Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration.
Molecular Therapy. Nucleic Acids
Fernandes, Hugo H; Zonnari, Alessandra A; Abreu, Ricardo R; Aday, Sezin S; Barão, Marta M; Albino, Inês I; Lino, Miguel M; Branco, Ana A; Seabra, Cátia C; Barata, Tânia T; Leal, Ermelindo C EC; Tralhão, José Guilherme JG; Gonçalves, Lino L; de Jong, Alwin A; Peters, Hendrika A B HAB; de Vries, Margreet R MR; da Costa Martins, Paula P; Quax, Paul H A PHA; Ferreira, Lino L
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discovery
Weiss, Andreas A; Lorthiois, Edwige E; Barys, Louise L; Beyer, Kim S KS; Bomio-Confaglia, Claudio C; Burks, Heather H; Chen, Xueying X; Cui, Xiaoming X; de Kanter, Ruben R; Dharmarajan, Lekshmi L; Fedele, Carmine C; Gerspacher, Marc M; Guthy, Daniel Alexander DA; Head, Victoria V; Jaeger, Ashley A; Núñez, Eloísa Jiménez EJ; Kearns, Jeffrey D JD; Leblanc, Catherine C; Maira, Sauveur-Michel SM; Murphy, Jason J; Oakman, Helen H; Ostermann, Nils N; Ottl, Johannes J; Rigollier, Pascal P; Roman, Danielle D; Schnell, Christian C; Sedrani, Richard R; Shimizu, Toshio T; Stringer, Rowan R; Vaupel, Andrea A; Voshol, Hans H; Wessels, Peter P; Widmer, Toni T; Wilcken, Rainer R; Xu, Kun K; Zecri, Frederic F; Farago, Anna F AF; Cotesta, Simona S; Brachmann, Saskia M SM
Transcriptional kinetics and molecular functions of long noncoding RNAs.
Nature Genetics
Johnsson, Per P; Ziegenhain, Christoph C; Hartmanis, Leonard L; Hendriks, Gert-Jan GJ; Hagemann-Jensen, Michael M; Reinius, Björn B; Sandberg, Rickard R
Follicular Helper T-Cell-Based Classification of Endometrial Cancer Promotes Precise Checkpoint Immunotherapy and Provides Prognostic Stratification.
Frontiers In Immunology
Chen, Yi Y; You, Shuwen S; Li, Jie J; Zhang, Yifan Y; Kokaraki, Georgia G; Epstein, Elisabeth E; Carlson, Joseph J; Huang, Wen-Kuan WK; Haglund, Felix F
H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans.
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum.
Journal Of Extracellular Vesicles
Santos, Mark F MF; Rappa, Germana G; Karbanová, Jana J; Fontana, Simona S; Bella, Maria Antonietta Di MAD; Pope, Marshall R MR; Parrino, Barbara B; Cascioferro, Stella Maria SM; Vistoli, Giulio G; Diana, Patrizia P; Cirrincione, Girolamo G; Arena, Goffredo O GO; Woo, Gyunghwi G; Huang, Kevin K; Huynh, Tony T; Moschetti, Marta M; Alessandro, Riccardo R; Corbeil, Denis D; Lorico, Aurelio A
Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.
Plos Genetics
Aiderus, Aziz A; Newberg, Justin Y JY; Guzman-Rojas, Liliana L; Contreras-Sandoval, Ana M AM; Meshey, Amanda L AL; Jones, Devin J DJ; Amaya-Manzanares, Felipe F; Rangel, Roberto R; Ward, Jerrold M JM; Lee, Song-Choon SC; Ban, Kenneth Hon-Kim KH; Rogers, Keith K; Rogers, Susan M SM; Selvanesan, Luxmanan L; McNoe, Leslie A LA; Copeland, Neal G NG; Jenkins, Nancy A NA; Tsai, Kenneth Y KY; Black, Michael A MA; Mann, Karen M KM; Mann, Michael B MB
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
Cancer Discovery
Leibold, Josef J; Ruscetti, Marcus M; Cao, Zhen Z; Ho, Yu-Jui YJ; Baslan, Timour T; Zou, Min M; Abida, Wassim W; Feucht, Judith J; Han, Teng T; Barriga, Francisco M FM; Tsanov, Kaloyan M KM; Zamechek, Leah L; Kulick, Amanda A; Amor, Corina C; Tian, Sha S; Rybczyk, Katarzyna K; Salgado, Nelson R NR; Sánchez-Rivera, Francisco J FJ; Watson, Philip A PA; de Stanchina, Elisa E; Wilkinson, John E JE; Dow, Lukas E LE; Abate-Shen, Cory C; Sawyers, Charles L CL; Lowe, Scott W SW
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Nature Communications
Jiang, Yao Y; Zhang, Yanqiong Y; Leung, Janet Y JY; Fan, Cheng C; Popov, Konstantin I KI; Su, Siyuan S; Qian, Jiayi J; Wang, Xiaodong X; Holtzhausen, Alisha A; Ubil, Eric E; Xiang, Yang Y; Davis, Ian I; Dokholyan, Nikolay V NV; Wu, Gang G; Perou, Charles M CM; Kim, William Y WY; Earp, H Shelton HS; Liu, Pengda P
Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.
Cancer Discovery
Fischer, Grant M GM; Jalali, Ali A; Kircher, David A DA; Lee, Won-Chul WC; McQuade, Jennifer L JL; Haydu, Lauren E LE; Joon, Aron Y AY; Reuben, Alexandre A; de Macedo, Mariana P MP; Carapeto, Fernando C L FCL; Yang, Chendong C; Srivastava, Anuj A; Ambati, Chandrashekar R CR; Sreekumar, Arun A; Hudgens, Courtney W CW; Knighton, Barbara B; Deng, Wanleng W; Ferguson, Sherise D SD; Tawbi, Hussein A HA; Glitza, Isabella C IC; Gershenwald, Jeffrey E JE; Vashisht Gopal, Y N YN; Hwu, Patrick P; Huse, Jason T JT; Wargo, Jennifer A JA; Futreal, P Andrew PA; Putluri, Nagireddy N; Lazar, Alexander J AJ; DeBerardinis, Ralph J RJ; Marszalek, Joseph R JR; Zhang, Jianjun J; Holmen, Sheri L SL; Tetzlaff, Michael T MT; Davies, Michael A MA
Genome-Informed Targeted Therapy for Osteosarcoma.
Cancer Discovery
Sayles, Leanne C LC; Breese, Marcus R MR; Koehne, Amanda L AL; Leung, Stanley G SG; Lee, Alex G AG; Liu, Heng-Yi HY; Spillinger, Aviv A; Shah, Avanthi T AT; Tanasa, Bogdan B; Straessler, Krystal K; Hazard, Florette K FK; Spunt, Sheri L SL; Marina, Neyssa N; Kim, Grace E GE; Cho, Soo-Jin SJ; Avedian, Raffi S RS; Mohler, David G DG; Kim, Mi-Ok MO; DuBois, Steven G SG; Hawkins, Douglas S DS; Sweet-Cordero, E Alejandro EA
Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Nagle, Alison M AM; Levine, Kevin M KM; Tasdemir, Nilgun N; Scott, Julie A JA; Burlbaugh, Kara K; Kehm, Justin J; Katz, Tiffany A TA; Boone, David N DN; Jacobsen, Britta M BM; Atkinson, Jennifer M JM; Oesterreich, Steffi S; Lee, Adrian V AV
PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.
Cancer Discovery
Kim, Seong M SM; Nguyen, Tricia T TT; Ravi, Archna A; Kubiniok, Peter P; Finicle, Brendan T BT; Jayashankar, Vaishali V; Malacrida, Leonel L; Hou, Jue J; Robertson, Jane J; Gao, Dong D; Chernoff, Jonathan J; Digman, Michelle A MA; Potma, Eric O EO; Tromberg, Bruce J BJ; Thibault, Pierre P; Edinger, Aimee L AL
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.
Ebiomedicine
Nogués, Laura L; Reglero, Clara C; Rivas, Verónica V; Salcedo, Alicia A; Lafarga, Vanesa V; Neves, Maria M; Ramos, Paula P; Mendiola, Marta M; Berjón, Alberto A; Stamatakis, Kostas K; Zhou, Xiao Zhen XZ; Lu, Kun Ping KP; Hardisson, David D; Mayor, Federico F; Penela, Petronila P
Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.
Cancer Immunology Research
Holtzhausen, Alisha A; Zhao, Fei F; Evans, Kathy S KS; Tsutsui, Masahito M; Orabona, Ciriana C; Tyler, Douglas S DS; Hanks, Brent A BA
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.
Science Signaling
Kusne, Yael Y; Carrera-Silva, Eugenio A EA; Perry, Anthony S AS; Rushing, Elisabeth J EJ; Mandell, Edward K EK; Dietrich, Justin D JD; Errasti, Andrea E AE; Gibbs, Daniel D; Berens, Michael E ME; Loftus, Joseph C JC; Hulme, Christopher C; Yang, Weiwei W; Lu, Zhimin Z; Aldape, Kenneth K; Sanai, Nader N; Rothlin, Carla V CV; Ghosh, Sourav S
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Molecular Systems Biology
Vizeacoumar, Franco J FJ; Arnold, Roland R; Vizeacoumar, Frederick S FS; Chandrashekhar, Megha M; Buzina, Alla A; Young, Jordan T F JT; Kwan, Julian H M JH; Sayad, Azin A; Mero, Patricia P; Lawo, Steffen S; Tanaka, Hiromasa H; Brown, Kevin R KR; Baryshnikova, Anastasia A; Mak, Anthony B AB; Fedyshyn, Yaroslav Y; Wang, Yadong Y; Brito, Glauber C GC; Kasimer, Dahlia D; Makhnevych, Taras T; Ketela, Troy T; Datti, Alessandro A; Babu, Mohan M; Emili, Andrew A; Pelletier, Laurence L; Wrana, Jeff J; Wainberg, Zev Z; Kim, Philip M PM; Rottapel, Robert R; O'Brien, Catherine A CA; Andrews, Brenda B; Boone, Charles C; Moffat, Jason J