Publications:

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Association of PCSK9 levels and genetic polymorphisms with stroke recurrence and functional outcome after acute ischemic stroke.

Annals Of Translational Medicine

Chen, Weiqi W; Wang, Yicong Y; Meng, Xia X; Pan, Yuesong Y; Wang, Mengxing M; Li, Hao H; Wang, Yilong Y; Wang, Yongjun Y

Publication Date: 2022-07

Variant appearance in text: rs7552841

PubMed Link: 35957726

Variant Present in the following documents:

• Main text
• atm-10-13-729.pdf

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Association of Common and Rare Genetic Variation in the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk.

Journal Of The American Heart Association

Ghouse, Jonas J; Ahlberg, Gustav G; Skov, Anne Guldhammer AG; Bundgaard, Henning H; Olesen, Morten S MS

Publication Date: 2022-06-21

Variant appearance in text: rs7552841

PubMed Link: 35703387

Variant Present in the following documents:

• JAH3-11-e025361-s001.pdf
• JAH3-11-e025361.pdf

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Investigating the effects of statins on ischemic heart disease allowing for effects on body mass index: a Mendelian randomization study.

Scientific Reports

Li, Shun S; Schooling, C M CM

Publication Date: 2022-03-03

Variant appearance in text: rs7552841

PubMed Link: 35241713

Variant Present in the following documents:

• Main text
• 41598_2022_Article_7344.pdf

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Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.

Frontiers In Cardiovascular Medicine

Basavaraju, Preethi P; Balasubramani, Rubadevi R; Kathiresan, Divya Sri DS; Devaraj, Ilakkiyapavai I; Babu, Kavipriya K; Alagarsamy, Vasanthakumar V; Puthamohan, Vinayaga Moorthi VM

Publication Date: 2021

Variant appearance in text: rs7552841

PubMed Link: 35071357

Variant Present in the following documents:

• Main text
• fcvm-08-788852.pdf

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Genetics Is of the Essence to Face NAFLD.

Biomedicines

Meroni, Marica M; Longo, Miriam M; Tria, Giada G; Dongiovanni, Paola P

Publication Date: 2021-09-30

Variant appearance in text: rs7552841

PubMed Link: 34680476

Variant Present in the following documents:

• Main text
• biomedicines-09-01359.pdf

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Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.

Nature Communications

Schmidt, Amand F AF; Hunt, Nicholas B NB; Gordillo-Marañón, Maria M; Charoen, Pimphen P; Drenos, Fotios F; Kivimaki, Mika M; Lawlor, Deborah A DA; Giambartolomei, Claudia C; Papacosta, Olia O; Chaturvedi, Nishi N; Bis, Joshua C JC; O'Donnell, Christopher J CJ; Wannamethee, Goya G; Wong, Andrew A; Price, Jackie F JF; Hughes, Alun D AD; Gaunt, Tom R TR; Franceschini, Nora N; Mook-Kanamori, Dennis O DO; Zwierzyna, Magdalena M; Sofat, Reecha R; Hingorani, Aroon D AD; Finan, Chris C

Publication Date: 2021-09-24

Variant appearance in text: rs7552841

PubMed Link: 34561430

Variant Present in the following documents:

• 41467_2021_25703_MOESM1_ESM.pdf

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.

Plos Genetics

Gormley, Mark M; Yarmolinsky, James J; Dudding, Tom T; Burrows, Kimberley K; Martin, Richard M RM; Thomas, Steven S; Tyrrell, Jessica J; Brennan, Paul P; Pring, Miranda M; Boccia, Stefania S; Olshan, Andrew F AF; Diergaarde, Brenda B; Hung, Rayjean J RJ; Liu, Geoffrey G; Legge, Danny D; Tajara, Eloiza H EH; Severino, Patricia P; Lacko, Martin M; Ness, Andrew R AR; Davey Smith, George G; Vincent, Emma E EE; Richmond, Rebecca C RC

Publication Date: 2021-04

Variant appearance in text: rs7552841

PubMed Link: 33886544

Variant Present in the following documents:

• Main text

View BVdb publication page

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Use of Multivariable Mendelian Randomization to Address Biases Due to Competing Risk Before Recruitment.

Frontiers In Genetics

Schooling, C M CM; Lopez, P M PM; Yang, Z Z; Zhao, J V JV; Au Yeung, Shiu Lun SL; Huang, Jian V JV

Publication Date: 2020

Variant appearance in text: rs7552841

PubMed Link: 33519914

Variant Present in the following documents:

• Main text

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PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study.

Archives Of Medical Science : Ams

Lyall, Donald M DM; Ward, Joey J; Banach, Maciej M; Smith, George Davey GD; Gill, Jason G JG; Pell, Jill P JP; Holmes, Michael V MV; Sattar, Naveed N

Publication Date: 2021

Variant appearance in text: rs7552841

PubMed Link: 33488877

Variant Present in the following documents:

• Main text
• AMS-17-1-127226.pdf

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Genetics of 35 blood and urine biomarkers in the UK Biobank.

Nature Genetics

Sinnott-Armstrong, Nasa N; Tanigawa, Yosuke Y; Amar, David D; Mars, Nina N; Benner, Christian C; Aguirre, Matthew M; Venkataraman, Guhan Ram GR; Wainberg, Michael M; Ollila, Hanna M HM; Kiiskinen, Tuomo T; Havulinna, Aki S AS; Pirruccello, James P JP; Qian, Junyang J; Shcherbina, Anna A; , ; Rodriguez, Fatima F; Assimes, Themistocles L TL; Agarwala, Vineeta V; Tibshirani, Robert R; Hastie, Trevor T; Ripatti, Samuli S; Pritchard, Jonathan K JK; Daly, Mark J MJ; Rivas, Manuel A MA

Publication Date: 2021-02

Variant appearance in text: PCSK9: 799+288C>T; rs7552841

PubMed Link: 33462484

Variant Present in the following documents:

• NIHMS1651539-supplement-2.xlsx, sheet 21

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Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation.

Elife

Schooling, C M CM; Zhao, J V JV; Au Yeung, S L SL; Leung, G M GM

Publication Date: 2020-08-25

Variant appearance in text: rs7552841

PubMed Link: 32838838

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.

Jacc. Basic To Translational Science

Perrot, Nicolas N; Valerio, Vincenza V; Moschetta, Donato D; Boekholdt, S Matthijs SM; Dina, Christian C; Chen, Hao Yu HY; Abner, Erik E; Martinsson, Andreas A; Manikpurage, Hasanga D HD; Rigade, Sidwell S; Capoulade, Romain R; Mass, Elvira E; Clavel, Marie-Annick MA; Le Tourneau, Thierry T; Messika-Zeitoun, David D; Wareham, Nicholas J NJ; Engert, James C JC; Polvani, Gianluca G; Pibarot, Philippe P; Esko, Tõnu T; Smith, J Gustav JG; Mathieu, Patrick P; Thanassoulis, George G; Schott, Jean-Jacques JJ; Bossé, Yohan Y; Camera, Marina M; Thériault, Sébastien S; Poggio, Paolo P; Arsenault, Benoit J BJ

Publication Date: 2020-07

Variant appearance in text: rs7552841

PubMed Link: 32760854

Variant Present in the following documents:

• Main text
• mmc1.pdf
• main.pdf

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Genetic drug target validation using Mendelian randomisation.

Nature Communications

Schmidt, Amand F AF; Finan, Chris C; Gordillo-Marañón, Maria M; Asselbergs, Folkert W FW; Freitag, Daniel F DF; Patel, Riyaz S RS; Tyl, Benoît B; Chopade, Sandesh S; Faraway, Rupert R; Zwierzyna, Magdalena M; Hingorani, Aroon D AD

Publication Date: 2020-06-26

Variant appearance in text: rs7552841

PubMed Link: 32591531

Variant Present in the following documents:

• 41467_2020_16969_MOESM1_ESM.pdf

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PCSK9 Protein and rs562556 Polymorphism Are Associated With Arterial Plaques in Healthy Middle-Aged Population: The STANISLAS Cohort.

Journal Of The American Heart Association

Ferreira, João Pedro JP; Xhaard, Constance C; Lamiral, Zohra Z; Borges-Canha, Marta M; Neves, João Sérgio JS; Dandine-Roulland, Claire C; LeFloch, Edith E; Deleuze, Jean-François JF; Bacq-Daian, Delphine D; Bozec, Erwan E; Girerd, Nicolas N; Boivin, Jean-Marc JM; Zannad, Faiez F; Rossignol, Patrick P

Publication Date: 2020-04-07

Variant appearance in text: rs7552841

PubMed Link: 32208829

Variant Present in the following documents:

• JAH3-9-e014758.pdf

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Genetic Determinants of Lipids and Cardiovascular Disease Outcomes: A Wide-Angled Mendelian Randomization Investigation.

Circulation. Genomic And Precision Medicine

Allara, Elias E; Morani, Gabriele G; Carter, Paul P; Gkatzionis, Apostolos A; Zuber, Verena V; Foley, Christopher N CN; Rees, Jessica M B JMB; Mason, Amy M AM; Bell, Steven S; Gill, Dipender D; Lindström, Sara S; Butterworth, Adam S AS; Di Angelantonio, Emanuele E; Peters, James J; Burgess, Stephen S; ,

Publication Date: 2019-12

Variant appearance in text: rs7552841

PubMed Link: 31756303

Variant Present in the following documents:

• hcg-12-e002711-s001.pdf

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A Genetic Approach to the Association Between PCSK9 and Sepsis.

Jama Network Open

Feng, QiPing Q; Wei, Wei-Qi WQ; Chaugai, Sandip S; Carranza Leon, Barbara G BG; Kawai, Vivian V; Carranza Leon, Daniel A DA; Jiang, Lan L; Zhong, Xue X; Liu, Ge G; Ihegword, Andrea A; Shaffer, Christian M CM; Linton, MacRae F MF; Chung, Cecilia P CP; Stein, C Michael CM

Publication Date: 2019-09-04

Variant appearance in text: rs7552841

PubMed Link: 31509211

Variant Present in the following documents:

• Main text
• jamanetwopen-2-e1911130-s001.pdf

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Genetic markers of lipid metabolism genes associated with low susceptibility to HCV infection.

Scientific Reports

Real, Luis Miguel LM; Macías, Juan J; Rivero-Juárez, Antonio A; Téllez, Francisco F; Merino, Dolores D; Moreno-Grau, Sonia S; Orellana, Adelina A; Gómez-Salgado, Juan J; Sáez, María E ME; Frías, Mario M; Corma-Gómez, Anaïs A; Merchante, Nicolás N; Ruiz, Agustín A; Caruz, Antonio A; Pineda, Juan A JA; ,

Publication Date: 2019-06-21

Variant appearance in text: rs7552841

PubMed Link: 31227787

Variant Present in the following documents:

• Main text

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Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC.

Frontiers In Genetics

Patrick, Matthew T MT; Stuart, Philip E PE; Raja, Kalpana K; Chi, Sunyi S; He, Zhi Z; Voorhees, John J JJ; Tejasvi, Trilokraj T; Gudjonsson, Johann E JE; Kahlenberg, J Michelle JM; Chandran, Vinod V; Rahman, Proton P; Gladman, Dafna D DD; Nair, Rajan P RP; Elder, James T JT; Tsoi, Lam C LC

Publication Date: 2019

Variant appearance in text: rs7552841

PubMed Link: 31031798

Variant Present in the following documents:

• Main text
• fgene-10-00304.pdf

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Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition.

Circulation. Genomic And Precision Medicine

Brumpton, Ben M BM; Fritsche, Lars G LG; Zheng, Jie J; Nielsen, Jonas Bille JB; Mannila, Maria M; Surakka, Ida I; Rasheed, Humaira H; Vie, Gunnhild Åberge GÅ; Graham, Sarah E SE; Gabrielsen, Maiken Elvestad ME; Laugsand, Lars Erik LE; Aukrust, Pål P; Vatten, Lars Johan LJ; Damås, Jan Kristian JK; Ueland, Thor T; Janszky, Imre I; Zwart, John-Anker JA; Van't Hooft, Ferdinand M FM; Seidah, Nabil Georges NG; Hveem, Kristian K; Willer, Cristen C; Smith, George Davey GD; Åsvold, Bjørn Olav BO; ,

Publication Date: 2019-01

Variant appearance in text: rs7552841

PubMed Link: 30645169

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Mendelian randomization study of the effects of blood lipids on breast cancer risk.

Nature Communications

Nowak, Christoph C; Ärnlöv, Johan J

Publication Date: 2018-09-27

Variant appearance in text: rs7552841

PubMed Link: 30262900

Variant Present in the following documents:

• 41467_2018_6467_MOESM1_ESM.pdf

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Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.

Scientific Reports

Guo, Tao T; Yin, Rui-Xing RX; Huang, Feng F; Yao, Li-Mei LM; Lin, Wei-Xiong WX; Pan, Shang-Ling SL

Publication Date: 2016-01-08

Variant appearance in text: PCSK9: 799+288C>T; rs7552841

PubMed Link: 26744084

Variant Present in the following documents:

• Main text
• srep19079.pdf

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Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia.

Journal Of Cellular And Molecular Medicine

Guo, Tao T; Yin, Rui-Xing RX; Lin, Wei-Xiong WX; Wang, Wei W; Huang, Feng F; Pan, Shang-Ling SL

Publication Date: 2016-02

Variant appearance in text: rs7552841

PubMed Link: 26493351

Variant Present in the following documents:

• Main text
• JCMM-20-243.pdf

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Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research

Han, Dengfeng D; Ma, Jianhua J; Zhang, Xiaoning X; Cai, Jian J; Li, Jinlan J; Tuerxun, Tuerhong T; Hao, Chenguang C; Du, Lei L; Lei, Jing J

Publication Date: 2014-09-30

Variant appearance in text: rs7552841

PubMed Link: 25266949

Variant Present in the following documents:

• Main text
• medscimonit-20-1758.pdf

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SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study.

Bmc Medical Genetics

Meyers, Kristin J KJ; Chu, Jian J; Mosley, Thomas H TH; Kardia, Sharon L R SL

Publication Date: 2010-11-10

Variant appearance in text: rs7552841

PubMed Link: 21067599

Variant Present in the following documents:

• Main text
• 1471-2350-11-160.pdf

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Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.

Journal Of Lipid Research

Guella, Ilaria I; Asselta, Rosanna R; Ardissino, Diego D; Merlini, Pier Angelica PA; Peyvandi, Flora F; Kathiresan, Sekar S; Mannucci, Pier Mannuccio PM; Tubaro, Marco M; Duga, Stefano S

Publication Date: 2010-11

Variant appearance in text: rs7552841

PubMed Link: 20699424

Variant Present in the following documents:

• Main text

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Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Human Molecular Genetics

Drenos, Fotios F; Talmud, Philippa J PJ; Casas, Juan P JP; Smeeth, Liam L; Palmen, Jutta J; Humphries, Steve E SE; Hingorani, Aroon D AD

Publication Date: 2009-06-15

Variant appearance in text: rs7552841

PubMed Link: 19336475

Variant Present in the following documents:

• ddp159_1.pdf

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Molecular population genetics of PCSK9: a signature of recent positive selection.

Pharmacogenetics And Genomics

Ding, Keyue K; Kullo, Iftikhar J IJ

Publication Date: 2008-03

Variant appearance in text: rs7552841

PubMed Link: 18300938

Variant Present in the following documents:

• Main text

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