PTEN c.118G>A ;(p.E40K)

Variant ID: 10-89653820-G-A

NM_000314.4(PTEN):c.118G>A;(p.E40K)

This variant was identified in 14 publications

View GRCh38 version.




Publications:


Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.

Acta Pharmaceutica Sinica. B
Zhou, Yujun Y; Tang, Jingshu J; Lan, Jiaqi J; Zhang, Yong Y; Wang, Hongyue H; Chen, Qiuyu Q; Kang, Yuying Y; Sun, Yang Y; Feng, Xinhong X; Wu, Lei L; Jin, Hongtao H; Chen, Shizhong S; Peng, Ying Y
Publication Date: 2023-02

Variant appearance in text: PTEN: E40K
PubMed Link: 36873166
Variant Present in the following documents:
  • main.pdf
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Concordance analysis of microsatellite instability status between polymerase chain reaction based testing and next generation sequencing for solid tumors.

Scientific Reports
Shimozaki, Keitaro K; Hayashi, Hideyuki H; Tanishima, Shigeki S; Horie, Sara S; Chida, Akihiko A; Tsugaru, Kai K; Togasaki, Kazuhiro K; Kawasaki, Kenta K; Aimono, Eriko E; Hirata, Kenro K; Nishihara, Hiroshi H; Kanai, Takanori T; Hamamoto, Yasuo Y
Publication Date: 2021-10-08

Variant appearance in text: PTEN: E40K
PubMed Link: 34625576
Variant Present in the following documents:
  • Main text
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Concordance analysis of microsatellite instability status between polymerase chain reaction based testing and next generation sequencing for solid tumors.

Scientific Reports
Shimozaki, Keitaro K; Hayashi, Hideyuki H; Tanishima, Shigeki S; Horie, Sara S; Chida, Akihiko A; Tsugaru, Kai K; Togasaki, Kazuhiro K; Kawasaki, Kenta K; Aimono, Eriko E; Hirata, Kenro K; Nishihara, Hiroshi H; Kanai, Takanori T; Hamamoto, Yasuo Y
Publication Date: 2021-10-08

Variant appearance in text: PTEN: E40K
PubMed Link: 34625576
Variant Present in the following documents:
  • Main text
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Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K.

Biomolecules
Yudushkin, Ivan I
Publication Date: 2019-02-16

Variant appearance in text: PTEN: E40K
PubMed Link: 30781447
Variant Present in the following documents:
  • Main text
  • biomolecules-09-00067.pdf
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Molecular and structural transition mechanisms in long-term volume overload.

European Journal Of Heart Failure
Mohamed, Belal A BA; Schnelle, Moritz M; Khadjeh, Sara S; Lbik, Dawid D; Herwig, Melissa M; Linke, Wolfgang A WA; Hasenfuss, Gerd G; Toischer, Karl K
Publication Date: 2016-04

Variant appearance in text: PTEN: E40K
PubMed Link: 26694078
Variant Present in the following documents:
  • Main text
  • EJHF-18-362.pdf
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The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

Cancer Biology & Therapy
Madhunapantula, SubbaRao V SV; Mosca, Paul J PJ; Robertson, Gavin P GP
Publication Date: 2011-12-15

Variant appearance in text: PTEN: E40K
PubMed Link: 22157148
Variant Present in the following documents:
  • Main text
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Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.

Molecular And Cellular Biology
Lee, Angel W AW; Mao, Yingwei Y; Penninger, Josef M JM; Yu, Soojie S
Publication Date: 2011-11

Variant appearance in text: PTEN: E40K
PubMed Link: 21930791
Variant Present in the following documents:
  • Main text
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Therapeutic Implications of Targeting AKT Signaling in Melanoma.

Enzyme Research
Madhunapantula, Subbarao V SV; Robertson, Gavin P GP
Publication Date: 2011-03-23

Variant appearance in text: PTEN: E40K
PubMed Link: 21461351
Variant Present in the following documents:
  • Main text
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Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.

The Journal Of Cell Biology
Catalucci, Daniele D; Zhang, Deng-Hong DH; DeSantiago, Jaime J; Aimond, Franck F; Barbara, Guillaume G; Chemin, Jean J; Bonci, Désiré D; Picht, Eckard E; Rusconi, Francesca F; Dalton, Nancy D ND; Peterson, Kirk L KL; Richard, Sylvain S; Bers, Donald M DM; Brown, Joan Heller JH; Condorelli, Gianluigi G
Publication Date: 2009-03-23

Variant appearance in text: PTEN: E40K
PubMed Link: 19307602
Variant Present in the following documents:
  • Main text
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Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations.

The Journal Of Biological Chemistry
Rodríguez-Escudero, Isabel I; Andrés-Pons, Amparo A; Pulido, Rafael R; Molina, María M; Cid, Víctor J VJ
Publication Date: 2009-05-15

Variant appearance in text: PTEN: E40K
PubMed Link: 19307184
Variant Present in the following documents:
  • Main text
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Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

Cancer Research
Cheung, Mitchell M; Sharma, Arati A; Madhunapantula, SubbaRao V SV; Robertson, Gavin P GP
Publication Date: 2008-05-01

Variant appearance in text: PTEN: E40K
PubMed Link: 18451171
Variant Present in the following documents:
  • Main text
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FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis.

Biochimica Et Biophysica Acta
Jagani, Zainab Z; Singh, Amrik A; Khosravi-Far, Roya R
Publication Date: 2008-01

Variant appearance in text: PTEN: E40K
PubMed Link: 17980712
Variant Present in the following documents:
  • Main text
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Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer.

Molecular And Cellular Biology
Zhang, Guoxin G; He, Bin B; Weber, Georg F GF
Publication Date: 2003-09

Variant appearance in text: PTEN: E40K
PubMed Link: 12944477
Variant Present in the following documents:
  • Main text
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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Condorelli, Gianluigi G; Drusco, Alessandra A; Stassi, Giorgio G; Bellacosa, Alfonso A; Roncarati, Roberta R; Iaccarino, Guido G; Russo, Matteo A MA; Gu, Yusu Y; Dalton, Nancy N; Chung, Clarence C; Latronico, Michael V G MV; Napoli, Claudio C; Sadoshima, Junichi J; Croce, Carlo M CM; Ross, John J
Publication Date: 2002-09-17

Variant appearance in text: PTEN: E40K
PubMed Link: 12237475
Variant Present in the following documents:
  • Main text
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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.

Molecular Biology Of The Cell
Edinger, Aimee L AL; Thompson, Craig B CB
Publication Date: 2002-07

Variant appearance in text: PTEN: E40K
PubMed Link: 12134068
Variant Present in the following documents:
  • Main text
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