Publications:

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PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway.

Aging

Zhao, Jing J; Yin, Linlin L; Jiang, Lin L; Hou, Li L; He, Ling L; Zhang, Chunyan C

Publication Date: 2021-06-10

Variant appearance in text: PTEN: K13R

PubMed Link: 34114972

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• Main text
• aging-13-203141.pdf

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The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.

Iscience

Kato, Takashi T; Yamada, Tatsuya T; Nakamura, Hideki H; Igarashi, Atsushi A; Anders, Robert A RA; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2020-10-23

Variant appearance in text: PTEN: K13R

PubMed Link: 33083717

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• Main text
• main.pdf
• mmc1.pdf

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PTEN in Autism and Neurodevelopmental Disorders.

Cold Spring Harbor Perspectives In Medicine

Rademacher, Sebastian S; Eickholt, Britta J BJ

Publication Date: 2019-11-01

Variant appearance in text: PTEN: K13R

PubMed Link: 31427284

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Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.

The Journal Of Biological Chemistry

Igarashi, Atsushi A; Itoh, Kie K; Yamada, Tatsuya T; Adachi, Yoshihiro Y; Kato, Takashi T; Murata, Daisuke D; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2018-06-15

Variant appearance in text: PTEN: K13R

PubMed Link: 29735527

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Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.

Oncogene

Yang, Jr-M JM; Schiapparelli, P P; Nguyen, H-N HN; Igarashi, A A; Zhang, Q Q; Abbadi, S S; Amzel, L M LM; Sesaki, H H; Quiñones-Hinojosa, A A; Iijima, M M

Publication Date: 2017-06-29

Variant appearance in text: PTEN: K13R

PubMed Link: 28263967

Variant Present in the following documents:

• Main text
• onc2016493a.pdf

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Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.

The Journal Of Biological Chemistry

Gupta, Amit A; Leslie, Nicholas R NR

Publication Date: 2016-08-26

Variant appearance in text: PTEN: K13R

PubMed Link: 27405757

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Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.

Plos One

Stumpf, Miriam M; Blokzijl-Franke, Sasja S; den Hertog, Jeroen J

Publication Date: 2016

Variant appearance in text: PTEN: K13R

PubMed Link: 27138341

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Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.

Scientific Reports

Nguyen, Hoai-Nghia HN; Yang, Jr-Ming JM; Miyamoto, Takafumi T; Itoh, Kie K; Rho, Elmer E; Zhang, Qiang Q; Inoue, Takanari T; Devreotes, Peter N PN; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2015-07-28

Variant appearance in text: PTEN: K13R

PubMed Link: 26216063

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PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.

Nature Communications

Lee, Min-Sik MS; Jeong, Man-Hyung MH; Lee, Hyun-Woo HW; Han, Hyun-Ji HJ; Ko, Aram A; Hewitt, Stephen M SM; Kim, Jae-Hoon JH; Chun, Kyung-Hee KH; Chung, Joon-Yong JY; Lee, Cheolju C; Cho, Hanbyoul H; Song, Jaewhan J

Publication Date: 2015-07-17

Variant appearance in text: PTEN: K13R

PubMed Link: 26183061

Variant Present in the following documents:

• ncomms8769-s1.pdf

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A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Plos One

Gil, Anabel A; Rodríguez-Escudero, Isabel I; Stumpf, Miriam M; Molina, María M; Cid, Víctor J VJ; Pulido, Rafael R

Publication Date: 2015

Variant appearance in text: PTEN: Lys13Arg

PubMed Link: 25875300

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Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Zhang, Shu S; Taghibiglou, Changiz C; Girling, Kimberly K; Dong, Zhifang Z; Lin, Shinn-Zong SZ; Lee, Wei W; Shyu, Woei-cherng WC; Wang, Yu Tian YT

Publication Date: 2013-05-01

Variant appearance in text: PTEN: K13R

PubMed Link: 23637190

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Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane.

Cellular Microbiology

Knodler, Leigh A LA; Winfree, Seth S; Drecktrah, Dan D; Ireland, Robin R; Steele-Mortimer, Olivia O

Publication Date: 2009-11

Variant appearance in text: PTEN: K13R

PubMed Link: 19614667

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• Main text
• cmi0011-1652.pdf

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Phosphorylation keeps PTEN phosphatase closed for business.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ross, Alonzo H AH; Gericke, Arne A

Publication Date: 2009-02-03

Variant appearance in text: PTEN: K13R

PubMed Link: 19174524

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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Rahdar, Meghdad M; Inoue, Takanari T; Meyer, Tobias T; Zhang, Jin J; Vazquez, Francisca F; Devreotes, Peter N PN

Publication Date: 2009-01-13

Variant appearance in text: PTEN: K13R

PubMed Link: 19114656

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Ubiquitination regulates PTEN nuclear import and tumor suppression.

Cell

Trotman, Lloyd C LC; Wang, Xinjiang X; Alimonti, Andrea A; Chen, Zhenbang Z; Teruya-Feldstein, Julie J; Yang, Haijuan H; Pavletich, Nikola P NP; Carver, Brett S BS; Cordon-Cardo, Carlos C; Erdjument-Bromage, Hediye H; Tempst, Paul P; Chi, Sung-Gil SG; Kim, Hyo-Jong HJ; Misteli, Tom T; Jiang, Xuejun X; Pandolfi, Pier Paolo PP

Publication Date: 2007-01-12

Variant appearance in text: PTEN: K13R

PubMed Link: 17218261

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