Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss.
Cell Death & Disease
Mejía-Hernández, Javier Octavio JO; Keam, Simon P SP; Saleh, Reem R; Muntz, Fenella F; Fox, Stephen B SB; Byrne, David D; Kogan, Arielle A; Pang, Lokman L; Huynh, Jennifer J; Litchfield, Cassandra C; Caramia, Franco F; Lozano, Guillermina G; He, Hua H; You, James M JM; Sandhu, Shahneen S; Williams, Scott G SG; Haupt, Ygal Y; Haupt, Sue S
Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target.
Cancers
Gillson, Josef J; Abd El-Aziz, Yomna S YS; Leck, Lionel Y W LYW; Jansson, Patric J PJ; Pavlakis, Nick N; Samra, Jaswinder S JS; Mittal, Anubhav A; Sahni, Sumit S
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response.
Genes & Development
Kundu, Samrat T ST; Rodriguez, B Leticia BL; Gibson, Laura A LA; Warner, Amanda N AN; Perez, Mabel G MG; Bajaj, Rakhee R; Fradette, Jared J JJ; Class, Caleb A CA; Solis, Luisa M LM; Rojas Alvarez, Frank R FR; Wistuba, Ignacio I II; Diao, Lixia L; Chen, Fengju F; Sachdeva, Mohit M; Wang, Jing J; Kirsch, David G DG; Creighton, Chad J CJ; Gibbons, Don L DL
The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids.
Cancers
Low, Ronnie Ren Jie RRJ; Lim, Wei Wen WW; Nguyen, Paul M PM; Lee, Belinda B; Christie, Michael M; Burgess, Antony W AW; Gibbs, Peter P; Grimmond, Sean M SM; Hollande, Frédéric F; Putoczki, Tracy L TL
Synoradzki, Kamil Jozef KJ; Bartnik, Ewa E; Czarnecka, Anna M AM; Fiedorowicz, Michał M; Firlej, Wiktoria W; Brodziak, Anna A; Stasinska, Agnieszka A; Rutkowski, Piotr P; Grieb, Paweł P
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.
Frontiers In Cell And Developmental Biology
Hartmann, Oliver O; Reissland, Michaela M; Maier, Carina R CR; Fischer, Thomas T; Prieto-Garcia, Cristian C; Baluapuri, Apoorva A; Schwarz, Jessica J; Schmitz, Werner W; Garrido-Rodriguez, Martin M; Pahor, Nikolett N; Davies, Clare C CC; Bassermann, Florian F; Orian, Amir A; Wolf, Elmar E; Schulze, Almut A; Calzado, Marco A MA; Rosenfeldt, Mathias T MT; Diefenbacher, Markus E ME
Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer.
Laboratory Investigation; A Journal Of Technical Methods And Pathology
Singh, Kanchan K; Pruski, Melissa M; Bland, Rachael R; Younes, Mamoun M; Guha, Sushovan S; Thosani, Nirav N; Maitra, Anirban A; Cash, Brooks D BD; McAllister, Florencia F; Logsdon, Craig D CD; Chang, Jeffrey T JT; Bailey-Lundberg, Jennifer M JM
Bone morphogenetic protein 7 promotes resistance to immunotherapy.
Nature Communications
Cortez, Maria Angelica MA; Masrorpour, Fatemeh F; Ivan, Cristina C; Zhang, Jie J; Younes, Ahmed I AI; Lu, Yue Y; Estecio, Marcos R MR; Barsoumian, Hampartsoum B HB; Menon, Hari H; Caetano, Mauricio da Silva MDS; Ramapriyan, Rishab R; Schoenhals, Jonathan E JE; Wang, Xiaohong X; Skoulidis, Ferdinandos F; Wasley, Mark D MD; Calin, George G; Hwu, Patrick P; Welsh, James W JW
Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.
Nature Communications
Li, Yinghua Y; Li, Bo B; Li, Wei W; Wang, Yuan Y; Akgül, Seçkin S; Treisman, Daniel M DM; Heist, Kevin A KA; Pierce, Brianna R BR; Hoff, Benjamin B; Ho, Cheng-Ying CY; Ferguson, David O DO; Rehemtulla, Alnawaz A; Zheng, Siyuan S; Ross, Brian D BD; Li, Jun Z JZ; Zhu, Yuan Y
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.
Plos Genetics
Kim, Olga O; Park, Eun Young EY; Klinkebiel, David L DL; Pack, Svetlana D SD; Shin, Yong-Hyun YH; Abdullaev, Zied Z; Emerson, Robert E RE; Coffey, Donna M DM; Kwon, Sun Young SY; Creighton, Chad J CJ; Kwon, Sanghoon S; Chang, Edmund C EC; Chiang, Theodore T; Yatsenko, Alexander N AN; Chien, Jeremy J; Cheon, Dong-Joo DJ; Yang-Hartwich, Yang Y; Nakshatri, Harikrishna H; Nephew, Kenneth P KP; Behringer, Richard R RR; Fernández, Facundo M FM; Cho, Chi-Heum CH; Vanderhyden, Barbara B; Drapkin, Ronny R; Bast, Robert C RC; Miller, Kathy D KD; Karpf, Adam R AR; Kim, Jaeyeon J
Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers.
Iscience
Pedrote, Murilo M MM; Motta, Michelle F MF; Ferretti, Giulia D S GDS; Norberto, Douglas R DR; Spohr, Tania C L S TCLS; Lima, Flavia R S FRS; Gratton, Enrico E; Silva, Jerson L JL; de Oliveira, Guilherme A P GAP
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell Reports
Blagih, Julianna J; Zani, Fabio F; Chakravarty, Probir P; Hennequart, Marc M; Pilley, Steven S; Hobor, Sebastijan S; Hock, Andreas K AK; Walton, Josephine B JB; Morton, Jennifer P JP; Gronroos, Eva E; Mason, Susan S; Yang, Ming M; McNeish, Iain I; Swanton, Charles C; Blyth, Karen K; Vousden, Karen H KH