Publications:

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles.

The Journal Of Biological Chemistry

Sarkar, Samantha K SK; Foo, Alexander C Y ACY; Matyas, Angela A; Asikhia, Ikhuosho I; Kosenko, Tanja T; Goto, Natalie K NK; Vergara-Jaque, Ariela A; Lagace, Thomas A TA

Publication Date: 2020-02-21

Variant appearance in text: PCSK9: F515L

PubMed Link: 31949048

Variant Present in the following documents:

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The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.

The Journal Of Biological Chemistry

Saavedra, Yascara Grisel Luna YG; Day, Robert R; Seidah, Nabil G NG

Publication Date: 2012-12-21

Variant appearance in text: PCSK9: F515L

PubMed Link: 23105118

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Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.

Plos One

Ding, Keyue K; McDonough, Samantha J SJ; Kullo, Iftikhar J IJ

Publication Date: 2007-10-31

Variant appearance in text: PCSK9: F515L

PubMed Link: 17971861

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The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hampton, Eric N EN; Knuth, Mark W MW; Li, Jun J; Harris, Jennifer L JL; Lesley, Scott A SA; Spraggon, Glen G

Publication Date: 2007-09-11

Variant appearance in text: PCSK9: F515L

PubMed Link: 17804797

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

American Journal Of Human Genetics

Kotowski, Ingrid K IK; Pertsemlidis, Alexander A; Luke, Amy A; Cooper, Richard S RS; Vega, Gloria L GL; Cohen, Jonathan C JC; Hobbs, Helen H HH

Publication Date: 2006-03

Variant appearance in text:

PubMed Link: 16465619

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