The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.
Cells
Garrido, Jose Antonio Ma G JAMG; Alcantara, Krizelle Mae M KMM; Danac, Joshua Miguel C JMC; Serrano, Fidel Emmanuel C FEC; Cutiongco-de la Paz, Eva Maria EM; Garcia, Reynaldo L RL
The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.
Cells
Garrido, Jose Antonio Ma G JAMG; Alcantara, Krizelle Mae M KMM; Danac, Joshua Miguel C JMC; Serrano, Fidel Emmanuel C FEC; Cutiongco-de la Paz, Eva Maria EM; Garcia, Reynaldo L RL
A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation.
Plos Genetics
Ganguly, Payel P; Madonsela, Landiso L; Chao, Jesse T JT; Loewen, Christopher J R CJR; O'Connor, Timothy P TP; Verheyen, Esther M EM; Allan, Douglas W DW
Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction.
Nature Communications
Post, Kathryn L KL; Belmadani, Manuel M; Ganguly, Payel P; Meili, Fabian F; Dingwall, Riki R; McDiarmid, Troy A TA; Meyers, Warren M WM; Herrington, Caitlin C; Young, Barry P BP; Callaghan, Daniel B DB; Rogic, Sanja S; Edwards, Matthew M; Niciforovic, Ana A; Cau, Alessandro A; Rankin, Catharine H CH; O'Connor, Timothy P TP; Bamji, Shernaz X SX; Loewen, Christopher J R CJR; Allan, Douglas W DW; Pavlidis, Paul P; Haas, Kurt K
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
Cell Reports
Chatterjee, Nilanjana N; Pazarentzos, Evangelos E; Mayekar, Manasi K MK; Gui, Philippe P; Allegakoen, David V DV; Hrustanovic, Gorjan G; Olivas, Victor V; Lin, Luping L; Verschueren, Erik E; Johnson, Jeffrey R JR; Hofree, Matan M; Yan, Jenny J JJ; Newton, Billy W BW; Dollen, John V JV; Earnshaw, Charles H CH; Flanagan, Jennifer J; Chan, Elton E; Asthana, Saurabh S; Ideker, Trey T; Wu, Wei W; Suzuki, Junji J; Barad, Benjamin A BA; Kirichok, Yuriy Y; Fraser, James S JS; Weiss, William A WA; Krogan, Nevan J NJ; Tulpule, Asmin A; Sabnis, Amit J AJ; Bivona, Trever G TG
Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.
American Journal Of Human Genetics
Smith, Iris Nira IN; Thacker, Stetson S; Seyfi, Marilyn M; Cheng, Feixiong F; Eng, Charis C
Hu, Qingsong Q; Li, Chunlai C; Wang, Shouyu S; Li, Yajuan Y; Wen, Bo B; Zhang, Yanyan Y; Liang, Ke K; Yao, Jun J; Ye, Youqiong Y; Hsiao, Heidi H; Nguyen, Tina K TK; Park, Peter K PK; Egranov, Sergey D SD; Hawke, David H DH; Marks, Jeffrey R JR; Han, Leng L; Hung, Mien-Chie MC; Zhang, Bing B; Lin, Chunru C; Yang, Liuqing L
Fricano-Kugler, Catherine J CJ; Getz, Stephanie A SA; Williams, Michael R MR; Zurawel, Ashley A AA; DeSpenza, Tyrone T; Frazel, Paul W PW; Li, Meijie M; O'Malley, Alistair J AJ; Moen, Erika L EL; Luikart, Bryan W BW
Shnitsar, Iryna I; Bashkurov, Mikhail M; Masson, Glenn R GR; Ogunjimi, Abiodun A AA; Mosessian, Sherly S; Cabeza, Eduardo Aguiar EA; Hirsch, Calley L CL; Trcka, Daniel D; Gish, Gerald G; Jiao, Jing J; Wu, Hong H; Winklbauer, Rudolf R; Williams, Roger L RL; Pelletier, Laurence L; Wrana, Jeffrey L JL; Barrios-Rodiles, Miriam M
A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.
Nature Communications
Conde-Perez, Alejandro A; Gros, Gwendoline G; Longvert, Christine C; Pedersen, Malin M; Petit, Valérie V; Aktary, Zackie Z; Viros, Amaya A; Gesbert, Franck F; Delmas, Véronique V; Rambow, Florian F; Bastian, Boris C BC; Campbell, Andrew D AD; Colombo, Sophie S; Puig, Isabel I; Bellacosa, Alfonso A; Sansom, Owen O; Marais, Richard R; Van Kempen, Leon C L T LC; Larue, Lionel L
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
Oncogene
Davidson, L L; Maccario, H H; Perera, N M NM; Yang, X X; Spinelli, L L; Tibarewal, P P; Glancy, B B; Gray, A A; Weijer, C J CJ; Downes, C P CP; Leslie, N R NR