Publications:

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Brain-restricted mTOR inhibition with binary pharmacology.

Nature

Zhang, Ziyang Z; Fan, Qiwen Q; Luo, Xujun X; Lou, Kevin K; Weiss, William A WA; Shokat, Kevan M KM

Publication Date: 2022-09

Variant appearance in text: RET: D842V

PubMed Link: 36104566

Variant Present in the following documents:

• 41586_2022_5213_MOESM3_ESM.xlsx, sheet 1

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: RET: Asp842Val

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

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Clinical and Molecular Characteristics of Rare Malignant Tumors of Colon and Rectum.

Biology

Ottaiano, Alessandro A; Santorsola, Mariachiara M; Perri, Francesco F; Pace, Ugo U; Marra, Bruno B; Correra, Marco M; Sabbatino, Francesco F; Cascella, Marco M; Petrillo, Nadia N; Ianniello, Monica M; Casillo, Marika M; Misso, Gabriella G; Delrio, Paolo P; Caraglia, Michele M; Nasti, Guglielmo G

Publication Date: 2022-02-08

Variant appearance in text: RET: D842V

PubMed Link: 35205133

Variant Present in the following documents:

• Main text

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Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy.

Medicinal Chemistry Research : An International Journal For Rapid Communications On Design And Mechanisms Of Action Of Biologically Active Agents

Singh, Sarbjit S; Utreja, Divya D; Kumar, Vimal V

Publication Date: 2022

Variant appearance in text: RET: D842V

PubMed Link: 34803342

Variant Present in the following documents:

• Main text
• 44_2021_Article_2819.pdf

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Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy.

Medicinal Chemistry Research : An International Journal For Rapid Communications On Design And Mechanisms Of Action Of Biologically Active Agents

Singh, Sarbjit S; Utreja, Divya D; Kumar, Vimal V

Publication Date: 2021-11-13

Variant appearance in text: RET: D842V

PubMed Link: 34803342

Variant Present in the following documents:

• Main text
• 44_2021_Article_2819.pdf

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Therapeutic Actionability of Circulating Cell-Free DNA Alterations in Carcinoma of Unknown Primary.

Jco Precision Oncology

Kato, Shumei S; Weipert, Caroline C; Gumas, Sophia S; Okamura, Ryosuke R; Lee, Suzanna S; Sicklick, Jason K JK; Saam, Jennifer J; Kurzrock, Razelle R

Publication Date: 2021

Variant appearance in text: RET: D842V

PubMed Link: 34778692

Variant Present in the following documents:

• po-5-po.21.00011.pdf

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Therapeutic Actionability of Circulating Cell-Free DNA Alterations in Carcinoma of Unknown Primary.

Jco Precision Oncology

Kato, Shumei S; Weipert, Caroline C; Gumas, Sophia S; Okamura, Ryosuke R; Lee, Suzanna S; Sicklick, Jason K JK; Saam, Jennifer J; Kurzrock, Razelle R

Publication Date: 2021

Variant appearance in text: RET: D842V

PubMed Link: 34778692

Variant Present in the following documents:

• po-5-po.21.00011.pdf

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Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.

Signal Transduction And Targeted Therapy

Zhong, Lei L; Li, Yueshan Y; Xiong, Liang L; Wang, Wenjing W; Wu, Ming M; Yuan, Ting T; Yang, Wei W; Tian, Chenyu C; Miao, Zhuang Z; Wang, Tianqi T; Yang, Shengyong S

Publication Date: 2021-05-31

Variant appearance in text: RET: D842V

PubMed Link: 34054126

Variant Present in the following documents:

• Main text
• 41392_2021_Article_572.pdf

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Clinical Potential of Kinase Inhibitors in Combination with Immune Checkpoint Inhibitors for the Treatment of Solid Tumors.

International Journal Of Molecular Sciences

Ahn, Ryuhjin R; Ursini-Siegel, Josie J

Publication Date: 2021-03-05

Variant appearance in text: RET: D842V

PubMed Link: 33807608

Variant Present in the following documents:

• ijms-22-02608-s001.pdf

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Druggable targets meet oncogenic drivers: opportunities and limitations of target-based classification of tumors and the role of Molecular Tumor Boards.

Esmo Open

Danesi, R R; Fogli, S S; Indraccolo, S S; Del Re, M M; Dei Tos, A P AP; Leoncini, L L; Antonuzzo, L L; Bonanno, L L; Guarneri, V V; Pierini, A A; Amunni, G G; Conte, P P

Publication Date: 2021-04

Variant appearance in text: RET: D842V

PubMed Link: 33540286

Variant Present in the following documents:

• Main text

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A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC).

Ebiomedicine

Low, Joo-Leng JL; Lau, Dawn Pingxi DP; Zhang, Xiaoqian X; Kwang, Xue-Lin XL; Rohatgi, Neha N; Chan, Jane Vin JV; Chong, Fui-Teen FT; Wong, Stephen Qi Rong SQR; Leong, Hui-Sun HS; Thangavelu, Matan Thangavelu MT; Rikka, Shivaji S; Skanderup, Anders Martin Jacobsen AMJ; Tan, Daniel Shao Weng DSW; Periyasamy, Giridharan G; Koh, Judice Lie Yong JLY; Iyer, N Gopalakrishna NG; DasGupta, Ramanuj R

Publication Date: 2021-02

Variant appearance in text: RET: D842V

PubMed Link: 33529999

Variant Present in the following documents:

• mmc2.xlsx, sheet 8

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Refreshing the biologic pipeline 2020.

Nature Biotechnology

Hodgson, John J

Publication Date: 2021-02

Variant appearance in text: RET: D842V

PubMed Link: 33510484

Variant Present in the following documents:

• 41587_2021_Article_814.pdf

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Tyrosine Kinase Receptors in Oncology.

International Journal Of Molecular Sciences

Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J

Publication Date: 2020-11-12

Variant appearance in text: RET: D842V

PubMed Link: 33198314

Variant Present in the following documents:

• ijms-21-08529.pdf

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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

The Journal Of Clinical Investigation

Willoughby, Catherine E CE; Jiang, Yanyan Y; Thomas, Huw D HD; Willmore, Elaine E; Kyle, Suzanne S; Wittner, Anita A; Phillips, Nicole N; Zhao, Yan Y; Tudhope, Susan J SJ; Prendergast, Lisa L; Junge, Gesa G; Lourenco, Luiza Madia LM; Finlay, M Raymond V MRV; Turner, Paul P; Munck, Joanne M JM; Griffin, Roger J RJ; Rennison, Tommy T; Pickles, James J; Cano, Celine C; Newell, David R DR; Reeves, Helen L HL; Ryan, Anderson J AJ; Wedge, Stephen R SR

Publication Date: 2020-01-02

Variant appearance in text: RET: D842V

PubMed Link: 31581151

Variant Present in the following documents:

• jci-130-127483-s144.pdf

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Multilaboratory Assessment of a New Reference Material for Quality Assurance of Cell-Free Tumor DNA Measurements.

The Journal Of Molecular Diagnostics : Jmd

He, Hua-Jun HJ; Stein, Erica V EV; Konigshofer, Yves Y; Forbes, Thomas T; Tomson, Farol L FL; Garlick, Russell R; Yamada, Emiko E; Godfrey, Tony T; Abe, Toshiya T; Tamura, Koji K; Borges, Michael M; Goggins, Michael M; Elmore, Sandra S; Gulley, Margaret L ML; Larson, Jessica L JL; Ringel, Lando L; Haynes, Brian C BC; Karlovich, Chris C; Williams, P Mickey PM; Garnett, Aaron A; Ståhlberg, Anders A; Filges, Stefan S; Sorbara, Lynn L; Young, Mathew R MR; Srivastava, Sudhir S; Cole, Kenneth D KD

Publication Date: 2019-07

Variant appearance in text: RET: 2525A>T; D842V

PubMed Link: 31055023

Variant Present in the following documents:

• main.pdf

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Computational algorithms for in silico profiling of activating mutations in cancer.

Cellular And Molecular Life Sciences : Cmls

Jordan, E Joseph EJ; Patil, Keshav K; Suresh, Krishna K; Park, Jin H JH; Mosse, Yael P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2019-07

Variant appearance in text: RET: D842V

PubMed Link: 30982079

Variant Present in the following documents:

• Main text

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Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia.

Cancers

Musumeci, Francesca F; Greco, Chiara C; Grossi, Giancarlo G; Molinari, Alessio A; Schenone, Silvia S

Publication Date: 2018-11-09

Variant appearance in text: RET: D842V

PubMed Link: 30423915

Variant Present in the following documents:

• Main text
• cancers-10-00430.pdf

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RTK-RAS pathway mutation is enriched in myeloid sarcoma.

Blood Cancer Journal

Choi, Mihong M; Jeon, Yoon Kyung YK; Sun, Choong-Hyun CH; Yun, Hong-Seok HS; Hong, Junshik J; Shin, Dong-Yeop DY; Kim, Inho I; Yoon, Sung-Soo SS; Koh, Youngil Y

Publication Date: 2018-05-23

Variant appearance in text: RET: D842V

PubMed Link: 29789584

Variant Present in the following documents:

• 41408_2018_Article_83.pdf

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Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.

Cell Death & Disease

Zhou, Qing Q; Eldakhakhny, Sahar S; Conforti, Franco F; Crosbie, Emma J EJ; Melino, Gerry G; Sayan, Berna S BS

Publication Date: 2018-05-01

Variant appearance in text: RET: D842V

PubMed Link: 29724995

Variant Present in the following documents:

• 41419_2018_521_MOESM3_ESM.xlsx, sheet 1

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Evidence for dispensability of protein kinase R in host control of tuberculosis.

European Journal Of Immunology

Mundhra, Shashirekha S; Bryk, Ruslana R; Hawryluk, Natalie N; Zhang, Tuo T; Jiang, Xiuju X; Nathan, Carl F CF

Publication Date: 2018-04

Variant appearance in text: RET: D842V

PubMed Link: 29436711

Variant Present in the following documents:

• Main text

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A robust targeted sequencing approach for low input and variable quality DNA from clinical samples.

Npj Genomic Medicine

So, Austin P AP; Vilborg, Anna A; Bouhlal, Yosr Y; Koehler, Ryan T RT; Grimes, Susan M SM; Pouliot, Yannick Y; Mendoza, Daniel D; Ziegle, Janet J; Stein, Jason J; Goodsaid, Federico F; Lucero, Michael Y MY; De La Vega, Francisco M FM; Ji, Hanlee P HP

Publication Date: 2018

Variant appearance in text: RET: Asp842Val

PubMed Link: 29354287

Variant Present in the following documents:

• 41525_2017_41_MOESM1_ESM.pdf

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Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.

Oncotarget

Gudernova, Iva I; Balek, Lukas L; Varecha, Miroslav M; Kucerova, Jana Fialova JF; Kunova Bosakova, Michaela M; Fafilek, Bohumil B; Palusova, Veronika V; Uldrijan, Stjepan S; Trantirek, Lukas L; Krejci, Pavel P

Publication Date: 2017-12-12

Variant appearance in text: RET: D842V

PubMed Link: 29312610

Variant Present in the following documents:

• Main text

View BVdb publication page

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Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.

Scientific Reports

Sako, Yukiya Y; Ninomiya, Kensuke K; Okuno, Yukiko Y; Toyomoto, Masayasu M; Nishida, Atsushi A; Koike, Yuka Y; Ohe, Kenji K; Kii, Isao I; Yoshida, Suguru S; Hashimoto, Naohiro N; Hosoya, Takamitsu T; Matsuo, Masafumi M; Hagiwara, Masatoshi M

Publication Date: 2017-05-30

Variant appearance in text: RET: D842V

PubMed Link: 28555643

Variant Present in the following documents:

View BVdb publication page

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Principles of Kinase Inhibitor Therapy for Solid Tumors.

Annals Of Surgery

Cohen, Noah A NA; Kim, Teresa S TS; DeMatteo, Ronald P RP

Publication Date: 2017-02

Variant appearance in text: RET: D842V

PubMed Link: 27058947

Variant Present in the following documents:

• Main text

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Mutation profiling in chinese patients with metastatic colorectal cancer and its correlation with clinicopathological features and anti-EGFR treatment response.

Oncotarget

Li, Zhe-Zhen ZZ; Wang, Feng F; Zhang, Zi-Chen ZC; Wang, Fang F; Zhao, Qi Q; Zhang, Dong-Sheng DS; Wang, Feng-Hua FH; Wang, Zhi-Qiang ZQ; Luo, Hui-Yan HY; He, Ming-Ming MM; Wang, De-Shen DS; Jin, Ying Y; Ren, Chao C; Qiu, Miao-Zhen MZ; Ren, Jian J; Pan, Zhi-Zhong ZZ; Li, Yu-Hong YH; Shao, Jiao-Yong JY; Xu, Rui-Hua RH

Publication Date: 2016-05-10

Variant appearance in text: RET: D842V

PubMed Link: 27050078

Variant Present in the following documents:

• oncotarget-07-28356.pdf

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Nature

Najm, Fadi J FJ; Madhavan, Mayur M; Zaremba, Anita A; Shick, Elizabeth E; Karl, Robert T RT; Factor, Daniel C DC; Miller, Tyler E TE; Nevin, Zachary S ZS; Kantor, Christopher C; Sargent, Alex A; Quick, Kevin L KL; Schlatzer, Daniela M DM; Tang, Hong H; Papoian, Ruben R; Brimacombe, Kyle R KR; Shen, Min M; Boxer, Matthew B MB; Jadhav, Ajit A; Robinson, Andrew P AP; Podojil, Joseph R JR; Miller, Stephen D SD; Miller, Robert H RH; Tesar, Paul J PJ

Publication Date: 2015-06-11

Variant appearance in text: RET: D842V

PubMed Link: 25896324

Variant Present in the following documents:

• NIHMS665856-supplement-supp_table_2.xlsx, sheet 1

View BVdb publication page

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Small-molecule inhibitors of the receptor tyrosine kinases: promising tools for targeted cancer therapies.

International Journal Of Molecular Sciences

Hojjat-Farsangi, Mohammad M

Publication Date: 2014-08-08

Variant appearance in text: RET: D842V

PubMed Link: 25110867

Variant Present in the following documents:

• Main text

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Crenolanib is a selective type I pan-FLT3 inhibitor.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Smith, Catherine Choy CC; Lasater, Elisabeth A EA; Lin, Kimberly C KC; Wang, Qi Q; McCreery, Melissa Quino MQ; Stewart, Whitney K WK; Damon, Lauren E LE; Perl, Alexander E AE; Jeschke, Grace R GR; Sugita, Mayumi M; Carroll, Martin M; Kogan, Scott C SC; Kuriyan, John J; Shah, Neil P NP

Publication Date: 2014-04-08

Variant appearance in text: RET: D842V

PubMed Link: 24623852

Variant Present in the following documents:

• Main text

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Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin.

Molecular Cancer

Jin, Yanli Y; Ding, Ke K; Li, Honglin H; Xue, Mengzhu M; Shi, Xiaoke X; Wang, Chengyan C; Pan, Jingxuan J

Publication Date: 2014-01-28

Variant appearance in text: RET: D842V

PubMed Link: 24472312

Variant Present in the following documents:

• 1476-4598-13-17.pdf

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Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534).

Plos One

Li, Samuel Q SQ; Cheuk, Adam T AT; Shern, Jack F JF; Song, Young K YK; Hurd, Laura L; Liao, Hongling H; Wei, Jun S JS; Khan, Javed J

Publication Date: 2013

Variant appearance in text: RET: D842V

PubMed Link: 24124571

Variant Present in the following documents:

• pone.0076551.s010.xlsx, sheet 1

View BVdb publication page

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Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Li, Tianhong T; Kung, Hsing-Jien HJ; Mack, Philip C PC; Gandara, David R DR

Publication Date: 2013-03-10

Variant appearance in text: RET: D842V

PubMed Link: 23401433

Variant Present in the following documents:

• Main text

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Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy.

Translational Oncogenomics

Sun, Daochun D; Tainsky, Michael A MA; Haddad, Ramsi R

Publication Date: 2012

Variant appearance in text: RET: D842V

PubMed Link: 22346343

Variant Present in the following documents:

• Main text

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Advances in the surgical management of gastrointestinal stromal tumor.

Advances In Surgery

Chaudhry, Umer I UI; DeMatteo, Ronald P RP

Publication Date: 2011

Variant appearance in text: RET: D842V

PubMed Link: 21954688

Variant Present in the following documents:

• Main text

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Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases.

Cancers

Shih, Andrew J AJ; Telesco, Shannon E SE; Radhakrishnan, Ravi R

Publication Date: 2011-03

Variant appearance in text: RET: D842V

PubMed Link: 21701703

Variant Present in the following documents:

• cancers-03-01195.pdf

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Optimal use of targeted agents for advanced gastrointestinal stromal tumours.

Oncology

Reichardt, Peter P

Publication Date: 2010

Variant appearance in text: RET: D842V

PubMed Link: 20389135

Variant Present in the following documents:

• Main text

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Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.

Blood

Weisberg, Ellen E; Choi, Hwan Geun HG; Ray, Arghya A; Barrett, Rosemary R; Zhang, Jianming J; Sim, Taebo T; Zhou, Wenjun W; Seeliger, Markus M; Cameron, Michael M; Azam, Mohammed M; Fletcher, Jonathan A JA; Debiec-Rychter, Maria M; Mayeda, Mark M; Moreno, Daisy D; Kung, Andrew L AL; Janne, Pasi Antero PA; Khosravi-Far, Roya R; Melo, Junia V JV; Manley, Paul W PW; Adamia, Sophia S; Wu, Catherine C; Gray, Nathanael N; Griffin, James D JD

Publication Date: 2010-05-27

Variant appearance in text: RET: D842V

PubMed Link: 20299508

Variant Present in the following documents:

• Main text

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Fluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors.

Current Chemical Genomics

Kupcho, Kevin R KR; Bruinsma, Rica R; Hallis, Tina M TM; Lasky, David A DA; Somberg, Richard L RL; Turek-Etienne, Tammy T; Vogel, Kurt W KW; Huwiler, Kristin G KG

Publication Date: 2008-02-25

Variant appearance in text: RET: D842V

PubMed Link: 20161827

Variant Present in the following documents:

• Main text

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Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

Angiogenesis

Gotink, Kristy J KJ; Verheul, Henk M W HM

Publication Date: 2010-03

Variant appearance in text: RET: D842V

PubMed Link: 20012482

Variant Present in the following documents:

• Main text

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Sequence and structure signatures of cancer mutation hotspots in protein kinases.

Plos One

Dixit, Anshuman A; Yi, Lin L; Gowthaman, Ragul R; Torkamani, Ali A; Schork, Nicholas J NJ; Verkhivker, Gennady M GM

Publication Date: 2009-10-16

Variant appearance in text: RET: D842V

PubMed Link: 19834613

Variant Present in the following documents:

• Main text
• pone.0007485.pdf

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