Publications:

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BDNF-dependent modulation of axonal transport is selectively impaired in ALS.

Acta Neuropathologica Communications

Tosolini, Andrew P AP; Sleigh, James N JN; Surana, Sunaina S; Rhymes, Elena R ER; Cahalan, Stephen D SD; Schiavo, Giampietro G

Publication Date: 2022-08-22

Variant appearance in text: RET: G93A

PubMed Link: 35996201

Variant Present in the following documents:

• Main text
• 40478_2022_Article_1418.pdf

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Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.

Cell Death & Disease

Rhymes, Elena R ER; Tosolini, Andrew P AP; Fellows, Alexander D AD; Mahy, William W; McDonald, Neil Q NQ; Schiavo, Giampietro G

Publication Date: 2022-07-07

Variant appearance in text: RET: G93A

PubMed Link: 35798698

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• Main text
• 41419_2022_Article_5031.pdf

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Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells.

Molecular Neurodegeneration

Li, Qian Q; Feng, Yi Y; Xue, Yingchao Y; Zhan, Xiping X; Fu, Yi Y; Gui, Gege G; Zhou, Weiqiang W; Richard, Jean-Philippe JP; Taga, Arens A; Li, Pan P; Mao, Xiaobo X; Maragakis, Nicholas J NJ; Ying, Mingyao M

Publication Date: 2022-01-10

Variant appearance in text: RET: G93A

PubMed Link: 35012575

Variant Present in the following documents:

• Main text

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Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells.

Molecular Neurodegeneration

Li, Qian Q; Feng, Yi Y; Xue, Yingchao Y; Zhan, Xiping X; Fu, Yi Y; Gui, Gege G; Zhou, Weiqiang W; Richard, Jean-Philippe JP; Taga, Arens A; Li, Pan P; Mao, Xiaobo X; Maragakis, Nicholas J NJ; Ying, Mingyao M

Publication Date: 2022-01-10

Variant appearance in text: RET: G93A

PubMed Link: 35012575

Variant Present in the following documents:

• Main text

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Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.

International Journal Of Molecular Sciences

Delgado-Minjares, Karen M KM; Martinez-Fong, Daniel D; Martínez-Dávila, Irma A IA; Bañuelos, Cecilia C; Gutierrez-Castillo, M E ME; Blanco-Alvarez, Víctor Manuel VM; Cardenas-Aguayo, Maria-Del-Carmen MD; Luna-Muñoz, José J; Pacheco-Herrero, Mar M; Soto-Rojas, Luis O LO

Publication Date: 2021-10-28

Variant appearance in text: RET: G93A

PubMed Link: 34769132

Variant Present in the following documents:

• Main text

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Evidence-Based Research Strategy of Traditional Chinese Medicine for Amyotrophic Lateral Sclerosis.

Evidence-Based Complementary And Alternative Medicine : Ecam

Pan, Hao H; Wang, Heng H; Tao, Yanlin Y; Yuan, Jinfeng J; Xu, Sanbin S; Ni, Jianli J; Huang, Meiqin M; Wu, Xiaojun X; Liu, Te T

Publication Date: 2021

Variant appearance in text: RET: G93A

PubMed Link: 34512775

Variant Present in the following documents:

• Main text

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GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries.

Neural Regeneration Research

Cintron-Colon, Alberto F AF; Almeida-Alves, Gabriel G; VanGyseghem, Juliana M JM; Spitsbergen, John M JM

Publication Date: 2022-04

Variant appearance in text: RET: G93A

PubMed Link: 34472460

Variant Present in the following documents:

• NRR-17-748.pdf

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Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases.

International Journal Of Molecular Sciences

Nam, Youngpyo Y; Moon, Gyeong Joon GJ; Kim, Sang Ryong SR

Publication Date: 2021-03-17

Variant appearance in text: RET: G93A

PubMed Link: 33802760

Variant Present in the following documents:

• Main text
• ijms-22-03064.pdf

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NURR1 Alterations in Perinatal Stress: A First Step towards Late-Onset Diseases? A Narrative Review.

Biomedicines

Bordoni, Laura L; Petracci, Irene I; Calleja-Agius, Jean J; Lalor, Joan G JG; Gabbianelli, Rosita R

Publication Date: 2020-12-08

Variant appearance in text: RET: G93A

PubMed Link: 33302583

Variant Present in the following documents:

• Main text
• biomedicines-08-00584.pdf

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Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration.

International Journal Of Molecular Sciences

Sidorova, Yulia A YA; Saarma, Mart M

Publication Date: 2020-09-08

Variant appearance in text: RET: G93A

PubMed Link: 32911810

Variant Present in the following documents:

• ijms-21-06575.pdf

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GDNF synthesis, signaling, and retrograde transport in motor neurons.

Cell And Tissue Research

Cintrón-Colón, Alberto F AF; Almeida-Alves, Gabriel G; Boynton, Alicia M AM; Spitsbergen, John M JM

Publication Date: 2020-10

Variant appearance in text: RET: G93A

PubMed Link: 32897420

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• Main text

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Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration.

Frontiers In Cellular Neuroscience

Saragovi, Horacio Uri HU; Galan, Alba A; Levin, Leonard A LA

Publication Date: 2019

Variant appearance in text: RET: G93A

PubMed Link: 31244606

Variant Present in the following documents:

• fncel-13-00231.pdf

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Mitochondrial Targeting in Neurodegeneration: A Heme Perspective.

Pharmaceuticals (Basel, Switzerland)

Fiorito, Veronica V; Chiabrando, Deborah D; Tolosano, Emanuela E

Publication Date: 2018-09-18

Variant appearance in text: RET: G93A

PubMed Link: 30231533

Variant Present in the following documents:

• pharmaceuticals-11-00087.pdf

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Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS.

Cell Death & Disease

Gibbs, Katherine L KL; Kalmar, Bernadett B; Rhymes, Elena R ER; Fellows, Alexander D AD; Ahmed, Mahmood M; Whiting, Paul P; Davies, Ceri H CH; Greensmith, Linda L; Schiavo, Giampietro G

Publication Date: 2018-05-22

Variant appearance in text: RET: G93A

PubMed Link: 29789529

Variant Present in the following documents:

• 41419_2018_624_MOESM1_ESM.pdf

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Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects.

Gene Therapy

Thomsen, G M GM; Alkaslasi, M M; Vit, J-P JP; Lawless, G G; Godoy, M M; Gowing, G G; Shelest, O O; Svendsen, C N CN

Publication Date: 2017-04

Variant appearance in text: RET: G93A

PubMed Link: 28276446

Variant Present in the following documents:

• gt20179a.pdf

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Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau.

Journal Of Alzheimer'S Disease : Jad

Hensley, Kenneth K; Kursula, Petri P

Publication Date: 2016-04-15

Variant appearance in text: RET: G93A

PubMed Link: 27079722

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The recent understanding of the neurotrophin's role in skeletal muscle adaptation.

Journal Of Biomedicine & Biotechnology

Sakuma, Kunihiro K; Yamaguchi, Akihiko A

Publication Date: 2011

Variant appearance in text: RET: G93A

PubMed Link: 21960735

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• Main text

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Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS.

Laboratory Investigation; A Journal Of Technical Methods And Pathology

Ryu, Hoon H; Jeon, Gye Sun GS; Cashman, Neil R NR; Kowall, Neil W NW; Lee, Junghee J

Publication Date: 2011-03

Variant appearance in text: RET: G93A

PubMed Link: 21283077

Variant Present in the following documents:

• nihms248958.pdf

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