Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity.
International Journal Of Molecular Sciences
Fassi, Enrico Mario Alessandro EMA; Garofalo, Mariangela M; Sgrignani, Jacopo J; Dei Cas, Michele M; Mori, Matteo M; Roda, Gabriella G; Cavalli, Andrea A; Grazioso, Giovanni G
Circulating Proprotein Convertase Subtilisin/Kexin type 9 level independently predicts incident cardiovascular events and all-cause mortality in hemodialysis black Africans patients.
Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity.
Pharmaceutics
Lammi, Carmen C; Fassi, Enrico M A EMA; Li, Jianqiang J; Bartolomei, Martina M; Benigno, Giulia G; Roda, Gabriella G; Arnoldi, Anna A; Grazioso, Giovanni G
Maligłówka, Mateusz M; Kosowski, Michał M; Hachuła, Marcin M; Cyrnek, Marcin M; Bułdak, Łukasz Ł; Basiak, Marcin M; Bołdys, Aleksandra A; Machnik, Grzegorz G; Bułdak, Rafał Jakub RJ; Okopień, Bogusław B
Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy Lifestyle With Risk of Coronary Artery Disease.
Jama Network Open
Fahed, Akl C AC; Wang, Minxian M; Patel, Aniruddh P AP; Ajufo, Ezimamaka E; Maamari, Dimitri J DJ; Aragam, Krishna G KG; Brockman, Deanna G DG; Vosburg, Trish T; Ellinor, Patrick T PT; Ng, Kenney K; Khera, Amit V AV
Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond.
Impact of Soy β-Conglycinin Peptides on PCSK9 Protein Expression in HepG2 Cells.
Nutrients
Macchi, Chiara C; Greco, Maria Francesca MF; Ferri, Nicola N; Magni, Paolo P; Arnoldi, Anna A; Corsini, Alberto A; Sirtori, Cesare R CR; Ruscica, Massimiliano M; Lammi, Carmen C
Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State.
Frontiers In Cardiovascular Medicine
Louloudis, Georgios G; Ambrosini, Samuele S; Paneni, Francesco F; Camici, Giovanni G GG; Benke, Dietmar D; Klohs, Jan J
Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits.
Nutrients
Okagu, Innocent U IU; Ndefo, Joseph C JC; Aham, Emmanuel C EC; Obeme-Nmom, Joy I JI; Agboinghale, Precious E PE; Aguchem, Rita N RN; Nechi, Regina N RN; Lammi, Carmen C
Familial Hypercholesterolemia Genetic Variations and Long-Term Cardiovascular Outcomes in Patients with Hypercholesterolemia Who Underwent Coronary Angiography.
Protective lipid-lowering variants in healthy older individuals without coronary heart disease.
Open Heart
Lacaze, Paul P; Riaz, Moeen M; Sebra, Robert R; Hooper, Amanda J AJ; Pang, Jing J; Tiller, Jane J; Polekhina, Galina G; Tonkin, Andrew A; Reid, Chris C; Zoungas, Sophia S; Murray, Anne M AM; Nicholls, Stephen S; Watts, Gerald G; Schadt, Eric E; McNeil, John J JJ
Publication Date: 2021-07
Variant appearance in text: PCSK9: 1120G>T; Asp374Tyr; rs137852912
Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy.
Identification of novel variants in the LDLR gene in Russian patients with familial hypercholesterolemia using targeted sequencing.
Biomedical Reports
Miroshnikova, Valentina V VV; Romanova, Olga V OV; Ivanova, Olga N ON; Fedyakov, Mikhail A MA; Panteleeva, Alexandra A AA; Barbitoff, Yury A YA; Muzalevskaya, Maria V MV; Urazgildeeva, Sorejya A SA; Gurevich, Victor S VS; Urazov, Stanislav P SP; Scherbak, Sergey G SG; Sarana, Andrey M AM; Semenova, Natalia A NA; Anisimova, Inga V IV; Guseva, Darya M DM; Pchelina, Sofya N SN; Glotov, Andrey S AS; Zakharova, Ekaterina Y EY; Glotov, Oleg S OS
Accumulation of Pericardial Fat Is Associated With Alterations in Heart Rate Variability Patterns in Hypercholesterolemic Pigs.
Circulation. Arrhythmia And Electrophysiology
Uceda, Domingo E DE; Zhu, Xiang-Yang XY; Woollard, John R JR; Ferguson, Christopher M CM; Patras, Ioannis I; Carlson, Daniel F DF; Asirvatham, Samuel J SJ; Lerman, Amir A; Lerman, Lilach O LO
A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles.
The Journal Of Biological Chemistry
Sarkar, Samantha K SK; Foo, Alexander C Y ACY; Matyas, Angela A; Asikhia, Ikhuosho I; Kosenko, Tanja T; Goto, Natalie K NK; Vergara-Jaque, Ariela A; Lagace, Thomas A TA
Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
Arteriosclerosis, Thrombosis, And Vascular Biology
Ben Djoudi Ouadda, Ali A; Gauthier, Marie-Soleil MS; Susan-Resiga, Delia D; Girard, Emmanuelle E; Essalmani, Rachid R; Black, Miles M; Marcinkiewicz, Jadwiga J; Forget, Diane D; Hamelin, Josée J; Evagelidis, Alexandra A; Ly, Kevin K; Day, Robert R; Galarneau, Luc L; Corbin, Francois F; Coulombe, Benoit B; Çaku, Artuela A; Tagliabracci, Vincent S VS; Seidah, Nabil G NG
Biodynamics: A novel quasi-first principles theory on the fundamental mechanisms of cellular function/dysfunction and the pharmacological modulation thereof.
Blending Gagne's Instructional Model with Peyton's Approach to Design an Introductory Bioinformatics Lesson Plan for Medical Students: Proof-of-Concept Study.
Jmir Medical Education
Tambi, Richa R; Bayoumi, Riad R; Lansberg, Peter P; Banerjee, Yajnavalka Y
Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.
Journal Of The American Heart Association
Yuan, Fang F; Guo, Liang L; Park, Kyoung-Ha KH; Woollard, John R JR; Taek-Geun, Kwon K; Jiang, Kai K; Melkamu, Tamene T; Zang, Bin B; Smith, Samantha L SL; Fahrenkrug, Scott C SC; Kolodgie, Frank D FD; Lerman, Amir A; Virmani, Renu R; Lerman, Lilach O LO; Carlson, Daniel F DF
Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
The Journal Of Biological Chemistry
Chorba, John S JS; Galvan, Adri M AM; Shokat, Kevan M KM
The Genetic Spectrum of Familial Hypercholesterolemia (FH) in the Iranian Population.
Scientific Reports
Fairoozy, R H RH; Futema, M M; Vakili, R R; Abbaszadegan, M R MR; Hosseini, S S; Aminzadeh, M M; Zaeri, H H; Mobini, M M; Humphries, S E SE; Sahebkar, A A
Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model.
Translational Research : The Journal Of Laboratory And Clinical Medicine
Hedayat, Ahmad F AF; Park, Kyoung-Ha KH; Kwon, Taek-Geun TG; Woollard, John R JR; Jiang, Kai K; Carlson, Daniel F DF; Lerman, Amir A; Lerman, Lilach O LO
Identification and in vitro characterization of two new PCSK9 Gain of Function variants found in patients with Familial Hypercholesterolemia.
Scientific Reports
Di Taranto, Maria Donata MD; Benito-Vicente, Asier A; Giacobbe, Carola C; Uribe, Kepa Belloso KB; Rubba, Paolo P; Etxebarria, Aitor A; Guardamagna, Ornella O; Gentile, Marco M; Martín, Cesar C; Fortunato, Giuliana G
Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9.
Ebiomedicine
Hyrina, Anastasia A; Olmstead, Andrea D AD; Steven, Paul P; Krajden, Mel M; Tam, Edward E; Jean, François F