RET c.2188C>G ;(p.L730V)

Variant ID: 10-43612083-C-G

NM_020975.4(RET):c.2188C>G;(p.L730V)

This variant was identified in 14 publications

View GRCh38 version.




Publications:


Precious Gene: The Application of RET-Altered Inhibitors.

Molecules (Basel, Switzerland)
Gou, Qitao Q; Gan, Xiaochuan X; Li, Longhao L; Gou, Qiheng Q; Zhang, Tao T
Publication Date: 2022-12-13

Variant appearance in text: RET: L730V
PubMed Link: 36557971
Variant Present in the following documents:
  • molecules-27-08839.pdf
View BVdb publication page



Integrated proteogenomic characterization of medullary thyroid carcinoma.

Cell Discovery
Shi, Xiao X; Sun, Yaoting Y; Shen, Cenkai C; Zhang, Yan Y; Shi, Rongliang R; Zhang, Fan F; Liao, Tian T; Lv, Guojun G; Zhu, Zhengcai Z; Jiao, Lianghe L; Li, Peng P; Xu, Tiansheng T; Qu, Ning N; Huang, Naisi N; Hu, Jiaqian J; Zhang, Tingting T; Gu, Yanzi Y; Qin, Guangqi G; Guan, Haixia H; Pu, Weilin W; Li, Yuan Y; Geng, Xiang X; Zhang, Yan Y; Chen, Tongzhen T; Huang, Shenglin S; Zhang, Zhikang Z; Ge, Shuting S; Wang, Wu W; Xu, Weibo W; Yu, Pengcheng P; Lu, Zhongwu Z; Wang, Yulong Y; Guo, Liang L; Wang, Yu Y; Guo, Tiannan T; Ji, Qinghai Q; Wei, Wenjun W
Publication Date: 2022-11-08

Variant appearance in text: RET: L730V
PubMed Link: 36344509
Variant Present in the following documents:
  • 41421_2022_Article_479.pdf
View BVdb publication page



Precision oncology for RET-related tumors.

Frontiers In Oncology
Verrienti, Antonella A; Grani, Giorgio G; Sponziello, Marialuisa M; Pecce, Valeria V; Damante, Giuseppe G; Durante, Cosimo C; Russo, Diego D; Filetti, Sebastiano S
Publication Date: 2022

Variant appearance in text: RET: L730V
PubMed Link: 36091144
Variant Present in the following documents:
  • Main text
  • fonc-12-992636.pdf
View BVdb publication page



Prognostic value of baseline genetic features and newly identified TP53 mutations in advanced breast cancer.

Molecular Oncology
Zhang, Lanxin L; Sun, Siwen S; Zhao, Xiaotian X; Liu, Jingwen J; Xu, Yang Y; Xu, Lingzhi L; Song, Chen C; Li, Na N; Yu, Jing J; Zhao, Shanshan S; Yu, Peiyao P; Fang, Fengqi F; Xie, Jiping J; Ji, Xuening X; Yu, Ruoying R; Ou, Qiuxiang Q; Zhao, Zuowei Z; Li, Man M
Publication Date: 2022-10

Variant appearance in text: RET: 2188C>G; L730V
PubMed Link: 35971249
Variant Present in the following documents:
  • MOL2-16-3689-s005.xlsx, sheet 1
View BVdb publication page



RET signaling pathway and RET inhibitors in human cancer.

Frontiers In Oncology
Regua, Angelina T AT; Najjar, Mariana M; Lo, Hui-Wen HW
Publication Date: 2022

Variant appearance in text: RET: L730v
PubMed Link: 35957881
Variant Present in the following documents:
  • Main text
  • fonc-12-932353.pdf
View BVdb publication page



Non-small-cell lung cancer: how to manage RET-positive disease.

Drugs In Context
Andrini, Elisa E; Mosca, Mirta M; Galvani, Linda L; Sperandi, Francesca F; Ricciuti, Biagio B; Metro, Giulio G; Lamberti, Giuseppe G
Publication Date: 2022

Variant appearance in text: RET: L730V
PubMed Link: 35912003
Variant Present in the following documents:
  • dic-2022-1-5.pdf
View BVdb publication page



Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.

Journal Of Advanced Research
Shehata, Moustafa A MA; Contreras, Julia J; Martín-Hurtado, Ana A; Froux, Aurane A; Mohamed, Hossam Taha HT; El-Sherif, Ahmed A AA; Plaza-Menacho, Iván I
Publication Date: 2022-05-17

Variant appearance in text: RET: L730V
PubMed Link: 35595215
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Novel Inhibitor-Based Therapies for Thyroid Cancer-An Update.

International Journal Of Molecular Sciences
Ratajczak, Maciej M; Gaweł, Damian D; Godlewska, Marlena M
Publication Date: 2021-10-31

Variant appearance in text: RET: L730V
PubMed Link: 34769260
Variant Present in the following documents:
  • Main text
  • ijms-22-11829.pdf
View BVdb publication page



Precision therapy for RET-altered cancers with RET inhibitors.

Trends In Cancer
Thein, Kyaw Z KZ; Velcheti, Vamsidhar V; Mooers, Blaine H M BHM; Wu, Jie J; Subbiah, Vivek V
Publication Date: 2021-12

Variant appearance in text: RET: L730V
PubMed Link: 34391699
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.

Scientific Reports
Moccia, Marialuisa M; Yang, Donglin D; Lakkaniga, Naga Rajiv NR; Frett, Brendan B; McConnell, Nicholas N; Zhang, Lingtian L; Brescia, Annalisa A; Federico, Giorgia G; Zhang, Lingzhi L; Salerno, Paolo P; Santoro, Massimo M; Li, Hong-Yu HY; Carlomagno, Francesca F
Publication Date: 2021-08-09

Variant appearance in text: RET: L730V
PubMed Link: 34373541
Variant Present in the following documents:
  • 41598_2021_Article_95612.pdf
View BVdb publication page



The L730V/I RET roof mutations display different activities toward pralsetinib and selpercatinib.

Npj Precision Oncology
Shen, Tao T; Hu, Xueqing X; Liu, Xuan X; Subbiah, Vivek V; Mooers, Blaine H M BHM; Wu, Jie J
Publication Date: 2021-06-07

Variant appearance in text: RET: L730V
PubMed Link: 34099825
Variant Present in the following documents:
  • Main text
  • 41698_2021_Article_188.pdf
  • 41698_2021_188_MOESM1_ESM.pdf
View BVdb publication page



Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports
Šimčíková, Daniela D; Heneberg, Petr P
Publication Date: 2019-12-09

Variant appearance in text: RET: L730V
PubMed Link: 31819097
Variant Present in the following documents:
  • 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8
View BVdb publication page



Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.

The Journal Of Biological Chemistry
Terzyan, Simon S SS; Shen, Tao T; Liu, Xuan X; Huang, Qingling Q; Teng, Peng P; Zhou, Mi M; Hilberg, Frank F; Cai, Jianfeng J; Mooers, Blaine H M BHM; Wu, Jie J
Publication Date: 2019-07-05

Variant appearance in text: RET: L730V
PubMed Link: 31118272
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drug resistance profiles of mutations in the RET kinase domain.

British Journal Of Pharmacology
Liu, Xuan X; Shen, Tao T; Mooers, Blaine H M BHM; Hilberg, Frank F; Wu, Jie J
Publication Date: 2018-09

Variant appearance in text: RET: L730V
PubMed Link: 29908090
Variant Present in the following documents:
  • Main text
View BVdb publication page