Variant ID: 1-55518752-C-T

NM_174936.3(PCSK9):c.799+288C>T

This variant was identified in 22 publications

View GRCh38 version.




Publications:


Investigating the effects of statins on ischemic heart disease allowing for effects on body mass index: a Mendelian randomization study.

Scientific Reports
Li, Shun S; Schooling, C M CM
Publication Date: 2022-03-03

Variant appearance in text: rs7552841
PubMed Link: 35241713
Variant Present in the following documents:
  • 41598_2022_Article_7344.pdf
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Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.

Frontiers In Cardiovascular Medicine
Basavaraju, Preethi P; Balasubramani, Rubadevi R; Kathiresan, Divya Sri DS; Devaraj, Ilakkiyapavai I; Babu, Kavipriya K; Alagarsamy, Vasanthakumar V; Puthamohan, Vinayaga Moorthi VM
Publication Date: 2021

Variant appearance in text: rs7552841
PubMed Link: 35071357
Variant Present in the following documents:
  • Main text
  • fcvm-08-788852.pdf
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Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis.

Journal Of The American Heart Association
Georgakis, Marios K MK; Malik, Rainer R; Burgess, Stephen S; Dichgans, Martin M
Publication Date: 2021-12-20

Variant appearance in text: rs7552841
PubMed Link: 34927447
Variant Present in the following documents:
  • JAH3-11-e023277.pdf
  • JAH3-11-e023277-s001.pdf
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Genetics Is of the Essence to Face NAFLD.

Biomedicines
Meroni, Marica M; Longo, Miriam M; Tria, Giada G; Dongiovanni, Paola P
Publication Date: 2021-09-30

Variant appearance in text: rs7552841
PubMed Link: 34680476
Variant Present in the following documents:
  • Main text
  • biomedicines-09-01359.pdf
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Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Hepatology Communications
Meroni, Marica M; Longo, Miriam M; Lombardi, Rosa R; Paolini, Erika E; Macchi, Chiara C; Corsini, Alberto A; Sirtori, Cesare R CR; Fracanzani, Anna Ludovica AL; Ruscica, Massimiliano M; Dongiovanni, Paola P
Publication Date: 2021-10-22

Variant appearance in text: rs7552841
PubMed Link: 34677008
Variant Present in the following documents:
  • HEP4-6-535.pdf
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Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.

Nature Communications
Schmidt, Amand F AF; Hunt, Nicholas B NB; Gordillo-Marañón, Maria M; Charoen, Pimphen P; Drenos, Fotios F; Kivimaki, Mika M; Lawlor, Deborah A DA; Giambartolomei, Claudia C; Papacosta, Olia O; Chaturvedi, Nishi N; Bis, Joshua C JC; O'Donnell, Christopher J CJ; Wannamethee, Goya G; Wong, Andrew A; Price, Jackie F JF; Hughes, Alun D AD; Gaunt, Tom R TR; Franceschini, Nora N; Mook-Kanamori, Dennis O DO; Zwierzyna, Magdalena M; Sofat, Reecha R; Hingorani, Aroon D AD; Finan, Chris C
Publication Date: 2021-09-24

Variant appearance in text: rs7552841
PubMed Link: 34561430
Variant Present in the following documents:
  • 41467_2021_25703_MOESM1_ESM.pdf
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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.

Plos Genetics
Gormley, Mark M; Yarmolinsky, James J; Dudding, Tom T; Burrows, Kimberley K; Martin, Richard M RM; Thomas, Steven S; Tyrrell, Jessica J; Brennan, Paul P; Pring, Miranda M; Boccia, Stefania S; Olshan, Andrew F AF; Diergaarde, Brenda B; Hung, Rayjean J RJ; Liu, Geoffrey G; Legge, Danny D; Tajara, Eloiza H EH; Severino, Patricia P; Lacko, Martin M; Ness, Andrew R AR; Davey Smith, George G; Vincent, Emma E EE; Richmond, Rebecca C RC
Publication Date: 2021-04

Variant appearance in text: rs7552841
PubMed Link: 33886544
Variant Present in the following documents:
  • Main text
  • pgen.1009525.s015.pdf
  • pgen.1009525.s018.pdf
  • pgen.1009525.pdf
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Use of Multivariable Mendelian Randomization to Address Biases Due to Competing Risk Before Recruitment.

Frontiers In Genetics
Schooling, C M CM; Lopez, P M PM; Yang, Z Z; Zhao, J V JV; Au Yeung, Shiu Lun SL; Huang, Jian V JV
Publication Date: 2020

Variant appearance in text: rs7552841
PubMed Link: 33519914
Variant Present in the following documents:
  • Main text
  • fgene-11-610852.pdf
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PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study.

Archives Of Medical Science : Ams
Lyall, Donald M DM; Ward, Joey J; Banach, Maciej M; Smith, George Davey GD; Gill, Jason G JG; Pell, Jill P JP; Holmes, Michael V MV; Sattar, Naveed N
Publication Date: 2021

Variant appearance in text: rs7552841
PubMed Link: 33488877
Variant Present in the following documents:
  • Main text
  • AMS-17-1-127226.pdf
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Genetics of 35 blood and urine biomarkers in the UK Biobank.

Nature Genetics
Sinnott-Armstrong, Nasa N; Tanigawa, Yosuke Y; Amar, David D; Mars, Nina N; Benner, Christian C; Aguirre, Matthew M; Venkataraman, Guhan Ram GR; Wainberg, Michael M; Ollila, Hanna M HM; Kiiskinen, Tuomo T; Havulinna, Aki S AS; Pirruccello, James P JP; Qian, Junyang J; Shcherbina, Anna A; , ; Rodriguez, Fatima F; Assimes, Themistocles L TL; Agarwala, Vineeta V; Tibshirani, Robert R; Hastie, Trevor T; Ripatti, Samuli S; Pritchard, Jonathan K JK; Daly, Mark J MJ; Rivas, Manuel A MA
Publication Date: 2021-02

Variant appearance in text: PCSK9: 799+288C>T; rs7552841
PubMed Link: 33462484
Variant Present in the following documents:
  • NIHMS1651539-supplement-2.xlsx
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Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation.

Elife
Schooling, C M CM; Zhao, J V JV; Au Yeung, S L SL; Leung, G M GM
Publication Date: 2020-08-25

Variant appearance in text: rs7552841
PubMed Link: 32838838
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis.

Jacc. Basic To Translational Science
Perrot, Nicolas N; Valerio, Vincenza V; Moschetta, Donato D; Boekholdt, S Matthijs SM; Dina, Christian C; Chen, Hao Yu HY; Abner, Erik E; Martinsson, Andreas A; Manikpurage, Hasanga D HD; Rigade, Sidwell S; Capoulade, Romain R; Mass, Elvira E; Clavel, Marie-Annick MA; Le Tourneau, Thierry T; Messika-Zeitoun, David D; Wareham, Nicholas J NJ; Engert, James C JC; Polvani, Gianluca G; Pibarot, Philippe P; Esko, Tõnu T; Smith, J Gustav JG; Mathieu, Patrick P; Thanassoulis, George G; Schott, Jean-Jacques JJ; Bossé, Yohan Y; Camera, Marina M; Thériault, Sébastien S; Poggio, Paolo P; Arsenault, Benoit J BJ
Publication Date: 2020-07

Variant appearance in text: rs7552841
PubMed Link: 32760854
Variant Present in the following documents:
  • Main text
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A Genetic Approach to the Association Between PCSK9 and Sepsis.

Jama Network Open
Feng, QiPing Q; Wei, Wei-Qi WQ; Chaugai, Sandip S; Carranza Leon, Barbara G BG; Kawai, Vivian V; Carranza Leon, Daniel A DA; Jiang, Lan L; Zhong, Xue X; Liu, Ge G; Ihegword, Andrea A; Shaffer, Christian M CM; Linton, MacRae F MF; Chung, Cecilia P CP; Stein, C Michael CM
Publication Date: 2019-09-04

Variant appearance in text: rs7552841
PubMed Link: 31509211
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic markers of lipid metabolism genes associated with low susceptibility to HCV infection.

Scientific Reports
Real, Luis Miguel LM; Macías, Juan J; Rivero-Juárez, Antonio A; Téllez, Francisco F; Merino, Dolores D; Moreno-Grau, Sonia S; Orellana, Adelina A; Gómez-Salgado, Juan J; Sáez, María E ME; Frías, Mario M; Corma-Gómez, Anaïs A; Merchante, Nicolás N; Ruiz, Agustín A; Caruz, Antonio A; Pineda, Juan A JA; ,
Publication Date: 2019-06-21

Variant appearance in text: rs7552841
PubMed Link: 31227787
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC.

Frontiers In Genetics
Patrick, Matthew T MT; Stuart, Philip E PE; Raja, Kalpana K; Chi, Sunyi S; He, Zhi Z; Voorhees, John J JJ; Tejasvi, Trilokraj T; Gudjonsson, Johann E JE; Kahlenberg, J Michelle JM; Chandran, Vinod V; Rahman, Proton P; Gladman, Dafna D DD; Nair, Rajan P RP; Elder, James T JT; Tsoi, Lam C LC
Publication Date: 2019

Variant appearance in text: rs7552841
PubMed Link: 31031798
Variant Present in the following documents:
  • Main text
View BVdb publication page



Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition.

Circulation. Genomic And Precision Medicine
Brumpton, Ben M BM; Fritsche, Lars G LG; Zheng, Jie J; Nielsen, Jonas Bille JB; Mannila, Maria M; Surakka, Ida I; Rasheed, Humaira H; Vie, Gunnhild Åberge GÅ; Graham, Sarah E SE; Gabrielsen, Maiken Elvestad ME; Laugsand, Lars Erik LE; Aukrust, Pål P; Vatten, Lars Johan LJ; Damås, Jan Kristian JK; Ueland, Thor T; Janszky, Imre I; Zwart, John-Anker JA; Van't Hooft, Ferdinand M FM; Seidah, Nabil Georges NG; Hveem, Kristian K; Willer, Cristen C; Smith, George Davey GD; Åsvold, Bjørn Olav BO; ,
Publication Date: 2019-01

Variant appearance in text: rs7552841
PubMed Link: 30645169
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.

Scientific Reports
Guo, Tao T; Yin, Rui-Xing RX; Huang, Feng F; Yao, Li-Mei LM; Lin, Wei-Xiong WX; Pan, Shang-Ling SL
Publication Date: 2016-01-08

Variant appearance in text: rs7552841
PubMed Link: 26744084
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia.

Journal Of Cellular And Molecular Medicine
Guo, Tao T; Yin, Rui-Xing RX; Lin, Wei-Xiong WX; Wang, Wei W; Huang, Feng F; Pan, Shang-Ling SL
Publication Date: 2016-02

Variant appearance in text: rs7552841
PubMed Link: 26493351
Variant Present in the following documents:
  • Main text
View BVdb publication page



Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Han, Dengfeng D; Ma, Jianhua J; Zhang, Xiaoning X; Cai, Jian J; Li, Jinlan J; Tuerxun, Tuerhong T; Hao, Chenguang C; Du, Lei L; Lei, Jing J
Publication Date: 2014-09-30

Variant appearance in text: rs7552841
PubMed Link: 25266949
Variant Present in the following documents:
  • Main text
View BVdb publication page



SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study.

Bmc Medical Genetics
Meyers, Kristin J KJ; Chu, Jian J; Mosley, Thomas H TH; Kardia, Sharon L R SL
Publication Date: 2010-11-10

Variant appearance in text: rs7552841
PubMed Link: 21067599
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.

Journal Of Lipid Research
Guella, Ilaria I; Asselta, Rosanna R; Ardissino, Diego D; Merlini, Pier Angelica PA; Peyvandi, Flora F; Kathiresan, Sekar S; Mannucci, Pier Mannuccio PM; Tubaro, Marco M; Duga, Stefano S
Publication Date: 2010-11

Variant appearance in text: rs7552841
PubMed Link: 20699424
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular population genetics of PCSK9: a signature of recent positive selection.

Pharmacogenetics And Genomics
Ding, Keyue K; Kullo, Iftikhar J IJ
Publication Date: 2008-03

Variant appearance in text: rs7552841
PubMed Link: 18300938
Variant Present in the following documents:
  • Main text
View BVdb publication page