Yujie Y

Publication Date: 2020

Variant appearance in text: PCSK9: R104C

PubMed Link: 33173529

Variant Present in the following documents:

• Main text
• fgene-11-01020.pdf

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Urine-Derived Stem Cells: The Present and the Future.

Stem Cells International

Ji, Xiaoli X; Wang, Min M; Chen, Fang F; Zhou, Junmei J

Publication Date: 2017

Variant appearance in text: PCSK9: R104C

PubMed Link: 29250119

Variant Present in the following documents:

• Main text

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The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol.

Global Cardiology Science & Practice

Seidah, Nabil G NG

Publication Date: 2017-03-31

Variant appearance in text: PCSK9: R104C

PubMed Link: 28971102

Variant Present in the following documents:

• Main text

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tmVar 2.0: integrating genomic variant information from literature with dbSNP and ClinVar for precision medicine.

Bioinformatics (Oxford, England)

Wei, Chih-Hsuan CH; Phan, Lon L; Feltz, Juliana J; Maiti, Rama R; Hefferon, Tim T; Lu, Zhiyong Z

Publication Date: 2018-01-01

Variant appearance in text: PCSK9: 310C>T; Arg104Cys

PubMed Link: 28968638

Variant Present in the following documents:

• Main text

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Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia.

Disease Models & Mechanisms

Si-Tayeb, Karim K; Idriss, Salam S; Champon, Benoite B; Caillaud, Amandine A; Pichelin, Matthieu M; Arnaud, Lucie L; Lemarchand, Patricia P; Le May, Cédric C; Zibara, Kazem K; Cariou, Bertrand B

Publication Date: 2016-01

Variant appearance in text: PCSK9: R104C

PubMed Link: 26586530

Variant Present in the following documents:

• Main text

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Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets.

Nutrition & Metabolism

Cariou, Bertrand B; Langhi, Cédric C; Le Bras, Maëlle M; Bortolotti, Murielle M; Lê, Kim-Anne KA; Theytaz, Fanny F; Le May, Cédric C; Guyomarc'h-Delasalle, Béatrice B; Zaïr, Yassine Y; Kreis, Roland R; Boesch, Chris C; Krempf, Michel M; Tappy, Luc L; Costet, Philippe P

Publication Date: 2013-01-08

Variant appearance in text: PCSK9: R104C

PubMed Link: 23298392

Variant Present in the following documents:

• Main text

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Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation.

The Journal Of Biological Chemistry

Benjannet, Suzanne S; Hamelin, Josée J; Chrétien, Michel M; Seidah, Nabil G NG

Publication Date: 2012-09-28

Variant appearance in text: PCSK9: R104C

PubMed Link: 22875854

Variant Present in the following documents:

• Main text

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Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

Journal Of Lipid Research

Calandra, Sebastiano S; Tarugi, Patrizia P; Speedy, Helen E HE; Dean, Andrew F AF; Bertolini, Stefano S; Shoulders, Carol C CC

Publication Date: 2011-11

Variant appearance in text: PCSK9: R104C

PubMed Link: 21862702

Variant Present in the following documents:

• Main text

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