Publications:

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Genetics, Safety, Cost-Effectiveness, and Accessibility of Injectable Lipid-Lowering Agents: A Narrative Review.

Journal Of Lipids

Sindi, Abdulmajeed Abdulghani A AAA

Publication Date: 2023

Variant appearance in text: PCSK9: F216L

PubMed Link: 36935878

Variant Present in the following documents:

• JL2023-2025490.pdf

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PCSK9 in Liver Cancers at the Crossroads between Lipid Metabolism and Immunity.

Cells

Alannan, Malak M; Seidah, Nabil G NG; Merched, Aksam J AJ

Publication Date: 2022-12-19

Variant appearance in text: PCSK9: F216L

PubMed Link: 36552895

Variant Present in the following documents:

• Main text
• cells-11-04132.pdf

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Genetic and molecular architecture of familial hypercholesterolemia.

Journal Of Internal Medicine

Abifadel, Marianne M; Boileau, Catherine C

Publication Date: 2022-10-04

Variant appearance in text: PCSK9: Phe216Leu

PubMed Link: 36196022

Variant Present in the following documents:

• Main text
• JOIM-293-144.pdf

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Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications.

Frontiers In Cardiovascular Medicine

Xia, Xiao-Dan XD; Peng, Zhong-Sheng ZS; Gu, Hong-Mei HM; Wang, Maggie M; Wang, Gui-Qing GQ; Zhang, Da-Wei DW

Publication Date: 2021

Variant appearance in text: PCSK9: F216L

PubMed Link: 34782856

Variant Present in the following documents:

• Main text
• fcvm-08-764038.pdf

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PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology.

Biomedicines

Sundararaman, Sai Sahana SS; Döring, Yvonne Y; van der Vorst, Emiel P C EPC

Publication Date: 2021-07-08

Variant appearance in text: PCSK9: F216L

PubMed Link: 34356856

Variant Present in the following documents:

• Main text
• biomedicines-09-00793.pdf

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PCSK9 Biology and Its Role in Atherothrombosis.

International Journal Of Molecular Sciences

Barale, Cristina C; Melchionda, Elena E; Morotti, Alessandro A; Russo, Isabella I

Publication Date: 2021-05-30

Variant appearance in text: PCSK9: F216L

PubMed Link: 34070931

Variant Present in the following documents:

• Main text
• ijms-22-05880.pdf

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Targeted Therapy in Cardiovascular Disease: A Precision Therapy Era.

Frontiers In Pharmacology

Xu, Mengda M; Song, Jiangping J

Publication Date: 2021

Variant appearance in text: PCSK9: F216L

PubMed Link: 33935716

Variant Present in the following documents:

• Main text

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PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects.

Frontiers In Cardiovascular Medicine

Li, Yan-Yan YY; Wang, Hui H; Yang, Xin-Xing XX; Geng, Hong-Yu HY; Gong, Ge G; Lu, Xin-Zheng XZ

Publication Date: 2020

Variant appearance in text: PCSK9: F216L

PubMed Link: 33244470

Variant Present in the following documents:

• Main text

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PCSK9 Variants in Familial Hypercholesterolemia: A Comprehensive Synopsis.

Frontiers In Genetics

Guo, Qianyun Q; Feng, Xunxun X; Zhou, Yujie Y

Publication Date: 2020

Variant appearance in text: PCSK9: F216L

PubMed Link: 33173529

Variant Present in the following documents:

• Main text
• fgene-11-01020.pdf

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In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex.

International Journal Of Molecular Sciences

Martin, William R WR; Lightstone, Felice C FC; Cheng, Feixiong F

Publication Date: 2020-02-25

Variant appearance in text: PCSK9: Phe216Leu

PubMed Link: 32106405

Variant Present in the following documents:

• Main text
• ijms-21-01550.pdf

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Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies.

Cardiovascular Research

Seidah, Nabil G NG; Prat, Annik A; Pirillo, Angela A; Catapano, Alberico Luigi AL; Norata, Giuseppe Danilo GD

Publication Date: 2019-03-01

Variant appearance in text: PCSK9: F216L

PubMed Link: 30629143

Variant Present in the following documents:

• Main text

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Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.

The Journal Of Biological Chemistry

Chorba, John S JS; Galvan, Adri M AM; Shokat, Kevan M KM

Publication Date: 2018-02-09

Variant appearance in text: PCSK9: F216L

PubMed Link: 29259136

Variant Present in the following documents:

• Main text

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The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol.

Global Cardiology Science & Practice

Seidah, Nabil G NG

Publication Date: 2017-03-31

Variant appearance in text: PCSK9: F216L

PubMed Link: 28971102

Variant Present in the following documents:

• Main text
• gcsp-2017-1-e201702.pdf

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The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease.

Embo Molecular Medicine

Kessler, Thorsten T; Vilne, Baiba B; Schunkert, Heribert H

Publication Date: 2016-07

Variant appearance in text: PCSK9: F216L

PubMed Link: 27189168

Variant Present in the following documents:

• Main text

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: PCSK9: F216L

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 3

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Profile of evolocumab and its potential in the treatment of hyperlipidemia.

Drug Design, Development And Therapy

Cicero, Arrigo F G AF; Colletti, Alessandro A; Borghi, Claudio C

Publication Date: 2015

Variant appearance in text: PCSK9: Phe216Leu

PubMed Link: 26109850

Variant Present in the following documents:

• dddt-9-3073.pdf

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PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells.

Current Opinion In Lipidology

Lagace, Thomas A TA

Publication Date: 2014-10

Variant appearance in text: PCSK9: F216L

PubMed Link: 25110901

Variant Present in the following documents:

• Main text
• colip-25-387.pdf

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Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases.

Scientifica

Ferri, Nicola N

Publication Date: 2012

Variant appearance in text: PCSK9: F216L

PubMed Link: 24278757

Variant Present in the following documents:

• SCIENTIFICA2012-927352.pdf

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c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.

Molecules (Basel, Switzerland)

Xu, Weiming W; Liu, Lizhi L; Hornby, David D

Publication Date: 2012-10-15

Variant appearance in text: PCSK9: F216L

PubMed Link: 23085658

Variant Present in the following documents:

• Main text
• molecules-17-12086.pdf

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Low prevalence of mutations in known loci for autosomal dominant hypercholesterolemia in a multiethnic patient cohort.

Circulation. Cardiovascular Genetics

Ahmad, Zahid Z; Adams-Huet, Beverley B; Chen, Chiyuan C; Garg, Abhimanyu A

Publication Date: 2012-12

Variant appearance in text: FH3: F216L

PubMed Link: 23064986

Variant Present in the following documents:

• Main text

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