Variant ID: 1-55518070-CG-GC

NM_174936.3(PCSK9):c.643_644delinsGC;(p.R215A)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Quantitative characterization of the mechanism of action and impact of a 'proteolysis-permitting' anti-PCSK9 antibody.

Mabs
Hansen, Ryan J RJ; Berna, Michael J MJ; Sperry, Andrea E AE; Beyer, Thomas P TP; Wroblewski, Victor J VJ; Schroeder, Krista M KM; Eacho, Patrick I PI
Publication Date: 2017

Variant appearance in text: PCSK9: R215A
PubMed Link: 27981884
Variant Present in the following documents:
  • Main text
View BVdb publication page



Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody.

Journal Of Lipid Research
Schroeder, Krista M KM; Beyer, Thomas P TP; Hansen, Ryan J RJ; Han, Bomie B; Pickard, Richard T RT; Wroblewski, Victor J VJ; Kowala, Mark C MC; Eacho, Patrick I PI
Publication Date: 2015-11

Variant appearance in text: PCSK9: R215A
PubMed Link: 26392590
Variant Present in the following documents:
  • Main text
View BVdb publication page



Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.

The Journal Of Biological Chemistry
Lipari, Michael T MT; Li, Wei W; Moran, Paul P; Kong-Beltran, Monica M; Sai, Tao T; Lai, Joyce J; Lin, S Jack SJ; Kolumam, Ganesh G; Zavala-Solorio, Jose J; Izrael-Tomasevic, Anita A; Arnott, David D; Wang, Jianyong J; Peterson, Andrew S AS; Kirchhofer, Daniel D
Publication Date: 2012-12-21

Variant appearance in text: PCSK9: R215A
PubMed Link: 23135270
Variant Present in the following documents:
  • Main text
View BVdb publication page