Publications:

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The Emerging Roles of Intracellular PCSK9 and Their Implications in Endoplasmic Reticulum Stress and Metabolic Diseases.

Metabolites

Lebeau, Paul F PF; Platko, Khrystyna K; Byun, Jae Hyun JH; Makda, Yumna Y; Austin, Richard C RC

Publication Date: 2022-02-26

Variant appearance in text: PCSK9: R434W

PubMed Link: 35323658

Variant Present in the following documents:

• metabolites-12-00215.pdf

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PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology.

Biomedicines

Sundararaman, Sai Sahana SS; Döring, Yvonne Y; van der Vorst, Emiel P C EPC

Publication Date: 2021-07-08

Variant appearance in text: PCSK9: R434W

PubMed Link: 34356856

Variant Present in the following documents:

• Main text
• biomedicines-09-00793.pdf

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Protective lipid-lowering variants in healthy older individuals without coronary heart disease.

Open Heart

Lacaze, Paul P; Riaz, Moeen M; Sebra, Robert R; Hooper, Amanda J AJ; Pang, Jing J; Tiller, Jane J; Polekhina, Galina G; Tonkin, Andrew A; Reid, Chris C; Zoungas, Sophia S; Murray, Anne M AM; Nicholls, Stephen S; Watts, Gerald G; Schadt, Eric E; McNeil, John J JJ

Publication Date: 2021-07

Variant appearance in text: PCSK9: 1300C>T; Arg434Trp; rs757143429

PubMed Link: 34341098

Variant Present in the following documents:

• Main text
• openhrt-2021-001710supp001.xlsx
• openhrt-2021-001710.pdf

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Development of a novel, fully human, anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy.

Ebiomedicine

Xu, Menglong M; Lei, Gaoxin G; Chen, Manman M; Wang, Ke K; Lv, Wenxiu W; Zhang, Panpan P; Hu, Tuo T; Gao, Jie J; Lu, Chenchen C; Mei, Ying Y; Xu, Zhipan Z; Bai, Zhengli Z; Hu, Huajing H; Jiang, Yiwei Y; Tan, Shuhua S

Publication Date: 2021-03

Variant appearance in text: PCSK9: R434W

PubMed Link: 33647772

Variant Present in the following documents:

• Main text
• main.pdf

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Pathway Mutations in Breast Cancer Using Whole-Exome Sequencing.

Oncology Research

Chang, Ya-Sian YS; Chang, Chieh-Min CM; Lin, Chien-Yu CY; Chao, Dy-San DS; Huang, Hsi-Yuan HY; Chang, Jan-Gowth JG

Publication Date: 2020-03-27

Variant appearance in text: PCSK9: R434W; rs757143429

PubMed Link: 31575382

Variant Present in the following documents:

• Main text

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Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain.

Plos One

Poirier, Steve S; Hamouda, Hocine Ait HA; Villeneuve, Louis L; Demers, Annie A; Mayer, Gaétan G

Publication Date: 2016

Variant appearance in text: PCSK9: R434W

PubMed Link: 27280970

Variant Present in the following documents:

• Main text

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Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9.

The Journal Of Biological Chemistry

Le, Quoc-Tuan QT; Blanchet, Matthieu M; Seidah, Nabil G NG; Labonté, Patrick P

Publication Date: 2015-09-18

Variant appearance in text: PCSK9: R434W

PubMed Link: 26195630

Variant Present in the following documents:

• Main text

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Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research

Han, Dengfeng D; Ma, Jianhua J; Zhang, Xiaoning X; Cai, Jian J; Li, Jinlan J; Tuerxun, Tuerhong T; Hao, Chenguang C; Du, Lei L; Lei, Jing J

Publication Date: 2014-09-30

Variant appearance in text: PCSK9: R434W

PubMed Link: 25266949

Variant Present in the following documents:

• Main text

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Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.

The Journal Of Biological Chemistry

Ly, Kévin K; Saavedra, Yascara Grisel Luna YG; Canuel, Maryssa M; Routhier, Sophie S; Desjardins, Roxane R; Hamelin, Josée J; Mayne, Janice J; Lazure, Claude C; Seidah, Nabil G NG; Day, Robert R

Publication Date: 2014-06-20

Variant appearance in text: PCSK9: R434W

PubMed Link: 24808179

Variant Present in the following documents:

• Main text

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The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.

The Journal Of Biological Chemistry

Saavedra, Yascara Grisel Luna YG; Day, Robert R; Seidah, Nabil G NG

Publication Date: 2012-12-21

Variant appearance in text: PCSK9: R434W

PubMed Link: 23105118

Variant Present in the following documents:

• Main text

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PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.

Journal Of Lipid Research

Rousselet, Estelle E; Marcinkiewicz, Jadwiga J; Kriz, Jasna J; Zhou, Ann A; Hatten, Mary E ME; Prat, Annik A; Seidah, Nabil G NG

Publication Date: 2011-07

Variant appearance in text: PCSK9: R434W

PubMed Link: 21518694

Variant Present in the following documents:

• Main text

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Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels.

Transactions Of The American Clinical And Climatological Association

Davignon, Jean J; Dubuc, Geneviève G

Publication Date: 2009

Variant appearance in text: PCSK9: R434W

PubMed Link: 19768174

Variant Present in the following documents:

• Main text

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A new method for measurement of total plasma PCSK9: clinical applications.

Journal Of Lipid Research

Dubuc, Geneviève G; Tremblay, Michel M; Paré, Guillaume G; Jacques, Hélène H; Hamelin, Josée J; Benjannet, Suzanne S; Boulet, Lucie L; Genest, Jacques J; Bernier, Lise L; Seidah, Nabil G NG; Davignon, Jean J

Publication Date: 2010-01

Variant appearance in text: PCSK9: R434W

PubMed Link: 19571328

Variant Present in the following documents:

• Main text

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