Publications:

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A Metabolic Enhancer Protects against Diet-Induced Obesity and Liver Steatosis and Corrects a Pro-Atherogenic Serum Profile in Mice.

Nutrients

Platko, Khrystyna K; Lebeau, Paul F PF; Nederveen, Joshua P JP; Byun, Jae Hyun JH; MacDonald, Melissa E ME; Bourgeois, Jacqueline M JM; Tarnopolsky, Mark A MA; Austin, Richard C RC

Publication Date: 2023-05-22

Variant appearance in text: PCSK9: Q152H

PubMed Link: 37242292

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PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity.

Journal Of Experimental & Clinical Cancer Research : Cr

Gu, Yan Y; Lin, Xiaozeng X; Dong, Ying Y; Wood, Geoffrey G; Seidah, Nabil G NG; Werstuck, Geoff G; Major, Pierre P; Bonert, Michael M; Kapoor, Anil A; Tang, Damu D

Publication Date: 2023-01-02

Variant appearance in text: PCSK9: Q152H

PubMed Link: 36588164

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• Main text
• 13046_2022_Article_2584.pdf

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PCSK9 in Liver Cancers at the Crossroads between Lipid Metabolism and Immunity.

Cells

Alannan, Malak M; Seidah, Nabil G NG; Merched, Aksam J AJ

Publication Date: 2022-12-19

Variant appearance in text: PCSK9: Q152H

PubMed Link: 36552895

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• Main text
• cells-11-04132.pdf

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Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond.

Current Atherosclerosis Reports

Seidah, Nabil G NG; Garçon, Damien D

Publication Date: 2022-10

Variant appearance in text: PCSK9: Q152H

PubMed Link: 35904732

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The Emerging Roles of Intracellular PCSK9 and Their Implications in Endoplasmic Reticulum Stress and Metabolic Diseases.

Metabolites

Lebeau, Paul F PF; Platko, Khrystyna K; Byun, Jae Hyun JH; Makda, Yumna Y; Austin, Richard C RC

Publication Date: 2022-02-26

Variant appearance in text: PCSK9: Q152H

PubMed Link: 35323658

Variant Present in the following documents:

• Main text
• metabolites-12-00215.pdf

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Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond.

International Journal Of Molecular Sciences

Grewal, Thomas T; Buechler, Christa C

Publication Date: 2022-01-19

Variant appearance in text: PCSK9: Q152H

PubMed Link: 35162992

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Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes.

Cardiovascular Therapeutics

Waluś-Miarka, Małgorzata M; Kapusta, Maria M; Miarka, Przemysław P; Kawalec, Ewa E; Idzior-Waluś, Barbara B

Publication Date: 2021

Variant appearance in text: PCSK9: Q152H

PubMed Link: 35024053

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PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology.

Biomedicines

Sundararaman, Sai Sahana SS; Döring, Yvonne Y; van der Vorst, Emiel P C EPC

Publication Date: 2021-07-08

Variant appearance in text: PCSK9: Gln152His

PubMed Link: 34356856

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• Main text
• biomedicines-09-00793.pdf

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The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.

The Journal Of Clinical Investigation

Lebeau, Paul F PF; Wassef, Hanny H; Byun, Jae Hyun JH; Platko, Khrystyna K; Ason, Brandon B; Jackson, Simon S; Dobroff, Joshua J; Shetterly, Susan S; Richards, William G WG; Al-Hashimi, Ali A AA; Won, Kevin Doyoon KD; Mbikay, Majambu M; Prat, Annik A; Tang, An A; Paré, Guillaume G; Pasqualini, Renata R; Seidah, Nabil G NG; Arap, Wadih W; Chrétien, Michel M; Austin, Richard C RC

Publication Date: 2021-01-19

Variant appearance in text: PCSK9: Gln152His

PubMed Link: 33211673

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PCSK9 Variants in Familial Hypercholesterolemia: A Comprehensive Synopsis.

Frontiers In Genetics

Guo, Qianyun Q; Feng, Xunxun X; Zhou, Yujie Y

Publication Date: 2020

Variant appearance in text: PCSK9: Q152H

PubMed Link: 33173529

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• Main text
• fgene-11-01020.pdf

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Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice.

Jhep Reports : Innovation In Hepatology

Lebeau, Paul F PF; Byun, Jae Hyun JH; Platko, Khrystyna K; Al-Hashimi, Ali A AA; Lhoták, Šárka Š; MacDonald, Melissa E ME; Mejia-Benitez, Aurora A; Prat, Annik A; Igdoura, Suleiman A SA; Trigatti, Bernardo B; Maclean, Kenneth N KN; Seidah, Nabil G NG; Austin, Richard C RC

Publication Date: 2019-12

Variant appearance in text: PCSK9: Q152H

PubMed Link: 32039393

Variant Present in the following documents:

• Main text
• mmc1.pdf
• main.pdf

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Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies.

Cardiovascular Research

Seidah, Nabil G NG; Prat, Annik A; Pirillo, Angela A; Catapano, Alberico Luigi AL; Norata, Giuseppe Danilo GD

Publication Date: 2019-03-01

Variant appearance in text: PCSK9: Q152H

PubMed Link: 30629143

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Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.

The Journal Of Biological Chemistry

Lebeau, Paul P; Platko, Khrystyna K; Al-Hashimi, Ali A AA; Byun, Jae Hyun JH; Lhoták, Šárka Š; Holzapfel, Nicholas N; Gyulay, Gabriel G; Igdoura, Suleiman A SA; Cool, David R DR; Trigatti, Bernardo B; Seidah, Nabil G NG; Austin, Richard C RC

Publication Date: 2018-05-11

Variant appearance in text: PCSK9: Q152H

PubMed Link: 29593095

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Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.

The Journal Of Biological Chemistry

Chorba, John S JS; Galvan, Adri M AM; Shokat, Kevan M KM

Publication Date: 2018-02-09

Variant appearance in text: PCSK9: Q152H

PubMed Link: 29259136

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PCSK9 as a therapeutic target for cardiovascular disease.

Experimental And Therapeutic Medicine

Zhang, Pei-Ying PY

Publication Date: 2017-03

Variant appearance in text: PCSK9: Q152H

PubMed Link: 28450903

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• Main text
• etm-13-03-0810.pdf

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Lowering serum lipids via PCSK9-targeting drugs: current advances and future perspectives.

Acta Pharmacologica Sinica

He, Ni-Ya NY; Li, Qing Q; Wu, Chun-Yan CY; Ren, Zhong Z; Gao, Ya Y; Pan, Li-Hong LH; Wang, Mei-Mei MM; Wen, Hong-Yan HY; Jiang, Zhi-Sheng ZS; Tang, Zhi-Han ZH; Liu, Lu-Shan LS

Publication Date: 2017-03

Variant appearance in text: PCSK9: Q152H

PubMed Link: 28112180

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Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor.

Protein Science : A Publication Of The Protein Society

Garvie, Colin W CW; Fraley, Cara V CV; Elowe, Nadine H NH; Culyba, Elizabeth K EK; Lemke, Christopher T CT; Hubbard, Brian K BK; Kaushik, Virendar K VK; Daniels, Douglas S DS

Publication Date: 2016-11

Variant appearance in text: PCSK9: Q152H

PubMed Link: 27534510

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Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain.

Plos One

Poirier, Steve S; Hamouda, Hocine Ait HA; Villeneuve, Louis L; Demers, Annie A; Mayer, Gaétan G

Publication Date: 2016

Variant appearance in text: PCSK9: Q152H

PubMed Link: 27280970

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• Main text
• pone.0157230.pdf

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β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells.

The Febs Journal

Starr, Amanda E AE; Lemieux, Valérie V; Noad, Jenny J; Moore, Jasmine I JI; Dewpura, Thilina T; Raymond, Angela A; Chrétien, Michel M; Figeys, Daniel D; Mayne, Janice J

Publication Date: 2015-07

Variant appearance in text: PCSK9: Q152H

PubMed Link: 25913303

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• Main text
• FEBS-282-2682.pdf

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The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis.

The Journal Of Biological Chemistry

Chorba, John S JS; Shokat, Kevan M KM

Publication Date: 2014-10-17

Variant appearance in text: PCSK9: Q152H

PubMed Link: 25210046

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Assessing the functional consequence of loss of function variants using electronic medical record and large-scale genomics consortium efforts.

Frontiers In Genetics

Sleiman, Patrick P; Bradfield, Jonathan J; Mentch, Frank F; Almoguera, Berta B; Connolly, John J; Hakonarson, Hakon H

Publication Date: 2014

Variant appearance in text: PCSK9: Q152H

PubMed Link: 24808909

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• Main text
• fgene-05-00105.pdf

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PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.

Plos One

Saavedra, Yascara Grisel Luna YG; Zhang, Jianbing J; Seidah, Nabil G NG

Publication Date: 2013

Variant appearance in text: PCSK9: Q152H

PubMed Link: 23951290

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The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

The Journal Of Biological Chemistry

Seidah, Nabil G NG; Sadr, Mohamad S MS; Chrétien, Michel M; Mbikay, Majambu M

Publication Date: 2013-07-26

Variant appearance in text: PCSK9: Q152H

PubMed Link: 23775089

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Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.

Lipids In Health And Disease

Mayne, Janice J; Ooi, Teik Chye TC; Raymond, Angela A; Cousins, Marion M; Bernier, Lise L; Dewpura, Thilina T; Sirois, Francine F; Mbikay, Majambu M; Davignon, Jean J; Chrétien, Michel M

Publication Date: 2013-05-10

Variant appearance in text: PCSK9: Q152H

PubMed Link: 23663650

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The genetic spectrum of familial hypercholesterolemia in Pakistan.

Clinica Chimica Acta; International Journal Of Clinical Chemistry

Ahmed, Waqas W; Whittall, Ros R; Riaz, Moeen M; Ajmal, Muhammad M; Sadeque, Ahmed A; Ayub, Humaira H; Qamar, Raheel R; Humphries, Steve E SE

Publication Date: 2013-06-05

Variant appearance in text: PCSK9: Q152H

PubMed Link: 23535506

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Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation.

The Journal Of Biological Chemistry

Benjannet, Suzanne S; Hamelin, Josée J; Chrétien, Michel M; Seidah, Nabil G NG

Publication Date: 2012-09-28

Variant appearance in text: PCSK9: Q152H

PubMed Link: 22875854

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