Publications:

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The Emerging Roles of Intracellular PCSK9 and Their Implications in Endoplasmic Reticulum Stress and Metabolic Diseases.

Metabolites

Lebeau, Paul F PF; Platko, Khrystyna K; Byun, Jae Hyun JH; Makda, Yumna Y; Austin, Richard C RC

Publication Date: 2022-02-26

Variant appearance in text: PCSK9: S462P

PubMed Link: 35323658

Variant Present in the following documents:

• Main text
• metabolites-12-00215.pdf

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PCSK9 as a Target for Development of a New Generation of Hypolipidemic Drugs.

Molecules (Basel, Switzerland)

Kuzmich, Nikolay N; Andresyuk, Elena E; Porozov, Yuri Y; Tarasov, Vadim V; Samsonov, Mikhail M; Preferanskaya, Nina N; Veselov, Valery V; Alyautdin, Renad R

Publication Date: 2022-01-10

Variant appearance in text: PCSK9: S462P

PubMed Link: 35056760

Variant Present in the following documents:

• molecules-27-00434.pdf

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PCSK9 as a Target for Development of a New Generation of Hypolipidemic Drugs.

Molecules (Basel, Switzerland)

Kuzmich, Nikolay N; Andresyuk, Elena E; Porozov, Yuri Y; Tarasov, Vadim V; Samsonov, Mikhail M; Preferanskaya, Nina N; Veselov, Valery V; Alyautdin, Renad R

Publication Date: 2022-01-10

Variant appearance in text: PCSK9: S462P

PubMed Link: 35056760

Variant Present in the following documents:

• molecules-27-00434.pdf

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Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications.

Frontiers In Cardiovascular Medicine

Xia, Xiao-Dan XD; Peng, Zhong-Sheng ZS; Gu, Hong-Mei HM; Wang, Maggie M; Wang, Gui-Qing GQ; Zhang, Da-Wei DW

Publication Date: 2021

Variant appearance in text: PCSK9: S462P

PubMed Link: 34782856

Variant Present in the following documents:

• Main text
• fcvm-08-764038.pdf

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Protective lipid-lowering variants in healthy older individuals without coronary heart disease.

Open Heart

Lacaze, Paul P; Riaz, Moeen M; Sebra, Robert R; Hooper, Amanda J AJ; Pang, Jing J; Tiller, Jane J; Polekhina, Galina G; Tonkin, Andrew A; Reid, Chris C; Zoungas, Sophia S; Murray, Anne M AM; Nicholls, Stephen S; Watts, Gerald G; Schadt, Eric E; McNeil, John J JJ

Publication Date: 2021-07

Variant appearance in text: PCSK9: 1384T>C; Ser462Pro; rs746115963

PubMed Link: 34341098

Variant Present in the following documents:

• Main text
• openhrt-2021-001710.pdf
• openhrt-2021-001710supp001.xlsx, sheet 1

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Construction of point mutation rabbits using CRISPR/Cas9.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal Of Zhejiang University. Medical Sciences

Yan, Kunning K; Zhang, Ting T; Zha, Yiwen Y; Liang, Jingyan J; Cheng, Yong Y

Publication Date: 2021-04-25

Variant appearance in text: PCSK9: S462P

PubMed Link: 34137224

Variant Present in the following documents:

• Main text

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PCSK9 Biology and Its Role in Atherothrombosis.

International Journal Of Molecular Sciences

Barale, Cristina C; Melchionda, Elena E; Morotti, Alessandro A; Russo, Isabella I

Publication Date: 2021-05-30

Variant appearance in text: PCSK9: S462P

PubMed Link: 34070931

Variant Present in the following documents:

• Main text
• ijms-22-05880.pdf

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PCSK9 Variants in Familial Hypercholesterolemia: A Comprehensive Synopsis.

Frontiers In Genetics

Guo, Qianyun Q; Feng, Xunxun X; Zhou, Yujie Y

Publication Date: 2020

Variant appearance in text: PCSK9: S462P

PubMed Link: 33173529

Variant Present in the following documents:

• Main text
• fgene-11-01020.pdf

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PCSK9: From Basic Science Discoveries to Clinical Trials.

Circulation Research

Shapiro, Michael D MD; Tavori, Hagai H; Fazio, Sergio S

Publication Date: 2018-05-11

Variant appearance in text: PCSK9: S462P

PubMed Link: 29748367

Variant Present in the following documents:

• Main text

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Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice.

Plos One

Kawakami, Ryo R; Nozato, Yoichi Y; Nakagami, Hironori H; Ikeda, Yuka Y; Shimamura, Munehisa M; Yoshida, Shota S; Sun, Jiao J; Kawano, Tomohiro T; Takami, Yoichi Y; Noma, Takahisa T; Rakugi, Hiromi H; Minamino, Tetsuo T; Morishita, Ryuichi R

Publication Date: 2018

Variant appearance in text: PCSK9: S462P

PubMed Link: 29438441

Variant Present in the following documents:

• Main text
• pone.0191895.pdf

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Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.

The Journal Of Biological Chemistry

Chorba, John S JS; Galvan, Adri M AM; Shokat, Kevan M KM

Publication Date: 2018-02-09

Variant appearance in text: PCSK9: S462P

PubMed Link: 29259136

Variant Present in the following documents:

• Main text

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Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9.

The Journal Of Biological Chemistry

Le, Quoc-Tuan QT; Blanchet, Matthieu M; Seidah, Nabil G NG; Labonté, Patrick P

Publication Date: 2015-09-18

Variant appearance in text: PCSK9: S462P

PubMed Link: 26195630

Variant Present in the following documents:

• Main text

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Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9).

Basic Research In Cardiology

Schulz, Rainer R; Schlüter, Klaus-Dieter KD; Laufs, Ulrich U

Publication Date: 2015-03

Variant appearance in text: PCSK9: S462P

PubMed Link: 25600226

Variant Present in the following documents:

• Main text
• 395_2015_Article_463.pdf

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Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases.

Scientifica

Ferri, Nicola N

Publication Date: 2012

Variant appearance in text: PCSK9: S462P

PubMed Link: 24278757

Variant Present in the following documents:

• SCIENTIFICA2012-927352.pdf

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The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.

The Journal Of Biological Chemistry

Saavedra, Yascara Grisel Luna YG; Day, Robert R; Seidah, Nabil G NG

Publication Date: 2012-12-21

Variant appearance in text: PCSK9: S462P

PubMed Link: 23105118

Variant Present in the following documents:

• Main text

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A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.

The Journal Of Biological Chemistry

Ni, Yan G YG; Condra, Jon H JH; Orsatti, Laura L; Shen, Xun X; Di Marco, Stefania S; Pandit, Shilpa S; Bottomley, Matthew J MJ; Ruggeri, Lionello L; Cummings, Richard T RT; Cubbon, Rose M RM; Santoro, Joseph C JC; Ehrhardt, Anka A; Lewis, Dale D; Fisher, Timothy S TS; Ha, Sookhee S; Njimoluh, Leila L; Wood, Dana D DD; Hammond, Holly A HA; Wisniewski, Douglas D; Volpari, Cinzia C; Noto, Alessia A; Lo Surdo, Paola P; Hubbard, Brian B; Carfí, Andrea A; Sitlani, Ayesha A

Publication Date: 2010-04-23

Variant appearance in text: PCSK9: S462P

PubMed Link: 20172854

Variant Present in the following documents:

• Main text

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